DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cac and CATSPER1

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	NP_444282.3	Gene:	CATSPER1 / 117144	HGNCID:	17116	Length:	780	Species:	Homo sapiens

Alignment Length:	381	Identity:	91/381 - (23%)
Similarity:	173/381 - (45%)	Gaps:	55/381 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   369 HIMEAR-------RRNAAKRKKLKSLGKSKSTDTEEEEAEEDYG-DDGYL---KT----RSKPQG 418
            |:...|       |.::..|.::..:.|...|.....:..||:| ::|..   ||    |::.:|
Human   352 HVAHPRGSAHSMTRSSSTIRSRVTQMSKKVHTQDISTKHSEDWGKEEGQFQKRKTGRLQRTRKKG 416

  Fly   419 SCTGF--WRAEK------RFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYY 475
            ..|..  |..||      .||..||:..::..|..|:..:|.||||.:..:.:.:.....|:.:.
Human   417 HSTNLFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFM 481

  Fly   476 A-EFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGL------- 532
            | :.||..:::.|..:|:.||| ..||...:|..|..:::.::.:.:..:..  ||.:
Human   482 ALDSIFFCIYVVEALLKIIALG-LSYFFDFWNNLDFFIMAMAVLDFLLMQTH--SFAIYHQSLFR 543

  Fly   533 -----SVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQ 592
                 ..|||||.:|:.:...:.:|::.:..:|..|:.||.::|.|:|..:.:|:.:...||
Human   544 ILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF--- 605

  Fly   593 FNLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYT 657
               ....|:...|.| ..:.|:|.:||.:||:      :|......:|..|.|..:|:.:...|.
Human   606 ---RKSDPKRFQNIF-TTIFTLFTLLTLDDWS------LIYMDSRAQGAWYIIPILVIYIIIQYF 660

  Fly   658 L-LNVFLAIAVDNLANA--QELTAAEEEQVEEDKEKQLQELEKEMEALQADGVHVE 710
            : ||:.:.:.||:...|  :.|..|::|:....:||.|::...|:.|.:...|..|
Human   661 IFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASE 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124
		Ion_trans	441..677	CDD:334124	59/251 (24%)
		Ion_trans	769..1050	CDD:334124
		Ion_trans	1094..1345	CDD:334124
		GPHH	1346..1416	CDD:339854
		Ca_chan_IQ	1418..1492	CDD:337190
CATSPER1	NP_444282.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..306
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..412		8/35 (23%)
		Ion_trans	483..677	CDD:278921	49/209 (23%)
		7TMR-DISM_7TM	486..629	CDD:284997	36/152 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810