DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and pkd-2

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	NP_502838.3	Gene:	pkd-2 / 178424	WormBaseID:	WBGene00004035	Length:	716	Species:	Caenorhabditis elegans

Alignment Length:	943	Identity:	183/943 - (19%)
Similarity:	314/943 - (33%)	Gaps:	326/943 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   666 AVDNLANAQELTAAEE-----------EQVEEDKEKQLQELEKEMEALQADGVHVENGDGAVAPS 719
            |.:..||..:..||.|           |:.|.||:|         ...|.:|:.......|....
Worm     6 ADERWANPPQPVAAAEHGPSFDHSMVSEEYEHDKKK---------NPAQKEGISFSQALLASGHE 61

  Fly   720 KSKGKKKEEEKKEEEEVTEGPKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSI 784
            ||.||.|                         |:..:.:..|.:.|        |::|::   .:
Worm    62 KSDGKIK-------------------------LTARSFMEVGGYAV--------FLIVLV---YV 90

  Fly   785 ALAAEDPVRENSRR----NKILNYFDYAFTGVF------TIEMLLKIVD-LGVILHPGSYLREFW 838
            |.|      :||.:    :|:::....|.||..      :...:..|.| |..:|.||.|    |
Worm    91 AFA------QNSIQSYYYSKVMSDLFVASTGASGAPAFGSCTSMDNIWDWLSQVLIPGIY----W 145

  Fly   839 NIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKS-------LRVLRVLRP----LKTIKRVPKLKA 892
            .                :.|.|:..:|:...::       :|:|:|...    :|:.:|..|
Worm   146 T----------------ETSNSTDNENMIYYENRLLGEPRIRMLKVTNDSCTVMKSFQREIK--- 191

  Fly   893 VFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGK---FFYCTDESKH------TSAECQGSY 948
              :|..|..:.:.:           .:::|    :|.   |.|.|.:...      |.|...|..
Worm   192 --ECFANYEEKLED-----------KTMVG----DGSVDAFIYATAKELENLKTVGTIASYGGGG 239

  Fly   949 F--------KYEEDELLPKQELRVW---KPRAFHYD--------NVAAAMLTLFAVQTGEG---W 991
            |        ..|....:...:...|   ..||...|        |:...:..||.:....|   .
Worm   240 FVQRLPVAGSTEAQSAIATLKANRWIDRGSRAIIVDFALYNANINLFCVVKLLFELPASGGVITT 304

  Fly   992 PQVLQHSMAATYEDRGPIQNFRIEMSIF--YIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDG 1054
            |:::.:.: .||:..|..:....| .||  :|:|||                 |:|.
Worm   305 PKLMTYDL-LTYQTSGGTRMMIFE-GIFCGFILYFI-----------------FEEL-------- 342

  Fly  1055 EIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQ 1119
                       |.||         ::|..:..:.|.:|        .::|:.|:...:::.
Worm   343 -----------FAIG---------RHRLHYLTQFWNLV--------DVVLLGFSVATIILS---- 375

  Fly  1120 GDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGSNS- 1183
                      :|...||   |..|..:|..|:.|   .|   ||.:|            ...||
Worm   376 ----------VNRTKTG---VNRVNSVIENGLTN---AP---FDDVT------------SSENSY 409

  Fly  1184 INVGFLRLFRA-ARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIK 1247
            :|:....:|.| .::.|.:....|:..|..|..:|.|.:....::.|:.||.:|..|...||
Worm   410 LNIKACVVFVAWVKVFKFISVNKTMSQLSSTLTRSAKDIGGFAVMFAVFFFAFAQFGYLCFG--- 471

  Fly  1248 LGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGSTLAYA 1312
                    |:..::.:.......|.|...|                  |...:..|.|......|
Worm   472 --------TQIADYSNLYNSAFALLRLILG------------------DFNFSALESCNRFFGPA 510

  Fly  1313 YFVSFIFFCSFLMLNLFVAVIMDNF----DYLTRDSSILGAHHLDEF---VRIWAEYD--PNATG 1368
            :|::::||.||::||:|:|:|.|::    ..|.|...  |...||.|   ||...:..  |:|.|
Worm   511 FFIAYVFFVSFILLNMFLAIINDSYVEVKAELARKKD--GEGILDWFMNKVRGLTKRGKRPDAPG 573

  Fly  1369 KIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMR 1433
            :   ...|:..|.|....|:..|..|    :...|.|:       ...|..:...:.|:::.::.
Worm   574 E---DATYEDYKLMLYRAGYAEKDIN----EAFTRFNV-------TSMTEHVPEKVAEDIADEVA 624

  Fly  1434 APEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLS-VGKIYAGFLILESWRSTRFG 1497
            ...|..:..||......|         ||..|   ||:.:...| |.:|......|::....|..
Worm   625 RMTEQKRNYMENHRDYAN---------LNRRV---DQMQESVFSIVDRIEGVNATLQTIEKQRVQ 677

  Fly  1498 QLDSG--MPMLEL--------QDASRHPSQESL 1520
            |.|.|  |.:..|        :.|:|.|:..|:
Worm   678 QQDGGNLMDLSALLTNQVRNRESAARRPTITSI 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124
		Ion_trans	441..677	CDD:334124	3/10 (30%)
		Ion_trans	769..1050	CDD:334124	60/335 (18%)
		Ion_trans	1094..1345	CDD:334124	53/256 (21%)
		GPHH	1346..1416	CDD:339854	17/74 (23%)
		Ca_chan_IQ	1418..1492	CDD:337190	14/74 (19%)
pkd-2	NP_502838.3	PKD_channel	119..538	CDD:285288	107/577 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910