Protein Alignment cac and egl-19

DIOPT Version :10

• Sequence 1: NP_001356945.1
• Gene: cac / 32158
• FlyBaseID: FBgn0263111
• Length: 2110
• Species: Drosophila melanogaster
• Sequence 2: NP_001023079.1
• Gene: egl-19 / 177513
• WormBaseID: WBGene00001187
• Length: 1877
• Species: Caenorhabditis elegans
• Alignment Length: 2011
• Identity: 828/2011 - (41%)
• Similarity: 1109/2011 - (55%)
• Gaps: 288/2011 - (14%)

  Fly     4 PKKEENPPGGGPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTV 68
            |.::.|.......||..|:.:|||||....|:||.|||:.:|..|.|||:.||:.:..|..|...
 Worm    54 PLRQTNVVERSERSLLCLSLNNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDY 118

  Fly    69 LAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFM-TQYPQIGPE- 131
            ....||..|..|:.:|.:|..|||:|:|.:.|..:||||.|||:||.:||.|.: |...::..:
 Worm   119 KNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQG 183

  Fly   132 VDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALH 196
            .|::.|||.||||||:||||:|||||||.:|::||.|||.|.|||||.|:|:||||||.:.|.||
 Worm   184 FDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLH 248

  Fly   197 KTCYSLEDPNKLVKEGESETPCNTDNILEKATGS-FVCNNTTSM--------CLEK--WEGPNSG 250
            .||.   ||.......:..|||.||     ..|| |.|..:.|:        |...  |.|||:|
 Worm   249 STCI---DPATGQLAQKDPTPCGTD-----TEGSAFKCQPSDSLTNMGVRWECSSNTTWPGPNNG 305

  Fly   251 ITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGE 315
            ||:|||.|.||||||||:::||||.::||.|||:|..:.|||||.|:::||||:|||||||||||
 Worm   306 ITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGE 370

  Fly   316 FAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAK 380
            |:|||||...|..|.|.|.:||||.:|.||::||.:||::....|...|:|
 Worm   371 FSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDE-------------- 421

  Fly   381 RKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAEK---RFRFWIRHTVKTQW 442
              .:......:..|.|.||..||.          :|........|.||   |.|...|..||:|.
 Worm   422 --PVAQTVVGEEADEEGEERVEDV----------RPSKWAARMKRLEKLNRRCRRACRRLVKSQT 474

  Fly   443 FYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNR 507
            |||.||:||.|||:.:..|||||..:|..|...|...|:.||..||.:|||:||...|..|.|||
 Worm   475 FYWLVILLVLLNTLVLTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNR 539

  Fly   508 FDCVVISGSIFE---VIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIIS 569
            |||.|:..||.|   |.:..:|  ..|:||||:.||||||||||||:||||||.|||||:|||||
 Worm   540 FDCFVVISSILEFVLVYFDLMK--PLGVSVLRSARLLRIFKVTKYWTSLRNLVSSLLNSLRSIIS 602

  Fly   570 LLFLLFLFILIFALLGMQLFGGQFNL----PGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQG 630
            ||.||||||:||||||||:|||:||.    |  .|..||:||..|||||||||||||||.|||.|
 Worm   603 LLLLLFLFIVIFALLGMQVFGGKFNFNPQQP--KPRANFDTFVQALLTVFQILTGEDWNTVMYHG 665

  Fly   631 IISQGG-AQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQLQE 694
            |.|.|| ...|:|..||:|||.:.|||.||||||||||||||:|..||.||:|:.:::.|.:.:|
 Worm   666 IESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAIAVDNLADADSLTNAEKEEEQQEIEGEDEE 730

  Fly   695 LEKEMEALQADGVHVENGDGAVAPSKSKGKKKEEEKKEEEEVTEGPKPMLPYSSMFILSPTNPIR 759
            .|:..:..:..|:....||..:..::.:       :..|.......||:...||:||||.||..|
 Worm   731 FEEGEDEGEEHGMDEPEGDEEMTSARPR-------RMSEVPAASTVKPIPKASSLFILSHTNSFR 788

  Fly   760 RGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDL 824
            ...:.|||..||...::..|.:||..||||||::.||.||.|||||||.||.|||:|:.||::..
 Worm   789 VFCNMVVNHSYFTNAVLFCILVSSAMLAAEDPLQANSTRNMILNYFDYFFTSVFTVEITLKVIVF 853

  Fly   825 GVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPK 889
            |::.|.||:.|..:|::|.:||..:..||......      :|.:|.||||||||||:.|.|...
 Worm   854 GLVFHKGSFCRNAFNLLDILVVAVSLTSFVLRTDA------MSVVKILRVLRVLRPLRAINRAKG 912

  Fly   890 LKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEE- 953
            ||.|..||:.::|.:.||::|..:.||:|::||||||.|.||.|.|.||.|.|||:|.|..||:
 Worm   913 LKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIHYEDG 977

  Fly   954 DELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSI 1018
            |...|..:.|||....|::|||..||::||.|.|.|||||:|..::.:..||:|||.|.|..:::
 Worm   978 DPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVAL 1042

  Fly  1019 FYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNT 1083
            |:|.:.||..||.:||||..:|:|||.:||.|.::.|:||||:.||:|.:.|:|..||:|:||
 Worm  1043 FFIAFIIVIAFFMMNIFVGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR-- 1105

  Fly  1084 FKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIG 1148
            .:|:||..|.|..|||.|.::||.||:.|..|::.....:|..|...|:.|||:|:.|.||||:.
 Worm  1106 LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVA 1170

