DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and slc9a2

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	XP_004911848.1	Gene:	slc9a2 / 101732511	XenbaseID:	XB-GENEPAGE-22069121	Length:	791	Species:	Xenopus tropicalis

Alignment Length:	933	Identity:	179/933 - (19%)
Similarity:	297/933 - (31%)	Gaps:	294/933 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1020 YIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERY---MPKNR 1081
            |.:...|.||.   :|:...:.:....|.:.....  .||     |.|:|...|..:   .|..:
Frog    14 YPLVSCVIPFV---LFIPQALASVSSSGTSSAITS--SKN-----DVTVGETRLSVFTLDYPHVQ 68

  Fly  1082 NTFKYKVWRIVVSTP---FEYF--IMMLIVFNTLLLMMKYHNQGDMY---EKSLKYINMGFTGMF 1138
            ..|:..:|.::.|..   |..:  :..::..:.||:::.....|.|:   |||...:......::
Frog    69 IPFEITLWILLASLAKIGFHLYQKLHTIVPESCLLILVGLVLGGIMFGVNEKSPPAMKTDVFFLY 133

  Fly  1139 SVETVLKIIGF--GVKNFFKDPWNIFDLITVLGSIVDALWMEFGSNSINVGFLRLFRAARL---- 1197
            .:..::...|:  ..:.||.:...||     ..::|..||     |:|.:| :.||...::
Frog   134 LLPPIVLDAGYFLPTRPFFDNAGTIF-----WYAVVGTLW-----NAIGIG-ISLFGICQIEAFG 187

  Fly  1198 ---IKLLRQGYTIRILLWTFVQSFKALPYVCLLI-AMLFFIYAIIGMQVFGNIKLGTVENSITRH 1258
               |.||:                      |||. :::..:..:..:.||.||           |
Frog   188 LTNISLLQ----------------------CLLFGSLISAVDPVAVLAVFENI-----------H 219

  Fly  1259 NNFQSFIQGVMLLFRCATGEAWPN----IMLACLKGKACDDDAEKAPGEYCGSTLAY-----AYF 1314
            .|.|.:|    |:|    ||:..|    ::|..|....|:....:....:.|..:.:     .:|
Frog   220 VNEQLYI----LVF----GESLLNDAVTVVLYNLFKSFCEMKTIETSDVFSGIAILFLVGIGGFF 276

  Fly  1315 VSFIF-----FCSFLMLNLFVAVIMDNFDYLTRDSSILGAH--HLDEFVRI------WAEY-DPN 1365
            :..||     |.:....|  :.||...|.:|....|.|.|.  ||...|.|      ..:| :.|
Frog   277 IGIIFGFVAAFTTRFTRN--IRVIEPLFVFLYSYLSYLTAEMFHLSGIVAITTCAVSMKKYVEEN 339

  Fly  1366 ATGKIHYTEMY--DMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPL---DDELRVQFT--TTLFAL 1423
            .:.|.:.|..|  .||.::...|.|             |.|.:..   :.|....|.  |..|.|
Frog   340 VSQKSYTTIKYFMKMLSSVSETLIF-------------IFMGVSTVGQNHEWNWAFVCFTLFFCL 391

  Fly  1424 IRENLSIKMRAPEEMDQADMELRETITNIW---PLQAKKM---------------LNLLVPPSDQ 1470
            .       .||      |.:.:...:.|.:   ||..|..               |..|:|.|..
Frog   392 F-------WRA------AGVFILTQLINFFRTIPLTMKDQFIIAYGGLRGAICFALVFLLPDSVF 443

  Fly  1471 LNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDASRHPSQESLTGAD-----AGHLHP 1530
            ..|.......|...|.       |.|.|..:..|::|..:..|...::.:...:     ..|:..
Frog   444 PRKNLFITAVIVVIFF-------TVFIQGITIRPLVEFLNVKRADKKQQIISEEIHSRFLDHVKA 501

  Fly  1531 GHSYMNGHRRSPSLRHNGSPLARSPSPRRRGHQYIHHD-------------IGFSDTVSNVVEMV 1582
            |...:.||                     .||.|....             |..::..|::|.:.
Frog   502 GVEDICGH---------------------WGHNYCKDKFKKFDEKFLRKLLIKENEPTSSIVSLY 545

  Fly  1583 KETRHPRHGNSHPRYPRGSWSASTSPARSPSPSRYGGHLSRSKRTQLPYPTYGTTSLCQRSRSPS 1647
            |:.          ...:....|.|..:|.||.|...              ||..    |:.:..|
Frog   546 KKL----------EIKQAIEMAETGLSRDPSLSSLS--------------TYEK----QKVKPLS 582

  Fly  1648 PARLQEMRE---------RDR-LGYGID--MGVTHVQHSYPTLASRRAGIGRRLPPTPSKPSTLQ 1700
            |..:.:||:         |.| |.|...  .|.|..:.:...|..||..:...|     |.|:
Frog   583 PTEVNDMRDMLTKNLYQIRQRTLSYNRHNLAGGTSEKQAKEILIRRRHSMRESL-----KKSS-- 640

  Fly  1701 LKPTNINFPKLNASPTHTHHSTPHSVHSLPHHRDLLRDPRDMYYSSRERERDRERLRDRDRDRDR 1765
                      ||:....|.|...:.  |||.|..|...|..       ::.....:.|.|.|
Frog   641 ----------LNSRRAATVHQARYL--SLPGHTKLFEGPTG-------KKTTSFTVGDSDSD--- 683

  Fly  1766 DRLHEYDLRYEYRDRERELYERERDRER-----EVERERLEYIAPLSFEQALAMGRTGRVLPSPV 1825
               ..|..:..:..|..::...:|.:.:     |.:.||      ...:..|...:|.|....|:
Frog   684 ---SSYSTQLNFHPRAGDILRDQRQKRQPYSSFEWKNER------DGADNVLDKAQTPRGPRDPL 739

  Fly  1826 LNGFKPKSGLNPRHSD--SDEED 1846
            |    |::...|...|  .||||
Frog   740 L----PRTRFEPLSEDKVKDEED 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124
		Ion_trans	441..677	CDD:334124
		Ion_trans	769..1050	CDD:334124	6/29 (21%)
		Ion_trans	1094..1345	CDD:334124	54/282 (19%)
		GPHH	1346..1416	CDD:339854	18/83 (22%)
		Ca_chan_IQ	1418..1492	CDD:337190	17/91 (19%)
slc9a2	XP_004911848.1	b_cpa1	63..618	CDD:273294	130/690 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900