DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and Cacna1d

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_006518538.1 Gene:Cacna1d / 12289 MGIID:88293 Length:2207 Species:Mus musculus


Alignment Length:2297 Identity:890/2297 - (38%)
Similarity:1204/2297 - (52%) Gaps:407/2297 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KKEENPPGGGPT-SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTV 68
            ||:.|.....|. :||.|:.:||||:....|:||.||:..:||.|.||||.||:....|..|...
Mouse    92 KKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNS 156

  Fly    69 LAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTG-FMTQYPQIGPEV 132
            ....|||.|..||.||.||..|||:|.||:||.::|:||.||::||.:|:.| |.....|:..|.
Mouse   157 TNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKET 221

  Fly   133 -------------DLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFA 184
                         |::.|||.||||||:||||:|||||||.||||||.|||.|.|||||.|:|:|
Mouse   222 EGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYA 286

  Fly   185 IIGLEFYSGALHKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNS 249
            |||||.:.|.:||||:..:  :.:|.| |...||.......:.|    .|.|.  |...|.|||.
Mouse   287 IIGLELFIGKMHKTCFFAD--SDIVAE-EDPAPCAFSGNGRQCT----ANGTE--CRSGWVGPNG 342

  Fly   250 GITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSG 314
            |||:|||..||||||||||||||||.:|||.|||:|..:.|:|||.||::||||:||||||||||
Mouse   343 GITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407

  Fly   315 EFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAA 379
            ||:|||||.:.|.:|.|||.:||||.:|.||::||.:||::....|....||            .
Mouse   408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE------------G 460

  Fly   380 KRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFW-------------------- 424
            ||.......:::|.:||....|            .:.||.|...|                    
Mouse   461 KRNTSMPTSETESVNTENVSGE------------GETQGCCGTLWCWWKRRGAAKTGPSGCRRWG 513

  Fly   425 ------RAEKRFRFW-------IRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYA 476
                  :..:|:|.|       .|..||:..|||.|||||||||:.::.|||.||.:||:....|
Mouse   514 QAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIA 578

  Fly   477 EFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGS-FGLSVLRALRL 540
            ..:.|.||..||.:|||:||.:.||.|.||||||.|:.|.|.|.|..|::..| .|:||.|.:||
Mouse   579 NKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRL 643

  Fly   541 LRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNL-PGGTPETNF 604
            |||||||::|:||.|||.||||||:||.|||.||||||:||:|||||||||:||. ...|..:.|
Mouse   644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTF 708

  Fly   605 NTFPIALLTVFQILTGEDWNEVMYQGIISQGG-AQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVD 668
            :.||.|||||||||||||||.|||.||::.|| :..|||..||||:|.:.|||.|||||||||||
Mouse   709 DNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVD 773

  Fly   669 NLANAQELTAAEEEQVEEDKEKQL---QELEKEMEALQADGVHVENGDGAV--------APSKSK 722
            |||:|:.|..|::|:.||.:.|::   :.||.:... :.:...:.|.|..|        |..|..
Mouse   774 NLADAESLNTAQKEEAEEKERKKIARKESLENKKNN-KPEVNQIANSDNKVTIDDYQEDAEDKDP 837

  Fly   723 --------GKKKEEEKKEEEEVTEGPKPM-------------LPY-SSMFILSPTNPIRRGAHWV 765
                    |:::|||:::|.||..||:|.             :|. |:.||||.|||||.|.|.:
Mouse   838 YPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKL 902

  Fly   766 VNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHP 830
            :|...|...|:|.|.:||.|||||||:|.:|.||.||.|||||||.:||:|:|||:...|..||.
Mouse   903 INHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHK 967

  Fly   831 GSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFD 895
            |::.|.::|::|.:||..:.||||...|.      :|.:|.||||||||||:.|.|...||.|..
Mouse   968 GAFCRNYFNLLDMLVVGVSLVSFGIQSSA------ISVVKILRVLRVLRPLRAINRAKGLKHVVQ 1026

  Fly   896 CVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDEL-LPK 959
            ||..:::.:.||:||..|.||:|:.||||||.|||:.||||:|....||:|.:..|::.:: .|.
Mouse  1027 CVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPV 1091

  Fly   960 QELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYF 1024
            ...|:|:...|::|||.:||:.||.|.|.||||.:|..::.:..|:.||:.|:|:|:|||:|:|.
Mouse  1092 VRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYI 1156

  Fly  1025 IVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVW 1089
            |:..||.:||||..:|:|||||||.|.::.|:||||:.|:::.:.||||.||:||  |.::||.|
Mouse  1157 IIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPK--NPYQYKFW 1219

  Fly  1090 RIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNF 1154
            .:|.|:||||.:.:||:.|||.|.|:::.|..|:..::..:||.|||:|:||.|||:|.|..|.:
Mouse  1220 YVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGY 1284

  Fly  1155 FKDPWNIFDLITVLGSIVDA-----------LWMEFG---------------------------- 1180
            |.|.||.||.:.|:|||:|.           .|..|.                            
Mouse  1285 FSDAWNTFDSLIVIGSIIDVALSEADHYFTDAWNTFDALIVVGSVVDIAITEVNPSESETIPLPT 1349

  Fly  1181 --------SNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAI 1237
                    ||.|::.|.||||..||:|||.:|..||.|||||::||:|||||.|||||||||||:
Mouse  1350 ATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAV 1414

  Fly  1238 IGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPG 1302
            ||||:||.:.:.. .|.|.|:||||:|.|.|:|||||||||||..||||||.||.||.|::..||
Mouse  1415 IGMQMFGKVAMRD-NNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPDSDYNPG 1478

