Protein Alignment cac and unc-77

DIOPT Version :9

• Sequence 1: NP_001356945.1
• Gene: cac / 32158
• FlyBaseID: FBgn0263111
• Length: 2110
• Species: Drosophila melanogaster
• Sequence 2: NP_001293824.1
• Gene: unc-77 / 177379
• WormBaseID: WBGene00006809
• Length: 1867
• Species: Caenorhabditis elegans
• Alignment Length: 1992
• Identity: 416/1992 - (20%)
• Similarity: 751/1992 - (37%)
• Gaps: 555/1992 - (27%)

  Fly    35 IEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTV-LAQKLE----KTEAYFLCIFCVEASLKILA 94
            :|| ..:.|..:::|..|:      |.|   :|: |.|.|.    ..:...:.||.:::.|:|..
 Worm    86 VEW-ALKIACTISMITVCI------HTP---RTIELFQPLNYIILAADFISVSIFMLDSVLRIHY 140

  Fly    95 LGLVLHKHSYLRNIWNIMDFFVVV---TGFMTQYPQI----GPEVDLR---TLRAIRVLRPLKLV 149
            .|:.....|||.|.|:....|:.:   ..|:....|:    .|.:.|.   ...|||.:||..::
 Worm   141 EGIFRCDSSYLSNRWSQFSVFISIIHLLSFLLHCYQLIDNFFPFLHLNYRAWYGAIRSIRPFIII 205

  Fly   150 SGIP----------SLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLE- 203
            ..||          .::.:||   ::...:..:.|..:|.:.::||.|::.: |.:...|...:
 Worm   206 RLIPLVVKFKLPKNRIEQLLK---RSSQQVKNVTLFFVFFMTLYAIFGIQLF-GRMDYHCVQPKT 266

  Fly   204 DPNK--LVKEGESETPCNTDNILEKATGSFVCNNTTSMCLE-----KWEGPNSGITSFDNIGFAM 261
            |||.  ::.....:|.|..:.|     |.:.| ....:|::     |.||   ....|::.|.::
 Worm   267 DPNNVTIMDLAIPDTMCAPEGI-----GGYEC-PAPMVCMQLNLNAKGEG---FYGMFNDFGASV 322

  Fly   262 LTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENR 326
            .||:...:.|||..:||...|:|.|...::||..||...::.:.|:.:.|::..||      |.|
 Worm   323 FTVYLAASEEGWVYVLYDCMDSLPSYLAFLYFCTLIFFLAWLVKNVFIAVITETFA------EIR 381

  Fly   327 QEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGKSK 391
            .:|.::               |  :.:||.|.|                   ..||||:..
 Worm   382 VQFSEM---------------W--QKKEVTLDE-------------------GFRKKLEKT---- 406

  Fly   392 STDTEEEEAEEDYGDDGY----LKTRSKPQGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVF 452
                          |||:    |....:|:|        .|:...|:   :::.:|..|||:.|.
 Worm   407 --------------DDGWRLIRLDGEVEPEG--------PKQKLQWM---LRSMYFQCFVIIFVV 446

  Fly   453 LNTVCVAVEHY-----GQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVV 512
            :|.:..|:..|     .:|.....:|:  |..|..||..|..||:...|.|.:......:|:.::
 Worm   447 INAIGNAMFVYRHDETDKPRKYNFYLF--EVGFTILFNVECIIKILCYGFRNFIRRGIFKFELIL 509

  Fly   513 ISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLF 577
            ..||....:....:...|  :..:..||||:.|.:..   |.:.|..:.:..:.:..|:.....|
 Worm   510 CLGSSLNCVKFFYERNYF--TYFQTFRLLRLIKASPI---LEDFVWKIFSPGKKLGGLVIFTIAF 569

  Fly   578 ILIFALLGMQLFGGQFNLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMI 642
            |..::.:.:|||....||      .:|.|||.|.:::|||:|.|.|.:.:.: ::.........:
 Worm   570 ICCYSAISLQLFYSVPNL------HHFRTFPQAFMSMFQIITQEGWTDFVVE-VLRATDDNLVPL 627

