Protein Alignment cac and na

DIOPT Version :10

• Sequence 1: NP_001356945.1
• Gene: cac / 32158
• FlyBaseID: FBgn0263111
• Length: 2110
• Species: Drosophila melanogaster
• Sequence 2: XP_061506126.1
• Gene: na / 1278744
• VectorBaseID: AGAMI1_006480
• Length: 1880
• Species: Anopheles gambiae
• Alignment Length: 2025
• Identity: 421/2025 - (20%)
• Similarity: 766/2025 - (37%)
• Gaps: 530/2025 - (26%)

  Fly    82 CIFCVE--ASL--------KILALGLVLHKHSYLRNIWNIMD----FFVVVTGFMTQYPQIGPEV 132
            |.||.:  |:|        ||...|.:..:..|.::.|...|    .|:.::..:..:..:|...
Mosquito    69 CTFCCDSVATLLFTSEMIAKIHIRGALRGEAPYFKDHWCQFDASMVLFLWLSVSLQVFEMLGIVP 133

  Fly   133 DLRTLRAIRVLRPLKLVSGIPSLQVVLK---------SIIK-AMAPLLQIGLLVLFAIVIFAIIG 187
            ....|..:|..|||.:   |..|:|.||         .|.| :...:..:.|..||.:.::.::|
Mosquito   134 KFSYLSTVRAPRPLIM---IRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLG 195

  Fly   188 LEFYSGALHKTC-YSLEDPNKLVKEGES--ETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNS 249
            ::|: |.|...| .:..:|..|.....:  :|.|:.|     ....:.|  .|.|...|.:..::
Mosquito   196 VQFF-GELKNHCVLNTTEPESLTINSLAIPDTFCSLD-----PNSGYQC--PTGMKCMKMDFLSN 252

  Fly   250 ---GITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGV 311
               |.|.|::|..::.||:|..:.|||..|:|...|:|.:.....||..:|...::.:.|:.:.|
Mosquito   253 YAMGFTGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAV 317

  Fly   312 LSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRR 376
            ::             :.|.::|.|.|....:.|::: ...|.::|..::
Mosquito   318 IT-------------ETFNEIRVQFQQMWGVRGHIQ-NSTASQIITGDD---------------- 352

  Fly   377 NAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAEKRFRFWIRHTV-KT 440
               ...||.::..:|......|                    :|               ||: ::
Mosquito   353 ---SGWKLVTIDDNKHGGIAPE--------------------TC---------------HTILRS 379

  Fly   441 QWFYWFVIVLVFLNTVCVAVEHY----GQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYF 501
            .:|...|:.:|..|.:..|..|:    .|.....|..||.|..|......|...|:|.||.|.||
Mosquito   380 PYFRMLVMTVVLANGIVTATMHFKHDGRQRQVFYEKYYYIEITFTFFLDLETLFKIYCLGWRSYF 444

  Fly   502 ESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRS 566
            :.|.::|:.::..|:...:|.:....|.....|||.:||::...:      |...|..:....:.
Mosquito   445 KHSIHKFELLLAIGTTLHIIPALYLSGFTYFQVLRVVRLIKASPM------LEGFVYKIFGPGKK 503

  Fly   567 IISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGI 631
            :.||:......::|.:.:.||||....:.      |.|.:||.|.:::|||||.|.|.|||.:.:
Mosquito   504 LGSLIIFTMCLLIISSSISMQLFCFLCDY------TKFESFPDAFMSMFQILTQEAWVEVMDETM 562

  Fly   632 ISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEE----EQVEEDKEK-- 690
            |........:: ::|||:..||....:|::|:|:.:|||...:::...::    ||..|.||.
Mosquito   563 IRTSKTLTPLV-AVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAEIKETLP 626

  Fly   691 -QLQELEK--------------------------------EMEALQADG---------------- 706
             :|:..||                                |||....:|
Mosquito   627 FRLRIFEKFPDSPQMAILHKIPNDFTLPKVRESFMKQFVLEMEPEDLEGYQRPMPECWDSRIAYK 691

  Fly   707 --------------------------VHV------------------------------------ 709
                                      .|:
Mosquito   692 KHRPINVMNKTAKVCMVGSDLRKLAITHIINDSNNQRLMLGDSSMLPVAGTKAGLKPQGTITQTK 756

  Fly   710 ---------------------------------ENGD-GAVA----------------------P 718
                                             |||| ||.:                      .
Mosquito   757 PWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIGAASRVTSSRARPHDLDIKILQAKRQQ 821

  Fly   719 SKSKGKKKEEEKKEEEEVTEGPKPMLPYSSMF---------------ILSPTNPIRR-----GAH 763
            ::.:..::||:.:|.....:.|...:|..|.|               :..|.....|     ..|
Mosquito   822 AEMRRNQREEDLRENHPFFDTPLFAVPRESRFRKICQRIVHGRYDARLKDPLTGKERKVQYKSLH 886

  Fly   764 WVVNL-PYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVI 827
            ..:.| .|.|:.::.|.::|.|::..|.| :.....:..|...:|.|....::|:.|||:..|:.
Mosquito   887 NFLGLVTYLDWVMIFVTTLSCISMMFETP-QYRVMEHVALQVAEYTFVIFMSLELALKILADGLF 950

  Fly   828 LHPGSYLREFWNIMDAVVVICAAVSFGFDM-----SGSSAGQNLSTIKSLRVLRVLRPLKTIKRV 887
            ..|.:|:::..:::| |.:...:.||...|     |.|||       :.|.:||.||||:....|
Mosquito   951 FTPKAYIKDVASVLD-VFIYVVSTSFLIWMPRQVPSNSSA-------QLLMILRCLRPLRIFTLV 1007

