Protein Alignment cac and Cacna1h

DIOPT Version :9

• Sequence 1: NP_001356945.1
• Gene: cac / 32158
• FlyBaseID: FBgn0263111
• Length: 2110
• Species: Drosophila melanogaster
• Sequence 2: XP_008765754.2
• Gene: Cacna1h / 114862
• RGDID: 68943
• Length: 2370
• Species: Rattus norvegicus
• Alignment Length: 2318
• Identity: 546/2318 - (23%)
• Similarity: 900/2318 - (38%)
• Gaps: 725/2318 - (31%)

  Fly     7 EENP---PGGGPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTV 68
            ||.|   |....|..|.|.:....|.:...::..|.||:..:|.|:.|||.|.:  ..|..|...
  Rat    66 EEQPVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHISMLVIMLNCVTLGM--FRPCEDVEC 128

  Fly    69 LAQK---LEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGP 130
            .:::   ||..:.:....|.||..:|::||||...| .||.:.||.:|||:|:.|.| :|...|.
  Rat   129 RSERCSILEAFDDFIFAFFAVEMVIKMVALGLFGQK-CYLGDTWNRLDFFIVMAGMM-EYSLDGH 191

  Fly   131 EVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGAL 195
            .|.|..:|.:||||||:.::.:||:::::..::..:..|..:.||..|...||.|:|::.::|.|
  Rat   192 NVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLL 256

  Fly   196 HKTCY-----------SLEDPNKLVKEGESETP--CNT--DNILEKATGSFVCNNTTS------M 239
            ...|:           :...|....:||| |.|  |::  ||.::|      |::..|      .
  Rat   257 RNRCFLDSAFVRNNNLTFLRPYYQTEEGE-ENPFICSSRRDNGMQK------CSHIPSRRELRVQ 314

  Fly   240 CLEKWE--------------------------------GPNSGITSFDNIGFAMLTVFQCITMEG 272
            |...||                                .|::|..:|||||:|.:.:||.||:||
  Rat   315 CTLGWEAYGQPQAEDGGAGRNACINWNQYYNVCRSGEFNPHNGAINFDNIGYAWIAIFQVITLEG 379

  Fly   273 WTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFA--KEREKVENRQE------- 328
            |..|:|:..|| .|.:|:|||:.||::|||||:||.|.|::.:|:  |:||....|::
  Rat   380 WVDIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRENQLMREQRARYLSN 443

  Fly   329 ------------------------FLKLRRQQQLERELNGYVEWICKAEEVI------------- 356
                                    |.|::|     |.|..|..|..:..:.:
  Rat   444 DSTLASFSEPGSCYEELLKYVGHIFRKVKR-----RSLRLYARWQSRWRKKVDPSSTVHGQGPGR 503

  Fly   357 ---LAEERTT------------------------------------------------------- 363
               .|..||.
  Rat   504 RPRRAGRRTASVHHLVYHHHHHHHHHYHFSHGGPRRPSPEPGAGDNRLVRACAPPSPPSPGHGPP 568

  Fly   364 EEEKMHIM----------EARRRNA-----AKRKKLKS--------------------------- 386
            :.|.:|.:          :.|.|.|     |...||.|
  Rat   569 DSESVHSIYHADCHVEGPQERARVAHSIATAASLKLASGLGTMNYPTILPSGTVNSKGGTSSRPK 633

  Fly   387 -----------------------------------LGKSKS------------------------ 392
                                               ||::.|
  Rat   634 GLRGAGAPGAAVHSPLSLGSPRPYEKIQHVVGEQGLGRASSHLSGLSVPCPLPSPQAGTLTCELK 698

  Fly   393 ---------TDTEEEEAEEDYGDDG----YLKTRSKPQGSC------------TGFWRAEKRF-- 430
                     .|.|.|.:..:.||..    |..|:....|.|            .|.....:|.
  Rat   699 SCPYCASALEDPEFEFSGSESGDSDAHGVYEFTQDVRHGDCRDPVQQPHEVGTPGHSNERRRTPL 763

  Fly   431 ----------RFW------IRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFI 479
                      ..|      :|..|.:::|...::..:.:||:.:.||::.||..||..|..:..:
  Rat   764 RKASQPGGIGHLWASFSGKLRRIVDSKYFNRGIMAAILVNTLSMGVEYHEQPEELTNALEISNIV 828

