DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and cacna1s

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_031752682.1 Gene:cacna1s / 100485035 XenbaseID:XB-GENE-5823874 Length:1689 Species:Xenopus tropicalis


Alignment Length:1579 Identity:746/1579 - (47%)
Similarity:996/1579 - (63%) Gaps:158/1579 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 GGPKKEENP-------PGGGPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEE 59
            |..||::.|       |   |.|||.|...||.||....|:||.|||..:||||.|||:.||:..
 Frog    11 GTQKKKKKPLVPPSPRP---PRSLFCLGLQNPFRKSCINIVEWKPFEMIILLTIFANCIALAIYL 72

  Fly    60 HLPGGDKTVLAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMT- 123
            .:|..|...:...|||.|..||.||.:||:|||:|.|.:||..:||||.|||:||.:|..|..| 
 Frog    73 PMPEDDTNSVNTILEKIEYIFLFIFTIEAALKIVAYGFILHSDAYLRNCWNILDFTIVSVGLFTI 137

  Fly   124 ---QYPQI-------GPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLF 178
               |..::       |...:::.|||.||||||:||||:|||||||.||||||.|||.|.|||||
 Frog   138 VLEQINKVQGVTAPGGTGFNVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLF 202

  Fly   179 AIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKEGESETPCNTDNILEKATG-SFVCNNTTSMCLE 242
            .|:|:||:|.|.:||.:|||||  .....::...|..:||:|       || ...|....|.|..
 Frog   203 MIIIYAIVGKELFSGKMHKTCY--YKATDVIATVEKPSPCST-------TGQGRQCAINGSECRG 258

  Fly   243 KWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNL 307
            .|.|||:|||.|||.|||||||:|||||||||.:|||.|||:|:.:.|||||.||::||||:|||
 Frog   259 WWPGPNNGITHFDNFGFAMLTVYQCITMEGWTEVLYWVNDAIGNEWPWIYFVSLILLGSFFVLNL 323

  Fly   308 VLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEV----------ILAEERT 362
            |||||||||.|||||.::|..|.|||.||.::.:|.||::||..||.:          ...||..
 Frog   324 VLGVLSGEFTKEREKAKSRGAFQKLREQQAMDEDLRGYLDWITHAEVMDPDMEQGDGFSQLEEGC 388

  Fly   363 TEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAE 427
            :|.|.::             :|:.:.|..|                :||.           ||..
 Frog   389 SETESLY-------------ELEGINKFIS----------------FLKQ-----------WRHW 413

  Fly   428 KR-FRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIK 491
            .| .|...|..||:::||||||:::..||:.:|.||:.||.:||:....|..:.|.:|..||.:|
 Frog   414 HRLLRRKCRDLVKSRFFYWFVILIILFNTITIATEHHNQPEWLTKAQDIANQVLLAMFTLEMVLK 478

  Fly   492 MYALGPRIYFESSFNRFDCVVISGSIFEV--IWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLR 554
            :||||.:.||.|.||||||.|:...|.|:  :.|.:. ...|:||||.:|||||||:|:||:||.
 Frog   479 IYALGFQSYFMSLFNRFDCFVVCTGILEILLVSSNIM-SPLGISVLRCIRLLRIFKITRYWTSLN 542

  Fly   555 NLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPG-GTPETNFNTFPIALLTVFQIL 618
            |||.|||||:|||.|||.|||||::||||||||:|||:|:... ....:.|:.||.:|:||||||
 Frog   543 NLVASLLNSVRSIASLLLLLFLFMIIFALLGMQMFGGKFDFEDTEIRRSTFDNFPQSLITVFQIL 607

  Fly   619 TGEDWNEVMYQGIISQGGAQ-KGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEE 682
            ||||||.|||.||::.||.. .||...||||:|.:.|||.||||||||||||||.|:.||:|::.
 Frog   608 TGEDWNSVMYNGIMAYGGPTFPGMFVCIYFIILFVCGNYILLNVFLAIAVDNLAEAENLTSAQKA 672

  Fly   683 QVEEDKEKQL----QELEKEMEALQADGVHVE-NGDGAVAPSKSKGKKKE--------------- 727
            :.||.|.|:|    .:..:|.:.|.|..:.:: .|:|....:|.|..:.|               
 Frog   673 KAEERKRKKLARAHPDKSEEEKLLLAKKLEMKAKGEGIPTTAKLKIDEFESNVNEIKDPYPSADF 737

  Fly   728 --EEKKEEEEVTEGPK--------------PMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIM 776
              ::::||.|:...|:              ||...||.||..|||..|...|.:||...|..||:
 Frog   738 PGDDEEEEPEIPISPRPRPLAELQLKEKAVPMPDASSFFIFGPTNKFRVLCHRIVNATTFTNFIL 802

