DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and cacna1g

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_031750725.1 Gene:cacna1g / 100497283 XenbaseID:XB-GENE-993391 Length:2361 Species:Xenopus tropicalis


Alignment Length:2508 Identity:564/2508 - (22%)
Similarity:944/2508 - (37%) Gaps:819/2508 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 PKKEENPPGG----------GPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALE 58
            |.|:...||.          .|...|.||:::..|.:...::..|.||...:|.|:.|||.|.:.
 Frog     9 PAKDPGDPGSELEGLPYPTLAPVVFFFLTQESRPRSWCLKMVCNPWFERFSMLVILLNCVTLGMF 73

  Fly    59 EHLPGGDKTVLAQK---LEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTG 120
            .  |..|....:|:   |:..:.:....|.||..:|:|||| :..|..||.:.||.:|..:||.|
 Frog    74 H--PCEDIACDSQRCKILQGFDDFIFAFFAVEMIIKMLALG-IFGKQCYLGDTWNCLDLVIVVAG 135

  Fly   121 FMTQYPQIGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAI 185
             |.:|......|....:|.:||||||:.::.:||:::::..::..:..|..:.||..|...||.|
 Frog   136 -MLEYSLDLQNVTFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGI 199

  Fly   186 IGLEFYSGALHKTCY---------SLEDPNKLVKEGESETP--CN----------------TDNI 223
            :|::.::|.|...|:         |||.......|.|.|.|  |:                .::.
 Frog   200 VGVQLWAGLLRNRCFLPENFSLPVSLELERYYQTENEDENPFICSQARENGMRYCRNVPAMREDG 264

  Fly   224 LEKATGSFVCNNTTSMCLEKW-----------EGPNSGITSFDNIGFAMLTVFQCITMEGWTAIL 277
            ||.....:..|||::.....|           ..|..|..:|||||:|.:.:||.||:|||..|:
 Frog   265 LECTLDHYFYNNTSNTSCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 329

  Fly   278 YWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLER-- 340
            |:..|| .|.:|:|||:.||:||||||:||.|.|::.:|::.:::   ..:.:|.:|.:.|..  
 Frog   330 YFVMDA-HSFYNFIYFILLIIIGSFFMINLCLVVIATQFSETKQR---ESQLMKEQRVRFLSNAS 390

  Fly   341 -------------ELNGYVEWICK--------------------AEEVI---------------- 356
                         ||..|:.:|.:                    |..|:                
 Frog   391 TLASFSEPGSCYDELLKYLVYITRKGSKRLVQFYRAAAFKAGLSARPVVKNSAEKPNRKHRRRRS 455

  Fly   357 -------------------------------LAEERT---------------------TEEEKMH 369
                                           |:|..|                     |..:.:|
 Frog   456 SVHHLIHHHHHHHHHYHLGNGSLRAPQASPELSEVETSSPHNTSRLMVPFAGSPIASATNTQSIH 520

  Fly   370 IM--------------------------EARRRNAAKRKKLKSLGKSKSTD-------------- 394
            .:                          |...|:....|...:|..|.|.|              
 Frog   521 SIYHADCHLEPVHCVQTFAHPGSSSENPEVLPRSITGGKNYPTLHPSASPDIQVDAEPVEPSEIT 585

  Fly   395 ------------------------------------------------------TEEEEAEEDYG 405
                                                                  ||..:.|....
 Frog   586 SDANIHPLPVFNSMNRLLETQSTGIGRGVCKISGQTANLESGSCDGEKCSHCKETELRDTEGPES 650

  Fly   406 D-DGYLKTRSKPQGS----CTGFWRAEKRF-------RFW------IRHTVKTQWFYWFVIVLVF 452
            | ||..:....||||    .|...||:.|.       :.|      .|..|.:::|...:::.:.
 Frog   651 DSDGCYEFTQDPQGSEQQQQTEAKRAKSRSQIPSKLQQLWKMVCETFRKIVDSKYFGRGIMIAIL 715

  Fly   453 LNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSI 517
            :||:.:.:|::.||..||..|..:..:|..||..||.:|:...||..|.::.:|.||.:::..|:
 Frog   716 INTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGIIVVISV 780

  Fly   518 FEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFA 582
            :|:|..:  ||  ||||||..||:|:.|:.::..:|:..::.|:.:|.::.:...||.|||.||:
 Frog   781 WEIIGQQ--GG--GLSVLRTFRLMRVLKLVRFMPALQRQLVVLMKTMDNVATFCMLLMLFIFIFS 841

