DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and Cacna1c

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_036021662.1 Gene:Cacna1c / 12288 MGIID:103013 Length:2245 Species:Mus musculus


Alignment Length:2108 Identity:874/2108 - (41%)
Similarity:1173/2108 - (55%) Gaps:336/2108 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 GGPKKEENPPGGG------PTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEH 60
            |.|||:     ||      |.:|..||..||||:....|:||.|||..:||||.||||.||:...
Mouse   117 GKPKKQ-----GGTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIP 176

  Fly    61 LPGGDKTVLAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQY 125
            .|..|.......||:.|..||.||.|||.||::|.||:.|.::||||.||::||.:||.|..:..
Mouse   177 FPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAI 241

  Fly   126 PQ-------------IGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVL 177
            .:             .|...|::.|||.||||||:||||:|||||||.||||||.|||.|.||||
Mouse   242 LEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL 306

  Fly   178 FAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLE 242
            |.|:|:||||||.:.|.:|||||:.|....:..| |..:||    .||...|. .|.|.| :|..
Mouse   307 FVIIIYAIIGLELFMGKMHKTCYNQEGIIDVPAE-EDPSPC----ALETGHGR-QCQNGT-VCKP 364

  Fly   243 KWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNL 307
            .|:||..|||:|||..||||||||||||||||.:|||..||:|....|:|||.|::.||||:|||
Mouse   365 GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNL 429

  Fly   308 VLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIME 372
            |||||||||:|||||.:.|.:|.|||.:||||.:|.||::||.:||::    :...|:|.|...:
Mouse   430 VLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDI----DPENEDEGMDEDK 490

  Fly   373 ARRRNAA----KRKKLKSLGKSKST---------DTEEEEAEEDYGDD------GYLKTRSKPQG 418
            .|.|.|.    .:||.|....|.||         :||....|...|.|      |........:.
Mouse   491 PRNRGAPAGLHDQKKGKFAWFSHSTETHVSMPTSETESVNTENVAGGDIEGENCGARLAHRISKS 555

  Fly   419 SCTGFWRAEKRF-RFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLG 482
            ..:.:||...|| |...|..||:..|||.||.||||||:.:|.|||.||.:|||....|....|.
Mouse   556 KFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLA 620

  Fly   483 LFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGS-FGLSVLRALRLLRIFKV 546
            ||.:||.:|||:||.:.||.|.||||||.::.|.|.|.|..|.|..| .|:||||.:|||||||:
Mouse   621 LFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKI 685

  Fly   547 TKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPG-GTPETNFNTFPIA 610
            |:||:||.|||.|||||:|||.|||.||||||:||:|||||||||:||... .|..:.|:.||.:
Mouse   686 TRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQS 750

  Fly   611 LLTVFQILTGEDWNEVMYQGIISQGGAQ-KGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQ 674
            ||||||||||||||.|||.||::.||.. .||:..||||:|.:.|||.||||||||||||||:|:
Mouse   751 LLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAE 815

  Fly   675 ELTAAEEEQVEEDKEKQL------------QE-LEK-----------EMEALQADG-------VH 708
            .||:|::|:.||.:.|:|            || :||           |::::.|||       ::
Mouse   816 SLTSAQKEEEEEKERKKLARPARTASPEKKQEVMEKPAVEESKEEKIELKSITADGESPPTTKIN 880

  Fly   709 VENGDGAVAPSKSKGKKKE-------EEKKEEEEVTEGPK--------------PMLPYSSMFIL 752
            :::    :.||:::.|...       ||.:||.|:..||:              ||...|:.||.
Mouse   881 MDD----LQPSENEDKSPHSNPDTAGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIF 941

  Fly   753 SPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNYF------------ 805
            ||.|..|...|.:||...|...|:..|.:|||:|||||||:..|.||.||.||            
Mouse   942 SPNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEI 1006

  Fly   806 --------DYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSA 862
                    ||.||.:||:|::||:...|..||.||:.|.::||:|.:||..:.:|||...|.   
Mouse  1007 ALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA--- 1068

  Fly   863 GQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFN 927
               ::.:|.||||||||||:.|.|...||.|..||..:::.:.||:||..|.||:|:.||||||.
Mouse  1069 ---INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFK 1130

  Fly   928 GKFFYCTDESKHTSAECQGSYFKYEEDEL-LPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGW 991
            ||.:.|:|.||.|.|||:|:|..|::.|: .|..:.|.|:...|.:|||.|||:.||.|.|.|||
Mouse  1131 GKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGW 1195

  Fly   992 PQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEI 1056
            |::|..|:.:..||:|||.|:|:|:|||:|:|.|:..||.:||||..:|:|||||||.|.::.|:
Mouse  1196 PELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCEL 1260

  Fly  1057 DKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGD 1121
            ||||:.|:::.:.||||.||:|||::  :||||.:|.||.|||.:.:||:.||:.|.|:::.|..
Mouse  1261 DKNQRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSC 1323

  Fly  1122 MYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDAL----------- 1175
            :::.::..:||.|||:|:||.:||:|.|..|.:|.||||:||.:.|:|||:|.:           
Mouse  1324 LFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDA 1388

