Protein Alignment cac and cacna1a

DIOPT Version :10

• Sequence 1: NP_001356945.1
• Gene: cac / 32158
• FlyBaseID: FBgn0263111
• Length: 2110
• Species: Drosophila melanogaster
• Sequence 2: XP_031755311.1
• Gene: cacna1a / 100492135
• XenbaseID: XB-GENE-1013831
• Length: 2302
• Species: Xenopus tropicalis
• Alignment Length: 2401
• Identity: 1026/2401 - (42%)
• Similarity: 1268/2401 - (52%)
• Gaps: 696/2401 - (28%)

  Fly    44 VLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNI 108
            :|.||||||:|||:|:|||.||||.::::|:.||.||:.|||.|..:||:|||...||.|||||.
 Frog     2 ILATIIANCIVLAMEQHLPVGDKTPMSERLDDTEPYFIGIFCFETGIKIIALGFAFHKGSYLRNG 66

  Fly   109 WNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIG 173
            ||||||.||::|.:.   ..|||.|||||||:||||||||||||||||||||||:|||.||||||
 Frog    67 WNIMDFVVVLSGIVA---STGPEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIG 128

  Fly   174 LLVLFAIVIFAIIGLEFYSGALHKTCYSL--EDPNKLVKEGESETPCNTDNILEKATGSFVCNNT 236
            ||:.|||:|||||||:||.|..|.:||.:  ||    ::|   |..|..|      :.|..|...
 Frog   129 LLLFFAILIFAIIGLDFYIGKFHTSCYDMAGED----IRE---EVLCGND------SSSRRCPEN 180

  Fly   237 TSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGS 301
            | .||.||||||:|||.||||.||:|||||||||||||.|||::||..||||||:||:|||:|||
 Frog   181 T-QCLSKWEGPNNGITQFDNILFAILTVFQCITMEGWTDILYYSNDVFGSAFNWLYFIPLIIIGS 244

  Fly   302 FFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEE 366
            ||||||||||||||||||||:||||:.|:|||||||:|||||||:|||.|| ||||||:.:..|:
 Frog   245 FFMLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYMEWISKA-EVILAEDDSDIEQ 308

  Fly   367 KMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYL-------KTRSKPQGSCTGFW 424
            ::....|.||...|:.|.:.|        ..||.||..||...:       ..:|....:.:...
 Frog   309 RLPYDGALRRPTIKKNKTELL--------NAEEGEEAIGDIASVGSPFARASIKSAKMENSSYMH 365

  Fly   425 RAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMF 489
            :.|:|.||.||..||||.|||.|:.||.|||:|||:.||||...|:|||||||||||||||||||
 Frog   366 KKERRIRFLIRRMVKTQAFYWVVLGLVALNTLCVAIVHYGQDDRLSEFLYYAEFIFLGLFMSEMF 430

  Fly   490 IKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVK-GGSFGLSVLRALRLLRIFKVTKYWSSL 553
            ||||.||.|.||.||||.|||.||:||||||:|:.|| |.|||:||||||||||||||||||:||
 Frog   431 IKMYGLGTRPYFHSSFNCFDCAVITGSIFEVVWAMVKPGTSFGISVLRALRLLRIFKVTKYWASL 495

  Fly   554 RNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPETNFNTFPIALLTVFQIL 618
            ||||||||:||:|||||||||||||::||||||||||||||....||.|||:|||.|::||||||
 Frog   496 RNLVISLLSSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEKTPATNFDTFPAAIMTVFQIL 560

  Fly   619 TGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQ 683
            ||||||.|||.||.||||.:.||::|||||:|.||||||||||||||||||||||||||..|:|:
 Frog   561 TGEDWNAVMYDGIKSQGGVKTGMVFSIYFIILTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 625

  Fly   684 VEEDKEKQLQELEKEM---------------------------------------------EALQ 703
            .|...:|...:..||:                                             |||.
 Frog   626 EEAANQKLAMQKAKEVAEVSPLSATNMSIAAKEQQKNQKTSMSVWEQRTNEIRRQNLMNSREALY 690

  Fly   704 A---------------------------------------------------------------- 704
            :
 Frog   691 SELDPEERWKLSFMRPDVKTHLDRPLVVDPQENRNNNTNKTRPGEGRNPIEQRLSQQRAEDYLRK 755

