DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and unc-2

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	NP_001355464.1	Gene:	unc-2 / 180570	WormBaseID:	WBGene00006742	Length:	2171	Species:	Caenorhabditis elegans

Alignment Length:	2108	Identity:	1090/2108 - (51%)
Similarity:	1352/2108 - (64%)	Gaps:	241/2108 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PKKEENPPGGGPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTV 68
            |.||:     ||:||||..|||.||:..:.||||.||||.:|||||.|||||::|:|||..||..
Worm   223 PVKEK-----GPSSLFIFAEDNIIRRNAKAIIEWGPFEYFILLTIIGNCVVLSMEQHLPKNDKKA 282

  Fly    69 LAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYP------- 126
            |::.||:||.||:.|||:|..||::|.|..|||.||||:.||||||.|||:|.:|..|
Worm   283 LSEWLERTEPYFMGIFCLECVLKVIAFGFALHKGSYLRSGWNIMDFIVVVSGVVTMLPFSPATQT 347

  Fly   127 --QIGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLE 189
              |....||||||||:||||||||||||||||||||||:.||||||||||||||||:||||||||
Worm   348 ANQPVDSVDLRTLRAVRVLRPLKLVSGIPSLQVVLKSILCAMAPLLQIGLLVLFAIIIFAIIGLE 412

  Fly   190 FYSGALHKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSF 254
            |||||.|..||:  :..::....|...||....   ...|.:.|:...:.||:||.|||.|||||
Worm   413 FYSGAFHSACYN--ERGEIENVSERPMPCTNKT---SPMGVYNCDVKGTTCLQKWIGPNYGITSF 472

  Fly   255 DNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKE 319
            |||||||:||||||||||||.::|:|||:|||.:||.||:||||:||||||||||||||||||||
Worm   473 DNIGFAMITVFQCITMEGWTTVMYYTNDSLGSTYNWAYFIPLIVLGSFFMLNLVLGVLSGEFAKE 537

  Fly   320 REKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKL 384
            ||:||||:||||||||||:|||||||:|||..||||||.|:|||||||..|||||||  |..|||
Worm   538 RERVENRREFLKLRRQQQIERELNGYLEWILTAEEVILKEDRTTEEEKAAIMEARRR--AANKKL 600

  Fly   385 KSLGKSKSTDTE------EEEAEEDYGDDGYLK----TRSKPQGSCTGFWRAEKRFRFWIRHTVK 439
            |...|.:||:||      |:|.||:|.|:|...    ...|.:|.|....:..|:.|..||..||
Worm   601 KQASKQQSTETEEDFEEDEDEMEEEYVDEGGTVEDEFAERKKRGCCHSVGKFIKQLRIQIRIMVK 665

  Fly   440 TQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESS 504
            ||.|||.||.||||||.|||.||||||.:.|:||.||||:|||:|:.||.:|::|:|.|.||.|.
Worm   666 TQIFYWSVITLVFLNTCCVASEHYGQPQWFTDFLKYAEFVFLGIFVVEMLLKLFAMGSRTYFASK 730

  Fly   505 FNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIIS 569
            |||||||||.||..||||:||.|||||:||:||||||||||:|.||.||||||.||:||||||||
Worm   731 FNRFDCVVIVGSAAEVIWAEVYGGSFGISVMRALRLLRIFKLTSYWVSLRNLVRSLMNSMRSIIS 795

  Fly   570 LLFLLFLFILIFALLGMQLFGGQFNLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQ 634
            ||||||||||||||||||||||:||.|...|.|:|:|||:||:||||||||||||||||..|.||
Worm   796 LLFLLFLFILIFALLGMQLFGGRFNFPTMHPYTHFDTFPVALITVFQILTGEDWNEVMYLAIESQ 860

  Fly   635 GGAQK-GMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKE 698
            ||... |..|||||||||||||||||||||||||||||||||||||||   .::|..:::|..:|
Worm   861 GGIYSGGWPYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEE---ADEKANEIEEESEE 922

  Fly   699 MEALQADGVH----VEN---GD-GAVAPSKSKGKKKEEEKKEEEEVTEGPKPMLPYSSMFILSPT 755
            ::....:|.|    :|.   || .|||.:..   ..:||.:|||....|||||:||||||.||||
Worm   923 LDEQYQEGDHCTIDMEGKTAGDMCAVARAMD---DLDEECEEEESPFGGPKPMVPYSSMFFLSPT 984