  Fly   583 LLGMQLFGGQF-------NLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKG 640
            :|||.|||.:|       .||   ...||::...|.:|||||||.||||:|:|.|:.|.....  
 Frog   842 ILGMHLFGCKFASEKDGDTLP---DRKNFDSLLWATVTVFQILTQEDWNKVLYNGMASTSSWA-- 901

  Fly   641 MIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEMEAL-QA 704
               ::|||.|:.||||.|.|:.:||.|:..       ..||....||....|..::..:::: |.
 Frog   902 ---ALYFIALMTFGNYVLFNLLVAILVEGF-------QTEEVSKREDMSAHLSCIQLPVDSIGQG 956

  Fly   705 DG-----------VHVENG-------------DG------------AVAP--------------- 718
            :|           .|:..|             ||            |..|               
 Frog   957 EGSQSGSESAHEDCHIRKGLSNASFTPLHGYPDGKSMLQPPLIIHTAATPMPMPKCALFGDIPMA 1021

  Fly   719 ---------------------SKSK---------------------------------------- 722
                                 |.|:                                        
 Frog  1022 GESRRESNVSGGPHACEIRSMSSSRNSPHSSWGAVCSWNSRRSSWNSIGRASSLKRHEQSGEHKS 1086

  Fly   723 -----GKKKEEEKKEEEEVTEGPKPML--------------------PYS--------------- 747
                 ||:..|....:|||:......|                    |||               
 Frog  1087 LLSADGKESSEGDTSDEEVSSRTGSSLNRMDLVGKREAYDMHDTLHVPYSYGMQSRHSLPGEYQD 1151

  Fly   748 -------------------------------------------------------SMFILSPTNP 757
                                                                   |:::..|.:.
 Frog  1152 CNGKTSPVFPPLHVEESKVDYSNNIDDDVNMSRGERLKAWIISHLPAWCKERETWSLYLFPPYSK 1216

  Fly   758 IRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDP-VRENSRRNKILNYFDYAFTGVFTIEMLLKI 821
            .|...:.::....||..::|:|.::.|.:|.|.| :..:|.....|...:|.||.:|..||.:|:
 Frog  1217 FRLMCNKIITHRMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTLIFLAEMTVKV 1281

  Fly   822 VDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKR 886
            |.:.......:|||..||::|.::|:.:.:.....|...|..:.|..::.||:||.||||:.|.|
 Frog  1282 VAMNFCFGGKAYLRSSWNVLDGMLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISR 1346

  Fly   887 VPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKH---TSAECQGSY 948
            ...||.|.:.:::|||.:.||:::...|..||.::|||||.|||:||..|...   ..::|..:.
 Frog  1347 AQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFYYCQGEDTRNITNKSDCLENK 1411

  Fly   949 FKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFR 1013
            :|              |....:::||:..|:::||.:.:.:||..::...:.|...|:.|:.|:.
 Frog  1412 YK--------------WARHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPVMNYN 1462

  Fly  1014 IEMSIFYIVYFIVFPFFFVNIFVALIIITF------QEQGEAELQDGE----IDKNQKS------ 1062
            ..|.:::|.:.::..||.:|:||.:::..|      ||:.||:.::.:    ::|.::|      
 Frog  1463 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEAKRREEKRLRRMEKKRRSKERELA 1527

  Fly  1063 --CIDFTI---GARPLERYMPKNRNTFKYKVWRIVV-----STPFEYFIMMLIVFNTLLLMMKYH 1117
              .:|..|   .|.|::....|...: :|...|:::     |...:.||..:|..|.:.:.|:::
 Frog  1528 DLMLDDVILEHSASPVKEAQCKPYYS-EYSHPRLLIHQMCTSHYLDLFITGVIGLNVITMAMEHY 1591

  Fly  1118 NQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGSN 1182
            .|..:.:::||..|..||.:|.:|:..|::.||.:.||||.||..||..||.||:.....|...|
 Frog  1592 QQPKVLDEALKICNYIFTLIFVLESGCKMVAFGFRRFFKDRWNQLDLAIVLLSIMGITLEEIEVN 1656

  Fly  1183 S---IN---VGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQ 1241
            :   ||   :..:|:.|.||::|||:....:|.||.|.:|:...:..:.||..:||||:|.:|::
 Frog  1657 ASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVLQALPQVGNLGLLFMLLFFIFAALGVE 1721

  Fly  1242 VFGNIKLGTVE--NSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEY 1304
            :||:::.....  ..:.||..|::|....:.|||.:||:.|..||...|:.  |::|:.      
 Frog  1722 LFGDLECTDSHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD--CNEDST------ 1778

  Fly  1305 CGST-LAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATG 1368
            |.:| ::..|||||:....|:::|:.:||:|.:.:...:::.        |...:.||       
 Frog  1779 CYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAK--------EEAELEAE------- 1828