  Fly   705 ----------------------------------------------------------------- 704
                                                                             
 Frog   756 QARFQERGGRGYDMGQEPGRRPRIKEQDIIRDGQDLGMQDRTGEMDGGIRPPQDPHRRHRGGGSK 820

  Fly   705 ------------------------------------------------------DGVHVENGDGA 715
                                                                  ||:.|..|.|.
 Frog   821 ESRSGSPLPRGDGDHRRHRPHRRTGEDNEDAGGGGGGGGRGGGGGGDRRPRHGRDGMRVREGGGG 885

  Fly   716 ----------------------------------------VAPSKSKG----------------- 723
                                                    .||:...|
 Frog   886 ESEGPEGERRRRHRHAAQSTYESDAKRDDRERRHRRRKEPTAPTPGSGGPNLSTTRPIQDRSRQE 950

  Fly   724 ----------------------------------------------------------------- 723
                                                                             
 Frog   951 NQNQQPENMDNIRNTKLVTSEPPAGGGVGGLNHSPAKIGNHTNCANNNSVPTGNATPRRTPHPTN 1015

  Fly   724 ----------------------------------------------------------KKKEEEK 730
                                                                      .||::||
 Frog  1016 SGPPPSAPDPSHTFSNPTETAKGTKTTEHTTVDIPPPFPPPVENAIGQANKIVAVSPLPKKDDEK 1080

  Fly   731 KEEEEVTE----GPKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDP 791
            |||||..:    |||||.|||||||||.|||:||..|::|.:.||:..|::||:|||||||||||
 Frog  1081 KEEEEDDDDGEKGPKPMPPYSSMFILSTTNPLRRLCHYIVTMRYFEMCILMVIAMSSIALAAEDP 1145

  Fly   792 VRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGF- 855
            |:.::.||.:|.||||.||||||.||::|:||||:|||.|:|.|:.||.:|.:||..|.|:|.|
 Frog  1146 VQPDAPRNNVLRYFDYVFTGVFTFEMVIKMVDLGLILHQGAYFRDLWNFLDFIVVCGALVAFAFS 1210

  Fly   856 -DMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFS 919
             :..|.|.|:::||||||||||||||||||||:|||||||||||||||||:||||||:||.|||:
 Frog  1211 SNQRGGSKGKDISTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFA 1275

  Fly   920 VIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFA 984
            |:.||||.|||||||||||....:|:|.|..|::.|:  |.:.|.||...||||||..|:||||.
 Frog  1276 VVAVQLFKGKFFYCTDESKEFQRDCRGEYLVYDKSEV--KAQKREWKKWPFHYDNVLWALLTLFT 1338

  Fly   985 VQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEA 1049
            |.||||||.||:||:.|||||:||...||:||||||:|||:||||||||||||||||||||||:.
 Frog  1339 VSTGEGWPDVLRHSVDATYEDQGPRPGFRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK 1403

  Fly  1050 ELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMM 1114
            .:::..::||:::||||.|.|:||.|:||:|:.:|:|::|:.|||.||||.||.||..||::|||
 Frog  1404 IMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMALIALNTIVLMM 1468

  Fly  1115 KYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEF 1179
            |:|...:.||..||..||.||.:||:|.:|||:.||..|:|:|.|||||.:||||||.|.:..|.
 Frog  1469 KFHGSSNTYENVLKTFNMVFTSLFSLECLLKIMAFGAPNYFRDAWNIFDFVTVLGSITDIVVTEL 1533

  Fly  1180 GSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFG 1244
            ..:.||:.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog  1534 WDSIINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFG 1598

  Fly  1245 NIKLGTVEN--SITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGS 1307
            ||.|...::  :||.||||::|.|.:|||||.||||||..|||:||.|:.||..:.....| |||
 Frog  1599 NIALDEEDDDTAITEHNNFRNFFQALMLLFRSATGEAWHEIMLSCLSGRPCDVGSGLKEKE-CGS 1662

  Fly  1308 TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHY 1372
            ..||.|||||||.|||||||||||||||||:||||||||||.|||||:||:||||||.|.|::.|
 Frog  1663 EFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMKY 1727

  Fly  1373 TEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKM-RAPE 1436
            |::|:||:.:.||||.|.|||.|:|||:|:||::|:.|:..|.|.:||.||||..|.||: :...
 Frog  1728 TDLYEMLRLISPPLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGA 1792