  Fly   777 VVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIM 841
            :.|.:|||:||||||:...|.||:||.||||.||.:||.|:.||:...|..||.||:.|.::||:
 Frog   803 LFILLSSISLAAEDPIEPESFRNQILAYFDYVFTAIFTTEIALKMTTYGAFLHKGSFCRNYFNIL 867

  Fly   842 DAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVN 906
            |.:||..:.||||...|.      :|.:|.||||||||||:.|.|...||.|..||..::|.:.|
 Frog   868 DLLVVAVSLVSFGIQSSA------ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIKTIGN 926

  Fly   907 ILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELLPKQEL--RVWKPRA 969
            |::|..|.||:||.||||||.|||:.|||.:|.|..||:| ||...:|....:.:|  |:|....
 Frog   927 IVLVTTLLQFMFSCIGVQLFKGKFYSCTDTTKMTEEECRG-YFIVAKDGDSTQIQLRERIWTHSD 990

  Fly   970 FHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNI 1034
            ||:|||.:.|::||.:.|.|||||:|..::.:..||.|||.|:|||:::|:|:|.|:..||.:||
 Frog   991 FHFDNVLSGMMSLFTISTFEGWPQLLYRAIDSHSEDMGPIYNYRIEIAVFFIIYIILIAFFMMNI 1055

  Fly  1035 FVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEY 1099
            ||..:|:|||||||.|.::.|:||||:.|:.:.:.||||.||:|||::  :||:|.:|.|:.|||
 Frog  1056 FVGFVIVTFQEQGEQEYKNCELDKNQRQCVQYALKARPLRRYIPKNQH--QYKIWYLVTSSYFEY 1118

  Fly  1100 FIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDL 1164
            .:..||:.||:.|.|:::.|...:......:|:.|||:|:||.|||:..|..|.:|.||||:||.
 Frog  1119 LMFALIMLNTISLGMQHYGQTAEFSHLSDILNVAFTGIFTVEMVLKLAAFKAKGYFGDPWNVFDF 1183

  Fly  1165 ITVLGSIVDALWMEF---------GS---NSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1217
            :.|:|||:|.:..|.         ||   :.|::.|.||||..||:|||.:|..:|.|||||::|
 Frog  1184 LIVIGSIIDVILSEIDTPEPVVTPGSEDTSRISITFFRLFRVMRLVKLLSRGEGVRTLLWTFIKS 1248

  Fly  1218 FKALPYVCLLIAMLFFIYAIIGMQVFGNIKL--GTVENSITRHNNFQSFIQGVMLLFRCATGEAW 1280
            |:|||||.|||.|||||||:|||||||.|.:  ||   .|.|:||||:|.|.|::||||||||||
 Frog  1249 FQALPYVALLIVMLFFIYAVIGMQVFGKIAMVDGT---QINRNNNFQTFPQAVLVLFRCATGEAW 1310

  Fly  1281 PNIMLACLKGKACDDDAEKAPGE--YCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRD 1343
            ..|:|||..||.||..::..|||  .||::.||.||:||...|:||::|||||||||||||||||
 Frog  1311 QEILLACSYGKLCDPKSDFLPGEEYTCGTSFAYFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1375

  Fly  1344 SSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPL 1408
            .||||.||||||.||||||||.|.|:|.:.::..:|:.:.||||||..||:|:|.|:|:.|||||
 Frog  1376 WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVSMNMPL 1440

  Fly  1409 DDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNK 1473
            :.:..|.|..|||:|:|..|.||...  ..:|::.|||..|..||...:.|:|:.::||   :..
 Frog  1441 NSDGTVTFNATLFSLVRTALKIKTEG--NFEQSNEELRMIIKKIWKRTSMKLLDQVIPP---IGD 1500

  Fly  1474 GKLSVGKIYAGFLILESWR 1492
            .:::|||.||.|||.|.:|
 Frog  1501 DEVTVGKFYAIFLIQEHFR 1519

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 164/298 (55%)
Ion_trans 441..677 CDD:334124 134/239 (56%)
Ion_trans 769..1050 CDD:334124 138/282 (49%)
Ion_trans 1094..1345 CDD:334124 141/266 (53%)
GPHH 1346..1416 CDD:339854 39/69 (57%)
Ca_chan_IQ 1418..1492 CDD:337190 28/73 (38%)
cacna1sXP_031752682.1 Ion_trans 50..340 CDD:395416 164/298 (55%)
Ion_trans 427..668 CDD:395416 135/241 (56%)
Ion_trans 794..1071 CDD:395416 138/283 (49%)
Ion_trans 1113..1377 CDD:395416 141/266 (53%)
GPHH 1386..1439 CDD:407139 28/52 (54%)
Ca_chan_IQ 1450..1521 CDD:400901 29/75 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
33.040

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