  Fly   480 FLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIF 544
            |..:|..||.:|:.|.||..|..:.:|.||.:|:..|::|:: .:..|   ||||||..||||:.
  Rat   829 FTSMFALEMLLKLLACGPLGYIRNPYNIFDGIVVVISVWEIV-GQADG---GLSVLRTFRLLRVL 889

  Fly   545 KVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPET-----NF 604
            |:.::..:||..::.|:.:|.::.:...||.|||.||::|||.|||.:|:|...:.:|     ||
  Rat   890 KLVRFLPALRRQLVVLMRTMDNVATFCMLLMLFIFIFSILGMHLFGCKFSLKTDSGDTVPDRKNF 954

  Fly   605 NTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDN 669
            ::...|::|||||||.||||.|:|.|:.|.....     ::||:.|:.||||.|.|:.:||.|:.
  Rat   955 DSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWA-----ALYFVALMTFGNYVLFNLLVAILVEG 1014

  Fly   670 LANAQELTAAEEE------QVEE--DKEKQLQELEKEMEAL------------------------ 702
            .....:.|.::.:      |:|.  ||.:.|:..|.:|.:|
  Rat  1015 FQAEGDATRSDTDEDKTSTQLEGDFDKLRDLRATEMKMYSLAVTPNGHLEGRGSLPPPLITHTAA 1079

  Fly   703 ----------QADGVHV-----ENGDGAV------------------------------------ 716
                      ..|..|.     .:..|:|
  Rat  1080 TPMPTPKSSPNLDVAHALLDSRRSSSGSVDPQLGDQKSLASLRSSPCTPWGPNSAGSSRRSSWNS 1144

  Fly   717 ---APS--------------KSKGKKKEEEKKEEEEVTEG------------------------- 739
               |||              ..:||...:::.|:...:.|
  Rat  1145 LGRAPSLKRRSQCGERESLLSGEGKGSTDDEAEDSRPSTGTHPGASPGPRATPLRRAESLDHRST 1209

  Fly   740 -----PKP---------------------------------------------------MLPYS- 747
                 |:|                                                   :.||:
  Rat  1210 LDLCPPRPAALLPTKFHDCNGQMVALPSEFFLRIDSHKEDAAEFDDDIEDSCCFRLHKVLEPYAP 1274

  Fly   748 ---------SMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDP-VRENSRRNKIL 802
                     ::::..|.|.:|.....|:....||..::|.|.::.|.:|.|.| :...|.....|
  Rat  1275 QWCRSRESWALYLFPPQNRLRVSCQKVIAHKMFDHVVLVFIFLNCITIALERPDIDPGSTERAFL 1339

  Fly   803 NYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLS 867
            :..:|.||.:|.:||::|:|.||::....:||:..||::|.::|:.:.|.....|:.:...:.|.
  Rat  1340 SVSNYIFTAIFVVEMMVKVVALGLLWGEHAYLQSSWNVLDGLLVLVSLVDIIVAMASAGGAKILG 1404

  Fly   868 TIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFY 932
            .::.||:||.||||:.|.|.|.||.|.:.:::||:.:.||:::...|..||.::|||||.|||:|
  Rat  1405 VLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYY 1469

  Fly   933 C--TD-ESKHTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQV 994
            |  || .:..|.|||..::::              |..|.:::||:..|:::||.:.:.:||..:
  Rat  1470 CEGTDTRNITTKAECHAAHYR--------------WVRRKYNFDNLGQALMSLFVLSSKDGWVNI 1520

  Fly   995 LQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITF---QEQGEAELQDGEI 1056
            :...:.|...|:.|:||....|.:::|.:.::..||.:|:||.:::..|   ::..|||    |.
  Rat  1521 MYDGLDAVGIDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAE----EA 1581

  Fly  1057 DKNQKSCIDFTIGARPLERYMPKNRNTF-----------------KYKVWRIVVSTPFEYFIMML 1104
            .:.::..:      |.|||   :.|:||                 :..:..:..|...:.||..:
  Rat  1582 RRREEKRL------RRLER---RRRSTFPNPEAQRRPYYADYSHTRRSIHSLCTSHYLDLFITFI 1637

