DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and egl-19

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_001023079.1 Gene:egl-19 / 177513 WormBaseID:WBGene00001187 Length:1877 Species:Caenorhabditis elegans


Alignment Length:2011 Identity:828/2011 - (41%)
Similarity:1109/2011 - (55%) Gaps:288/2011 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 PKKEENPPGGGPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTV 68
            |.::.|.......||..|:.:|||||....|:||.|||:.:|..|.|||:.||:.:..|..|...
 Worm    54 PLRQTNVVERSERSLLCLSLNNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDY 118

  Fly    69 LAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFM-TQYPQIGPE- 131
            ....||..|..|:.:|.:|..|||:|:|.:.|..:||||.|||:||.:||.|.: |...::..: 
 Worm   119 KNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG 183

  Fly   132 VDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALH 196
            .|::.|||.||||||:||||:|||||||.:|::||.|||.|.|||||.|:|:||||||.:.|.||
 Worm   184 FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 248

  Fly   197 KTCYSLEDPNKLVKEGESETPCNTDNILEKATGS-FVCNNTTSM--------CLEK--WEGPNSG 250
            .||.   ||.......:..|||.||     ..|| |.|..:.|:        |...  |.|||:|
 Worm   249 STCI---DPATGQLAQKDPTPCGTD-----TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNG 305

  Fly   251 ITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGE 315
            ||:|||.|.||||||||:::||||.::||.|||:|..:.|||||.|:::||||:|||||||||||
 Worm   306 ITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGE 370

  Fly   316 FAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAK 380
            |:|||||...|..|.|.|.:||||.:|.||::||.:||::....|...|:|              
 Worm   371 FSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE-------------- 421

  Fly   381 RKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAEK---RFRFWIRHTVKTQW 442
              .:......:..|.|.||..||.          :|........|.||   |.|...|..||:|.
 Worm   422 --PVAQTVVGEEADEEGEERVEDV----------RPSKWAARMKRLEKLNRRCRRACRRLVKSQT 474

  Fly   443 FYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNR 507
            |||.||:||.|||:.:..|||||..:|..|...|...|:.||..||.:|||:||...|..|.|||
 Worm   475 FYWLVILLVLLNTLVLTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNR 539

  Fly   508 FDCVVISGSIFE---VIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIIS 569
            |||.|:..||.|   |.:..:|  ..|:||||:.||||||||||||:||||||.|||||:|||||
 Worm   540 FDCFVVISSILEFVLVYFDLMK--PLGVSVLRSARLLRIFKVTKYWTSLRNLVSSLLNSLRSIIS 602

  Fly   570 LLFLLFLFILIFALLGMQLFGGQFNL----PGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQG 630
            ||.||||||:||||||||:|||:||.    |  .|..||:||..|||||||||||||||.|||.|
 Worm   603 LLLLLFLFIVIFALLGMQVFGGKFNFNPQQP--KPRANFDTFVQALLTVFQILTGEDWNTVMYHG 665

  Fly   631 IISQGG-AQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQLQE 694
            |.|.|| ...|:|..||:|||.:.|||.||||||||||||||:|..||.||:|:.:::.|.:.:|
 Worm   666 IESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNAEKEEEQQEIEGEDEE 730

  Fly   695 LEKEMEALQADGVHVENGDGAVAPSKSKGKKKEEEKKEEEEVTEGPKPMLPYSSMFILSPTNPIR 759
            .|:..:..:..|:....||..:..::.:       :..|.......||:...||:||||.||..|
 Worm   731 FEEGEDEGEEHGMDEPEGDEEMTSARPR-------RMSEVPAASTVKPIPKASSLFILSHTNSFR 788

  Fly   760 RGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDL 824
            ...:.|||..||...::..|.:||..||||||::.||.||.|||||||.||.|||:|:.||::..
 Worm   789 VFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVF 853

  Fly   825 GVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPK 889
            |::.|.||:.|..:|::|.:||..:..||......      :|.:|.||||||||||:.|.|...
 Worm   854 GLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDA------MSVVKILRVLRVLRPLRAINRAKG 912

  Fly   890 LKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEE- 953
            ||.|..||:.::|.:.||::|..:.||:|::||||||.|.||.|.|.||.|.|||:|.|..||: 
 Worm   913 LKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDG 977

  Fly   954 DELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSI 1018
            |...|..:.|||....|::|||..||::||.|.|.|||||:|..::.:..||:|||.|.|..:::
 Worm   978 DPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVAL 1042

  Fly  1019 FYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNT 1083
            |:|.:.||..||.:||||..:|:|||.:||.|.::.|:||||:.||:|.:.|:|..||:|:||  
 Worm  1043 FFIAFIIVIAFFMMNIFVGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR-- 1105

  Fly  1084 FKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIG 1148
            .:|:||..|.|..|||.|.::||.||:.|..|::.....:|..|...|:.|||:|:.|.||||:.
 Worm  1106 LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVA 1170

  Fly  1149 FGVKNFFKDPWNIFDLITVLGSIVDALWMEF---GSNSINVGFLRLFRAARLIKLLRQGYTIRIL 1210
            ...||:..|.||:|||:.|:||.:|..:.:.   |:|.|::.|.||||..||:|||.:|..||.|
 Worm  1171 LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTL 1235