  Fly  1149 FGVKNFFKDPWNIFDLITVLGSIVDALWMEF---GSNSINVGFLRLFRAARLIKLLRQGYTIRIL 1210
            ...||:..|.||:|||:.|:||.:|..:.:.   |:|.|::.|.||||..||:|||.:|..||.|
 Worm  1171 LNPKNYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTL 1235

  Fly  1211 LWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCA 1275
            ||||::||:|||||.|||.:||||||:||||.||.:.|.. ..||.|:|||.||...:::|||.|
 Worm  1236 LWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDD-STSIHRNNNFHSFPAAILVLFRSA 1299

  Fly  1276 TGEAWPNIMLAC--LKGKACD---DDAEKA--PGEYCGSTLAYAYFVSFIFFCSFLMLNLFVAVI 1333
            |||||.:|||:|  .:...||   ||..|.  ....||:..||.||:||...||||::|||||||
 Worm  1300 TGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINLFVAVI 1364

  Fly  1334 MDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAY 1398
            ||||||||||.||||.|||:||||:|:||||:|.|:|.:.::..:|:.:.||||||..||:|||.
 Worm  1365 MDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLAC 1429

  Fly  1399 KKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNL 1463
            |:|:.|||||:.:..|.|..|||||:|.||  |:.....:|:|:.:||..|..||....|.:|:.
 Worm  1430 KRLVSMNMPLNSDGTVCFNATLFALVRTNL--KIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDE 1492

  Fly  1464 LVPPSDQLNKGKLSVGKIYAGFLILESWRSTRF---------GQLDSGMPM-LELQDASR--HPS 1516
            :|||:.:  :..::|||.||.|||.:.:|  ||         |.|.:..|. :.||...|  |..
 Worm  1493 VVPPAGK--EDDVTVGKFYATFLIQDYFR--RFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEI 1553

  Fly  1517 QESLTGADAGHLHPGHSYMN---GHRRSPSLRHNGSPLARSPSPRRRGHQYIHHDIGFSDTVSNV 1578
            ...|..|.:|:|....::..   .|||..||.:|                .:|...|..
 Worm  1554 GPELKRAISGNLETDFNFDEPEPQHRRPHSLFNN----------------LVHRLSGAG------ 1596

  Fly  1579 VEMVKETRHPRHGNSHPRYPRGSWSASTSPARSPSPSRYGGHLSRSKRTQLPYPTYGTTSLCQRS 1643
                  ::.|   ..|.|..:||......| ||.||                     |.||....
 Worm  1597 ------SKSP---TEHERIEKGSTLLPFQP-RSFSP---------------------THSLAGAE 1630

  Fly  1644 RSPSPARLQEMRERDRLGYGIDMGVTHVQHSYPTLASRRAGIGRRLPPTPSKPSTLQLKPTNINF 1708
            .||.|:::..       |..|:..:     :.|.:    .|..||||..|
 Worm  1631 GSPVPSQMHR-------GAPINQSI-----NLPPV----NGSARRLPALP--------------- 1664

  Fly  1709 PKLNASPTHTHHSTPHSVHSLPHHRDLLRDPRDMYYSSRERERDRERLRDRDRDRDRDRLHEYDL 1773
            |..|    |.|..|...    |.:|| ..|......|||....:|....|.|.:....|......
 Worm  1665 PYAN----HIHDETDDG----PRYRD-TGDRAGYDQSSRMVVANRNLPVDPDEEEQWMRSGGPSN 1720

  Fly  1774 RYEYRD---RERELYERERDREREVERERLEYIAPLSFE------QALAMGRTGRVLP---SPVL 1826
            |.:.|:   ||..|          |.|.....:|.:|.|      :.:..|::.| ||   .|||
 Worm  1721 RSDRRNPHLREPML----------VARGAALALAGMSSEAYEGTYRPVGEGKSVR-LPFSSRPVL 1774

  Fly  1827 NGFKPKSGLNP------------RHSDSDEEDWCXQRLXLRSRNRKDQIWVXHQAICSSLSAPNL 1879
               :|.....|            |::|:        |: ..:|...::.:        ||....:
 Worm  1775 ---RPAEDSRPVDRLIGQSLGLGRYADA--------RIVGAARREIEEAY--------SLGEQEI 1820

  Fly  1880 DHNFDTIRHSYQIPEHLQNLPYLCPPVHQHQHQHQTQTQNQ--------------RQHQDQ 1926
            |...|::                 .|:.||...|..:..|:              |||..:
 Worm  1821 DLAADSL-----------------APLMQHVGMHDIRDINENSRSALLRPAENSSRQHDSR 1864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:459842	153/299 (51%)
		Ion_trans	441..677	CDD:459842	151/243 (62%)
		Ion_trans	769..1050	CDD:459842	132/281 (47%)
		Ion_trans	1094..1345	CDD:459842	134/260 (52%)
		GPHH	1354..1407	CDD:465306	28/52 (54%)
		Ca_chan_IQ	1417..1496	CDD:462591	30/78 (38%)
		AF-4	<1512..>1704	CDD:461550	39/196 (20%)
egl-19	NP_001023079.1	Ion_trans	87..379	CDD:459842	153/299 (51%)
		Ion_trans	493..714	CDD:459842	141/224 (63%)
		Ion_trans	797..1074	CDD:459842	132/282 (47%)
		Ion_trans	1116..1376	CDD:459842	134/260 (52%)
		GPHH	1385..1438	CDD:465306	28/52 (54%)
		Ca_chan_IQ	1448..1523	CDD:462591	32/80 (40%)
		CAC1F_C	1545..1827	CDD:465298	82/404 (20%)