  Fly  1105 IVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLG 1169
            |..|.:.:.|:::||....:::|||.|..||.:|..|..||::.||.:.||||.||..||..||.
  Rat  1638 ICLNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLL 1702

  Fly  1170 SIVDALWMEFGSNS---IN---VGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLI 1228
            ||:.....|...|:   ||   :..:|:.|.||::|||:....:|.||.|.||:...:..:.||.
  Rat  1703 SIMGIALEEIEMNAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1767

  Fly  1229 AMLFFIYAIIGMQVFGNIKLGTVEN---SITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKG 1290
            .:||||||.:|:::||.::. :.:|   .::||..|.:|....:.|||.:||:.|..||...|:.
  Rat  1768 MLLFFIYAALGVELFGRLEC-SEDNPCEGLSRHATFTNFGMAFLTLFRVSTGDNWNGIMKDTLRE 1831

  Fly  1291 KACDDDAEKAPGEYCGS---TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHL 1352
            ...:|       ::|.|   .|:..|||:|:....|:::|:.|||:|               .||
  Rat  1832 CTRED-------KHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLM---------------KHL 1874

  Fly  1353 DEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPL----------GFGNKCPNRLAYKKLI---RM 1404
            :|..: .|..|.....:|. .||........||.          |.....||.|..:|:.   .:
  Rat  1875 EESNK-EAREDAEMDAEIE-LEMAQGSTAQPPPTAQPPSPQESQGTQPDTPNLLVVRKVSVSRML 1937

  Fly  1405 NMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSD 1469
            ::|.|        :.:|..:     ....||......::|: ||.|.  |:.:.....|....|.
  Rat  1938 SLPND--------SYMFRPV-----APAAAPHSHPLQEVEM-ETYTG--PVTSAHSPPLEPRASF 1986

  Fly  1470 QLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSY 1534
            |:.....|..::......|....:.|...|..   :|..|:|....|.|.......|...|.::
  Rat  1987 QVPSAASSPARVSDPLCALSPRGTPRSLSLSR---ILCRQEAMHSESLEGKVDDVGGDSIPDYT- 2047

  Fly  1535 MNGHRRSPSLRHNGSPLARSP--SPRRRGHQYIHHDIG-----------------FSDTVSNVVE 1580
            ......|.|....|:|  |||  |||....:...|..|                 .:|.....|.
  Rat  2048 EPAENMSTSQASTGAP--RSPPCSPRPASVRTRKHTFGQRCISSRPPTLGGDEAEAADPADEEVS 2110

  Fly  1581 MVKETRHPRHGNSHPRYPRGSWSAST--SPARSPSPSRYGGHLSRSKRTQLPYPTYGTTSLCQRS 1643
            .:..:.||             |.|:.  ||..||:.|...|.:. |.|....:.:....|...:.
  Rat  2111 HITSSAHP-------------WPATEPHSPEASPTASPVKGTMG-SGRDPRRFCSVDAQSFLDKP 2161

  Fly  1644 RSPSPARLQEMRERDRLGYGIDMGVTHVQHS---------YPTLASRRAGIGRRL--------PP 1691
            ..|...|...:.        :|.|.:|::..         .|.|.|||.   :::        ||
  Rat  2162 GRPDAQRWSSVE--------LDNGESHLESGEVRGRASELEPALGSRRK---KKMSPPCISIEPP 2215

  Fly  1692 TPSKPSTLQLKPTNINFPKLNASPTHTHHSTPHSVHSLPHHRD 1734
            |..:.|:   :|     |......|.....||....:|  |||
  Rat  2216 TEDEGSS---RP-----PAAEGGNTTLRRRTPSCEAAL--HRD 2248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	110/344 (32%)
		Ion_trans	441..677	CDD:334124	87/240 (36%)
		Ion_trans	769..1050	CDD:334124	89/287 (31%)
		Ion_trans	1094..1345	CDD:334124	88/262 (34%)
		GPHH	1346..1416	CDD:339854	17/82 (21%)
		Ca_chan_IQ	1418..1492	CDD:337190	13/73 (18%)
Cacna1h	XP_008765754.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820