  Fly  1211 LWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCA 1275
            ||||::||:|||||.|||.:||||||:||||.||.:.|.. ..||.|:|||.||...:::|||.|
 Worm  1236 LWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDD-STSIHRNNNFHSFPAAILVLFRSA 1299

  Fly  1276 TGEAWPNIMLAC--LKGKACD---DDAEKA--PGEYCGSTLAYAYFVSFIFFCSFLMLNLFVAVI 1333
            |||||.:|||:|  .:...||   ||..|.  ....||:..||.||:||...||||::|||||||
 Worm  1300 TGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVI 1364

  Fly  1334 MDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAY 1398
            ||||||||||.||||.|||:||||:|:||||:|.|:|.:.::..:|:.:.||||||..||:|||.
 Worm  1365 MDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLAC 1429

  Fly  1399 KKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNL 1463
            |:|:.|||||:.:..|.|..|||||:|.||  |:.....:|:|:.:||..|..||....|.:|:.
 Worm  1430 KRLVSMNMPLNSDGTVCFNATLFALVRTNL--KIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDE 1492

  Fly  1464 LVPPSDQLNKGKLSVGKIYAGFLILESWRSTRF---------GQLDSGMPM-LELQDASR--HPS 1516
            :|||:.:  :..::|||.||.|||.:.:|  ||         |.|.:..|. :.||...|  |..
 Worm  1493 VVPPAGK--EDDVTVGKFYATFLIQDYFR--RFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEI 1553

  Fly  1517 QESLTGADAGHLHPGHSYMN---GHRRSPSLRHNGSPLARSPSPRRRGHQYIHHDIGFSDTVSNV 1578
            ...|..|.:|:|....::..   .|||..||.:|                .:|...|..      
 Worm  1554 GPELKRAISGNLETDFNFDEPEPQHRRPHSLFNN----------------LVHRLSGAG------ 1596

  Fly  1579 VEMVKETRHPRHGNSHPRYPRGSWSASTSPARSPSPSRYGGHLSRSKRTQLPYPTYGTTSLCQRS 1643
                  ::.|   ..|.|..:||......| ||.||                     |.||....
 Worm  1597 ------SKSP---TEHERIEKGSTLLPFQP-RSFSP---------------------THSLAGAE 1630

  Fly  1644 RSPSPARLQEMRERDRLGYGIDMGVTHVQHSYPTLASRRAGIGRRLPPTPSKPSTLQLKPTNINF 1708
            .||.|:::..       |..|:..:     :.|.:    .|..||||..|               
 Worm  1631 GSPVPSQMHR-------GAPINQSI-----NLPPV----NGSARRLPALP--------------- 1664

  Fly  1709 PKLNASPTHTHHSTPHSVHSLPHHRDLLRDPRDMYYSSRERERDRERLRDRDRDRDRDRLHEYDL 1773
            |..|    |.|..|...    |.:|| ..|......|||....:|....|.|.:....|......
 Worm  1665 PYAN----HIHDETDDG----PRYRD-TGDRAGYDQSSRMVVANRNLPVDPDEEEQWMRSGGPSN 1720

  Fly  1774 RYEYRD---RERELYERERDREREVERERLEYIAPLSFE------QALAMGRTGRVLP---SPVL 1826
            |.:.|:   ||..|          |.|.....:|.:|.|      :.:..|::.| ||   .|||
 Worm  1721 RSDRRNPHLREPML----------VARGAALALAGMSSEAYEGTYRPVGEGKSVR-LPFSSRPVL 1774

  Fly  1827 NGFKPKSGLNP------------RHSDSDEEDWCXQRLXLRSRNRKDQIWVXHQAICSSLSAPNL 1879
               :|.....|            |::|:        |: ..:|...::.:        ||....:
 Worm  1775 ---RPAEDSRPVDRLIGQSLGLGRYADA--------RIVGAARREIEEAY--------SLGEQEI 1820

  Fly  1880 DHNFDTIRHSYQIPEHLQNLPYLCPPVHQHQHQHQTQTQNQ--------------RQHQDQ 1926
            |...|::                 .|:.||...|..:..|:              |||..:
 Worm  1821 DLAADSL-----------------APLMQHVGMHDIRDINENSRSALLRPAENSSRQHDSR 1864

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 153/299 (51%)
Ion_trans 441..677 CDD:334124 151/243 (62%)
Ion_trans 769..1050 CDD:334124 132/281 (47%)
Ion_trans 1094..1345 CDD:334124 134/260 (52%)
GPHH 1346..1416 CDD:339854 38/69 (55%)
Ca_chan_IQ 1418..1492 CDD:337190 29/73 (40%)
egl-19NP_001023079.1 Ion_trans 105..379 CDD:278921 144/281 (51%)
Ion_trans 493..714 CDD:278921 141/224 (63%)
Ion_trans 815..1074 CDD:278921 127/264 (48%)
Ion_trans 1134..1376 CDD:278921 125/242 (52%)
GPHH 1384..1447 CDD:293510 32/62 (52%)
Ca_chan_IQ 1449..1521 CDD:285917 30/77 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.850

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