  Fly   888 PKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYE 952
            |.::.|...:....|.::.:..:.||..|||:..||||:.|:...|.|.:.....:|.|.:.:
Mosquito  1008 PHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTIEKREDCVGVFMR-- 1070

  Fly   953 EDELLPKQEL--------------RVW-KPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAAT 1002
             ...:.|.:|              ||| .||.|::||:..|||.||.|.:.:||..|....:.|.
Mosquito  1071 -RVFVTKMKLTPGVNESYPSMLVPRVWANPRRFNFDNIGDAMLALFEVLSYKGWIDVRDVLIKAL 1134

  Fly  1003 YEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQE-QGEAEL---QDGEIDKNQKSC 1063
                ||:.      :|:..||..:.....:.:||.::|..:.| :|.|.|   |....|..::..
Mosquito  1135 ----GPVH------AIYIHVYIFLGCMIGLTLFVGVVIANYSENKGTALLTVDQRRWCDLKKRLK 1189

  Fly  1064 IDFTIGARPLERYMPKNRNTFKYK--VWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKS 1126
            |     |:||  ::|...:..|::  |:.|.....|:..|.::::.|::||.:.: .:.:::.:.
Mosquito  1190 I-----AQPL--HLPPRPDGRKFRAFVYDITQHIAFKRCIAVVVLVNSMLLSITW-TKDEVHTER 1246

  Fly  1127 LKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGSN-----SINV 1186
            |..::...|.:|.:|.|:|.|.|..:.:::...|.:||:..:..:|   |:...:.     |..:
Mosquito  1247 LVIVSTILTFVFVIEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVV---WIFLQTTLRSDLSYFI 1308

  Fly  1187 GFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTV 1251
            ||:.:.  .|...:..:..|:::|:.|...|.....::...:.:|.|.||:.|..:||.:|.|
Mosquito  1309 GFMVVI--LRFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYG-- 1369

  Fly  1252 ENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACL-KGKACDDDAEKAPGEYCGS-TLAYAYF 1314
             ..|.|..||.|.:.||.:|||..|||.|..||..|: :...|...|.....: ||: |.:..||
Mosquito  1370 -EGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTPAANYWETD-CGNFTASLIYF 1432

  Fly  1315 VSFIFFCSFLMLNLFVAVIMDNFD--YLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYD 1377
            .:|....::::|||.||:||:||.  |...:.::|....:..|...|...|.:..|.|....:..
Mosquito  1433 CTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKF 1497

  Fly  1378 MLK------NMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFAL------IRENLSI 1430
            :|:      ..||.       .:||.:|.:......|.:...|.|...:..|      ||:.|.:
Mosquito  1498 ILRLLKGRLECDPQ-------KDRLLFKYMCYELDKLHNGEDVTFHDVINMLSYRSVDIRKALQL 1555

  Fly  1431 -KMRAPEEMDQ-ADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRS 1493
             ::.|.||.:. .:.|:.:.....|.....|.:        :.|........:.||.......:.
Mosquito  1556 EELLAREEFEYIIEEEVAKQTIRTWLEGCLKKI--------RANNVAKQQNSLIAGLRATNDQKQ 1612

  Fly  1494 TRFGQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSPSLRHNGSPLA-RSPSP 1557
                |........:.|...:...|:..||..|                     :...|| :.|:|
Mosquito  1613 ----QQQQQQQQQQQQQQQQQQQQQQQTGTTA---------------------SSQQLAQQQPTP 1652

  Fly  1558 RRRGHQYIHHDIGFSDTVSNVVEMVKETRHPRHGNSHPRYPRGSWSASTSPARSPSPS-RYGGHL 1621
            .:...|                :...:|:      |||...:....:||:.:::||.: ...|.|
Mosquito  1653 AQPAQQ----------------QQATQTQ------SHPSQAQSPLQSSTTTSQAPSSAVTSPGQL 1695

  Fly  1622 SRSKRTQLPYPTYGTTSLCQRSRSPSPA-RLQEMRERDRLGYGIDMGVTHVQHSYPTLASRR--- 1682
            |:.....   || |..::.    .|.|: .:.:...:|     |:....:.:.:..|:.:|.
Mosquito  1696 SKQADES---PT-GKDAVA----GPDPSDTITDQTAKD-----IENNAKNRKKTAATVLNRSDST 1747

  Fly  1683 -AGIGRR-LPPTPSKPSTLQLKPTNINFPKLNASP---------------------THTHHST-- 1722
             :..||: |.||.|.|.....|...::..|...:|                     .|.|||:
Mosquito  1748 GSSSGRKFLAPTLSDPQAKNEKDRYLSKKKQQRAPPSISVGVKASHLSEIGGHSLHLHYHHSSFS 1812

  Fly  1723 ---PHSVHSLPHHRDLLRDPRDMYYSSRERERDRERLRDRDRDRDRDRLHEYDLRYEYRD--RER 1782
               .||.|: |||..|       ::..:::::.:::.:.:..:..:....:.::.||..|  :|:
Mosquito  1813 HGGEHSPHA-PHHHHL-------HHHQQQQQQQQQQQQQQQANMSKFGHSQANMIYEVHDWWQEQ 1869

  Fly  1783 EL--YERERD 1790
            .|  :..|.|
Mosquito  1870 VLSTHSEEED 1879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:459842	61/271 (23%)
		Ion_trans	441..677	CDD:459842	66/239 (28%)
		Ion_trans	769..1050	CDD:459842	81/301 (27%)
		Ion_trans	1094..1345	CDD:459842	70/259 (27%)
		GPHH	1354..1407	CDD:465306	11/58 (19%)
		Ca_chan_IQ	1417..1496	CDD:462591	13/86 (15%)
		AF-4	<1512..>1704	CDD:461550	37/199 (19%)
na	XP_061506126.1	None