DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and Scn4a

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_573462.2 Gene:Scn4a / 110880 MGIID:98250 Length:1841 Species:Mus musculus


Alignment Length:1859 Identity:472/1859 - (25%)
Similarity:823/1859 - (44%) Gaps:407/1859 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            :|::|:..:.:|:....::....|...:::||:.|||.:.: .:.|...|.|        |..|.
Mouse   110 ALYMLSPFSIVRRVAIKVLIHALFSMFIMITILTNCVFMTM-SNPPSWSKDV--------EYTFT 165

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|:..|:.:|:||.|..:...::||:.||.:||.|:...::|::..:|   ::..||..||||.|
Mouse   166 GIYTFESLIKMLARGFCIDDFTFLRDPWNWLDFSVITMAYVTEFVDLG---NISALRTFRVLRAL 227

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDP------ 205
            |.::.||.|:.::.::|:::..|..:.:|.:|.:.:||::||:.:.|.|.:.|.....|      
Mouse   228 KTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPMNDTNT 292

  Fly   206 ----------------------NKLVKEGES---------ETPCNTDN---ILEKATGSFVCNNT 236
                                  |......||         |...|.:.   .||.:..:.:|.|:
Mouse   293 TWYGNDTWYGNDTWYGNDTWYGNDTWNSQESWVSNSTFDWEAYINDEGNFYFLEGSNDALLCGNS 357

  Fly   237 TSM--------CLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYF 293
            :..        |::....||.|.||:|...:|.|.:|:.:|.:.|..:...|..|.|..: .|:|
Mouse   358 SDAGHCPEGYECMKAGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTY-MIFF 421

  Fly   294 VPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILA 358
            |.:|.:|||:::||:|.|::..:|::                                 .|..||
Mouse   422 VVIIFLGSFYLINLILAVVAMAYAEQ---------------------------------NEATLA 453

  Fly   359 EERTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEE--EEAEED--YGDD--GYLKT---RS 414
            |::..|||...::|      ..:|..:.|.|:|:....|  |||:.|  :..|  |.|.|   :.
Mouse   454 EDQEKEEEFQQMLE------KFKKHQEELEKAKAAQALEGGEEADGDPTHSKDCNGSLDTSGEKG 512

  Fly   415 KPQGSCTGFWRAEKRFRFWIR-----HTVKTQWFY--------------WF-------------- 446
            .|:.||:    ||......:.     |.....|:|              |.              
Mouse   513 PPRPSCS----AESAISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWVKFKHIILLIVMDPF 573

  Fly   447 ----VIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNR 507
                :.:.:.|||:.:|:|||.........|.....:|.|:|.:||.:|:.|:.|..||:..:|.
Mouse   574 VDLGITICIVLNTLFMAMEHYPMTEHFDNVLSVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNI 638

  Fly   508 FDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLF 572
            ||..:::.|:.|:..:.|:    ||||||:.||||:||:.|.|.:|..|:..:.||:.::.:|..
Mouse   639 FDSFIVTLSLVELGLANVQ----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL 699

  Fly   573 LLFLFILIFALLGMQLFGGQF-----------NLPGGTPETNFNTFPIALLTVFQILTGEDWNEV 626
            :|.:.:.|||::||||||..:           :||.......|::|    |.||:||.|| |.|.
Mouse   700 VLAIIVFIFAVVGMQLFGKSYKECVCKIASDCSLPRWHMHDFFHSF----LIVFRILCGE-WIET 759

  Fly   627 MYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEE------QVE 685
            |:..:...|.|   |..:::.:|:|: ||..:||:|||:.:.:. :|..|.|::|:      |:.
Mouse   760 MWDCMEVAGQA---MCLTVFLMVMVI-GNLVVLNLFLALLLSSF-SADSLAASDEDGEMNNLQIA 819

  Fly   686 EDKEK----------------QLQELEKEMEALQADGVHVENGDGAVAPSKSKGKK--KEEEKKE 732
            ..:.|                ::..|:..|.:|...|...|||:   :|.:.:.|:  .|:..||
Mouse   820 IGRIKWGIAFAKTFLLGLLHGKILSLKDIMLSLGEPGGAGENGE---SPPEDEKKEPPPEDGNKE 881

  Fly   733 EEE--------VTEGPKPML----------PYSSMFI---------------------------- 751
            .::        :|:||:..:          ||.::.:                            
Mouse   882 LKDNHILNHVGLTDGPRSSIEMDHLNFINNPYLTIHVPIASEESDLEMPTEEETDTFSEPEDIKK 946

  Fly   752 -LSP--------------------------TNP-------------------------------- 757
             |.|                          .||                                
Mouse   947 PLQPLYDGNSSVCSTADYKPPEEDPEEQAEENPEGELPEECFTEACVKRCPCLYVDISQGRGKMW 1011

  Fly   758 --IRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSR-RNKILNYFDYAFTGVFTIEMLL 819
              :||....:|...:|:.||:.:|.:||.|||.||...|..| ...||.|.|..||.:|.:||||
Mouse  1012 WTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIQTILEYADKVFTYIFILEMLL 1076

  Fly   820 KIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTI 884
            |.|..|..:    |....|..:|.::|..:.:|...:..|.|   .|..|||||.||.||||:.:
Mouse  1077 KWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYS---ELGPIKSLRTLRALRPLRAL 1134

