DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and scn3a

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_012826714.1 Gene:scn3a / 100125099 XenbaseID:XB-GENE-5812330 Length:2019 Species:Xenopus tropicalis


Alignment Length:1999 Identity:498/1999 - (24%)
Similarity:817/1999 - (40%) Gaps:556/1999 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 TSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYF 80
            ::|:|||..||:|:.:..|:....|...::.||:.||..:.: .:.|...|.|        |..|
 Frog   108 SALYILTPFNPLRRISIKILVHSLFSMLIMCTILTNCFFMTM-SNPPEWTKNV--------EYTF 163

  Fly    81 LCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRP 145
            ..|:..|:.:||||.|..|...::||:.||.:||.|:|..::|::..:|   ::..||..||||.
 Frog   164 TGIYTFESLVKILARGFCLESFTFLRDPWNWLDFSVIVMAYVTEFVDLG---NVSALRTFRVLRA 225

  Fly   146 LKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLE---DPNK 207
            ||.:|.||.|:.::.::|:::..|..:.:|.:|.:.:||:|||:.:.|.|...|....   :|| 
 Frog   226 LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGHLRNKCVRWPPEYEPN- 289

  Fly   208 LVKEGESET----------PCNTDN-ILEKATGSF--------VCNNTTS--------MCLEKWE 245
             :....:||          |.|.:. |||:....|        :|.|::.        :||:...
 Frog   290 -ITSYFNETAGLYINVTLNPFNREEYILEETNFYFLPGTRDALLCGNSSDAGQCPKGYVCLKTGR 353

  Fly   246 GPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLG 310
            .||.|.||||...:|.|::|:.:|.:.|..:...|..|.|..: .|:||.:|.:|||:::||:|.
 Frog   354 NPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTY-MIFFVLVIFLGSFYLINLILA 417

  Fly   311 VLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILA----------------- 358
            |::..:.::.:..        |...:|.|.|....:|.:.|.:|.|.|                 
 Frog   418 VVAMAYEEQNQAT--------LEEAEQKEAEFQLMMEQLKKHQEEIQAAALAAETMDGSREFSGG 474

  Fly   359 ------EERTTEEEKMHIMEAR-RRNAAKRKKLKSLGKSKSTDTE-------------------- 396
                  .|.::|..|.....|: |||..|::|.|..|:.:..|.|                    
 Frog   475 TGYGGLSESSSEASKPSSKSAKERRNRRKKRKQKEQGEDEKADDEKFHKSASETSIKRKGFRFSI 539

  Fly   397 --------------------------------------------EEEAEEDYGDD---------- 407
                                                        :..:|.|:.||          
 Frog   540 EGNRLTYEKKYSSPHQSRLSFRGSLFFPRRDSRASLCSFRGRGKDVGSENDFADDEHSTFEDNES 604

  Fly   408 ---------------------------------------------GYLKTRSKPQG--------- 418
                                                         |.:.....|.|         
 Frog   605 RRGSLFVPHRHGERRNSNISQTSKASRTLPVLPVNGKMHSTVDCNGVVSLLGGPSGPTSPAGLLL 669

  Fly   419 ----------------------------------------------------------------S 419
                                                                            .
 Frog   670 PEVIIDKPASDDNGTNTENELRKRRLSSYHVSMDFLEDPILRQRALSIASNLTNTMEELEESREK 734

  Fly   420 CTGFW-RAEKRFRFW--------IRHTVKTQWFYWFV----IVLVFLNTVCVAVEHYGQPSFLTE 471
            |...| :....:..|        |:|.|.......||    .:.:.|||:.:|:|||........
 Frog   735 CPPCWNKFANTYLIWDCSDSWLKIKHVVNLIVMDPFVDLAITICIVLNTLFMAMEHYPITDEFAG 799

  Fly   472 FLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLR 536
            .|.....:|.|:|.:||..|:.||.|..||:..:|.||.|::|.|:.|:..|:|:    ||||||
 Frog   800 ALNVGNLVFTGIFTAEMVFKLIALDPYYYFQVGWNIFDGVIVSLSLMELGLSDVE----GLSVLR 860

  Fly   537 ALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFN------L 595
            :.||||:||:.|.|.:|..|:..:.||:.::.:|..:|.:.:.|||::||||||..:.      .
 Frog   861 SFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIA 925

  Fly   596 PGG--TPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTL 658
            |..  .|..:.|.|..:.|.||::|.|| |.|.|:..:...|.|   |..:::.:|:|: ||..:
 Frog   926 PDDCELPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQA---MCLTVFMMVMVI-GNLVV 985

  Fly   659 LNVFLAIAV-----DNLA----------------------------------NA--QELTAAEEE 682
            ||:|||:.:     ||||                                  ||  ::..|.||.
 Frog   986 LNLFLALLLSSFSSDNLAATEDDNEMNNLQIAVARMHEGIAYVKRKMREFIQNAFVKKQKALEET 1050

  Fly   683 QVEEDKEKQLQ---------ELEKEMEALQADG--VHVENGDG---------------------- 714
            :..||.:.|..         |:.||.:.|: ||  ....:|.|                      
 Frog  1051 KPLEDMQNQKDSCISNHTTVEISKEYDYLK-DGNVTTATSGIGSSVEKYIIDESDYMSFIHNPSL 1114

  Fly   715 ------AVAPSKSKGKKKEE-----------EKKEEEEVTEG------------PKPMLPYSSMF 750
                  ||..|..:....||           ||......:||            |.|.:..... 
 Frog  1115 TVTVPIAVGESDFENLNTEEFSSESDLEESKEKLNSSSSSEGSTVDIRPAGEGEPVPQVEVEEF- 1178

