DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and Cacna1e

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_011246211.1 Gene:Cacna1e / 12290 MGIID:106217 Length:2466 Species:Mus musculus


Alignment Length:2347 Identity:1027/2347 - (43%)
Similarity:1280/2347 - (54%) Gaps:599/2347 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            ||||..|||.:|||.:.:|:||||||.:|.||||||:|||||:|||..|||.::::|||||.||:
Mouse   215 SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFI 279

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFM-TQYPQIGPEVDLRTLRAIRVLRP 145
            .|||.||.:||:|||.:.||.|||||.||:|||.||::|.: |........||||||||:|||||
Mouse   280 GIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRP 344

  Fly   146 LKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVK 210
            |||||||||||:|||||:|||.||||||||:.|||::|||||||||||.||:.|:.   .|..:.
Mouse   345 LKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFM---NNSGIL 406

  Fly   211 EG-ESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWT 274
            || :...||.    ::.....:.|.:        |.|||.|||.||||.||:|||||||||||||
Mouse   407 EGFDPPHPCG----VQGCPAGYECKD--------WIGPNDGITQFDNILFAVLTVFQCITMEGWT 459

  Fly   275 AILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLE 339
            .:||.||||||:.:||:||:|||:|||||:|||||||||||||||||:||||:.|:|||||||:|
Mouse   460 TVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIE 524

  Fly   340 RELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDY 404
            ||||||..||.|||||:||||  .:......:|..||...||.:.:::.:..|     :|...|.
Mouse   525 RELNGYRAWIDKAEEVMLAEE--NKNSGTSALEVLRRATIKRSRTEAMTRDSS-----DEHCVDI 582

  Fly   405 GDDGYLKTR-----SKPQGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYG 464
            ...|....|     :|..|: :.|...|:..|..|||.||:|.|||.|:.:|.|||.|||:.|:.
Mouse   583 SSVGTPLARASIKSTKVDGA-SYFRHKERLLRISIRHMVKSQVFYWIVLSVVALNTACVAIVHHN 646

  Fly   465 QPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVK-GG 528
            ||.:||..||||||:|||||:.||.:|||.:|||:||.||||.||..|..||||||:|:..: |.
Mouse   647 QPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGT 711

  Fly   529 SFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQF 593
            |||:|||||||||||||:||||:||||||:||::||:|||||||||||||::|||||||||||:|
Mouse   712 SFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF 776

  Fly   594 NLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTL 658
            |...|||..||:|||.|::||||||||||||||||.||.||||...||..:||||||.|||||||
Mouse   777 NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTL 841

  Fly   659 LNVFLAIAVDNLANAQELTAAEEEQ--------------------------VEEDK--------- 688
            |||||||||||||||||||..|:|:                          :|.|:         
Mouse   842 LNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMW 906

  Fly   689 -------------------EKQLQELEKEM-----EALQA------------------------- 704
                               |::..:|.:.|     |||..                         
Mouse   907 EPRSSHLRERRRRHHMSVWEQRTSQLRRHMQMSSQEALNKEEAPPMNPLNPLNPLSPLNPLNAHP 971

  Fly   705 ----------------------------------------------------------------- 704
                                                                             
Mouse   972 SLYRRPRPIEGLALGLGLEKCEEERISRGGSLKGDIGGLTSALDNQRSPLSLGKREPPWLPRSCH 1036

  Fly   705 ------------------------------------------------------------DGVHV 709
                                                                        :||.|
Mouse  1037 GNCDPIQQEAGGGETVVTFEDRARHRQSQRRSRHRRVRTEGKDSASASRSRSASQERSLDEGVSV 1101

  Fly   710 E---------------------------------------------------------------- 710
            |                                                                
Mouse  1102 EGEKEHEPHSSHRSKEPTIHEEERTQDLRRTNSLMVPRGSGLVGALDEAETPLVQPQPELEVGKD 1166

  Fly   711 ----------------------------------------------------------------- 710
                                                                             
Mouse  1167 AALTEQEAEGSSEQALLGDVQLDVGRGISQSEPDLSCMTANMDKATTESTSVTVAIPDVDPLVDS 1231

  Fly   711 -------NGDGAVAPSKSKGKKKEEE-----KKEEEEVTEGPKPMLPYSSMFILSPTNPIRRGAH 763
                   ..||..:|.|....|:|||     ||:::|..|..|.|:|:|||||.|.||||||..|
Mouse  1232 TVVNISNKTDGEASPLKEAETKEEEEEVEKKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRRACH 1296

  Fly   764 WVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVIL 828
            ::|||.||:..|::||:.|||||||||||..||.|||:|.||||.||||||.||::|::|.|:||
Mouse  1297 YIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLIL 1361

  Fly   829 HPGSYLREFWNIMDAVVVICAAVSFGF-DMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKA 892
            ..|||.|:.|||:|.|||:.|.|:|.. :..|::.|:::.|||||||||||||||||||:|||||
Mouse  1362 QDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKA 1426

  Fly   893 VFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELL 957
            ||||||.|||||.||||||.||.|||:||.||||.||||||||.||.|..||.|:|..:|::::.
Mouse  1427 VFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKNKME 1491

  Fly   958 PKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIV 1022
            .|.  |.||...|||||:..|:||||.|.||||||||||||:..|.|||||.::.|:||||||:|
Mouse  1492 VKG--REWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVV 1554

  Fly  1023 YFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYK 1087
            ||:||||||||||||||||||||||:..:::..::||:::||||.|.|:||.||||:||:||:|:
Mouse  1555 YFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYR 1619

  Fly  1088 VWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVK 1152
            ||..|||..|||.||.:|..||::|||||::....||.:|||:|:.||.:||:|.|||:|.||..
Mouse  1620 VWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFL 1684

