Protein Alignment cac and cacna1h

DIOPT Version :10

• Sequence 1: NP_001356945.1
• Gene: cac / 32158
• FlyBaseID: FBgn0263111
• Length: 2110
• Species: Drosophila melanogaster
• Sequence 2: XP_031748783.1
• Gene: cacna1h / 100494894
• XenbaseID: XB-GENE-6042121
• Length: 2460
• Species: Xenopus tropicalis
• Alignment Length: 2682
• Identity: 599/2682 - (22%)
• Similarity: 1008/2682 - (37%)
• Gaps: 925/2682 - (34%)

  Fly     1 MGGPKKEENP-PGGGPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGG 64
            ||..:.|:.| |...||..|.|::....|.:...::..|.||:..:|.|:.|||.|.:.:  |..
 Frog    62 MGSEEGEQVPYPALAPTVFFCLSQTTRPRNWCLRLVCNPWFEHVSMLVILLNCVTLGMFQ--PCE 124

  Fly    65 DKTVLAQK---LEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYP 126
            |...::::   ||..:.:....|.||..:|::|||:...| .||.:.||.:|||:|:.| |.:|.
 Frog   125 DTNCMSERCNILEAFDGFIFAFFAVEMVIKMVALGIFGQK-CYLGDTWNWLDFFIVMAG-MLEYS 187

  Fly   127 QIGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFY 191
            ..|..|.|..:|.:||||||:.::.:||:::::..::..:..|..:.||..|...||.|:|::.:
 Frog   188 LDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252

  Fly   192 SGALHKTCYSLEDPNKLVK------------EGESETP--C--NTDN-------ILEKATGSFV- 232
            :|.|...|:.  |.|.::.            :...:.|  |  |.||       |..|...|.|
 Frog   253 AGLLRNRCFM--DTNFVMSYNFTPLRPYYQVDDAEDNPYICSSNRDNGMLKCQDIPPKMDCSHVY 315

  Fly   233 ---------C---NNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALG 285
                     |   |...::|......|:.|..:|||||:|.:.:||.||:|||..|:|:..|| .
 Frog   316 YSDFPSRNSCVNINQYYNVCKPGEFNPHKGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA-H 379

  Fly   286 SAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENR--QE-------------------- 328
            |.:|:|||:.||::|||||:||.|.|::.:|::.::: ||:  ||
 Frog   380 SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR-ENQLMQEQRARYLSNDSTIASFSEPGS 443

  Fly   329 ------------FLKLRRQQQLERELNGYVEW--------------------------------- 348
                        |.|::|     |.|..|..|
 Frog   444 CYEELLKYICHIFRKVKR-----RTLRLYNNWQNKRRKKVQPNSNTNSQGRHRKCKRRITSIHHL 503

  Fly   349 ---------------------------ICKAEEVIL--------------AEERTTEEEKMHI-- 370
                                       ||..|..|:              .:..:...|.:|.
 Frog   504 IHHHHHHHHHHYHISNGSPRGPRSSPEICDVEMKIMKPKNQLRLPPASPSLQSMSPNSEAVHSIY 568

  Fly   371 -----MEARRRNAAKRK------------------------------------------------ 382
                 :||.:|.::|..
 Frog   569 HADCHLEAPQRKSSKSSNASSNIKLNAGLNHSNMNYPTIMPSQANKTSPATLPKGKRNGSNAVSL 633

  Fly   383 -------KLKSLGKS-----------------------------------------------KST 393
                   |..|.||:                                               ::.
 Frog   634 LSSPVSMKADSFGKTNHLVGEHGLCRSSSKLSGLSVPCSLPSPQPSPLLCEIQNCPYCANLLENP 698

  Fly   394 DTEEEEAEEDYGDDGYL--------------------KTRSKPQGSCTGFWRAEKRFRFWIRHTV 438
            |.|..::|....|...:                    |.::||:       .|.|.:..|...||
 Frog   699 DLELSDSESCESDSNGVYEFTQDLRRGDQRDQVQKGRKLKTKPK-------EANKVYLLWEEFTV 756

  Fly   439 K------TQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGP 497
            :      :::|...:::.:.:||:.:.:|::.||..||..|..:..:|..:|..||.:|:.|.|.
 Frog   757 RLKRIVDSKYFNRGIMIAILINTLSMGIEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAFGI 821

  Fly   498 RIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLN 562
            ..|.::.:|.||.:::..|::|:| .:..|   ||||||..||||:.|:.::..:||..::.|:.
 Frog   822 FQYIKNPYNIFDGIIVVISVWEII-GQSDG---GLSVLRTFRLLRVLKLVRFMPALRRQLVVLVK 882

  Fly   563 SMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPET-----NFNTFPIALLTVFQILTGED 622
            :|.::.:...||.|||.||::|||.|||.:|.....|.||     ||::...|::|||||||.||
 Frog   883 TMDNVATFCMLLMLFIFIFSILGMHLFGCKFTWTADTGETVKDRKNFDSLLWAIVTVFQILTQED 947

