DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and cacna1e

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_017949086.2 Gene:cacna1e / 100488514 XenbaseID:XB-GENE-1012852 Length:2393 Species:Xenopus tropicalis


Alignment Length:2273 Identity:1028/2273 - (45%)
Similarity:1285/2273 - (56%) Gaps:544/2273 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            ||||..|||.||||.:.:|:||||||.:|.||||||:|||||:||||.|||.::::|||||.||:
 Frog   224 SLFIFGEDNIIRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPGDDKTPMSRRLEKTEPYFI 288

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFM-TQYPQIGPEVDLRTLRAIRVLRP 145
            .|||.||.:||:|||||.||.|||||.||:|||.||::|.: |........||||||||:|||||
 Frog   289 GIFCFEAGIKIVALGLVFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRP 353

  Fly   146 LKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCY----SLE-DP 205
            |||||||||||:|||||:|||.||||||||:.|||::|||||||||||.|||.||    .:| ||
 Frog   354 LKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHKACYRNNSGMELDP 418

  Fly   206 NKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITM 270
            .      :...||.    :.:....:.|        ::|.|||.|||.||||.||:|||||||||
 Frog   419 M------DPPHPCG----VPRCPAGYEC--------KEWIGPNDGITQFDNILFAVLTVFQCITM 465

  Fly   271 EGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQ 335
            ||||.:||.||||||:.:||:||:|||:|||||:|||||||||||||||||:||||:.|:|||||
 Frog   466 EGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQ 530

  Fly   336 QQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEA 400
            ||:|||||||..||.|||||:||||  .:......:|..||...||.:         |:....::
 Frog   531 QQIERELNGYRAWIDKAEEVMLAEE--NKNSGTSALEVLRRATIKRSR---------TEAMNRDS 584

  Fly   401 EEDYGDD--------GYLKTRSKPQGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVC 457
            .||:..|        .....:|......:.|...||..|..:||.:|:|.|||.|:.:|.|||.|
 Frog   585 TEDHCVDISSVGTPLARASIKSTKMDGASYFRHKEKLLRVSVRHMIKSQVFYWMVLGVVALNTFC 649

  Fly   458 VAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIW 522
            ||:.|:.|..:|:..||||||:|||||:.||..|||.:|||:||.||||.|||.|..||||||:|
 Frog   650 VAIVHHNQTLWLSNVLYYAEFLFLGLFLVEMAFKMYGMGPRLYFHSSFNCFDCGVTIGSIFEVLW 714

  Fly   523 SEVK-GGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGM 586
            :..: |.|||:|||||||||||||:||||:||||||:||:|||:|||||||||||||::||||||
 Frog   715 AIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMNSMKSIISLLFLLFLFIVVFALLGM 779

  Fly   587 QLFGGQFNLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLV 651
            ||:||:||...|||..||:|||.|::||||||||||||||||.||.||||.:.||..|||||||.
 Frog   780 QLYGGRFNFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVRSGMWSSIYFIVLT 844

  Fly   652 LFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQ-LQE--------------LEKE--- 698
            ||||||||||||||||||||||||||..|:|:.|...:|. ||:              :|||   
 Frog   845 LFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNASCIEKERRK 909

  Fly   699 ----------------------MEALQA--------------------------DGVHVE----- 710
                                  .||||:                          :.||.:     
 Frog   910 RHTLSIWEQRTSQLRRHIQMSSQEALQSEELAALNPHSSIYRKTKEAAEQNTEKEEVHQDAKLAI 974

  Fly   711 ------------------------------------NG--------------------------- 712
                                                ||                           
 Frog   975 DPVEGPPEGEGSPSNRNLRENWRQKSRHGNSENTEPNGTTPEEAMRRRQSQRRSRHRRVRTEGRE 1039

  Fly   713 ----------------------DGAVAP-SKSKGKKKE--------------------------- 727
                                  ||...| .||.|:.||                           
 Frog  1040 QCSNPNSTSASREGGLDKVSAEDGRTIPEEKSNGEAKEVKGVDDEPLKICISSRNCEDRNIRTLG 1104