  Fly   643 YSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEE-------------------------- 681
            .::||:...||....:|::|:|:.:|||...:||...::
 Worm   628 VALYFVAYHLFVTLIVLSLFVAVILDNLEMDEELKKVKQLRAREATTSMRSTLPWRLRVFEKFPT 692

  Fly   682 ------------------------------------EQVEEDKE--------------------- 689
                                                :.:|.|.|
 Worm   693 RPQMAAMRKADSDFPMPKVRGSFTHQFAVDHSLETTDVIESDFEFPKRIMKSAGKRKISKSGLTF 757

  Fly   690 KQL--------------------QELEKEMEAL----QADG------------------------ 706
            :|:                    |.|...:..|    ::.|
 Worm   758 RQIGSTSLRCSLNNLLEMSDRTRQSLSNSLSFLPHFTRSSGSLYPRKDALPKSRSMTGKFLQTAV 822

  Fly   707 ------VHVENGDGAVAPSKSKGKKKE----------EEKKEEEEVT-----EGPKPMLPY--SS 748
                  ::.|||| ...||.|..||..          ::|::..|:|     |..:...|:  ..
 Worm   823 RNKQFNMYSENGD-LSRPSDSAPKKNAKQGEIDIRALQQKRQLAEITRNRIEEDMRENHPFFDRP 886

  Fly   749 MFILSPTNPIRRGAHWVVN-----------------------------LPYFDFFIMVVISMSSI 784
            :|::...:.:|.....:|:                             :||.|:.:..|..:|.|
 Worm   887 LFLVGRASQLREFCKKMVHSKYDSQDDGTNGGAKTKKRFKEIRALIGIMPYIDWAMATVTIVSCI 951

  Fly   785 ALAAEDP---VREN-SRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVV 845
            ::..|.|   ..|| ...|..|...||.|....|.|:.:||:..|:...|.:.:|:...:|:..:
 Worm   952 SMLFESPWPTTGENLVMNNGYLQISDYFFVLSMTFELCVKIIANGLFFTPKAVVRDVGGVMNLFI 1016

  Fly   846 VICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIV 910
            ...:.:...:........   |..:.|.:.|.:|||:....||.::.|........|.::.:.|:
 Worm  1017 YFTSVIFLAWMPKHVEIN---SLAQFLMICRAMRPLRIYTLVPHIRRVVLEFFRGFKEILLVTIL 1078

  Fly   911 YILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFK---------YEED--ELLPKQEL-R 963
            .|:..|||:..|||:..||...|.|.:..:...|.|.:::         |.:|  .:.||..: |
 Worm  1079 MIVVMFIFASFGVQIVGGKLAACNDPTVSSRENCTGVFWQKLFVTRLEVYGKDTEAMHPKIMVPR 1143

  Fly   964 VW-KPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVF 1027
            || .||.|::|:|..|||.||...:.:|| .|::..:   :...||      ...:|..:|..:.
 Worm  1144 VWTNPRNFNFDHVGNAMLALFETLSFKGW-NVIRDIL---WSRHGP------WAVVFIHIYVFIG 1198

  Fly  1028 PFFFVNIFVALIIITF-QEQGEAELQDGEIDKNQ----KSCIDFTIGARPLE-RYMPKNRNTFKY 1086
            ....:.:||.::|..: |.:|.|.|   .:|:.:    |:.:..   |:||. ...|......:.
 Worm  1199 CMIGLTLFVGVVIANYTQNRGTALL---TVDQRRWHDLKARLKM---AQPLHVPPKPSESARLRT 1257

  Fly  1087 KVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYI----------NMGFTGMFSVE 1141
            |::.:.:|..|.....:|:|.|:..|::.::.:.:  |:...|:          ||    :|.:|
 Worm  1258 KLYDLTMSRWFNQAFALLVVLNSFTLVIPWNVEEE--EQRATYVFTVTALAAFMNM----LFVIE 1316

  Fly  1142 TVLKIIGFGVKNFFKDPWNIFD-LITVLGSIVDALW------MEFGSNSINV------------- 1186
            .:||:|.:....|::...|..| ||||.|    .:|      :...|:.|:|
 Worm  1317 IILKVIAYTFSGFWQSRRNRVDLLITVFG----VIWIFLHFFVALPSSKIDVDVQVELKKFTYTF 1377