  Fly  1153 NFFKDPWNIFDLITVLGSIVDALWME---FGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTF 1214
            |:|:|.|||||.|||:|||.:.:..:   ..::..|:.||:||||||||||||||||||||||||
Mouse  1685 NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTF 1749

  Fly  1215 VQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEA 1279
            ||||||||||||||||||||||||||||||||||.. |:.|.|||||:||...:|||||.|||||
Mouse  1750 VQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDE-ESHINRHNNFRSFFGSLMLLFRSATGEA 1813

  Fly  1280 WPNIMLACLKGKACDDDAEKAPG----EYCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYL 1340
            |..|||:||..|.|:.|.....|    |.||:.|||.|||||||||||||||||||||||||:||
Mouse  1814 WQEIMLSCLGEKGCEPDTTAPSGQNESERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYL 1878

  Fly  1341 TRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMN 1405
            ||||||||.||||||||:|||||..|.|:|||||||:||..|.||||.|.:||:::|||:|:.||
Mouse  1879 TRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMN 1943

  Fly  1406 MPLDDELRVQFTTTLFALIRENLSIKM-RAPEEMDQADMELRETITNIWPLQAKKMLNLLVP--- 1466
            ||:.:::.|.||:||.||||..|.||: :...:..|.|.||::....|||..::|||:||||   
Mouse  1944 MPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPK 2008

  Fly  1467 PSDQLNKGKLSVGKIYAGFLILESWRSTRF----GQLD--SGMPMLELQDASRHPSQESLTGADA 1525
            .||      |:||||||..:|::.::.::.    .||:  ...||.:..:.|..| ||.:..|.|
Mouse  2009 ASD------LTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAPMFQRMEPSSLP-QEIIANAKA 2066

  Fly  1526 -GHLHPGH-SYMNGHRRSPSLRHNGSPLARSP---------SPRRRGHQYIHHDIGFSDTVSNV- 1578
             .:|.... |.::|....||:    |||  ||         .|...|.        |.:..|.| 
Mouse  2067 LPYLQQDPVSGLSGRSGYPSM----SPL--SPQEIFQLACMDPADDGQ--------FQEQQSLVN 2117

  Fly  1579 -----VEMVKETRHPRHGNSHP---RYPRGSWSASTSP--------ARSPSPSRYGGHLSRSKRT 1627
                 |..:|..:...||...|   :...||..||:.|        ...||..|......|.||:
Mouse  2118 AQEPEVSELKSVQSSNHGIYLPPDTQEHAGSGRASSMPRLTMDPQVVTDPSSMRRSFSTIRDKRS 2182

  Fly  1628 QLPYPTYGTTSLCQRSRSPSPARLQEM-RERDRLGYGIDMGVTHVQHSYPTLASRRAGIGRRLPP 1691
            ...:                   |:|. .||.               |..|..|||.        
Mouse  2183 NSSW-------------------LEEFSMERS---------------SENTYKSRRR-------- 2205

  Fly  1692 TPSKPSTLQLKPTNINFPKLNASPTHTHHSTPHSVHSLPHHRDLLRDPRDMYYSSRERERDRERL 1756
              |..|:|:|....:|....:.|.||..                         ..|||.|.:||.
Mouse  2206 --SYHSSLRLSAHRLNSDSGHKSDTHRS-------------------------GGRERGRSKERK 2243

  Fly  1757 R----DRDRDRDRDRLHEYDLRYEYRDRERELYE-RERDRERE--------------------VE 1796
            .    |..|....:|..:.|.....|.:.|...| |.:...|:                    ..
Mouse  2244 HLLSPDVSRCNSEERGTQADWESPERRQSRSPSEGRSQTPNRQGTGSLSESSIPSISDTSTPRRS 2308

  Fly  1797 RERLEYIAP-----LSFEQALAMGRTGRVLPSP-----------------------VLNGFKPKS 1833
            |.:|..:.|     ||:..  .|..||.:.|.|                       ..|...|:.
Mouse  2309 RRQLPPVPPKPRPLLSYSS--LMRHTGGISPPPDGSEGGSPLASQALESNSACLTESSNSLHPQQ 2371

  Fly  1834 GLNPR------------HSDSDEEDWCXQRLXLRSRNRKDQIWVXHQAICSSLSAPNLDHNFDTI 1886
            |.:|.            |.||...| |.:          ::......|:.:||...|...:...:
Mouse  2372 GQHPSPQHYISEPYLALHEDSHASD-CGE----------EETLTFEAAVATSLGRSNTIGSAPPL 2425

  Fly  1887 RHSYQIP 1893
            |||:|:|
Mouse  2426 RHSWQMP 2432

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 183/288 (64%)
Ion_trans 441..677 CDD:334124 172/236 (73%)
Ion_trans 769..1050 CDD:334124 188/281 (67%)
Ion_trans 1094..1345 CDD:334124 171/257 (67%)
GPHH 1346..1416 CDD:339854 44/69 (64%)
Ca_chan_IQ 1418..1492 CDD:337190 33/77 (43%)
Cacna1eXP_011246211.1 Ion_trans 235..509 CDD:366146 183/288 (64%)
Ion_trans 622..861 CDD:366146 173/238 (73%)
Ion_trans 1302..1536 CDD:366146 151/235 (64%)
Ion_trans 1626..1883 CDD:366146 171/257 (67%)
GPHH 1892..1945 CDD:374878 34/52 (65%)
Ca_chan_IQ 1956..2029 CDD:370105 33/78 (42%)
SR-25 2168..>2243 CDD:371095 27/143 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 389 1.000 Domainoid score I785
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1858 1.000 Inparanoid score I62
Isobase 1 0.950 - 0 Normalized mean entropy S4478
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 1 1.100 - - O PTHR45628
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X841
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
109.810

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