  Fly   728 ----------------------------------------------------------------- 727
                                                                             
 Frog  1105 CEGIALNDTPLQDVNSQEKDSSPPDLDCSEQALLGSIQSQESPNPTSCSLPDVSSSTERVTESTV 1169

  Fly   728 ------------------------------EEKKEEEEVTEG--------------PKPMLPYSS 748
                                          :::|||||..:|              ||.::||||
 Frog  1170 ITLPDTGMPTDCTVVQMSEGRDGEVNFGSSQQEKEEEEAEDGEERTIKRKEKLLESPKAIVPYSS 1234

  Fly   749 MFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVF 813
            |.|.|.|||||:..|::|||.||:..|::||:.|||||||||||..||.|||:|.||||.|||||
 Frog  1235 MLIFSSTNPIRKVCHYIVNLRYFEMSILLVIAASSIALAAEDPVLTNSDRNKVLRYFDYVFTGVF 1299

  Fly   814 TIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGF-DMSGSSAGQNLSTIKSLRVLRV 877
            |.||::|::|.|:|||.|||.|:.|||:|.|||:.|.::|.. ::.|::.|:::.||||||||||
 Frog  1300 TFEMIIKMIDQGLILHEGSYFRDLWNILDFVVVVGALIAFALANVLGTNKGRDIKTIKSLRVLRV 1364

  Fly   878 LRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSA 942
            |||||||||:|||||||||||||||||.||||||.||.|||:||.||||.||||||||.||.|..
 Frog  1365 LRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKETEK 1429

  Fly   943 ECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRG 1007
            ||.|||..:|::::..|:  |.||...|||||:..|:||||.|.||||||||||||:..|.||||
 Frog  1430 ECIGSYIDHEKNKMEVKR--REWKRHDFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDITEEDRG 1492

  Fly  1008 PIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARP 1072
            |.::.|:||||||::||:||||||||||||||||||||||:..:::..::||:::||||.|.|:|
 Frog  1493 PSRSNRMEMSIFYVIYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACIDFAISAKP 1557

  Fly  1073 LERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGM 1137
            |.||||:||:||:|:||..|||..|||.||.:|..||::|||||::....||.:|||:|:.||.:
 Frog  1558 LTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPYTYELALKYLNIAFTML 1622

  Fly  1138 FSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWME---FGSNSINVGFLRLFRAARLIK 1199
            ||:|.:||||.||..|:|:|.|||||.|||:|||.:.:..:   ..::|.|:.||:|||||||||
 Frog  1623 FSLECILKIIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSSFNMSFLKLFRAARLIK 1687

  Fly  1200 LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSF 1264
            |||||||||||||||||||||||||||||||||||||||||||||||:| ..::.|.|||||:||
 Frog  1688 LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIRL-EEDSHINRHNNFRSF 1751

  Fly  1265 IQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPG----EYCGSTLAYAYFVSFIFFCSFLM 1325
            ...:|||||.||||||..|||:||..|.|:.|...|.|    |.||:.|||.|||||||||||||
 Frog  1752 FSSLMLLFRSATGEAWQEIMLSCLSDKGCEPDTSAASGHNENERCGTELAYVYFVSFIFFCSFLM 1816

  Fly  1326 LNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGN 1390
            ||||||||||||:||||||||||.||||||||||||||..|.|:|.|.:||.:::.:.||||.|.
 Frog  1817 LNLFVAVIMDNFEYLTRDSSILGPHHLDEFVRIWAEYDRAACGRIPYKDMYKLVRVISPPLGLGE 1881

  Fly  1391 KCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKM-RAPEEMDQADMELRETITNIWP 1454
            .||.|:|.|:|:.||||:.:::.|.||:||.||||..|.||: :...:..|.|.||::.|..|||
 Frog  1882 NCPYRVACKRLVLMNMPVSEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKDILAIWP 1946

