DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and scn2a

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	XP_031749252.1	Gene:	scn2a / 100486750	XenbaseID:	XB-GENE-6447552	Length:	1970	Species:	Xenopus tropicalis

Alignment Length:	1818	Identity:	463/1818 - (25%)
Similarity:	778/1818 - (42%)	Gaps:	456/1818 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 TSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYF 80
            ::|:|||..||:|:....|:....|...::.||:.|||.:.| .:.|...|.|        |..|
Frog   106 SALYILTPFNPVRQAAIKILVHSLFNMLIMCTILTNCVFMTL-SNPPEWTKNV--------EYTF 161

  Fly    81 LCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRP 145
            ..|:.:|:.:||||.|..|.|.::||:.||.:||.|:|..::|::..:|   ::..||..||||.
Frog   162 TGIYTLESLIKILARGFCLEKFTFLRDPWNWLDFSVIVLAYVTEFVNLG---NVSALRTFRVLRA 223

  Fly   146 LKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTC----------- 199
            ||.:|.||.|:.::.::|:::..|..:.:|.:|.:.:||:|||:.:.|.|...|
Frog   224 LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGHLRNKCLLWPYNSSVDI 288

  Fly   200 --YSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTS--------MCLEKWEGPNSGITSF 254
              |...:.:...|             ||......||.|::.        :|::....||.|.|||
Frog   289 SLYEHFNESLFYK-------------LENQKDPLVCGNSSDTGKCPEGYVCVKAGRNPNYGYTSF 340

  Fly   255 DNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKE 319
            |...:|.|::|:.:|.:.|..:...|..|.|..: .|:||.:|.:|||:::||:|.|::..:.::
Frog   341 DTFNWAFLSLFRLMTQDCWENLYQLTLRAAGKTY-MIFFVLVIFLGSFYLVNLILAVVAMAYEEQ 404

  Fly   320 -----REKVENRQEFLKLRRQQQLERELNGYVEWIC-----KAEEVIL--AEERTTEEEKMHIME 372
                 .|.|:...||.:|::||:..:.|...|..:.     .:|||.|  |.|.::...|:....
Frog   405 NQATIEEAVQKEAEFQRLKKQQEEAQALAAAVADVFGESQELSEEVGLEDASECSSTVSKLSSKS 469

  Fly   373 AR-RRNAAKRKK------------LKSLGKSKSTD---------TEE----EE------------ 399
            |: |||..|::|            .:...||.|.|         |.|    ||
Frog   470 AKERRNWRKQRKQVAHCDGQEKGDKEKCYKSGSEDSIKRKGLNFTREGRRLEEYRKSSMPHQSLL 534

  Fly   400 ----------------------------AEEDYGDD-----------------GYLKTRSK---- 415
                                        :|.|:.||                 |..:.|..
Frog   535 SIQGPVFSPRRNSKTSIFSFKDRAKDVGSENDFADDERSTFEEDSRRDPLFVPGRHRARRNSNIS 599

  Fly   416 -----------------------------------------PQGS-------------------- 419
                                                     |:|:
Frog   600 QTSRSSRILPLLSMNGKMHSTVDCNGVVSLVGGSSAPIGLFPEGTTTETDRKRRPSSYKISMDLM 664

  Fly   420 -----------------------------CTGFW-RAEKRFRFW--------IRHTVKTQWFYWF 446
                                         |...| :....|..|        ::..||......|
Frog   665 EDPSLRQRAQSIASILTNTMEELQESRRKCPSCWYKFANCFLIWDCCEAWLKVKRIVKLIVMDPF 729

  Fly   447 V----IVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNR 507
            |    .:.:.|||:.:||||.....:....|.....:|.|:|.:||.:|:.||.|..||:..:|.
Frog   730 VDLAITISIVLNTIFMAVEHAHMTPYFISVLTTGNQVFTGIFTAEMVLKLIALDPYYYFQEGWNI 794

  Fly   508 FDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLF 572
            ||.:::|.|:.|:..|    .:.|.||||:.||||:||:.|.|.:|..|:..:.||:.::.:|..
Frog   795 FDGLIVSLSLMELGLS----STGGFSVLRSFRLLRVFKLAKSWPTLNKLIKIIGNSVGALGNLTL 855

  Fly   573 LLFLFILIFALLGMQLFGGQF---------NLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMY 628
            :|.:.:.|||::||||||..:         |..  .|..:.|.|..:.|.||::|.|| |.|.|:
Frog   856 VLAIIVFIFAVVGMQLFGKSYKECVCKIAENCE--LPRWHMNDFFHSFLIVFRVLCGE-WIETMW 917

  Fly   629 QGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEE----------- 682
            ..:...|   :.|...::.:|:|: ||..:||:|||:.:.:. ::..|:|.:|:
Frog   918 DCMEVAG---QSMCLLVFMLVMVI-GNLVVLNLFLALLLSSF-SSDNLSATDEDSEINNIQIAVG 977

  Fly   683 ------------------------QVEEDKEKQLQE-----------------LEKEMEALQADG 706
                                    |.:.::.|||:|                 |:::.:...:||
Frog   978 RIQRGVASGKIILREFFEKLFLQKQKDINETKQLEETPGKNDTCVLGNAVVEILKEKNDVRDSDG 1042

