DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and cacna1a

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_031755311.1 Gene:cacna1a / 100492135 XenbaseID:XB-GENE-1013831 Length:2302 Species:Xenopus tropicalis


Alignment Length:2401 Identity:1026/2401 - (42%)
Similarity:1268/2401 - (52%) Gaps:696/2401 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 VLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNI 108
            :|.||||||:|||:|:|||.||||.::::|:.||.||:.|||.|..:||:|||...||.|||||.
 Frog     2 ILATIIANCIVLAMEQHLPVGDKTPMSERLDDTEPYFIGIFCFETGIKIIALGFAFHKGSYLRNG 66

  Fly   109 WNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIG 173
            ||||||.||::|.:.   ..|||.|||||||:||||||||||||||||||||||:|||.||||||
 Frog    67 WNIMDFVVVLSGIVA---STGPEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIG 128

  Fly   174 LLVLFAIVIFAIIGLEFYSGALHKTCYSL--EDPNKLVKEGESETPCNTDNILEKATGSFVCNNT 236
            ||:.|||:|||||||:||.|..|.:||.:  ||    ::|   |..|..|      :.|..|...
 Frog   129 LLLFFAILIFAIIGLDFYIGKFHTSCYDMAGED----IRE---EVLCGND------SSSRRCPEN 180

  Fly   237 TSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGS 301
            | .||.||||||:|||.||||.||:|||||||||||||.|||::||..||||||:||:|||:|||
 Frog   181 T-QCLSKWEGPNNGITQFDNILFAILTVFQCITMEGWTDILYYSNDVFGSAFNWLYFIPLIIIGS 244

  Fly   302 FFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEE 366
            ||||||||||||||||||||:||||:.|:|||||||:|||||||:|||.|| ||||||:.:..|:
 Frog   245 FFMLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYMEWISKA-EVILAEDDSDIEQ 308

  Fly   367 KMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYL-------KTRSKPQGSCTGFW 424
            ::....|.||...|:.|.:.|        ..||.||..||...:       ..:|....:.:...
 Frog   309 RLPYDGALRRPTIKKNKTELL--------NAEEGEEAIGDIASVGSPFARASIKSAKMENSSYMH 365

  Fly   425 RAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMF 489
            :.|:|.||.||..||||.|||.|:.||.|||:|||:.||||...|:|||||||||||||||||||
 Frog   366 KKERRIRFLIRRMVKTQAFYWVVLGLVALNTLCVAIVHYGQDDRLSEFLYYAEFIFLGLFMSEMF 430

  Fly   490 IKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVK-GGSFGLSVLRALRLLRIFKVTKYWSSL 553
            ||||.||.|.||.||||.|||.||:||||||:|:.|| |.|||:||||||||||||||||||:||
 Frog   431 IKMYGLGTRPYFHSSFNCFDCAVITGSIFEVVWAMVKPGTSFGISVLRALRLLRIFKVTKYWASL 495

  Fly   554 RNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPETNFNTFPIALLTVFQIL 618
            ||||||||:||:|||||||||||||::||||||||||||||....||.|||:|||.|::||||||
 Frog   496 RNLVISLLSSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEKTPATNFDTFPAAIMTVFQIL 560

  Fly   619 TGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQ 683
            ||||||.|||.||.||||.:.||::|||||:|.||||||||||||||||||||||||||..|:|:
 Frog   561 TGEDWNAVMYDGIKSQGGVKTGMVFSIYFIILTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 625

  Fly   684 VEEDKEKQLQELEKEM---------------------------------------------EALQ 703
            .|...:|...:..||:                                             |||.
 Frog   626 EEAANQKLAMQKAKEVAEVSPLSATNMSIAAKEQQKNQKTSMSVWEQRTNEIRRQNLMNSREALY 690

  Fly   704 A---------------------------------------------------------------- 704
            :                                                                
 Frog   691 SELDPEERWKLSFMRPDVKTHLDRPLVVDPQENRNNNTNKTRPGEGRNPIEQRLSQQRAEDYLRK 755