  Fly  1437 EMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQL-- 1499
            :..|.|.:||:.:..|||..::|.|:|||.|....:   |:||||||..:|:|.:|.::..:|
 Frog  1793 DKQQMDSQLRKEMMAIWPNMSQKTLDLLVTPHKSTD---LTVGKIYAAMMIMEYYRQSKAKRLQA 1854

  Fly  1500 -------------------------------------DSGMP---MLELQ--------------- 1509
                                                 :.|:|   |.|.|
 Frog  1855 LQEEQNRTPLMFQRMEPPSPTQDGPLGINALPSSQAGEMGLPEGGMKESQSWMTQRAQQMFQKTG 1919

  Fly  1510 -----------DASRHP-SQESLTGADAGHLHPGHS------YMNGHRRSPSLRH---------- 1546
                       :.:..| ||:|:..:|.|  ..|:|      .|.||.|:.|:..
 Frog  1920 TWSPERARTQENTNSWPNSQQSVEMSDMG--RDGYSDSEQYLVMEGHGRAASMPRLPADNQQRRK 1982

  Fly  1547 ------------NGSPLARSPS--------------------------------PRRRGH----- 1562
                        :|||:.||.|                                .|.|||
 Frog  1983 TRTRGSNLSTITDGSPMKRSASMLGHSQSKGIRLDEYSLERVTPEEGPRHGHQRRRERGHRVSDR 2047

  Fly  1563 ---QYIHHDIGFS---DTVSNVVEMVKETR--------------HPRHGNSHPRYPRGSWSASTS 1607
               :|:..:.|..   .|.:...::..|.|              |..|.:.||...|........
 Frog  2048 SLTRYVDLESGLGTELSTTTQSCDLPTEERGRTRDRKHHHHHHHHHHHHHHHPSTERERLEYGRP 2112

  Fly  1608 PARSPSPSR-YGGHLSRSKRTQ-LPYPTYGTTSLCQRSRSPSPARLQEMRERDRLGYGIDMGVTH 1670
            .:||||..| |..|...|.... .|.|:....|..:|.|...|......|.|......:....:.
 Frog  2113 SSRSPSTGRDYAPHRQGSSSVDGSPVPSTSGASTPRRGRRQLPQLPTTPRPRVTYSPVVRRPASV 2177

  Fly  1671 VQHSYPTLASRRAGIGRRLPPTPSKPSTLQLKPTNINFPKLNASPTHTHHSTPHSV--------H 1727
            ......:|......|.||.|.|.::||:.:.:..|      |.||....|:..|..        |
 Frog  2178 CSPQQQSLCRMTTPIQRRYPQTENRPSSNERRSVN------NDSPRSHRHTRGHCTEVPRAGCRH 2236

  Fly  1728 SLPHHRDLLRDPRDMYYSSRERERDRERLRDRDRDRDRDRLHEYDLRYEYRDRERELYERERDRE 1792
            |.|:......||                             |..|.|                ..
 Frog  2237 SGPYRDSSFEDP-----------------------------HPCDQR----------------SS 2256

  Fly  1793 REVERERLEYIAPLSFEQALAMGRTGRVLPSPVLNGFK---PKS--GLNPRHSDSDEEDWC 1848
            |..|...:..::|           .||.||    ||:.   |:|  ..:.|:|:|:|:|||
 Frog  2257 RTAESGGVPPLSP-----------RGRRLP----NGYSHGTPRSTKSRHERYSESEEDDWC 2302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:459842	185/281 (66%)
		Ion_trans	441..677	CDD:459842	187/236 (79%)
		Ion_trans	769..1050	CDD:459842	190/282 (67%)
		Ion_trans	1094..1345	CDD:459842	172/252 (68%)
		GPHH	1354..1407	CDD:465306	31/52 (60%)
		Ca_chan_IQ	1417..1496	CDD:462591	32/79 (41%)
		AF-4	<1512..>1704	CDD:461550	57/279 (20%)
cacna1a	XP_031755311.1	Ion_trans	1..267	CDD:459842	185/281 (66%)
		Ion_trans	382..620	CDD:459842	188/237 (79%)
		Ion_trans	1123..1358	CDD:459842	152/236 (64%)
		Ion_trans	1448..1700	CDD:459842	172/252 (68%)
		GPHH	1709..1762	CDD:465306	31/52 (60%)
		Ca_chan_IQ	1772..1849	CDD:462591	32/79 (41%)
		PHA03307	2112..>2292	CDD:223039	49/245 (20%)