  Fly   751 ILSPTNP-----------------------------IRRGAHWVVNLPYFDFFIMVVISMSSIAL 786
                ..|                             :|:....:|...:|:.||:.:|.|||.||
 Frog  1179 ----QEPDACFTDGCIRRFPCCVVDVSHGKWKQWWNLRKTCFLIVEHNWFETFIIFMILMSSGAL 1239

  Fly   787 AAEDPVRENSRRNK-ILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAA 850
            |.||...|..:..| ||.|.|..||.:|.:|||||.|..|.    ..|....|..:|.::|..:.
 Frog  1240 AFEDIYIEQRKTIKIILEYADKVFTYIFILEMLLKWVAYGF----QKYFTNAWCWLDFLIVDVSL 1300

  Fly   851 VSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQ 915
            ||...:..|.|   .|..|||||.||.||||:.:.|...::.|.:.:|.::.:::|:|:|.::|.
 Frog  1301 VSLIANALGYS---ELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFW 1362

  Fly   916 FIFSVIGVQLFNGKFFYC---TDE------SKHTSAECQGSYFKYEEDELLPKQELRVWKPRAFH 971
            .|||::||.:|:||:.||   ||:      ..:..::|.         :|:.:.:...||....:
 Frog  1363 LIFSIMGVNMFSGKYGYCVNYTDDVVFDYTIVNNRSQCM---------DLISENKTARWKNVKVN 1418

  Fly   972 YDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFV 1036
            :|||....|.|..|.|.:||.:::..::.:..::..|.....:.|.::::::.|...||.:|:|:
 Frog  1419 FDNVGFGYLALLQVATFKGWMEIMYAAVDSRKQEEQPKYEDNLYMYLYFVIFIIFGSFFTLNLFI 1483

  Fly  1037 ALIIITFQEQ-----GEAELQDGEIDKNQKSCIDF--TIGARPLERYMPKNRNTFKYKVWRIVVS 1094
            .:||..|.:|     |    ||..:.:.||...:.  .:|::..::.:|:..|.|:..|:..|..
 Frog  1484 GVIIDNFNQQKKKFGG----QDIFMTEEQKKYYNAMKKLGSKKPQKPVPRPDNKFQGAVFDFVSK 1544

  Fly  1095 TPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPW 1159
            .||:..||:||..|.:.:|::..:|....|.:|.:||..|..:|:.|.|||:|... ..:|...|
 Frog  1545 QPFDIAIMILICLNMVTMMIETDDQSIETENNLYWINAVFIVLFTGECVLKLISLR-HYYFTIGW 1608

  Fly  1160 NIFDLITVLGSIV-----DALWMEFGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1219
            ||||.:.|:.|||     |.:...|.|.:: ...:||.|..|:::|::....||.||:..:.|..
 Frog  1609 NIFDFVVVILSIVGMFLADLIEKYFVSPTL-FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLP 1672

  Fly  1220 ALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIM 1284
            ||..:.||:.::.|||||.||..|..:|   .|..|....||::|...::.||:..|...|..::
 Frog  1673 ALFNIGLLLFLVMFIYAIFGMSNFAYVK---KEAGIDDMFNFETFGNSMICLFQITTSAGWDGLL 1734

  Fly  1285 LACLKGKA--CDDDAEKAPGEY---CGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRD 1343
            ...|...|  ||..||.:....   ||: ::...:|||:|.....:::|:::|||::||...|.:
 Frog  1735 APILNSGAPDCDPKAEHSGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1799

  Fly  1344 SS-ILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMP 1407
            |: .||....:.|..:|.::|.|||..|.|.::.|....:||||....  ||.   .:||.|::|
 Frog  1800 SAEPLGEDDFEMFYEVWEKFDSNATQFIQYVKLTDFADALDPPLRMPK--PNN---AQLIAMDLP 1859

  Fly  1408 LDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLN 1472
            :....|:.....|||..:..|.       |.|:.| .||:      |::.:.|.:         |
 Frog  1860 MVSGDRIHCLDVLFAFTKRVLG-------EGDEMD-NLRQ------PMEERFMAS---------N 1901

  Fly  1473 KGKLSVGKI----------YAGFLILESWR--STRFGQLDSGMPMLELQDASRHPSQESLTGADA 1525
            ..|.|...|          .|..:|...:|  :.|.|          ::.||...:||.  |.|.
 Frog  1902 PSKASYEPITSTLRRKQEELAAIVIQRCYRCYALRKG----------IKHASFMYNQEK--GKDG 1954

  Fly  1526 GHLHPGHSY----MNGHRRSPSLRHNGSPLARSP-------SPRRRGHQ 1563
            |.|......    :||:  |.:.:.:.:|...||       .|.:..|:
 Frog  1955 GSLLTRKDMLSDRLNGN--STTEKADITPSTTSPPSYDSVTKPDKEKHE 2001

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 92/316 (29%)
Ion_trans 441..677 CDD:334124 90/288 (31%)
Ion_trans 769..1050 CDD:334124 92/295 (31%)
Ion_trans 1094..1345 CDD:334124 84/261 (32%)
GPHH 1346..1416 CDD:339854 22/69 (32%)
Ca_chan_IQ 1418..1492 CDD:337190 17/83 (20%)
scn3aXP_012826714.1 Ion_trans 151..430 CDD:278921 87/292 (30%)
Na_trans_cytopl 512..627 CDD:288761 6/114 (5%)
Ion_trans 786..982 CDD:278921 72/204 (35%)
Na_trans_assoc 1008..1216 CDD:284034 29/213 (14%)
Ion_trans 1239..1496 CDD:278921 83/272 (31%)
Na_channel_gate 1488..1540 CDD:240441 12/55 (22%)
Ion_trans 1562..1800 CDD:278921 77/242 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.