  Fly   707 VHVENGDGA------------------------VAPSKS----------KGKKKEEEKKE----- 732
            :..|.|...                        :||.:|          ..:...||.||
Frog  1043 MTSEIGSSVEKSAENEKEYMTVINKTSLTVAVPIAPGESDFENPNTEEFSSESDPEETKEKIKVS 1107

  Fly   733 ------------------------EEEVTEGPKPMLPYS--SMFILSPTN----------PIRRG 761
                                    |.|.|..|:|.....  :.|.....|          .:|:.
Frog  1108 SSSEGSTIDIRAPGVERIEEFLDYEYEETFDPEPCFTDDCVASFTCCQINIENGTGRDWWNLRKT 1172

  Fly   762 AHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNK-ILNYFDYAFTGVFTIEMLLKIVDLG 825
            .:.:|...:|:.||:.:|.:||.|||.||...|..|..| ||.|.|..|..:|.:|||||.|..|
Frog  1173 CYTIVEHSWFESFIIFMILLSSGALAFEDIYVEQRRNVKAILEYADKVFAYIFIMEMLLKWVAYG 1237

  Fly   826 VILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKL 890
            .|    .|....|..:|.::|..:.||...:..|.|   .|..|||||.||.||||:.:.|...:
Frog  1238 FI----KYFTNAWCWLDFIIVDISLVSLIANALGYS---ELGAIKSLRTLRALRPLRALSRFEGM 1295

  Fly   891 KAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDE 955
            :.|.:.::.::.:::|:|:|.::|..|||::||.||.|||:||.:.:         |...:...:
Frog  1296 RVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCVNTT---------SGVPFPATD 1351

  Fly   956 LLPKQELRV---------WKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQN 1011
            :....:.|:         ||....::|||.|..|.|..|.|.:||..::..::.:...:..|...
Frog  1352 VNNYSDCRMYINTTGAARWKNVKVNFDNVGAGYLALLQVATFKGWMPIMYAAVDSREINEQPKYE 1416

  Fly  1012 FRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAEL--QDGEIDKNQKSCIDF--TIGARP 1072
            ....|.::::.:.|...||.:|:|:.:||..|.:| :.:|  ||..:.:.||...:.  .:|::.
Frog  1417 NNTTMYLYFVAFIIFGSFFTLNLFIGVIIDNFNQQ-KKKLGGQDIFMTEEQKKYYNAMKKLGSKK 1480

  Fly  1073 LERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGM 1137
            .::.:|:..|..:..::..|....|:..||:||..|.:.:|::..:|....|..|..||..|..:
Frog  1481 PQKPIPRPANCCQGLIFDFVTKQAFDIIIMILIFLNMVTMMIETDDQSQEMEMYLYRINAVFIIL 1545

  Fly  1138 FSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIV-----DALWMEFGSNSINVGFLRLFRAARL 1197
            |:.|.:||:|... :.:|...||||||:.|:.|||     |.:...|.|.:: ...:||.|..|:
Frog  1546 FTGEFLLKLISLR-QYYFTIGWNIFDLVVVILSIVGMFLADIIERYFFSPTL-FRVIRLARIGRI 1608

  Fly  1198 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQ 1262
            ::|::....||.||:..:.|..||..:.||:.::.|||||.||..|..:|   .::.|....||:
Frog  1609 LRLIKAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK---KQSGIDDMFNFE 1670

  Fly  1263 SFIQGVMLLFRCATGEAWPNIMLACLKG--KACDDDAEKAPGEY----CGS-TLAYAYFVSFIFF 1320
            :|...::.||:..|...|..::...|..  ..||.:||. ||..    ||: ::...:|||:|..
Frog  1671 TFGNSMICLFQITTSAGWDLLLEPILNSGEPDCDPNAEH-PGSLFKGDCGNPSVGIFFFVSYIII 1734

  Fly  1321 CSFLMLNLFVAVIMDNFDYLTRDSS-ILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDP 1384
            ...:::|:::|||::||...|.:|: .||....:.|..:|.::||:|:..|.|:::.|....:||
Frog  1735 SFLIVVNMYIAVILENFSVATEESAEPLGEDDFEMFYEVWEKFDPSASQFIEYSKLSDFADALDP 1799

  Fly  1385 PLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRE 1447
            ||....  ||.:   :||.|::|:....|:.....|||..:..|.    ...|||.....:.|
Frog  1800 PLRVPK--PNNI---QLIAMDLPMVSGDRIHCLDILFAFTKRVLG----EGGEMDSLRQPMEE 1853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	90/312 (29%)
		Ion_trans	441..677	CDD:334124	80/248 (32%)
		Ion_trans	769..1050	CDD:334124	91/290 (31%)
		Ion_trans	1094..1345	CDD:334124	83/262 (32%)
		GPHH	1346..1416	CDD:339854	21/69 (30%)
		Ca_chan_IQ	1418..1492	CDD:337190	8/30 (27%)
scn2a	XP_031749252.1	Ion_trans	127..408	CDD:395416	89/306 (29%)
		Na_trans_cytopl	488..678	CDD:403218	16/189 (8%)
		Ion_trans	727..940	CDD:395416	73/223 (33%)
		Na_trans_assoc	966..1175	CDD:399489	25/208 (12%)
		Ion_trans	1179..1454	CDD:395416	91/291 (31%)
		Na_channel_gate	1446..1498	CDD:240441	10/52 (19%)
		Ion_trans	1503..1758	CDD:395416	83/260 (32%)
		GPHH	1770..1817	CDD:407139	17/51 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000