DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and Scn10a

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_001192250.1 Gene:Scn10a / 20264 MGIID:108029 Length:1958 Species:Mus musculus


Alignment Length:1822 Identity:446/1822 - (24%)
Similarity:744/1822 - (40%) Gaps:481/1822 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            :|::.:..|.||:....:.....|...:.:||:.|||.:.         :|.|.:|||..   |.
Mouse   109 ALWLFSPFNLIRRTAIKVSVHSWFSIFITVTILVNCVCMT---------RTDLPEKLEYA---FT 161

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLR---TLRAIRVL 143
            .::..||.:||||.|..|::.:|||:.||.:||.|:...:      :|..:|||   .||..|||
Mouse   162 VVYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAY------VGAAIDLRGISGLRTFRVL 220

  Fly   144 RPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKL 208
            |.||.||.||.|:|::.::|.::..|..:.:|.:|.:.:||::||:.:.|.|         .||.
Mouse   221 RALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFALVGLQLFKGNL---------KNKC 276

  Fly   209 VKEGESETPCNTDNILEKATGS----------FVCNNTTS--------MCLEKWEGPNSGITSFD 255
            :|.|..  |...||:..:..|.          .:|.|.:.        :|.:..:.|:...||||
Mouse   277 IKNGTD--PHKADNLSSEMAGDIFIKPGTTDPLLCGNGSDAGHCPNDYVCRKTSDNPDFNYTSFD 339

  Fly   256 NIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKER 320
            :..:|.|::|:.:|.:.|..:...|..|.|..: .::||.:|.:|||:::||:|.|::..:.::.
Mouse   340 SFAWAFLSLFRLMTQDSWERLYQQTLRASGKMY-MVFFVLVIFLGSFYLVNLILAVVTMAYEEQS 403

  Fly   321 EKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHI-MEARRRNAAKRK-K 383
            :..        :...:..|::....:|.:.|.:||:.|....|.....|. .....:||.:|: :
Mouse   404 QAT--------IAEIEAKEKKFKEALEVLQKEQEVLAALGIDTTSLYSHNGSPLAPKNANERRPR 460

  Fly   384 LKSLGKSKSTDTEEEEAEEDYG--------------------------------------DDGYL 410
            :||.....|||.......:.|.                                      |||..
Mouse   461 VKSRMSEGSTDDNRSLQSDPYNQRRMSFLGLSSGRRRASHSSVFHFRAPSQDVSFPDGILDDGVF 525

  Fly   411 K-----------------------------------------TRSKPQGS-CTGF---------- 423
            .                                         .|..|.|. .||.          
Mouse   526 HGDQESRRSSILLGRGAGQAGPLPRSPLPQSPNPGPRRGEEGQRGVPTGELATGAPEGPALDAAG 590

  Fly   424 -------------WRAE-------------------------------------------KRFRF 432
                         :||:                                           |:|:.
Mouse   591 QKNFLSADYLNEPFRAQRAMSVVSIMTSVIEELEESKLKCPPCLISLAQKYLIWECCPKWKKFKM 655

  Fly   433 WIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGP 497
            .:...|...:....:.:.:.:|||.:|:|||.........|.....:|...|..||..|:.|..|
Mouse   656 VLFELVTDPFAELTITLCIVVNTVFMAMEHYPMTDAFDAMLQAGNIVFTVFFTMEMAFKIIAFDP 720

  Fly   498 RIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLN 562
            ..||:..:|.||||:::.|:.|:  |..|.||  |||||..||||:||:.|.|.:|..|:..:.|
Mouse   721 YYYFQKKWNIFDCVIVTVSLLEL--STSKKGS--LSVLRTFRLLRVFKLAKSWPTLNMLIKIIGN 781

  Fly   563 SMRSIISLLFLLFLFILIFALLGMQLFGGQFNL-PGGTPETN-----------FNTFPIALLTVF 615
            |:.::.:|.|:|.:.:.||||:|.||....:.. ..|....|           |::|    |.||
Mouse   782 SVGALGNLTFILAIIVFIFALVGKQLLSENYGCRRDGISVWNGERLRWHMCDFFHSF----LVVF 842

  Fly   616 QILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAE 680
            :||.|| |.|.|:   :....:|..:..:::..|:|| ||..:||:|:|:.: |..:|..|||.|
Mouse   843 RILCGE-WIENMW---VCMEVSQDYICLTLFLTVMVL-GNLVVLNLFIALLL-NSFSADNLTAPE 901

  Fly   681 EE-------------------------------------QVE----------------------- 685
            ::                                     :||                       
Mouse   902 DDGEVNNLQVALARIQVFGHRASRAITSYIRSHCRLRWPKVETQLGMKPPLTSCKAENHIATDAV 966

  Fly   686 ----------------------------------EDKEKQLQELEKEMEALQADGVHVENGDGA- 715
                                              .:.|..|.|||:::|.........|:..|. 
Mouse   967 NAAVGNLAKPALGGPKENHGDFITDPNVWVSVPIAEGESDLDELEEDVEHASQSSWQEESPKGQQ 1031

  Fly   716 --------------------------VAP----------------------SKSKGKKKEEEKKE 732
                                      :||                      |.|:|...:....|
Mouse  1032 ELLQQVQKCEDHQAARSPPSGMSSEDLAPYLGERWQREESPRVPAEGVDDTSSSEGSTVDCPDPE 1096

