Protein Alignment cac and SCN11A

DIOPT Version :9

• Sequence 1: NP_001356945.1
• Gene: cac / 32158
• FlyBaseID: FBgn0263111
• Length: 2110
• Species: Drosophila melanogaster
• Sequence 2: XP_016861136.1
• Gene: SCN11A / 11280
• HGNCID: 10583
• Length: 1916
• Species: Homo sapiens
• Alignment Length: 1783
• Identity: 444/1783 - (24%)
• Similarity: 792/1783 - (44%)
• Gaps: 371/1783 - (20%)

  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            :|||....|.||.....:.....|...::.|:|.|||.:|     .|..|...:...:..|..|.
Human   233 ALFIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMA-----TGPAKNSNSNNTDIAECVFT 292

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|:..||.:||||.|.:|.:.|:||:.||.:|..|:....::..|  |..:.|..||..||.|.|
Human   293 GIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIP--GITIKLLPLRTFRVFRAL 355

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKE 211
            |.:|.:..|:|::.::::::..|:.:.:|..|.:.|||::|.:.:.|:|:..|.|.:..|  :..
Human   356 KAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKN--ISN 418

  Fly   212 GESETPC--NTDNILE-KATGSFVCNNTTSM---CLEKWEGPNSGITSFDNIGFAMLTVFQCITM 270
            .|:...|  ..:|..| |..|.::.|:..|:   |......|:...|:|||.|::.|.:|:.:|.
Human   419 PEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQ 483

  Fly   271 EGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKERE----KVENRQEFLK 331
            :.|..:...|....| .::..:|:.:|.:|||:::||.|.|::..:.::.:    ::|.:::..:
Human   484 DSWEKLYQQTLRTTG-LYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQ 547

  Fly   332 LRRQQQLERELNGYVEWICKAEEVILAEERT--TEEEKMHIMEARRRNAAKRKK----LKSLGKS 390
             ..||.|:.|         |...|.:..:|:  |..|..:....:|:....:|:    |:..||.
Human   548 -EAQQLLKEE---------KEALVAMGIDRSSLTSLETSYFTPKKRKLFGNKKRKSFFLRESGKD 602

  Fly   391 K--STDTEEE--------------------EAEEDYGDDGY--------------LKTRSKPQ-- 417
            :  .:|::|:                    :..:::||...              :|.:.|.|
Human   603 QPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTITMKEQEKSQEP 667

  Fly   418 --------------GSCTGFWRAEKRFRFWIRHTVKTQWFYWFVI-VLVFLNTVCVAVEHYGQPS 467
                          .:|...|...|:    :..||.|..|....| :.:.:|||.:|:||:...:
Human   668 CLPCGENLASKYLVWNCCPQWLCVKK----VLRTVMTDPFTELAITICIIINTVFLAMEHHKMEA 728

  Fly   468 FLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGL 532
            ...:.|.....:|..:|::||.:|:.||.|..||...:|.||.:|...|..:|:...::..|:
Human   729 SFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSW-- 791

  Fly   533 SVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNL-- 595
            ..||:.|:||:||:.|.|.:|..|:..:.||:.::.||..:|.:.|.||:::||||||..||.
Human   792 PFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQK 856

  Fly   596 ------PGGTPET-----NFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIV 649
                  |.|...:     :...|..:.|.||:||.|| |.|.|:: .:.:..|...:.. |.||:
Human   857 SPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWE-CMQEANASSSLCV-IVFIL 918

  Fly   650 LVLFGNYTLLNVFLAIAVDNLANAQE--------------------------------------- 675
            :.:.|...:||:|:|:.:::.:|.:.
Human   919 ITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRRAFCFVRHTLEHFCHKWC 983

  Fly   676 -----------------------------------------LT------------------AAEE 681
                                                     ||                  |.||
Human   984 RKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLAPLAEEE 1048

  Fly   682 EQVE---EDKEKQLQELEKEMEALQADGVHVENGDGAVAPSKSKGKKKEEEKKEEEE---VTEGP 740
            :.||   ||..:::.:.|.|.:|.:   :|.||    ..|:..:.:..|.:...|:|   ..:.|
Human  1049 DDVEFSGEDNAQRITQPEPEQQAYE---LHQEN----KKPTSQRVQSVEIDMFSEDEPHLTIQDP 1106