  Fly  1369 KIHYTEMYDMLKNMDPP-----------LGFGNKCPNRLAYKKLIRMNMPLDDELRV------QF 1416
                .|:...::||..|           ||:    |...:|..:..:....|.:|.:      ..
 Frog  1829 ----MELEFQIQNMQVPDPDPFMWAGRDLGY----PQEGSYGYMNSVQDKADSQLSLVNPMERHM 1885

  Fly  1417 TTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSD------QLNKGK 1475
            ..|:..||:.:|           :.:|:|.:.      |......:..:||||      |:...:
 Frog  1886 FDTISLLIQGSL-----------EGEMKLMDN------LSGSVCHHYALPPSDKGSSEKQIPLAE 1933

  Fly  1476 LSVGKIYAGFLILESW-------------RSTRFGQLDS--GMP----MLELQDAS-----RHPS 1516
            :....:.:..|..:||             ....||.|::  |:|    ...:::|:     |.||
 Frog  1934 MEGLSMTSDILSEKSWSLALTDDSLPDDPNPNPFGVLETKLGLPEEKHSATVEEATNLLSVRKPS 1998

  Fly  1517 QESLTGADAGHLHPGHSYMNGHRRSPSLRHNGSPLARSPSPRRRGHQYIHHDIGFSDTVSNVVEM 1581
                  ....|..|..|||         ...||..  :....:|.|.|  ...|.|.||.:    
 Frog  1999 ------VCRTHSLPNDSYM---------LQTGSTC--TECQEQRNHCY--QKSGSSSTVQS---- 2040

  Fly  1582 VKETRHPRHGNSHPRYPRGS--WSASTSPARSPSPSRYGGHLSRSKRTQLPYPTYGTTSLCQRSR 1644
                 .|...||..:.|:.|  :.||.|...|..|             :||.|.          |
 Frog  2041 -----QPNDLNSLLQVPQISIPYEASGSTVISEIP-------------KLPAPL----------R 2077

  Fly  1645 SPSPARL---QEMRERDRLGYGIDMGVTHVQHSYPTLASRRAGIGRRLPPTPSKPSTLQLKPTNI 1706
            |||..|:   ||....|.|.:..|             :...|||               .:|..:
 Frog  2078 SPSANRMLRRQEAIRTDSLEFFPD-------------SKENAGI---------------TEPPPV 2114

  Fly  1707 NFPKLNASPTHTHHSTPHSVHSLPHHRDLLRDPRDMYYSSRERERDRERLRDRDRDRDRDRLHEY 1771
            ..|.... ||    .||.:.  :...|.|.:..|...|:.:.::..:                  
 Frog  2115 YIPMCQV-PT----ETPSAF--IEPERTLCQLKRRSVYTQQVQDTCK------------------ 2154

  Fly  1772 DLRYEYRDRERELYERERDREREVERERL-------------------EYIAPLSFEQALAMGRT 1817
              .:.|.|..:...:..|:..:..|:|.|                   .|.|..|..|.|.:|.:
 Frog  2155 --MFRYPDASQTNMDTLRETSKIPEKEDLLSAACCRRHLNSKTCKALSVYSAAYSLSQKLKLGNS 2217

  Fly  1818 GRVLPSPVLNGFKPKSGLNPRHSDSDEEDWCXQRLXLRSRNRKDQIWVXHQAICSSLSAPNLDHN 1882
            |.|    :|...|....::..........|...       .|:..|     .||   |..|..|:
 Frog  2218 GNV----ILKDMKRFYSVDAHGVLKKTSSWLDD-------PRRHSI-----EIC---SLENTLHH 2263

  Fly  1883 FDT------IRHSYQIPEHLQNLPY------LCPP-VH 1907
            :.|      |.|.:|..|.||.:..      :||. ||
 Frog  2264 YSTSRSCGFISHVFQKKEDLQIVQRTGGQDPVCPDCVH 2301

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 104/327 (32%)
Ion_trans 441..677 CDD:334124 86/242 (36%)
Ion_trans 769..1050 CDD:334124 85/290 (29%)
Ion_trans 1094..1345 CDD:334124 82/259 (32%)
GPHH 1346..1416 CDD:339854 13/86 (15%)
Ca_chan_IQ 1418..1492 CDD:337190 15/92 (16%)
cacna1gXP_031750725.1 Ion_trans 52..375 CDD:395416 104/330 (32%)
Ion_trans 703..932 CDD:395416 86/247 (35%)
Ion_trans 1227..1499 CDD:395416 82/285 (29%)
Ion_trans 1568..1809 CDD:395416 81/248 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.010

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