  Fly  1187 GFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTV 1251
            |:|.:.  .|...:..:..|:::|:.|.:.|.....::...:.:|...||..|:.:|..:|.|.
 Worm  1378 GYLVVI--LRFFTIASRNSTLKMLMLTVIMSMFRSFFIITALFLLVLFYAYTGVILFPMVKYGM- 1439

  Fly  1252 ENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEY-----------C 1305
              ::::|.||::..:.:::||||.|||.|.:||..|::         .||..|           |
 Worm  1440 --AVSKHVNFRTASEALVVLFRCLTGEDWNDIMHDCMR---------SAPFCYWNEGMNYWETDC 1493

  Fly  1306 GSTLAYAYFVSFIFFCSFLML------NLFVAVIMDNFD--YLTRDSSILGAHHLDEFVRIWAEY 1362
            |:     ::.:.|:||||.::      ||.|||||:||.  |.:.:.::|....:..|..:|...
 Worm  1494 GN-----FYGAIIYFCSFYLIITYIVRNLLVAVIMENFSLFYSSEEDALLSYADIRNFQYVWNMV 1553

  Fly  1363 DPNATGKIHYTEMYDMLK------NMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLF 1421
            |......|....:..:|:      .:||.       .:|:.:|.:......|.:...|.|...|:
 Worm  1554 DQEQKRTIPVERVKFLLRLLKGRLEVDPE-------KDRILFKHMCYEMERLHNGEEVSFHDVLY 1611

  Fly  1422 ALIRENLSIK--MRAPEEMDQADMEL-------RETITNIWPLQA--KKMLNLLVPPSDQLNKGK 1475
            .|...::.|:  ::..|.:.:.::|.       ::|| ..| |:.  :||.|    ||.:..:|.
 Worm  1612 MLSYRSVDIRKSLQLEELLQREELEFIIEEEVAKQTI-RTW-LEGCLRKMRN----PSQKDAEGV 1670

  Fly  1476 LSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHR- 1539
            |..|                     .|.|::       |.|         ||....|......|
 Worm  1671 LPFG---------------------GGHPVI-------HSS---------GHSSISHEETVAQRL 1698

  Fly  1540 RSPSLRHNG-------SPLARSPSPRRRGHQYIHHDIGFSDTVSNVVEMVKETRHPRHGNSHPRY 1597
            |..::|.:.       |....:|.|.|:.....:......|.:|......:..|....|:|..:.
 Worm  1699 RFENIRGDSVDTEETESSEEETPPPIRKKAAVKNRRGSIPDVLSRTGLFQEAARKFMVGSSSEKK 1763

  Fly  1598 PRGSWSAST---SPARSPSPSRYGGHLSRSKRTQLPYPTYGTTSLCQRSR-SP-SPARLQEMRER 1657
            ...|.|..|   .|.|:.|..|.|.  .:.|...|....|....:.:|.. || ||..|.:
 Worm  1764 QVKSRSPETVQLLPKRANSEIRKGS--GQPKNFHLQLNVYDLPDVEERGEDSPFSPKNLSD---- 1822

  Fly  1658 DRLGYGIDMGVTHVQHSYPTLASRRAGIGRRLPPTPSKPSTL 1699
            |..|....:.:|      |:|.         :|||...|..|
 Worm  1823 DFNGEHSPLVIT------PSLP---------VPPTHGSPRPL 1849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	73/319 (23%)
		Ion_trans	441..677	CDD:334124	60/240 (25%)
		Ion_trans	769..1050	CDD:334124	76/298 (26%)
		Ion_trans	1094..1345	CDD:334124	75/299 (25%)
		GPHH	1346..1416	CDD:339854	12/75 (16%)
		Ca_chan_IQ	1418..1492	CDD:337190	17/84 (20%)
unc-77	NP_001293824.1	Ion_trans	107..383	CDD:278921	69/294 (23%)
		Ion_trans	455..660	CDD:278921	52/218 (24%)
		Ion_trans	973..1214	CDD:278921	63/253 (25%)
		Ion_trans	1310..1534	CDD:278921	67/250 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.950