  Fly   705 ----------------------------------------------------------------- 704
                                                                             
 Frog   756 QARFQERGGRGYDMGQEPGRRPRIKEQDIIRDGQDLGMQDRTGEMDGGIRPPQDPHRRHRGGGSK 820

  Fly   705 ------------------------------------------------------DGVHVENGDGA 715
                                                                  ||:.|..|.|.
 Frog   821 ESRSGSPLPRGDGDHRRHRPHRRTGEDNEDAGGGGGGGGRGGGGGGDRRPRHGRDGMRVREGGGG 885

  Fly   716 ----------------------------------------VAPSKSKG----------------- 723
                                                    .||:...|                 
 Frog   886 ESEGPEGERRRRHRHAAQSTYESDAKRDDRERRHRRRKEPTAPTPGSGGPNLSTTRPIQDRSRQE 950

  Fly   724 ----------------------------------------------------------------- 723
                                                                             
 Frog   951 NQNQQPENMDNIRNTKLVTSEPPAGGGVGGLNHSPAKIGNHTNCANNNSVPTGNATPRRTPHPTN 1015

  Fly   724 ----------------------------------------------------------KKKEEEK 730
                                                                      .||::||
 Frog  1016 SGPPPSAPDPSHTFSNPTETAKGTKTTEHTTVDIPPPFPPPVENAIGQANKIVAVSPLPKKDDEK 1080

  Fly   731 KEEEEVTE----GPKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDP 791
            |||||..:    |||||.|||||||||.|||:||..|::|.:.||:..|::||:|||||||||||
 Frog  1081 KEEEEDDDDGEKGPKPMPPYSSMFILSTTNPLRRLCHYIVTMRYFEMCILMVIAMSSIALAAEDP 1145

  Fly   792 VRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGF- 855
            |:.::.||.:|.||||.||||||.||::|:||||:|||.|:|.|:.||.:|.:||..|.|:|.| 
 Frog  1146 VQPDAPRNNVLRYFDYVFTGVFTFEMVIKMVDLGLILHQGAYFRDLWNFLDFIVVCGALVAFAFS 1210

  Fly   856 -DMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFS 919
             :..|.|.|:::||||||||||||||||||||:|||||||||||||||||:||||||:||.|||:
 Frog  1211 SNQRGGSKGKDISTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFA 1275

  Fly   920 VIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFA 984
            |:.||||.|||||||||||....:|:|.|..|::.|:  |.:.|.||...||||||..|:||||.
 Frog  1276 VVAVQLFKGKFFYCTDESKEFQRDCRGEYLVYDKSEV--KAQKREWKKWPFHYDNVLWALLTLFT 1338

  Fly   985 VQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEA 1049
            |.||||||.||:||:.|||||:||...||:||||||:|||:||||||||||||||||||||||:.
 Frog  1339 VSTGEGWPDVLRHSVDATYEDQGPRPGFRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK 1403

  Fly  1050 ELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMM 1114
            .:::..::||:::||||.|.|:||.|:||:|:.:|:|::|:.|||.||||.||.||..||::|||
 Frog  1404 IMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMALIALNTIVLMM 1468

  Fly  1115 KYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEF 1179
            |:|...:.||..||..||.||.:||:|.:|||:.||..|:|:|.|||||.:||||||.|.:..|.
 Frog  1469 KFHGSSNTYENVLKTFNMVFTSLFSLECLLKIMAFGAPNYFRDAWNIFDFVTVLGSITDIVVTEL 1533

  Fly  1180 GSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFG 1244
            ..:.||:.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog  1534 WDSIINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFG 1598

  Fly  1245 NIKLGTVEN--SITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGS 1307
            ||.|...::  :||.||||::|.|.:|||||.||||||..|||:||.|:.||..:.....| |||
 Frog  1599 NIALDEEDDDTAITEHNNFRNFFQALMLLFRSATGEAWHEIMLSCLSGRPCDVGSGLKEKE-CGS 1662

  Fly  1308 TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHY 1372
            ..||.|||||||.|||||||||||||||||:||||||||||.|||||:||:||||||.|.|::.|
 Frog  1663 EFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMKY 1727

  Fly  1373 TEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKM-RAPE 1436
            |::|:||:.:.||||.|.|||.|:|||:|:||::|:.|:..|.|.:||.||||..|.||: :...
 Frog  1728 TDLYEMLRLISPPLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGA 1792

