DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and lov-1

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_496184.3 Gene:lov-1 / 174576 WormBaseID:WBGene00003058 Length:3284 Species:Caenorhabditis elegans


Alignment Length:1337 Identity:235/1337 - (17%)
Similarity:423/1337 - (31%) Gaps:503/1337 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   186 IGLEFYSGALHKTCYSLEDPNKLVK---------EGESETPCNTDNILEKATGSFVCNNTTSMCL 241
            :.:::...|:.|.||..:..:.:..         :|.....|:||::...:.|:|          
 Worm  2168 VPMDYQVAAVSKGCYFYQKTSDVFNSEGMYPSDGQGMQFVNCSTDHLTMFSVGAF---------- 2222

  Fly   242 EKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFV------PLIVIG 300
                                                   |..:.:.|::.|.|      ..::|.
 Worm  2223 ---------------------------------------NPTIDADFSYNYNVNEIEKNVKVMIA 2248

  Fly   301 SFFMLNLVLGVL--SGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEE--- 360
            :.||| :|.|.|  :....:.::....|..|||.....      :||:        .::|.|   
 Worm  2249 AVFML-VVYGCLTINAIICQRKDASRGRLRFLKDNEPH------DGYM--------YVIAVETGY 2298

  Fly   361 ---RTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEE---EAEEDYG-DDGYLKTRSKPQG 418
               .||:......:.....:...|          |..:||:   |....:| .|.::.|.:.|.|
 Worm  2299 RMFATTDSTICFNLSGNEGDQIFR----------SFRSEEDGNWEFPFSWGTTDRFVMTTAFPLG 2353

  Fly   419 SCTGFWRAEKRFRFWI--------------RHTVK---TQWFYWFVIVLVFLNTVCVAVEHYGQP 466
            ..       :..|.|:              |..||   ||..|:|.     .|.........|:.
 Worm  2354 EL-------EYMRLWLDDAGLDHRESWYCNRIIVKDLQTQDIYYFP-----FNNWLGTKNGDGET 2406

  Fly   467 SFLTEFLYYAEFI--FLGLFMSEMFIKMYALGPRIYFESSFNR---------------FDCVVIS 514
            ..|....|...|:  .:.:.|....|..:|:     |....||               |..||:|
 Worm  2407 ERLARVEYKRRFLDESMSMHMLAQTISWFAM-----FTGGGNRLRDRVSRQDYSVSIIFSLVVVS 2466

  Fly   515 GSIFEVIWSE----------------VKGGSFGLS---VLRALRLLRIFKVTK-------YWSSL 553
            .....::.|:                :|..:||:.   ::..|..|.|...||       |:...
 Worm  2467 MISITILKSDNSIISDSKSVSEFTFTIKDIAFGVGFGVLITFLNSLHILLCTKCRSHSEHYYYKK 2531

  Fly   554 R------------NLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPETNFNT 606
            |            :..:.:....|:||  :|.:.:.::..:..||.|.           :...|:
 Worm  2532 RKREDPEFKDNSGSWPMFMAGMARTII--VFPVLMGLIYISGAGMSLM-----------DDLANS 2583

  Fly   607 FPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLA 671
            |.|..| :..||    | .|:::.|       ||:|::  |::|....::.::|..         
 Worm  2584 FYIRFL-ISLIL----W-AVVFEPI-------KGLIWA--FLILKTRKSHKIINKL--------- 2624

  Fly   672 NAQELTAAEEEQVEEDKEKQLQELEKEMEALQADGVHVENGDGAVAPSKSKGKKKEEEKKEEEEV 736
                             |:.|...:.....|:.....:|.|.|......:|.:..|..|..:|::
 Worm  2625 -----------------EEALLRAKPAETFLRNPYGKIEKGLGTEIADVTKLRDTENRKMRDEQL 2672