  Fly   756 NPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLK 820
            ||.|...|.:|...||:..:|.||.:||::|||||||.|.:.|||:|.|.||.|||||..|||||
Worm   985 NPFRVLIHSIVCTKYFEMMVMTVICLSSVSLAAEDPVDEENPRNKVLQYMDYCFTGVFACEMLLK 1049

  Fly   821 IVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIK 885
            ::|.|::||||||.|:||||:|.:||.||..:|||..:..|||:||:||||||||||||||||||
Worm  1050 LIDQGILLHPGSYCRDFWNILDGIVVTCALFAFGFAGTEGSAGKNLNTIKSLRVLRVLRPLKTIK 1114

  Fly   886 RVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFK 950
            |:|||||||||||||||||.||||||.||||||:||.|||||||||:|||:::..:..|.|.:|.
Worm  1115 RIPKLKAVFDCVVNSLKNVFNILIVYFLFQFIFAVIAVQLFNGKFFFCTDKNRKFANTCHGQFFV 1179

  Fly   951 YEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIE 1015
            |:.....|:.|.|.|:.|.|:|||...||||||.|.||||||.:.|:||..|:||:||...||:|
Worm  1180 YDNQNDPPRVEQREWRLRPFNYDNTINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVE 1244

  Fly  1016 MSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKN 1080
            :::||:::||||||||||||||||||||||||||||.:|::|||||.||||.:.|||...:||::
Worm  1245 VALFYVMFFIVFPFFFVNIFVALIIITFQEQGEAELSEGDLDKNQKQCIDFALNARPRSLFMPED 1309

  Fly  1081 RNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLK 1145
            :|:.||::||:|.|.|||||||.:|..|||:|||||:|....||:.|:..|...|.:|:||::||
Worm  1310 KNSTKYRIWRLVTSPPFEYFIMTMICCNTLILMMKYYNNPLFYEEILRLFNTALTAVFTVESILK 1374

  Fly  1146 IIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGSNSINVGFLRLFRAARLIKLLRQGYTIRIL 1210
            |:.|||:|:|:|.||.||.:||:|||.|||..|||.:.:::||||||||||||:||:||||||||
Worm  1375 ILAFGVRNYFRDGWNRFDFVTVVGSITDALVTEFGGHFVSLGFLRLFRAARLIRLLQQGYTIRIL 1439

  Fly  1211 LWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCA 1275
            ||||||||||||||||||.||||||||:||||||||.|... ..|.||||||||...|:||||||
Worm  1440 LWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVFGNIWLNAA-TEINRHNNFQSFFNAVILLFRCA 1503

  Fly  1276 TGEAWPNIMLACLKGKAC------DDDAEKAPGEYCGSTLAYAYFVSFIFFCSFLMLNLFVAVIM 1334
            |||.|.:||:|.::||.|      :.:.||  |:.|||.::||||.||:|..|||||||||||||
Worm  1504 TGEGWQDIMMAAVQGKDCARAGSAEINFEK--GQTCGSNVSYAYFTSFVFLSSFLMLNLFVAVIM 1566

  Fly  1335 DNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYK 1399
            ||||||||||||||.||||||:|:||:|||.|||:|||:|||:||:.|.||:|||.|||.|||||
Worm  1567 DNFDYLTRDSSILGPHHLDEFIRVWADYDPAATGRIHYSEMYEMLRIMAPPVGFGKKCPYRLAYK 1631

  Fly  1400 KLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKK-MLNL 1463
            .|||||||:.::..|.|||||||||||:||||||..||||:||.|||.|:..||||:||| |::|
Worm  1632 HLIRMNMPVAEDGTVHFTTTLFALIRESLSIKMRPVEEMDEADEELRLTLKKIWPLKAKKNMVDL 1696

  Fly  1464 LVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDASRHPSQESLTGADAGHL 1528
            :|||:.:|...||:|||||||.||||::|:.:                         :|.:.|
Worm  1697 VVPPNHELCFQKLTVGKIYAGLLILENYRARK-------------------------SGTEVG-- 1734

  Fly  1529 HPGHSYMNGHRRSPSLRHNGSPLARSPSPRRRGHQYIHHDIGFSDTVSNVVEMVKETRH--PRHG 1591
              |.....|..||         |..:.......|.            |:..:..:||..  |:|.
Worm  1735 --GQGLFGGGLRS---------LVAAAKAAESQHS------------SHTPQPPEETTPIIPQHA 1776