  Fly  1437 EMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQL-- 1499
            :..|.|.:||:.:..|||..::|.|:|||.|....:   |:||||||..:|:|.:|.::..:|  
 Frog  1793 DKQQMDSQLRKEMMAIWPNMSQKTLDLLVTPHKSTD---LTVGKIYAAMMIMEYYRQSKAKRLQA 1854

  Fly  1500 -------------------------------------DSGMP---MLELQ--------------- 1509
                                                 :.|:|   |.|.|               
 Frog  1855 LQEEQNRTPLMFQRMEPPSPTQDGPLGINALPSSQAGEMGLPEGGMKESQSWMTQRAQQMFQKTG 1919

  Fly  1510 -----------DASRHP-SQESLTGADAGHLHPGHS------YMNGHRRSPSLRH---------- 1546
                       :.:..| ||:|:..:|.|  ..|:|      .|.||.|:.|:..          
 Frog  1920 TWSPERARTQENTNSWPNSQQSVEMSDMG--RDGYSDSEQYLVMEGHGRAASMPRLPADNQQRRK 1982

  Fly  1547 ------------NGSPLARSPS--------------------------------PRRRGH----- 1562
                        :|||:.||.|                                .|.|||     
 Frog  1983 TRTRGSNLSTITDGSPMKRSASMLGHSQSKGIRLDEYSLERVTPEEGPRHGHQRRRERGHRVSDR 2047

  Fly  1563 ---QYIHHDIGFS---DTVSNVVEMVKETR--------------HPRHGNSHPRYPRGSWSASTS 1607
               :|:..:.|..   .|.:...::..|.|              |..|.:.||...|........
 Frog  2048 SLTRYVDLESGLGTELSTTTQSCDLPTEERGRTRDRKHHHHHHHHHHHHHHHPSTERERLEYGRP 2112

  Fly  1608 PARSPSPSR-YGGHLSRSKRTQ-LPYPTYGTTSLCQRSRSPSPARLQEMRERDRLGYGIDMGVTH 1670
            .:||||..| |..|...|.... .|.|:....|..:|.|...|......|.|......:....:.
 Frog  2113 SSRSPSTGRDYAPHRQGSSSVDGSPVPSTSGASTPRRGRRQLPQLPTTPRPRVTYSPVVRRPASV 2177

  Fly  1671 VQHSYPTLASRRAGIGRRLPPTPSKPSTLQLKPTNINFPKLNASPTHTHHSTPHSV--------H 1727
            ......:|......|.||.|.|.::||:.:.:..|      |.||....|:..|..        |
 Frog  2178 CSPQQQSLCRMTTPIQRRYPQTENRPSSNERRSVN------NDSPRSHRHTRGHCTEVPRAGCRH 2236

  Fly  1728 SLPHHRDLLRDPRDMYYSSRERERDRERLRDRDRDRDRDRLHEYDLRYEYRDRERELYERERDRE 1792
            |.|:......||                             |..|.|                ..
 Frog  2237 SGPYRDSSFEDP-----------------------------HPCDQR----------------SS 2256

  Fly  1793 REVERERLEYIAPLSFEQALAMGRTGRVLPSPVLNGFK---PKS--GLNPRHSDSDEEDWC 1848
            |..|...:..::|           .||.||    ||:.   |:|  ..:.|:|:|:|:|||
 Frog  2257 RTAESGGVPPLSP-----------RGRRLP----NGYSHGTPRSTKSRHERYSESEEDDWC 2302

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 185/281 (66%)
Ion_trans 441..677 CDD:334124 187/236 (79%)
Ion_trans 769..1050 CDD:334124 190/282 (67%)
Ion_trans 1094..1345 CDD:334124 172/252 (68%)
GPHH 1346..1416 CDD:339854 41/69 (59%)
Ca_chan_IQ 1418..1492 CDD:337190 31/74 (42%)
cacna1aXP_031755311.1 Ion_trans 1..267 CDD:395416 185/281 (66%)
Ion_trans 382..620 CDD:395416 188/237 (79%)
Ion_trans 1123..1358 CDD:395416 152/236 (64%)
Ion_trans 1448..1700 CDD:395416 172/252 (68%)
GPHH 1709..1762 CDD:407139 31/52 (60%)
Ca_chan_IQ 1773..1846 CDD:400901 31/75 (41%)
PHA03307 2112..>2292 CDD:223039 49/245 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 390 1.000 Domainoid score I783
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45628
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X841
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.020

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