DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and Cacna1a

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	XP_006530650.1	Gene:	Cacna1a / 12286	MGIID:	109482	Length:	2464	Species:	Mus musculus

Alignment Length:	2517	Identity:	1075/2517 - (42%)
Similarity:	1328/2517 - (52%)	Gaps:	711/2517 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            |||:.:|||.:|||.:.|.|||||||.:|.||||||:|||||:|||..|||.::::|:.||.||:
Mouse   168 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFI 232

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|||.||.:||:|||...||.|||||.||:|||.||:||.:.   .:|.|.|||||||:||||||
Mouse   233 GIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILA---TVGTEFDLRTLRAVRVLRPL 294

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKE 211
            ||||||||||||||||:|||.||||||||:.|||:||||||||||.|..|.||:. |..:.:  :
Mouse   295 KLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE-EGTDDI--Q 356

  Fly   212 GESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAI 276
            |||..||.|:   |.|.   .|.|.|. |...|||||:|||.||||.||:|||||||||||||.:
Mouse   357 GESPAPCGTE---EPAR---TCPNGTK-CQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDL 414

  Fly   277 LYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERE 341
            ||.:|||.|:.:||:||:|||:|||||||||||||||||||||||:||||:.|||||||||:|||
Mouse   415 LYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 479

  Fly   342 LNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGD 406
            ||||:|||.|||||||||:.|..|:: |..:.   .|.:|..||   |||:.....||||:...|
Mouse   480 LNGYMEWISKAEEVILAEDETDVEQR-HPFDV---GALRRATLK---KSKTDLLNPEEAEDQLAD 537

  Fly   407 DGYL-------KTRSKPQGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYG 464
            ...:       ..:|....:.|.|.:.|:|.||:||..||||.|||.|:.||.|||:|||:.||.
Mouse   538 IASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYN 602

  Fly   465 QPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVK-GG 528
            ||.:|::||||||||||||||||||||||.||.|.||.||||.|||.||.||||||||:.:| |.
Mouse   603 QPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGT 667

  Fly   529 SFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQF 593
            |||:||||||||||||||||||:||||||:||||||:|||||||||||||::|||||||||||||
Mouse   668 SFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF 732

  Fly   594 NLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTL 658
            |...|||.|||:|||.|::||||||||||||||||.||.||||.|.||::|||||||.|||||||
Mouse   733 NFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTL 797

  Fly   659 LNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEM------------------------ 699
            |||||||||||||||||||..|:|:.|...:|...:..||:
Mouse   798 LNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKP 862

  Fly   700 ----------------------------------------------------------------- 699

Mouse   863 TKSVWEQRTSEMRKQNLLASREALYGDAAERWPTPYARPLRPDVKTHLDRPLVVDPQENRNNNTN 927

  Fly   700 -----EALQ-------------------------------------------------------- 703
                 |||:
Mouse   928 KSRAPEALRPTARPRESARDPDARRAWPGSPERAPGREGPYGRESEPQQREHAPPREHAPWDADT 992

  Fly   704 ------------------------------------------------------ADG-------- 706
                                                                  |||
Mouse   993 ERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERK 1057

  Fly   707 ----------------------------------------------------------------- 706

Mouse  1058 RRHRHGPPAHDDRERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDLPLAEDLDNMKNNKLA 1122

  Fly   707 ------VHVENGDGAVAPSKSK---------------------------GK-------------- 724
                  .|...|...:.||.:|                           |.
Mouse  1123 TGEPASPHDSLGHSGLPPSPAKIGNSTNPGPALATNPQNAASRRTPNNPGNPSNPGPPKTPENSL 1187

  Fly   725 --------------------------------------------------KKEEEKKEEEEV--- 736
                                                              |||||||||||.
Mouse  1188 IVTNPSSTQPNSAKTARKPEHMAVEIPPACPPLNHTVVQVNKNANPDPLPKKEEEKKEEEEADPG 1252

  Fly   737 TEGPKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKI 801
            .:|||||.|||||||||.|||:||..|:::||.||:..|::||:||||||||||||:.|:.||.:
Mouse  1253 EDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNV 1317

  Fly   802 LNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMS--GSSAGQ 864
            |.||||.||||||.||::|::|||::||.|:|.|:.|||:|.:||..|.|:|.|..|  |:|.|:
Mouse  1318 LRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTSSTRGNSKGK 1382

  Fly   865 NLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGK 929
            :::|||||||||||||||||||:|||||||||||||||||.||||||:||.|||:|:.||||.||
Mouse  1383 DINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGK 1447

  Fly   930 FFYCTDESKHTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQV 994
            ||:||||||....:|:|.|..||::|:  |...|.||...||||||..|:||||.|.||||||||
Mouse  1448 FFHCTDESKEFERDCRGKYLLYEKNEV--KARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQV 1510

  Fly   995 LQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKN 1059
            |:||:.||:|::||...:|:||||||:|||:||||||||||||||||||||||:..:::..::||
Mouse  1511 LKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKN 1575

  Fly  1060 QKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYE 1124
            :::||||.|.|:||.|:||:|:.:|:|::|:.|||.||||.||.:|..||::||||::.....||
Mouse  1576 ERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYE 1640

  Fly  1125 KSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFG--SNSINVG 1187
            .:|:..|:.||.:||:|.|||::.||:.|:|:|.|||||.:||||||.|.|..|||  :|.||:.
Mouse  1641 NALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNPNNFINLS 1705

  Fly  1188 FLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL-GTV 1251
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.: |..
Mouse  1706 FLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDGED 1770

  Fly  1252 ENS------ITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGSTLA 1310
            |:|      ||.||||::|.|.:|||||.||||||.||||:||.||.||.::.....: ||:..|
Mouse  1771 EDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTAD-CGNEFA 1834

