DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and PKD1L1

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	XP_016867287.1	Gene:	PKD1L1 / 168507	HGNCID:	18053	Length:	2920	Species:	Homo sapiens

Alignment Length:	842	Identity:	134/842 - (15%)
Similarity:	231/842 - (27%)	Gaps:	374/842 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   970 FHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNI 1034
            |||:         |:.|.|......|.|.....|                   ||::.....::.
Human  1282 FHYE---------FSYQIGNTSKHTLYHGRDTQY-------------------YFVLPAGEHLDN 1318

  Fly  1035 FVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEY 1099
            :..::        ..|:.||:..|.|...:..|:
Human  1319 YKVMV--------STEITDGKGSKVQPCTVVVTV------------------------------- 1344

  Fly  1100 FIMMLIVFNTLLLMMKYHNQG----DMYEKSLKYINMGFTGMFSVETVLKIIG--FGVKNFFKDP 1158
                         :.:||...    |:|..|||.:           :.|:::|  ..::|:
Human  1345 -------------LPRYHGNDCLGEDLYNSSLKNL-----------STLQLMGSYTEIRNY---- 1381

  Fly  1159 WNIFDLITVLGSIVDALWMEFGSNSIN---------------VGFLRLFRAARLIKLLRQ----- 1203
                  |||:..|:..|..|..:.|.|               :.|:........:.:||.
Human  1382 ------ITVITRILSRLSKEDKTASCNQWSRIQDALISSVCRLAFVDQEEMIGSVLMLRDLVSFS 1440

  Fly  1204 ---GYTIRILLWTFVQSFKAL-----PYV------CLLIAMLFFIYAI----------------- 1237
               |:...:|:..:.::..|.     |:|      ..||.::..::.:
Human  1441 NKLGFMSAVLILKYTRALLAQGQFSGPFVIDKGVRLELIGLISRVWEVSEQENSKEEVYRHEEGI 1505

  Fly  1238 -------IGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDD 1295
                   :|.....::..|.:|.....|.|.||.:|.:        |....::
Human  1506 TVISDLLLGCLSLNHVSTGQMEFRTLLHYNLQSSVQSL--------GSVQVHL------------ 1550

  Fly  1296 DAEKAPGEYCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWA 1360
                 ||:..|.:.|.|...|   .|....|.||            :.:...|:.
Human  1551 -----PGDLAGHSPAGAETQS---PCYISQLILF------------KKNPYPGSQ---------- 1585

  Fly  1361 EYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIR 1425
              .|...|.:....:|......  |:       ||...:|.:.:....:|.|..:...|.|.|:|
Human  1586 --APGQIGGVVGLNLYTCSSRR--PI-------NRQWLRKPVMVEFGEEDGLDNRRNKTTFVLLR 1639

  Fly  1426 ENLSIKM-----RAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNK----GKLSVGKI 1481
            :.:::..     ..|:|..|.::|..:.:|..:|:......:....|||.|.|    ...|:.:|
Human  1640 DKVNLHQFTELSENPQESLQIEIEFSKPVTRAFPVMLLVRFSEKPTPSDFLVKQIYFWDESIVQI 1704

  Fly  1482 Y----------AGFLIL----------------------------------ESWRSTRFGQLDSG 1502
            |          .|:|.|                                  ..|:|.||......
Human  1705 YIPAASQKDASVGYLSLLDADYDRKPPNRYLAKAVNYTVHFQWIRCLFWDKREWKSERFSPQPGT 1769

  Fly  1503 MP----------------------MLELQDASR---HPSQESLTGA------------------- 1523
            .|                      ..|:.|.|:   ||  |:|..:
Human  1770 SPEKVNCSYHRLAAFALLRRKLKASFEVSDISKLQSHP--ENLLPSIFIMGSVILYGFLVAKSRQ 1832

  Fly  1524 -------DAGHLHPGHSYMNGHRRSPSLRHNGSPLARSPSPRRRGHQYI--HHDIGFSDTVSNVV 1579
                   .||::....:.:.||:....:...|   .|:|: |.....||  ..|.|.|:|
Human  1833 VDHHEKKKAGYIFLQEASLPGHQLYAVVIDTG---FRAPA-RLTSKVYIVLCGDNGLSET----- 1888

  Fly  1580 EMVKETRHPRHGNSHPRYPRGS--------------------WSASTSPARSPSPSRYGGHL 1621
               ||...|    ..|.:.|.|                    |..|    |.|||..:..|:
Human  1889 ---KELSCP----EKPLFERNSRHTFILSAPAQLGLLRKIRLWHDS----RGPSPGWFISHV 1939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124
		Ion_trans	441..677	CDD:334124
		Ion_trans	769..1050	CDD:334124	11/79 (14%)
		Ion_trans	1094..1345	CDD:334124	47/314 (15%)
		GPHH	1346..1416	CDD:339854	10/69 (14%)
		Ca_chan_IQ	1418..1492	CDD:337190	21/126 (17%)
PKD1L1	XP_016867287.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910