DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and AgaP_AGAP002578

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	XP_003436161.1	Gene:	AgaP_AGAP002578 / 1273390	VectorBaseID:	AGAP002578	Length:	1875	Species:	Anopheles gambiae

Alignment Length:	1890	Identity:	1556/1890 - (82%)
Similarity:	1687/1890 - (89%)	Gaps:	57/1890 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGGPKKEENPP--GGGPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPG 63
            ||||..:...|  ||||||||||:|||.||||||||||||||||||||||||||||||||||||.
Mosquito     1 MGGPSSQGGQPLAGGGPTSLFILSEDNIIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPH 65

  Fly    64 GDKTVLAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQI 128
            ||||:|||||||||||||.||||||||||||||.|:||||||||||||||||||||||:|.:||.
Mosquito    66 GDKTILAQKLEKTEAYFLGIFCVEASLKILALGFVMHKHSYLRNIWNIMDFFVVVTGFITLFPQK 130

  Fly   129 GPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSG 193
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   131 GPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSG 195

  Fly   194 ALHKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFDNIG 258
            |||::||||||.:::|||||..||||.||.....||::|||::.|.|:|:|||||.|||||||||
Mosquito   196 ALHRSCYSLEDISQIVKEGEFPTPCNADNDTIAPTGAYVCNSSDSTCIEQWEGPNFGITSFDNIG 260

  Fly   259 FAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKV 323
            ||||||||||||||||||||||||||||.|||||||||||:||||||||||||||||||||||||
Mosquito   261 FAMLTVFQCITMEGWTAILYWTNDALGSTFNWIYFVPLIVLGSFFMLNLVLGVLSGEFAKEREKV 325

  Fly   324 ENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLG 388
            ||||||||||||||||:||||||||||||||||||||||||||::||||||||.||||||||:||
Mosquito   326 ENRQEFLKLRRQQQLEKELNGYVEWICKAEEVILAEERTTEEERLHIMEARRRAAAKRKKLKNLG 390

  Fly   389 KSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFL 453
            |||||||||::.:||.|||||||.:.|.||.|.|||||||||||||||||||||||||||||||.
Mosquito   391 KSKSTDTEEDDPDEDCGDDGYLKAKVKTQGKCKGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFF 455

  Fly   454 NTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIF 518
            |||||||||||||::||:||||||::||||||.||:|||||||||||||||||||||||||||||
Mosquito   456 NTVCVAVEHYGQPNWLTQFLYYAEYVFLGLFMMEMWIKMYALGPRIYFESSFNRFDCVVISGSIF 520

  Fly   519 EVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFAL 583
            ||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   521 EVVWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFAL 585

  Fly   584 LGMQLFGGQFNLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFI 648
            |||||||||||||.|||.||||||||||||||||||||||||||||||.||||.:||||||:|||
Mosquito   586 LGMQLFGGQFNLPDGTPPTNFNTFPIALLTVFQILTGEDWNEVMYQGIESQGGHKKGMIYSLYFI 650

  Fly   649 VLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEMEAL--QADG----V 707
            :||||||||||||||||||||||||||||||||||:||:||||..||:||||||  |.||    |
Mosquito   651 ILVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQLEENKEKQQMELDKEMEALHMQNDGSPPRV 715

  Fly   708 HVEN-----GDGAVAPSKSKGKKKEEEKKEEEEVTEGPKPMLPYSSMFILSPTNPIRRGAHWVVN 767
            .|.:     |:|:...:||| ||.||::::::|:.:||||||||||||:||||||||.|||||||
Mosquito   716 EVSSPSPTRGNGSGGSTKSK-KKDEEKEEDDDEIPDGPKPMLPYSSMFVLSPTNPIRCGAHWVVN 779

  Fly   768 LPYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGS 832
            |.|||||||||||:|||||||||||.|:|.||||||:||||||||||||||||||||||||||||
Mosquito   780 LRYFDFFIMVVISLSSIALAAEDPVEEDSPRNKILNFFDYAFTGVFTIEMLLKIVDLGVILHPGS 844

  Fly   833 YLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCV 897
            |||||||:|||||||||||||||||:|||||||||||||||||||||||||||||||||||||||
Mosquito   845 YLREFWNVMDAVVVICAAVSFGFDMTGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCV 909

  Fly   898 VNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELLPKQEL 962
            |||||||:|||||||||||||:||.|||||||||||||:|||||.||:|.:|.|:..:.||::|.
Mosquito   910 VNSLKNVINILIVYILFQFIFAVIAVQLFNGKFFYCTDDSKHTSEECKGHFFVYDGADQLPRREP 974

  Fly   963 RVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVF 1027
            |.||.::|||||||.|||||||||||||||||||:||||||||:|||||||||||||||||||||
Mosquito   975 REWKTQSFHYDNVATAMLTLFAVQTGEGWPQVLQNSMAATYEDKGPIQNFRIEMSIFYIVYFIVF 1039

  Fly  1028 PFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIV 1092
            |||||||||||||||||||||||||||||||||||||||||||||||||||..||:|||||||||
Mosquito  1040 PFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPNKRNSFKYKVWRIV 1104

  Fly  1093 VSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKD 1157
            ||||||||||||||||||||||||||||..:||||||:||||||||||||:||||||||||||||
Mosquito  1105 VSTPFEYFIMMLIVFNTLLLMMKYHNQGKEFEKSLKYLNMGFTGMFSVETILKIIGFGVKNFFKD 1169