  Fly   885 KRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYF 949
            .|...::.|.:.::.::.:::|:|:|.::|..|||::||.||.|||:||.:.:.....:......
Mouse  1135 SRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISVVNN 1199

  Fly   950 KYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRI 1014
            |.|.:.|:...::| |.....:||||....|:|..|.|.:||..::..::.:..::..|.....:
Mouse  1200 KSECESLMYTGQVR-WMNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPDYEVNL 1263

  Fly  1015 EMSIFYIVYFIVFPFFFVNIFVALIIITFQEQ----GEAELQDGEIDKNQKSCIDFTIGARPLER 1075
            .|.::::::.|...||.:|:|:.:||..|.:|    |..::...|..|...:.:. .:|::..::
Mouse  1264 YMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGKDIFMTEEQKKYYNAMK-KLGSKKPQK 1327

  Fly  1076 YMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSV 1140
            .:|:.:|..:..|:..|....|:..||:||..|.:.:|::..:|..:....|..|||.|..:|:.
Mouse  1328 PIPRPQNKIQGMVYDFVTKQVFDISIMILICLNMVTMMVETDDQSQLKVDILYNINMVFIIVFTG 1392

  Fly  1141 ETVLKIIGFGVKN-FFKDPWNIFDLITVLGSIV-----DALWMEFGSNSINVGFLRLFRAARLIK 1199
            |.|||:  |.::: :|...|||||.:.|:.|||     |.:...|.|.:: ...:||.|..|:::
Mouse  1393 ECVLKM--FALRHYYFTIGWNIFDFVVVILSIVGLALSDLIQKYFVSPTL-FRVIRLARIGRVLR 1454

  Fly  1200 LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSF 1264
            |:|....||.||:..:.|..||..:.||:.::.|||:|.||..|..:|   .|:.|....||::|
Mouse  1455 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVK---KESGIDDMFNFETF 1516

  Fly  1265 IQGVMLLFRCATGEAWPNIMLACLKG--KACDDDAEKAPGEY----CGS-TLAYAYFVSFIFFCS 1322
            ...::.||...|...|..::...|..  ..||...|. ||..    ||: ::...:|.|:|....
Mouse  1517 GNSIICLFEITTSAGWDGLLNPILNSGPPDCDPTLEN-PGTNIKGDCGNPSIGICFFCSYIIISF 1580

  Fly  1323 FLMLNLFVAVIMDNFDYLTRDSS-ILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPL 1386
            .:::|:::|:|::||:..|.:|| .|.....:.|...|.::||:||..|.|:.:.|.:..:..||
Mouse  1581 LIVVNMYIAIILENFNVATEESSEPLCEDDFEMFYETWEKFDPDATQFIDYSRLSDFVDTLQEPL 1645

  Fly  1387 GFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADME-LRETIT 1450
            ....  ||::   |||.:::|:....::.....||||.:|.|.         |..:|: |::|  
Mouse  1646 KIAK--PNKI---KLITLDLPMVPGDKIHCLDILFALTKEVLG---------DSGEMDALKQT-- 1694

  Fly  1451 NIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDA-SRH 1514
                ::.|.|         ..|..|:|...|           :|...:....:..:::|.| .||
Mouse  1695 ----MEEKFM---------AANPSKVSYEPI-----------TTTLKRKQEEVCAIKIQRAYRRH 1735

  Fly  1515 PSQESLTGADAGHLHPGHSYMNGHRRSPSLRHNGSP----LARSPSPRRRGHQYIHHDIGFSDTV 1575
            ..|.|:..|         |||  :|.|.....:|:|    |..:...:..|.:  ..|.|    |
Mouse  1736 LLQRSVKQA---------SYM--YRHSQEGNGDGAPEKEGLLANTMNKMYGSE--KEDNG----V 1783

  Fly  1576 SNVVEMVKETRHPRHGNSHPRYPRGSWSASTSPARSPSP 1614
            .:..|..|::.......:....|..|.:|.|.|..||.|
Mouse  1784 QSQGEKEKDSTEDAGPTTEVTAPSSSDTALTPPPPSPPP 1822

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 85/334 (25%)
Ion_trans 441..677 CDD:334124 83/278 (30%)
Ion_trans 769..1050 CDD:334124 91/285 (32%)
Ion_trans 1094..1345 CDD:334124 81/263 (31%)
GPHH 1346..1416 CDD:339854 18/69 (26%)
Ca_chan_IQ 1418..1492 CDD:337190 16/74 (22%)
Scn4aNP_573462.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 32..63
I. /evidence=ECO:0000305 113..448 87/380 (23%)
Ion_trans 130..451 CDD:395416 86/366 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 484..522 13/41 (32%)
II. /evidence=ECO:0000305 554..826 86/285 (30%)
Ion_trans 571..784 CDD:395416 72/225 (32%)
Na_trans_assoc 810..1020 CDD:399489 25/212 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 854..896 10/44 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 925..983 4/57 (7%)
III. /evidence=ECO:0000305 1007..1320 96/321 (30%)
Ion_trans 1024..1298 CDD:395416 90/281 (32%)
Na_channel_gate 1290..1342 CDD:240441 9/52 (17%)
Important for rapid channel inactivation. /evidence=ECO:0000250|UniProtKB:P15390 1304..1306 0/1 (0%)
IV. /evidence=ECO:0000305 1329..1627 93/304 (31%)
Ion_trans 1347..1603 CDD:395416 81/262 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1776..1841 13/53 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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