  Fly   623 WNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQ---- 683
            ||.|:|.|:.|.....     ::||:.|:.||||.|.|:.:||.|:......:.|.::.|:
 Frog   948 WNMVLYNGMASTSSWA-----ALYFVALMTFGNYVLFNLLVAILVEGFQAEGDATRSDTEEDKAS 1007

  Fly   684 --VEEDKE--KQLQELEKEMEALQA----------------------------------DGVHVE 710
              .:||.|  |:|:..|.:|.:|..                                  |..| .
 Frog  1008 GNFDEDLEKLKELRAAELKMYSLAVTPNGHLDPRSSMPPPIIMRTAATPMPTPKSSPCMDSSH-P 1071

  Fly   711 NGDG------AVAPS-------------------------------KSKGK----KKEEEKKEEE 734
            .||.      ::.||                               .|.|:    ||:.:..|.|
 Frog  1072 FGDSRRESSVSIDPSIVDQKSLASLRSTPCTPWGTYSNWGSRRSSWNSLGRAPSIKKKSQSGERE 1136

  Fly   735 EVTEGP----------------------------------------------------------- 740
            .:..|.
 Frog  1137 SLLSGEGKGSTDDDSDDCKSSPAARVSLHRRAGSLDTRGSLDIPDFLQVPTLRHSLSVSPLAMVP 1201

  Fly   741 --------------------------------------------KPMLPYS----------SMFI 751
                                                        |.:.||.          |:::
 Frog  1202 SDYQDCNGKMMHVPSDLFVRVEKHREDPLEYEDDIEDSYCFRIRKMLEPYKPTWCKTHEDWSLYM 1266

  Fly   752 LSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDP-VRENSRRNKILNYFDYAFTGVFTI 815
            .||.|..|.....|:....||..::|.|.::.|.:|.|.| :..||.....|:..:|.||.:|.:
 Frog  1267 FSPQNQFRMMCQKVIAHKMFDHVVLVFIFLNCITIALERPDIDPNSLERIFLSVSNYIFTAIFVL 1331

  Fly   816 EMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRP 880
            ||.:|:|.||.:....:||:..||::|.::|..:.:.....::.:...:.|..::.||:||.|||
 Frog  1332 EMAIKVVALGFVSGENTYLQSSWNVLDGILVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRP 1396

  Fly   881 LKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTD-ESKHTS--A 942
            |:.|.|.|.||.|.:.:::||:.:.||:::...|..||.::|||||.|||:||.. |:::.:  :
 Frog  1397 LRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGLETRNITNRS 1461

  Fly   943 ECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRG 1007
            ||..:.:|              |..|.:::||:..|:::||.:.:.:||..::...:.|...|..
 Frog  1462 ECTRARYK--------------WVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVATDVQ 1512

  Fly  1008 PIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITF------QEQGEAELQDGE----IDKNQKS 1062
            |::|....|.:::|.:.::..||.:|:||.:::..|      ||..||..::.:    ::|.::|
 Frog  1513 PVKNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRS 1577

  Fly  1063 CIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTP-----FEYFIMMLIVFNTLLLMMKYHNQGDM 1122
            ...:...|:....|.       :|...|:.:.|.     .:.||..:|..|.:.:.|:::||...
 Frog  1578 KALYMSEAQRRPYYA-------EYSPARLYIHTMCTSHYLDLFITCIICINVITMSMEHYNQPKS 1635

  Fly  1123 YEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGSNS---I 1184
            .:::|||.|..||.:|..|.:.|::.||.:.||||.||..||..||.||:.....|...|:   |
 Frog  1636 LDEALKYCNYVFTIVFVFEALFKLVAFGFRRFFKDRWNQLDLAIVLLSIMGITLEEIEINASLPI 1700

  Fly  1185 N---VGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI 1246
            |   :..:|:.|.||::|||:....:|.||.|.||:...:..:.||..:||||||.:|:::||.:
 Frog  1701 NPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKL 1765

  Fly  1247 KLGTVEN---SITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGST 1308
             :...||   .::||..|::|....:.|||.:||:.|..||...|  :.|:.|.:        :.
 Frog  1766 -VCNEENPCEGLSRHATFENFGMAFLTLFRVSTGDNWNGIMKDTL--RECNSDDK--------NC 1819

  Fly  1309 LAY------AYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNAT 1367
            |.|      .|||:|:....|:::|:.|||:|               .||:|..: .|:.|....
 Frog  1820 LTYLPVISPVYFVTFVLIAQFVLVNVVVAVLM---------------KHLEESNK-EAKEDAEMD 1868

  Fly  1368 GKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKM 1432
            .:|   || :|.:.:.|..|   .|......|.......||..||..|...   |:.:||:::.:
 Frog  1869 AEI---EM-EMSRALTPISG---GCTPASDGKGTEGGQDPLKGELLKQVGG---AVCQENVTLVI 1923