  Fly   737 TEGPKPMLP-YSSMFILSPTNPIRRGAHWVVNLPYF-----DFFIMVVISMSSIALAAEDPVREN 795
            ....:.||. ::|::|:             |.|.|:     .::..  :.||:|       :..|
 Worm  2673 FITIRDMLCFFASLYIM-------------VMLTYYCKDRHGYWYQ--LEMSTI-------LNIN 2715

  Fly   796 SRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSF--GFDMS 858
            .:     ||.|..|..:                   .:..:||:.....:......|:  |....
 Worm  2716 QK-----NYGDNTFMSI-------------------QHADDFWDWARESLATALLASWYDGNPAY 2756

  Fly   859 GSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGV 923
            |..|..|....:|:.:       .||::| :.|...:|.            ::..||...:..|.
 Worm  2757 GMRAYMNDKVSRSMGI-------GTIRQV-RTKKSAECT------------MFKQFQGYINDCGE 2801

  Fly   924 QLFNGKFFYCTDESKHTSAECQGSYFKYE-------EDELLPK--QELRVWKPRAFHY------- 972
            :|        |.:::..:...|..:.:.|       .||...|  :||.........|       
 Worm  2802 EL--------TSKNEEKTLYMQAGWTELESENGTDASDEYTYKTSEELSTETVSGLLYSYSGGGY 2858

  Fly   973 ----DNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVN 1033
                ....|.::|||.....|.|  :..|:.|...|    ...:..:::.|.:|..:|       
 Worm  2859 TISMSGTQAEIITLFNKLDSERW--IDDHTRAVIIE----FSAYNAQINYFSVVQLLV------- 2910

  Fly  1034 IFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVS---- 1094
                                 ||.|:         |.     |:|   |::...| |::.|    
 Worm  2911 ---------------------EIPKS---------GI-----YLP---NSWVESV-RLIKSEGSD 2936

  Fly  1095 -TPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLK--------IIGFG 1150
             |..:|:.|:.|.|:.|:.              :|.|.....|.:.|.|.:|        :....
 Worm  2937 GTVVKYYEMLYIFFSVLIF--------------VKEIVFYLYGRYKVITTMKPTRNPFKIVYQLA 2987

  Fly  1151 VKNFFKDPWNIFDLI------------TVLGSIVDALWMEFGSNSINVGFLRL------------ 1191
            :.||  .|||..|||            |:.....:....:|.:|:.| .::.|            
 Worm  2988 LGNF--SPWNFMDLIVGALAVASVLAYTIRQRTTNRAMEDFNANNGN-SYINLTEQRNWEIVFSY 3049

  Fly  1192 -------FRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF-------IYAIIGMQV 1242
                   |.:.::|::||....|.:|..|...:..|:  |...||.|||       :||::|.::
 Worm  3050 CLAGAVFFTSCKMIRILRFNRRIGVLAATLDNALGAI--VSFGIAFLFFSMTFNSVLYAVLGNKM 3112

  Fly  1243 FGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGS 1307
            .|                    .:.:|..|:.|         ||.:.||.  |.....|    .|
 Worm  3113 GG--------------------YRSLMATFQTA---------LAGMLGKL--DVTSIQP----IS 3142

  Fly  1308 TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDS 1344
            ..|:...:.::...|.|:|.|:|.:||..|:.:..||
 Worm  3143 QFAFVVIMLYMIAGSKLVLQLYVTIIMFEFEEIRNDS 3179

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 21/154 (14%)
Ion_trans 441..677 CDD:334124 51/290 (18%)
Ion_trans 769..1050 CDD:334124 47/307 (15%)
Ion_trans 1094..1345 CDD:334124 65/302 (22%)
GPHH 1346..1416 CDD:339854
Ca_chan_IQ 1418..1492 CDD:337190
lov-1NP_496184.3 GPS 2177..2226 CDD:197639 10/97 (10%)
PLAT_polycystin 2288..2413 CDD:238850 27/154 (18%)
PKD_channel 2723..3175 CDD:285288 111/604 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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