  Fly  1311 YAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEM 1375
            |.|||||||.|||||||||||||||||:||||||||||.|||||:||:||||||.|.|:|||.:|
Mouse  1835 YFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDM 1899

  Fly  1376 YDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKM-RAPEEMD 1439
            |.:|:.:.||||.|.|||:|:|.|:|:||::|:.|:..|.|.:||.||||..|.||: :...:..
Mouse  1900 YSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQ 1964

  Fly  1440 QADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQL----- 1499
            |.|.|||:.:..|||..::|.|:|||.|....:   |:||||||..:|:|.:|.::..:|
Mouse  1965 QMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTD---LTVGKIYAAMMIMEYYRQSKAKKLQAMRE 2026

  Fly  1500 -DSGMPMLELQDASRHPSQE---SLTGADAGHLHPGHSYM---NGHRRSPSLRHNGSPLARSPSP 1557
             .:..|::..:.....|:||   |.....:..|.||...|   .|.:.|||.
Mouse  2027 EQNRTPLMFQRMEPPSPTQEGGPSQNALPSTQLDPGGGLMAHEGGMKESPSW------------- 2078

  Fly  1558 RRRGHQYIHHDIGFSDTVSNVVEMVKETRHPRHGNSHPRYPRGSWSASTSPARSPSPSRYGGHLS 1622
                            ......||.::|              |:|    ||.|.|.
Mouse  2079 ----------------VTQRAQEMFQKT--------------GTW----SPERGPP--------- 2100

  Fly  1623 RSKRTQLPYPTYGTTSLCQRSRSPSPARLQEMRERDRLGYGIDMGVTHVQHSYPTLASRRAGIGR 1687
                ..:|             .|...::..||||....||      :..:|..|.....||....
Mouse  2101 ----IDMP-------------NSQPNSQSVEMREMGTDGY------SDSEHYLPMEGQTRAASMP 2142

  Fly  1688 RLPPTPSKPSTLQLKPTNINFPKLNASPTHTHHSTPHSVHSLPHHRDLLRDPRDMYYSSRERERD 1752
            |||                                                      :..:|.|.
Mouse  2143 RLP------------------------------------------------------AENQRRRG 2153

  Fly  1753 RERLRDRDRDRDRD--------------RLHEYDLRYEYRDRERELYERERDR-EREVERERLEY 1802
            |.|..|.....|..              ||.:|.|.....:..:..::|.||| .|..||....|
Mouse  2154 RPRGNDLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRYHQRRRDRGHRTSERSLGRY 2218

  Fly  1803 I-APLSFEQALAMGRTGRVLPSPVLNGFKPKSGLNPRHSDSDEEDWCXQRLXLRSRNRKDQIWVX 1866
            . ........|:|......|||                .|.|::..       |.::||.:
Mouse  2219 TDVDTGLGTDLSMTTQSGDLPS----------------KDRDQDRG-------RPKDRKHR---- 2256

  Fly  1867 HQAICSSLSAPNLDHNFDTIRHSYQIPEHLQNLPYLCPPVHQHQHQHQTQTQNQRQHQDQHLYQR 1931
                                      |.|           |.|.|.|.....:    :|::..:|
Mouse  2257 --------------------------PHH-----------HHHHHHHHPPAPD----RDRYAQER 2280

  Fly  1932 YGTNVSTPKLGTTISDIKLAGVSLQELSPNRQPQSQQKQEQQLHQDGWLRWYRQSGPYGSPVMAS 1996
                   |..|.         ...:|...:|.|  .:.:|...|:.|      .|...|||.
Mouse  2281 -------PDTGR---------ARAREQRWSRSP--SEGREHTTHRQG------SSSVSGSPA--- 2318

  Fly  1997 LPETRATS-PHSDIEFIRTMKRSETGTTAITPRTTKTEAMILSVPITITSPL----AIKKIYSDN 2056
             |.|..|| |...        |.:...|..|||           |:...||.    |.:::....
Mouse  2319 -PSTSGTSTPRRG--------RRQLPQTPCTPR-----------PLVSYSPAPRRPAARRMAGPA 2363

  Fly  2057 DINYNTERGTDNDRVDDAPAHHYHQP-----ELTTPDLQDEPPLQQH 2098
            .....:.||.  .|....|||....|     :.|.||...|||...|
Mouse  2364 APPGGSPRGC--RRAPRWPAHAPEGPRPRGADYTEPDSPREPPGGAH 2408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	190/286 (66%)
		Ion_trans	441..677	CDD:334124	190/236 (81%)
		Ion_trans	769..1050	CDD:334124	188/282 (67%)
		Ion_trans	1094..1345	CDD:334124	174/259 (67%)
		GPHH	1346..1416	CDD:339854	41/69 (59%)
		Ca_chan_IQ	1418..1492	CDD:337190	32/74 (43%)
Cacna1a	XP_006530650.1	Ion_trans	188..462	CDD:366146	190/286 (66%)
		Ion_trans	579..817	CDD:366146	191/237 (81%)
		PHA03247	<895..1277	CDD:223021	41/381 (11%)
		Ion_trans	1285..1520	CDD:366146	153/236 (65%)
		Ion_trans	1610..1869	CDD:366146	174/259 (67%)
		GPHH	1878..1931	CDD:374878	31/52 (60%)
		Ca_chan_IQ	1942..2015	CDD:370105	32/75 (43%)
		PHA03307	2046..>2460	CDD:223039	110/613 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	389	1.000	Domainoid score	I785
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1858	1.000	Inparanoid score	I62
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0000179
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100303
Panther	1	1.100	-	-	O	PTHR45628
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	1	1.000	-	-		X841
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.860