  Fly  1158 PWNIFDLITVLGSIVDALWMEFG---SNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1219
            ||||||.|||:|||:|||.:|.|   .||.|||||||||||||||||||||||||||||||||||
Mosquito  1170 PWNIFDFITVIGSIIDALVLELGVSNENSFNVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1234

  Fly  1220 ALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIM 1284
            |||||||||||||||||||||||||||:|.. |:||||||||:||:||:||||||||||:|||||
Mosquito  1235 ALPYVCLLIAMLFFIYAIIGMQVFGNIELDP-ESSITRHNNFRSFVQGLMLLFRCATGESWPNIM 1298

  Fly  1285 LACLKGKACDDDAEKAPGEYCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGA 1349
            ||||||:.||..|.| |.|.|||||||||||||||||||||||||||||||||||||||||||||
Mosquito  1299 LACLKGRPCDPRANK-PNETCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGA 1362

  Fly  1350 HHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRV 1414
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|.:|
Mosquito  1363 HHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDAEGKV 1427

  Fly  1415 QFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVG 1479
            .|||||||||||||:||||..|||||||.|||.||::||||||||||:||||.:::||.|||:||
Mosquito  1428 AFTTTLFALIRENLNIKMRTAEEMDQADAELRHTISHIWPLQAKKMLDLLVPLNEELNAGKLTVG 1492

  Fly  1480 KIYAGFLILESWRSTRFGQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSPSL 1544
            |||||.|||||||:|:|||::|.:|:.||||.||.||.||||.|| |||||||:|.|||||||||
Mosquito  1493 KIYAGLLILESWRNTKFGQVESDLPVSELQDVSRQPSLESLTPAD-GHLHPGHAYHNGHRRSPSL 1556

  Fly  1545 RHNGSPLARSPSPRRRGHQYIHHDIGFSDTVSNVVEMVKET-RHPRH--GNSHPRYPRGSWSAST 1606
            |.. |||.|:||||:| ||  .|:||||||||||||:.||. |..||  |.:| |:.||||||||
Mosquito  1557 RRE-SPLVRTPSPRKR-HQ--QHEIGFSDTVSNVVEIQKEEHRRGRHHFGYAH-RHNRGSWSAST 1616

  Fly  1607 SPARSPSPSRYGGHLSRSKRT-------QLPYPTYGTTSLCQRSRSPSPAR-LQEMRERD--RLG 1661
            ||||||||||:|.|.|...|:       .|.:..|.||.||:||||||||: |||:|:||  |..
Mosquito  1617 SPARSPSPSRFGVHSSAQHRSSKDRSKNHLVHQPYDTTILCERSRSPSPAQLLQELRDRDQARRK 1681

  Fly  1662 YGIDMGVTHVQHSYPTLASRRAGIGRRLPPTPSKPSTLQLKPTNINFPKLNASPTHTHHS---TP 1723
            |...|| :|||||||.|.:||.|.||||||||.||||||||.|||||||||||||||.||   ||
Mosquito  1682 YRNGMG-SHVQHSYPVLVTRRQGHGRRLPPTPCKPSTLQLKQTNINFPKLNASPTHTGHSSHNTP 1745

  Fly  1724 HSVHSLPHHRDLLRDP------RDMYYSSRERERDRERLRDRDRDRDRDRLHE-YDLRYEYRDRE 1781
            |||||||..|:.||:|      ||:||..|:|||||||.|:     .|:|.|| |.:|||:||||
Mosquito  1746 HSVHSLPQSREFLREPRERDHDRDLYYRERDRERDRERFRN-----SRERSHEDYSVRYEFRDRE 1805

  Fly  1782 RELYERERDREREVER--ERLEYIAPLSFEQALAMGRT-GRVLPSPVLNGFKPKSGLNPRHSDSD 1843
            ||||||||:.|||.||  ||:|:..|||:||||||||| |||||||:|||:|||..|:.||||||
Mosquito  1806 RELYEREREIEREFEREFERMEHSVPLSYEQALAMGRTGGRVLPSPILNGYKPKGALHSRHSDSD 1870

  Fly  1844 EEDWC 1848
            :||||
Mosquito  1871 DEDWC 1875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	252/286 (88%)
		Ion_trans	441..677	CDD:334124	219/235 (93%)
		Ion_trans	769..1050	CDD:334124	248/280 (89%)
		Ion_trans	1094..1345	CDD:334124	220/253 (87%)
		GPHH	1346..1416	CDD:339854	66/69 (96%)
		Ca_chan_IQ	1418..1492	CDD:337190	58/73 (79%)
AgaP_AGAP002578	XP_003436161.1	Ion_trans	57..326	CDD:278921	234/268 (87%)
		Ion_trans	460..679	CDD:278921	203/218 (93%)
		Ion_trans	798..1062	CDD:278921	233/263 (89%)
		Ion_trans	1124..1358	CDD:278921	202/235 (86%)
		GPHH	1366..1429	CDD:293510	59/62 (95%)
		Ca_chan_IQ	1431..1505	CDD:285917	58/73 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	503	1.000	Domainoid score	I1195
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20184
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56527
OrthoDB	1	1.010	-	-		D1411at7147
OrthoFinder	1	1.000	-	-		FOG0000179
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45628
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X841
TreeFam	0	0.000	Not matched by this tool.
	9	9.030