DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and scn1a

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_012826731.2 Gene:scn1a / 100488621 XenbaseID:XB-GENE-978019 Length:2020 Species:Xenopus tropicalis


Alignment Length:1866 Identity:476/1866 - (25%)
Similarity:782/1866 - (41%) Gaps:509/1866 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 TSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYF 80
            ::|:|||..||:||....::....|...::.||:.|||.:.: .:.|...|.|        |..|
 Frog   107 SALYILTPFNPLRKVAIKVLVHSLFSMLIMCTILTNCVFMTM-SNPPEWTKNV--------EYTF 162

  Fly    81 LCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRP 145
            ..|:..|:.:||||.|..|.|.::||:.||.:||.|:|..::|::..:|   ::..||..||||.
 Frog   163 TGIYTFESLIKILARGFCLEKFTFLRDPWNWLDFSVIVMAYVTEFVNLG---NVSALRTFRVLRA 224

  Fly   146 LKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTC----------- 199
            ||.:|.||.|:.::.::|:::..|..:.:|.:|.:.:||:|||:.:.|.|...|           
 Frog   225 LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGHLRNKCLQWPPIDYFPL 289

  Fly   200 ----------YSLEDP-----NKLVKEGESETPCNTDNILEKATGSFVCNNTTS--------MCL 241
                      .::.||     |......|..|..|....||......:|.|::.        :|:
 Frog   290 INIPPILNGTMNIHDPFGNTTNSTFDWEEYITDKNHFYKLEGQKDFLLCGNSSDSGQCPKGYICV 354

  Fly   242 EKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLN 306
            :..:.||.|.||||...:|.|::|:.:|.:.|..:...|..|.|..: .|:||.:|.:|||:::|
 Frog   355 KTGKNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTY-MIFFVLVIFLGSFYLVN 418

  Fly   307 LVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILA------------- 358
            |:|.|::..:.::.:..        |...:|.|.|....:|.:.|.:|...|             
 Frog   419 LILAVVAMAYEEQNQAT--------LEEAEQKEAEFQQMLEQLKKQQEEAQAAAVAALNMSREYS 475

  Fly   359 --------EERTTEEEKMHIMEAR-RRNAAKRKKLKSLG------------KSKSTDT------- 395
                    .|.::|..|:....|: |||..|::|.|.||            ||:|..:       
 Frog   476 EDGGFGPLSESSSEASKLSSKSAKDRRNRKKKRKQKELGEEYEKGDDEKFPKSESETSIKRKGFR 540

  Fly   396 ----------------------------------------------EEEEAEEDYGDD------- 407
                                                          ::..:|.|:.||       
 Frog   541 FSIEGNRLTYENKFSSPHQSLLSIRGSLFSPRRNSRASLFSFRNRAKDVGSENDFADDEHSTFED 605

  Fly   408 -----GYL---------------------KTRS-------------------------------- 414
                 |.|                     ||.:                                
 Frog   606 NESRRGSLFVPNRHGERRNSNISQVSKSSKTMTVLPANGKMHSTVDCNGVVSLLGGPSVPTSPVG 670

  Fly   415 -------------------------KPQGSC-----------TGFWRA---------------EK 428
                                     |.:.||           |...||               |.
 Frog   671 LLLPEVIVDKPASDDNGTTTETEIRKRKSSCYQVPMDLLEDPTARQRALSVASILTNTVEELEES 735

  Fly   429 R-------------FRFW--------IRHTVKTQWFYWFV----IVLVFLNTVCVAVEHYGQPSF 468
            |             |..|        ::|.||......||    .:.:.|||:.:|:|||.....
 Frog   736 RQKCPPCWYKFANTFLIWDCCENWLTVKHIVKLIVMDPFVDLAITICIVLNTLFMAMEHYPMTKE 800

  Fly   469 LTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLS 533
            ..:.|.....:|.|:|.:||..|:.||.|..||:..:|.||.:::|.|:.|:..:.|:    |||
 Frog   801 FNDVLSIGNLVFTGIFTAEMVFKLIALDPYYYFQEGWNIFDGIIVSLSLMELGLANVE----GLS 861

  Fly   534 VLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQF----- 593
            |||:.||||:||:.|.|.:|..|:..:.||:.::.:|..:|.:.:.|||::||||||..:     
 Frog   862 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVC 926

  Fly   594 ----NLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFG 654
                |..  .|..:.|.|..:.|.||::|.|| |.|.|:..:...|   :.|...::.:|:|: |
 Frog   927 KIAENCE--LPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAG---QSMCLLVFMLVMVI-G 984

  Fly   655 NYTLLNVFLAIAVDNLANAQELTAAEEEQ----------------------VEE----------- 686
            |..:||:|||:.:.:. ::..|||.:::.                      :.|           
 Frog   985 NLVVLNLFLALLLSSF-SSDNLTATDDDNEMNNLQIAVGRIQRGIDYVKKTIRECIQKAFVKKQK 1048

  Fly   687 --DKEKQLQELEKEMEALQADGVHVE--------NGDG--------------------------- 714
              |:.|.|:||..:.|:...:...||        .||.                           
 Frog  1049 GLDEIKPLEELHNKRESCLFNHNAVEINKVLDYHKGDNGTTSGVGSSVEKYIIDENDYMSFIHNP 1113