  Fly   741 KPMLPYSSMFILSPTNPI------------------------------------RRGAHWVV--N 767
            :.....:|  |||..:.|                                    :|...||:  |
Human  1107 RKKSDVTS--ILSECSTIDLQDGFGWLPEMVPKKQPERCLPKGFGCCFPCCSVDKRKPPWVIWWN 1169

  Fly   768 L----------PYFDFFIMVVISMSSIALAAEDPVRENSRR-NKILNYFDYAFTGVFTIEMLLKI 821
            |          .:|:.||:.||.:||.||..||...||..: .::||..|..||.:|.:||:||.
Human  1170 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKW 1234

  Fly   822 VDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKR 886
            |..|.    |.|....|..:|.::||.:..:.          .||..:||.|.||.||||:.:.:
Human  1235 VAFGF----GKYFTSAWCCLDFIIVIVSVTTL----------INLMELKSFRTLRALRPLRALSQ 1285

  Fly   887 VPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYC---TDESKH-----TSAE 943
            ...:|.|.:.::.::..::|:|:|.::|..:|.::||..|:|||..|   ||...:     ..::
Human  1286 FEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVINYTIITNKSQ 1350

  Fly   944 CQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGP 1008
            |:...|.              |..:..::|||..|.|.|..|.|.:||..::..::.:|.:::.|
Human  1351 CESGNFS--------------WINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQP 1401

  Fly  1009 IQNFRIEMSIFYIVYFIVF----PFFFVNIFVALIIITF-QEQGEAELQDGEIDKNQKSCIDF-- 1066
                ..|.:....:||:||    .||.:|:|:.:||..| |:|.:...||..:.:.||...:.
Human  1402 ----EFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMK 1462

  Fly  1067 TIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYIN 1131
            .:|::..::.:|:..|..:..|:.||.|..|:..|:.||:.|.:.:|.:.:||....:..|.::|
Human  1463 KLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLN 1527

  Fly  1132 MGFTGMFSVETVLKIIGFGVKN-FFKDPWNIFDLITVLGSIVDALWMEFGSNSINVGF------- 1188
            ..|..:|::|.::||  |.::. :|.:.||:||.:.||.|||..: :....|..::.|
Human  1528 WVFVVIFTLECLIKI--FALRQYYFTNGWNLFDCVVVLLSIVSTM-ISTLENQEHIPFPPTLFRI 1589

  Fly  1189 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVEN 1253
            :||.|..|:::|:|....||.||:..:.|..:|..:.||:.::.|||||:||..|..:   ..|:
Human  1590 VRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKV---NPES 1651

  Fly  1254 SITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGK-ACDDDAEKA--PGEYCGSTLAYAYFV 1315
            .|....||::|...::.||:.:|...|.:::...|:.| :|:..:|..  ||      :|.:|||
Human  1652 GIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPG------IATSYFV 1710

  Fly  1316 SFIFFCSFLMLNLFVAVIMDNFDYLTRDS-SILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDML 1379
            |:|.....:::|:::|||::||:..|.:| ..||....|.|..:|.::||.||..|.|:.:.|..
Human  1711 SYIIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFA 1775

  Fly  1380 KNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADME 1444
            ..:..||....  ||:  |:.|: |::|:..|.|:.....|||.....|.    ..:.:|.....
Human  1776 DALPEPLRVAK--PNK--YQFLV-MDLPMVSEDRLHCMDILFAFTARVLG----GSDGLDSMKAM 1831

  Fly  1445 LRETITNIWPLQAKKMLNLLVPPS--DQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLE 1507
            :.|......||  ||:...:|..:  .:..:|...:.|.:..:::    :.|:..|.|..    :
Human  1832 MEEKFMEANPL--KKLYEPIVTTTKRKEEERGAAIIQKAFRKYMM----KVTKGDQGDQN----D 1886

  Fly  1508 LQDASRHPSQE------SLTGADAGHLH 1529
            |::....|.|.      |..|...|.:|
Human  1887 LENGPHSPLQTLCNGDLSSFGVAKGKVH 1914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	82/296 (28%)
		Ion_trans	441..677	CDD:334124	76/329 (23%)
		Ion_trans	769..1050	CDD:334124	87/294 (30%)
		Ion_trans	1094..1345	CDD:334124	80/262 (31%)
		GPHH	1346..1416	CDD:339854	22/69 (32%)
		Ca_chan_IQ	1418..1492	CDD:337190	13/75 (17%)
SCN11A	XP_016861136.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820