  Fly   733 E---------EEVTEGPKPMLP------------YSSMFILSPTNPIRRGAHWVVNLPYFDFFIM 776
            |         ||:.| |....|            .:|.|..:....:|:..:.:|...:|:.||:
Mouse  1097 EILRKIPELAEELDE-PDDCFPEGCTRRCPCCKVNTSKFPWATGWQVRKTCYRIVEHSWFESFII 1160

  Fly   777 VVISMSSIALAAEDP-VRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNI 840
            .:|.:||.|||.||. :.|..|...:|.|.|..||.:|..|||||.|..|.    ..|....|..
Mouse  1161 FMILLSSGALAFEDNYLEEKPRVKSVLEYTDRVFTFIFVFEMLLKWVAYGF----KKYFTNAWCW 1221

  Fly   841 MDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVV 905
            :|.::|..:..|.   ::......::::||:||.||.||||:.:.|...::.|.|.:|.::.:::
Mouse  1222 LDFLIVNISLTSL---IAKILEYSDVASIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIM 1283

  Fly   906 NILIVYILFQFIFSVIGVQLFNGKFFYCTDESKH-----------TSAEC-----QGSYFKYEED 954
            |:|:|.::|..|||::||.||.|||..|.|...:           ..::|     .|.:|     
Mouse  1284 NVLLVCLIFWLIFSIMGVNLFAGKFSRCVDTRSNPFSVVNSTFVTNKSDCYNQNNTGHFF----- 1343

  Fly   955 ELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIF 1019
                      |.....::||||...|.|..|.|.:||..:    |.|..:.|........|.|::
Mouse  1344 ----------WVNVKVNFDNVAMGYLALLQVATFKGWMDI----MYAAVDSRDINSQPNWEESLY 1394

  Fly  1020 YIVYFIVF----PFFFVNIFVALIIITF-QEQGEAELQDGEIDKNQKSCIDF--TIGARPLERYM 1077
            ..:||:||    .||.:|:||.:||..| |::.:...||..:.:.||...:.  .:|::..::.:
Mouse  1395 MYLYFVVFIIFGGFFTLNLFVGVIIDNFNQQKKKIRGQDIFMTEEQKKYYNAMKKLGSKKPQKPI 1459

  Fly  1078 PKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVET 1142
            |:..|.::..|:.||....|:..||.||..|.:.:|::..||.:...|.|..||..|..:|:.|.
Mouse  1460 PRPLNKYQGFVFDIVTRQAFDIIIMALICLNMITMMVETDNQSEEKTKVLGRINQFFVAVFTGEC 1524

  Fly  1143 VLKIIGFGVKN-FFKDPWNIFDLITVL--------GSIVDALWMEFGSNSINVGFLRLFRAARLI 1198
            |:|:  |.::. :|.:.||:||.|.|:        .:|:.:|...|....:.|  :||.|..|::
Mouse  1525 VMKM--FALRQYYFTNGWNVFDFIVVILSISSLLFSAILSSLESYFSPTLLRV--IRLARIGRIL 1585

  Fly  1199 KLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQS 1263
            :|:|....||.||:..:.|..||..:.||:.::.|||:|.||..|.|:   ..|..|....||::
Mouse  1586 RLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMASFANV---IDEAGIDDMFNFKT 1647

  Fly  1264 FIQGVMLLFRCATGEAWPNIMLACLK--GKACDDDAEKAPGE--YCGS-TLAYAYFVSFIFFCSF 1323
            |...::.||:..|...|..::...|.  ...||.:...:.|.  .||| .:...:|.::|.....
Mouse  1648 FGNSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNRPNSNGSKGNCGSPAVGILFFTTYIIISFL 1712

  Fly  1324 LMLNLFVAVIMDNFDYLTRDSS-ILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLG 1387
            :::|:::|||::||:..|.:|: .|.....|.|...|.::||.||..|.::.:.|....:..||.
Mouse  1713 IVVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFIAFSALSDFADTLSGPLR 1777

  Fly  1388 FGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMD--QADMELRETIT 1450
            ...  ||:   ..||:|::||....::.....|||..:..|.    ...|:|  :.:||.:...|
Mouse  1778 IPK--PNQ---NILIQMDLPLVPGDKIHCLDILFAFTKNVLG----ESGELDSLKTNMEEKFMAT 1833

  Fly  1451 NI 1452
            |:
Mouse  1834 NL 1835

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 90/307 (29%)
Ion_trans 441..677 CDD:334124 81/247 (33%)
Ion_trans 769..1050 CDD:334124 93/302 (31%)
Ion_trans 1094..1345 CDD:334124 78/264 (30%)
GPHH 1346..1416 CDD:339854 19/69 (28%)
Ca_chan_IQ 1418..1492 CDD:337190 10/37 (27%)
Scn10aNP_001192250.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 27..54
I. /evidence=ECO:0000305 116..404 93/317 (29%)
Ion_trans 147..406 CDD:278921 84/288 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 444..483 10/38 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 539..583 5/43 (12%)
II. /evidence=ECO:0000305 646..910 88/277 (32%)
Ion_trans 681..893 CDD:278921 77/225 (34%)
Na_trans_assoc 903..1148 CDD:284034 25/245 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1006..1094 12/87 (14%)
III. /evidence=ECO:0000305 1141..1450 99/334 (30%)
Ion_trans 1170..1428 CDD:278921 86/283 (30%)
Na_channel_gate 1420..1472 CDD:240441 10/51 (20%)
IV. /evidence=ECO:0000305 1459..1758 91/305 (30%)
Ion_trans 1494..1733 CDD:278921 72/245 (29%)
GPHH 1743..1800 CDD:293510 18/61 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1901..1958
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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