  Fly  1592 NSHPRYPRGSWSASTSPARSPSPSRYGGHLSRSKRTQLPYPTYGTTSLCQRSRSPSPARLQEMRE 1656
            ......|  :.||..|..:....|..||        |.||..:  .|.....:|...
Worm  1777 QQFSAAP--TMSAQGSLQQMQGTSSGGG--------QRPYSLF--NSFVDTIKSGKQ-------- 1821

  Fly  1657 RDRLGYGIDMGVTHVQH-SYPTLASRRAGIGRRLPPTPSKPSTLQLKPTNINFPKLNASPTHTHH 1720
                    |..||.||: |......:....||||....||             .:...|..|..|
Worm  1822 --------DGDVTDVQYQSVDQQHEKMNSTGRRLSDMFSK-------------IRRGTSADHNPH 1865

  Fly  1721 STPHSV------HSLPHHRDLLR----DPRDMY-YSSRERERDRERLRDRDRDRDRD---RLHEY 1771
            .|.|.:      .|.|.:|.:.|    .|.:.| :..|.|.......|...:...||   |.:.|
Worm  1866 QTEHLLAQDNRSPSSPRYRSMARASPPSPAERYGHPPRYRTESPPSSRSEYQMSIRDPIIRRNRY 1930

  Fly  1772 DLRYEYRDRERELYERERDREREVERER----LEYIAPLSFEQALAMGRTGRVLPSPVLNGFKPK 1832
            :.....|......|.:::.::::...::    |::....:::......|
Worm  1931 NTMEHSRSSHDPQYHQDQQQQQQPHHQQHSQHLQHSHHKTYQNHNQYSR---------------- 1979

  Fly  1833 SGLNPRHSD--SDEEDWCXQRLXLRSRNRKDQIWVXHQAICSSLSAPNLDHNFDTIRHSYQIPE- 1894
               :|.:||  |..|.:..:|...|.::...|                     |.......:|.
Worm  1980 ---SPIYSDDSSVAESYRREREFRRYQDSTPQ---------------------DVSEDDDPMPTA 2020

  Fly  1895 -HLQNLPYLCP-PVHQHQHQHQTQTQNQRQHQDQHLYQRYGTNVSTPKLGTTIS-DIKLAGVSLQ 1956
             ..:.||.:.. |.| ::..:|..:.|      |||...||       |||... |...:.
Worm  2021 VRARRLPLISTMPTH-YESAYQPSSYN------QHLNDSYG-------LGTGYQRDYHTSH---- 2067

  Fly  1957 ELSPNRQPQSQQKQEQQLHQDGWLRWYRQSGPYGSPVMASLPETRATSP--HSDIEFIRTMKRSE 2019
              |.:..|.|||:|.|.::....|...|.|..|.:|..:...|..:.||  :.......:.:|..
Worm  2068 --SHSHHPTSQQQQHQPMYSTSPLISPRSSHSYYTPRSSQYYEIPSPSPDIYPSYRGSASPRRYP 2130

  Fly  2020 TGTTAITPRTTKTEAMIL-----SVPIT 2042
            |.|..:.|....:.|.::     |:|::
Worm  2131 TSTVVVAPDREGSSARVIQAQPGSIPLS 2158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	191/295 (65%)
		Ion_trans	441..677	CDD:334124	182/236 (77%)
		Ion_trans	769..1050	CDD:334124	184/280 (66%)
		Ion_trans	1094..1345	CDD:334124	168/256 (66%)
		GPHH	1346..1416	CDD:339854	48/69 (70%)
		Ca_chan_IQ	1418..1492	CDD:337190	51/74 (69%)
unc-2	NP_001355464.1	Ion_trans	254..536	CDD:366146	184/286 (64%)
		Ion_trans	667..904	CDD:366146	182/236 (77%)
		Ion_trans	998..1279	CDD:366146	184/280 (66%)
		Ion_trans	1323..1577	CDD:366146	168/256 (66%)
		GPHH	1586..1639	CDD:374878	38/52 (73%)
		Ca_chan_IQ	1650..1726	CDD:370105	51/75 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159854
Domainoid	1	1.000	391	1.000	Domainoid score	I400
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20184
Inparanoid	1	1.050	1847	1.000	Inparanoid score	I23
Isobase	1	0.950	-	0	Normalized mean entropy	S4478
OMA	1	1.010	-	-		QHG56527
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0000179
OrthoInspector	1	1.000	-	-		oto19394
orthoMCL	1	0.900	-	-		OOG6_100303
Panther	1	1.100	-	-	LDO	PTHR45628
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	1	1.000	-	-		X841
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890