  Fly  1433 RAPEEMDQADMELRETI--TNIWPLQAKKMLNLLVPP-------------SDQLNKGKLSVGKI- 1481
              ||.|:.|.: |.:.:  .:|:..||   |.|.:.|             ....::..|:|.||
 Frog  1924 --PESMEGAAL-LNDAVPACSIYQQQA---LPLPLQPCVLGHEDGDFQRRDGSGSRNLLAVKKIS 1982

  Fly  1482 YAGFLILESWRSTRFGQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSPSLRH 1546
            .:..|.|.:         ||.|....|...|.:|.||..|..|               .||
 Frog  1983 VSRMLSLPN---------DSYMFRPVLPAKSSYPLQEVETTED---------------NSP---- 2019

  Fly  1547 NGSPLARSPSPRRRGHQYIHHDIGFSDTVSNV-VEMVKETRHPRHGNSH--PRYPRGSWSASTSP 1608
            :||..:            :|...|.::::.|: ||...:.....|.:|.  |:.|....|
 Frog  2020 HGSTAS------------LHSQPGDNNSLLNIPVECQPQASVSNHQDSADLPKIPPPHTS----- 2067

  Fly  1609 ARSPSPSRYGGHLSRSKRTQLPYPTYGTTSLCQRSRSPSPARLQEMRERDRLGYGIDMGVTHVQH 1673
            :||||       |:||.|.|                  ...|:..:   |:.|...|:.|...:.
 Frog  2068 SRSPS-------LNRSLRRQ------------------EAIRMDSV---DQGGDSKDLNVESTES 2104

  Fly  1674 SY---PTLASRRAGIGRRLPPTPSKPSTLQLKPTNINFPKLNASPTHTH---HSTPHSVHSLPHH 1732
            .:   |::.:        |.|.......:.|:.|..:.|:|:..|.|:.   |:..:|.||:|
 Frog  2105 LHLGAPSVTT--------LVPNLLCTLNVSLQGTPQSSPRLSPQPRHSSVLTHNHVYSQHSIP-- 2159

  Fly  1733 RDLLRDPRDMYYSSRERERDRERLRDRDRDRDRDRLHEYDLRYEYRDRERELYERERDREREVER 1797
                  .|....||..                             .:.|..::|.....:.||.
 Frog  2160 ------SRPSSVSSGN-----------------------------SNPEESMFESSDLADEEVS- 2188

  Fly  1798 ERLEYIAPLSFEQALAMGRTGRVLPSPVLNGFKPKSGLNPRHSDSDEEDWCXQRLXLRSRNRKDQ 1862
                                                     |.:|..:||...     |.||...
 Frog  2189 -----------------------------------------HINSSAKDWRGS-----SNNRSHS 2207

  Fly  1863 IWVXHQAICSSLSAPNLDHNFDTIRHSYQIPEHLQNLPYLCPPVHQHQHQHQTQTQNQRQHQDQH 1927
            :    ....|..|:|                          ||:
 Frog  2208 V----SPFISQSSSP--------------------------PPL--------------------- 2221

  Fly  1928 LYQRYGTNVSTPKLGTTISDIKLAGVSLQELSPNRQPQSQQKQEQQLHQDGWLR---WYRQSGPY 1989
                      :|.|....|.:.|||.|.::        ...|:...:...|:|.   |......:
 Frog  2222 ----------SPSLKNCNSTVSLAGSSGKD--------KDLKKFYSVDTQGFLAKPCWGDDQRRH 2268

  Fly  1990 GSPVMASLP----------ETRATSP---HSDIEFIRTMKR---------------SETGTTAIT 2026
            ...:..|:.          |.:..|.   .||.|:|..::|               .:.|.||
 Frog  2269 SIEICPSIDDGDSCFDLSMEDKHCSSVLIRSDPEYINGVRRKKKMSPPCISIDPPMEDEGGTA-- 2331

  Fly  2027 PRTTKTEAMILSVPITITSPLAIKKIYSDN-DINYNTERGTDNDRVDDAPAHHYHQPELTTPDLQ 2090
               ::|:|...|:.:...:|......|.|: |:       :||...|          :::..|.:
 Frog  2332 ---SRTKASENSMMLRRRTPSCESTAYRDSLDL-------SDNQLGD----------QISKTDRR 2376

  Fly  2091 DEPPLQQHHQHYPQYSY 2107
            .:.|.:..|...|.||:
 Frog  2377 TQVPCRNEHLIIPSYSF 2393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:459842	105/325 (32%)
		Ion_trans	441..677	CDD:459842	86/240 (36%)
		Ion_trans	769..1050	CDD:459842	87/290 (30%)
		Ion_trans	1094..1345	CDD:459842	88/270 (33%)
		GPHH	1354..1407	CDD:465306	11/52 (21%)
		Ca_chan_IQ	1417..1496	CDD:462591	20/94 (21%)
		AF-4	<1512..>1704	CDD:461550	38/197 (19%)
cacna1h	XP_031748783.1	Ion_trans	99..418	CDD:459842	105/326 (32%)
		Ion_trans	764..998	CDD:459842	86/242 (36%)
		Ion_trans	1283..1555	CDD:459842	84/285 (29%)
		Ion_trans	1607..1838	CDD:459842	81/241 (34%)