  Fly   715 --------AVAPSKSKGKKKE--------EEKKEEEEVT-----------------EGPKPMLPY 746
                    ||..|..:....|        ||.||:..:|                 ||....:..
 Frog  1114 SLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNMTSSSEGSTVDIRPPGVVAEGEGEPIDI 1178

  Fly   747 SSMFILSPTN----------PI-------RRGAHW---------VVNLPYFDFFIMVVISMSSIA 785
            .|...|.|..          ||       .:|..|         :|...:|:.||:.:|.:||.|
 Frog  1179 ESEEALEPDACFTEGCVKRFPICYVNIEENKGKLWWTFRKTCYTIVEHNWFETFIIFMILLSSGA 1243

  Fly   786 LAAEDPVRENSRRNK-ILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICA 849
            ||.||...|..:..| :|.|.|..||.:|.:|||||.|..|.:    .|....|..:|.::|..:
 Frog  1244 LAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFV----KYFTNAWCWLDFLIVDVS 1304

  Fly   850 AVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILF 914
            .||...:..|.|   .|..|||||.||.||||:.:.|...::.|.:.::.::.:::|:|:|.::|
 Frog  1305 LVSLVANALGYS---ELGAIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIF 1366

  Fly   915 QFIFSVIGVQLFNGKFFYCT---------DESKHTSAECQGSYFKYEEDELLPKQELRVWKPRAF 970
            ..|||::||.||.||:::|.         |...:..::|            |...|...||....
 Frog  1367 WLIFSIMGVNLFAGKYYHCVNTTTGEMLLDTQVNNRSDC------------LHLNESARWKNVKV 1419

  Fly   971 HYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVF----PFFF 1031
            ::|||.|..|.|..|.|.:||..:    |.|..:.|...:..|.|.:::..:||::|    .||.
 Frog  1420 NFDNVGAGYLALLQVATFKGWMDI----MYAAVDSRKVEEQPRYEDNLYMYLYFVIFIIFGSFFT 1480

  Fly  1032 VNIFVALIIITFQEQ-----GEAELQDGEIDKNQKSCIDF--TIGARPLERYMPKNRNTFKYKVW 1089
            :|:|:.:||..|.:|     |    ||..:.:.||...:.  .:|::..::.:|:..|.::..|:
 Frog  1481 LNLFIGVIIDNFNQQKKKFGG----QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPPNKYQGLVF 1541

  Fly  1090 RIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNF 1154
            ..|....|:..||:||..|.:.:|::...|....|.:|.:||:.|..:|:.|.:||||... ..:
 Frog  1542 DFVTKQAFDIIIMILICLNMVTMMIETDEQSQDMENNLYWINLVFIILFTGECILKIISLR-HYY 1605

  Fly  1155 FKDPWNIFDLITVLGSIV-----DALWMEFGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTF 1214
            |...|||||.:.|:.|||     |.:...|.|.:: ...:||.|..|:::|::....||.||:..
 Frog  1606 FTIGWNIFDFVVVILSIVGMFLADMIEKYFVSPTL-FRVIRLARIGRILRLIKGAKGIRTLLFAL 1669

  Fly  1215 VQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEA 1279
            :.|..||..:.||:.::.|||||.||..|..:|   .|:.|....||::|...::.||:..|...
 Frog  1670 MMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK---KESGIDDMFNFETFGNSMICLFQITTSAG 1731

  Fly  1280 WPNIMLACLKGKA--CDDDAEKAPGEY----CGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNF 1337
            |..::...|...|  ||...|. ||..    ||: ::...:|||:|.....:::|:::|||::||
 Frog  1732 WDGLLAPILNSGAPDCDPQMEH-PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1795

  Fly  1338 DYLTRDSS-ILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKL 1401
            ...|.:|: .||....:.|..:|.::||:||..|.|:::.:....:||||....  |||:   :|
 Frog  1796 SVATEESAEPLGEDDFEMFYEVWEKFDPDATQFIEYSKLSNFADALDPPLRIAK--PNRV---QL 1855

  Fly  1402 IRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRE 1447
            |.|::|:....|:.....|||..:..|.    ..:|||...:.:.|
 Frog  1856 IAMDLPMVSGDRIHCLDILFAFTKRVLG----EGDEMDALRLPMEE 1897

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 91/320 (28%)
Ion_trans 441..677 CDD:334124 81/248 (33%)
Ion_trans 769..1050 CDD:334124 95/299 (32%)
Ion_trans 1094..1345 CDD:334124 84/262 (32%)
GPHH 1346..1416 CDD:339854 22/69 (32%)
Ca_chan_IQ 1418..1492 CDD:337190 8/30 (27%)
scn1aXP_012826731.2 Ion_trans 128..435 CDD:395416 91/319 (29%)
Na_trans_cytopl 515..723 CDD:403218 17/207 (8%)
Ion_trans 772..985 CDD:395416 74/223 (33%)
Na_trans_assoc 1011..1222 CDD:399489 29/210 (14%)
Ion_trans 1226..1498 CDD:395416 94/294 (32%)
Na_channel_gate 1490..1542 CDD:240441 11/55 (20%)
Ion_trans 1547..1802 CDD:395416 84/260 (32%)
GPHH 1814..1861 CDD:407139 18/51 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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