  Fly  1176 WMEF------GS-------------------------NS-INVGFLRLFRAARLIKLLRQGYTIR 1208
            |..|      ||                         || |::.|.||||..||:|||.:|..||
Mouse  1389 WNTFDALIVVGSIVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIR 1453

  Fly  1209 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLG-TVENSITRHNNFQSFIQGVMLLF 1272
            .|||||::||:|||||.|||.|||||||:|||||||.|.|. |.|  |.|:||||:|.|.|:|||
Mouse  1454 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTE--INRNNNFQTFPQAVLLLF 1516

  Fly  1273 RCATGEAWPNIMLACLKGKACDDDAE---KAPGEY-CGSTLAYAYFVSFIFFCSFLMLNLFVAVI 1333
            ||||||||.:|||||:.||.|..::|   ...||. |||:.|..||:||...|:||::|||||||
Mouse  1517 RCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1581

  Fly  1334 MDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAY 1398
            ||||||||||.||||.||||||.||||||||.|.|:|.:.::..:|:.:.||||||..||:|:|.
Mouse  1582 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVAC 1646

  Fly  1399 KKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNL 1463
            |:|:.|||||:.:..|.|..|||||:|..|.||...  .::||:.|||..|..||...:.|:|:.
Mouse  1647 KRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEG--NLEQANEELRAIIKKIWKRTSMKLLDQ 1709

  Fly  1464 LVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDASRHPSQESLTGADAGHL 1528
            :|||:   ...:::|||.||.|||.|.:|..:         ..:.|.....|||.:.....|| |
Mouse  1710 VVPPA---GDDEVTVGKFYATFLIQEYFRKFK---------KRKEQGLVGKPSQRNALSLQAG-L 1761

  Fly  1529 HPGHSYMNGHRRSPS------------LRHNGSPLARSPSPRRRGHQYIHHDIGF-SDTVSNVVE 1580
            ...|......||:.|            ::...|..:.....||.|..:.:|...: ||:..|..:
Mouse  1762 RTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVTYYQSDSRGNFPQ 1826

  Fly  1581 MVKETRHPRHGNSHPRYPRGSWSAST-SPARSP------SPSRY-----GGHLSRSKRTQL---P 1630
            .. .|:.|.|.|.     .|:..|.| ||:...      :||.|     ..:::.:..|.|   |
Mouse  1827 TF-ATQRPLHINK-----TGNNQADTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRFP 1885

  Fly  1631 YPT-YGTTSLCQRSRSP--SPARLQEMRERDRLGYGIDMGVTHVQHSYPTLASRR--------AG 1684
            :|. |.:|........|  |||                   ..||.:...|:|:|        |.
Mouse  1886 HPAGYSSTVSTVEGHGPPLSPA-------------------VRVQEAAWKLSSKRCHSRESQGAT 1931

  Fly  1685 IGRRLPPTPSKPSTLQLKPTNINFPKLNASPTHTHHSTPHSVHSLPHHRDLLRDPRDMYYSSRER 1749
            :.:.:.|..::...:..:....:.|.|.::...::....|...:.|.     .|.|::..|.:  
Mouse  1932 VNQEIFPDETRSVRMSEEAEYCSEPSLLSTDMFSYQEDEHRQLTCPE-----EDKREIQPSPK-- 1989

  Fly  1750 ERDRERLRDRDRDRDRDRLHEYDLRYEYRDRERELYERERDREREVERERLEYIAPLSF--EQAL 1812
               |..||.....| |...|            .|..:|::|:..::.::.   ..||..  .|||
Mouse  1990 ---RSFLRSASLGR-RASFH------------LECLKRQKDQGGDISQKT---ALPLHLVHHQAL 2035

  Fly  1813 AM------------------------------GRTGRVLPSPVLNGFKPKSGLNPR------HSD 1841
            |:                              ||..|.:|:..|.|.:....||..      .|.
Mouse  2036 AVAGLSPLLQRSHSPTTFPRPCPTPPVTPGSRGRPLRPIPTLRLEGAESSEKLNSSFPSIHCSSW 2100

  Fly  1842 SDEEDWCXQRLXLRSRNRKDQIWVXHQA 1869
            |:|...| ... :..|.|...:.| .||
Mouse  2101 SEETTACSGSSSMARRARPVSLTVPSQA 2128

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 163/299 (55%)
Ion_trans 441..677 CDD:334124 147/238 (62%)
Ion_trans 769..1050 CDD:334124 138/301 (46%)
Ion_trans 1094..1345 CDD:334124 149/298 (50%)
GPHH 1346..1416 CDD:339854 39/69 (57%)
Ca_chan_IQ 1418..1492 CDD:337190 31/73 (42%)
Cacna1cXP_036021662.1 Ion_trans 153..446 CDD:395416 163/299 (55%)
Ion_trans 578..819 CDD:395416 148/240 (62%)
Ion_trans 957..1254 CDD:395416 138/302 (46%)
Ion_trans 1296..1593 CDD:395416 149/298 (50%)
GPHH 1602..1655 CDD:407139 28/52 (54%)
Ca_chan_IQ 1666..1737 CDD:400901 32/75 (43%)
CAC1F_C 1759..2194 CDD:407123 83/422 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.750

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