  Fly  1303 E--YCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPN 1365
            |  .|||..|..||:||...|:||::|||||||||||||||||.||||.||||||.|||:||||.
Mouse  1479 EEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPE 1543

  Fly  1366 ATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSI 1430
            |.|:|.:.::..:|:.:.||||||..||:|:|.|:|:.|||||:.:..|.|..|||||:|..|.|
Mouse  1544 AKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKI 1608

  Fly  1431 KMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTR 1495
            |...  .::||:.|||..|..||...:.|:|:.:|||:   ...:::|||.||.|||.:.:|..:
Mouse  1609 KTEG--NLEQANEELRAVIKKIWKKTSMKLLDQVVPPA---GDDEVTVGKFYATFLIQDYFRKFK 1668

  Fly  1496 FGQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSPSLRHNGSPLARSPSPRRR 1560
             .:.:.|:       ..::|::.:.....||       ....|...|.:|...|...:...|   
Mouse  1669 -KRKEQGL-------VGKYPAKNTTIALQAG-------LRTLHDIGPEIRRAISCDLQDDEP--- 1715

  Fly  1561 GHQYIHHDIGFSDTVSNVVEMVKET-----RHPRHGNSHPRYPRGSWSASTSPARSPSPSRYGGH 1620
                       .|:.....::.|..     .|..|.||..|......:.:..|.....||     
Mouse  1716 -----------EDSKPEEEDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPS----- 1764

  Fly  1621 LSRSKRTQLP-YPTYGTTSLCQRSRSPSPARLQEMRERDRLGYGIDMGVTHVQHSYPTLASRRAG 1684
            :..:..|:.| :|..|.:. |                             |..|::.:       
Mouse  1765 MPPASDTEKPLFPPAGNSG-C-----------------------------HNHHNHNS------- 1792

  Fly  1685 IGRRLPPTPSKPSTLQLKPTNINFPKLNASPTHTHHSTPHSVHSLPH-----HRDLLRDPRDMYY 1744
            ||::.|.:           ||.|..  ||:.:...|..|.|:.:|.|     |.....|......
Mouse  1793 IGKQAPTS-----------TNANLN--NANMSKAAHGKPPSIGNLEHVSENGHYSCKHDRELQRR 1844

  Fly  1745 SSRERERDRER-LRDRDRD-------RDRDRLHEYDLRYEYRD----RERELYERER----DRER 1793
            ||.:|.|..|. :|....|       |:...:|.|     :||    .|:|.:..|.    |...
Mouse  1845 SSIKRTRYYETYIRSESGDEQFPTICREDPEIHGY-----FRDPRCLGEQEYFSSEECCEDDSSP 1904

  Fly  1794 EVERERLEYI-----APLSFEQALAMGRTGRVLPSPVLNGFKPKSGLN--------------PRH 1839
            ...|:...|.     :.:.||:.     .|...|...|......:|.:              |.|
Mouse  1905 TWSRQNYNYYNRYPGSSMDFERP-----RGYHHPQGFLEDDDSPTGYDSRRSPRRRLLPPTPPSH 1964

  Fly  1840 SDSDEEDWCXQRLXLRSRNRKDQIWVXHQAICSSLSAPNLDHNFDTIRHSYQIPEHLQNLPYLCP 1904
            ..|.....|     ||.::.:|.:          |.:|.|.|.                   ...
Mouse  1965 RRSSFNFEC-----LRRQSSQDDV----------LPSPALPHR-------------------AAL 1995

  Fly  1905 PVHQHQHQHQT----QTQNQRQHQDQHLYQRYGTNVSTPKLGTTISDIKLAGVSLQELSPNRQPQ 1965
            |:|..|.|...    .:...:::...|..:.:.|..:||              ..::.||...|.
Mouse  1996 PLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATP--------------PYRDWSPCYTPL 2046

  Fly  1966 SQQKQEQ----------QLHQDGWLR-----WYRQSGPYGSPVMASLPETRATSPHSDIEFIRTM 2015
            .|..:.:          .||:..|..     .||...|....|.:|.....:....|....:..:
Mouse  2047 IQVDRSESMDQVNGSLPSLHRSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAV 2111

  Fly  2016 KRSE-TGTTAITPR---TTKTEAMILSVPITITSPLAIKKIYSDNDINYNTERGTDNDRV--DDA 2074
            ..|| .|..|..|:   .||.|       |.....|.|.::.|......|   |:...|.  |..
Mouse  2112 LISEGLGRYARDPKFVSATKHE-------IADACDLTIDEMESAASTLLN---GSVCPRANGDMG 2166

  Fly  2075 PAHHYHQPELTT--PDLQDEPP 2094
            |..|....||..  |...||.|
Mouse  2167 PISHRQDYELQDFGPGYSDEEP 2188

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 162/300 (54%)
Ion_trans 441..677 CDD:334124 147/238 (62%)
Ion_trans 769..1050 CDD:334124 135/281 (48%)
Ion_trans 1094..1345 CDD:334124 149/299 (50%)
GPHH 1346..1416 CDD:339854 38/69 (55%)
Ca_chan_IQ 1418..1492 CDD:337190 30/73 (41%)
Cacna1dXP_006518538.1 Ion_trans 125..417 CDD:366146 162/300 (54%)
Ion_trans 545..780 CDD:366146 147/234 (63%)
Ion_trans 905..1182 CDD:366146 135/282 (48%)
Ion_trans 1224..1523 CDD:366146 149/299 (50%)
GPHH 1532..1585 CDD:374878 27/52 (52%)
Ca_chan_IQ 1596..1667 CDD:370105 31/75 (41%)
CAC1F_C 1690..2206 CDD:374867 119/643 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.750

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