  Fly  1455 LQAKKMLNLLVP---PSDQLNKGKLSVGKIYAGFLILESWRSTRF----GQLD--SGMPMLELQD 1510
            ..::||::||||   .||      |:||||||..:|::.::.::.    .||:  ...||.:..:
 Frog  1947 NLSQKMIDLLVPMPRASD------LTVGKIYAAMMIMDYYKQSKAKKQRQQLEEQKNAPMFQRME 2005

  Fly  1511 ASRHP-------------SQESLTG----ADAGHLHPGHSY----MNGHR--------------- 1539
            ||..|             .|::|:|    .....|.|...:    ::|..               
 Frog  2006 ASALPEEILSNAKALPYLQQDTLSGLGGFPSLSPLSPEEVFQPPCLDGEEEEDFEEQLSLEPEVR 2070

  Fly  1540 --RSPSLRHNGS-----------PLARSPSPRRRGHQYIHHDI-----GFSDTVSNVVE---MVK 1583
              |...|.:.||           .:..|..||...:..:..|:     .||.|....|.   :.:
 Frog  2071 EFRREQLPNRGSYIPVEMLERPASVRASSMPRLAENPQVLSDVSSMRRSFSTTAEKRVRSSWLDE 2135

  Fly  1584 ETRHPRHGNSHPRYPRGSWSAS---------TSPARSPSPSRYGG-HLSRSK-RTQLPYPTYGTT 1637
            .|......:...||.|.|:.||         |.........|.|| ...||| |..|..|   ..
 Frog  2136 FTMDRSSTDCAYRYQRRSYHASLRLSAHRLNTDTGHWSDNHRSGGRERGRSKERKHLLSP---DP 2197

  Fly  1638 SLC-QRSRSPSPARLQEMRERDRLGYGIDMGVTHVQHSYPTLAS-------------RRAGIGRR 1688
            |.| ...|||..|    ...||.     .:...|...|...|.|             ||   |||
 Frog  2198 SRCNSEERSPQAA----CEHRDH-----QLSPGHTPSSVQILDSLSESCTPSDTSTPRR---GRR 2250

  Fly  1689 ----LPPTP----SKPSTLQLK-----PTNINFPKLNASPTHTHHSTP----HSVHSLPHHRDLL 1736
                :||||    |..|.::.:     |.|.|...|.:.|..|..|..    .|..|.|.|  .:
 Frog  2251 QLPSVPPTPRPLISFSSLIRRQKHSPPPQNKNDTILPSEPGLTESSCSLGGHQSSQSTPQH--YI 2313

  Fly  1737 RDPRDMYYSSRERERDRERLRDRDRDRDRDRLHEYDLRYEYRDRERELYERERDREREVERERLE 1801
            .:|   |.:                      |||                       |::.....
 Frog  2314 SEP---YLA----------------------LHE-----------------------EMQSSDCP 2330

  Fly  1802 YIAPLSFEQALA--MGRTGRVLPSPVLNGF---------KPKSGLNP-----RHSDSDEEDWC 1848
            ....|:||.|:|  :||:..:..:|:.:|:         :.|.|:.|     ..||::|:|.|
 Frog  2331 AEDTLTFEVAVATSLGRSNTIGSAPLRHGWQMPNGHYRRRRKGGIPPVIPSRELSDTEEDDRC 2393

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 188/292 (64%)
Ion_trans 441..677 CDD:334124 172/236 (73%)
Ion_trans 769..1050 CDD:334124 189/281 (67%)
Ion_trans 1094..1345 CDD:334124 171/257 (67%)
GPHH 1346..1416 CDD:339854 39/69 (57%)
Ca_chan_IQ 1418..1492 CDD:337190 33/77 (43%)
cacna1eXP_017949086.2 Ion_trans 244..519 CDD:395416 188/292 (64%)
Ion_trans 632..871 CDD:395416 173/238 (73%)
Ion_trans 1255..1485 CDD:395416 152/231 (66%)
Ion_trans 1579..1836 CDD:395416 171/257 (67%)
GPHH 1845..1898 CDD:407139 29/52 (56%)
Ca_chan_IQ 1909..1982 CDD:400901 33/78 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 390 1.000 Domainoid score I783
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1771 1.000 Inparanoid score I66
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45628
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X841
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.070

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