DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and cacna1hb

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_021331616.1 Gene:cacna1hb / 100007317 ZFINID:ZDB-GENE-090312-128 Length:2102 Species:Danio rerio


Alignment Length:2209 Identity:527/2209 - (23%)
Similarity:878/2209 - (39%) Gaps:642/2209 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 LLTIIANCVVLA-------LEEHLPGGDKTVLAQKLEKTEAYFLCIFCVEASLKILALGLVLHKH 102
            :|.|:.|||.|.       ||.|.   |:..:.|..:.   :....|.||..:|::||| |....
Zfish     1 MLVILLNCVTLGMFQPCQDLECHT---DRCSILQAFDD---FIFAFFAVEMVVKMVALG-VFGPK 58

  Fly   103 SYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMA 167
            .||.:.||.:|.|:|:.| |.:|...|..|....:|.:||||||:.::.:||:::::..::..:.
Zfish    59 CYLGDTWNRLDLFIVMAG-MLEYSLDGHNVSFSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLP 122

  Fly   168 PLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCY-------------SLEDPNKLVKEGESETPCN 219
            .|..:.||..|...||.|:|::.::|.|...|:             |:.:..::.:..:....|:
Zfish   123 MLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFFDNNIRMLYNVSGSVSEYYRVDETDDIPFICS 187

  Fly   220 TD---------NILEKATGSFVC----NNTTSMCLEK--------W-----------EGPNSGIT 252
            |:         |:.::......|    :|.|.:..::        |           ..|::|..
Zfish   188 TNRENGMLRCSNVPKRRVAGADCELTADNVTELVFKEAPHHGCVNWNLYYNTCNASEHNPHNGAI 252

  Fly   253 SFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFA 317
            :|||||:|.:.:||.||:|||..|:|:..|| .|.:|:|||:.||::|||||:||.|.|::.:|:
Zfish   253 NFDNIGYAWIAIFQVITLEGWADIMYYVMDA-HSFYNFIYFIFLIIVGSFFMINLCLVVIATQFS 316

  Fly   318 --KEREK---VENRQEF-------LKLRRQQQLERELNGYVEWICKA--EEVI-----LAEER-- 361
              |:||.   .|.|..|       ..|........|:..|:..:|:.  ..|:     |..:|  
Zfish   317 ETKQRENQLMQEQRARFRSNESTLASLAEPGSCYEEMLKYLAHVCRKLWRHVVRIYGDLCPKRRK 381

  Fly   362 --------------------------TTEEEKMHIMEARR---------------RNAAKRKKLK 385
                                      .|:...:|.....:               |:|...||..
Zfish   382 GVANPGTSLSVGGTNGYWSDNGTKMGPTQYCMLHYHHPHQHYISNGIEMKTLQLDRDAHIAKKTP 446

  Fly   386 SL--------------------------------------------------------------- 387
            ||                                                               
Zfish   447 SLPLALQNLKGLRLGMNYPTILPSKMYTNSHARGVKAPAFHHGIYGRKISVCGGYHDTYKLQHGV 511

  Fly   388 ------------------------------GKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGS--- 419
                                          |...:.|:..|...|..|.|...:.|.....:   
Zfish   512 YPGTCSSVCVDSRVGLVSSQSSSCPICAQEGDGVNCDSNGESDPEKQGPDVGSEQRKTNLDAEEK 576

  Fly   420 ----------CTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLY 474
                      |..:.||.      ::..|.:::|...:::.:.:||:.:.||::.||..||:.|.
Zfish   577 VSEKRNCVCMCVHYARAV------LKRIVDSKYFNRGIMIAILINTLSMGVEYHEQPDELTDVLE 635

  Fly   475 YAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALR 539
            .:..:|..||:.||.:|:.|.|...|..:.:|.||.:::..|:.|:: .:..|   |.||||..|
Zfish   636 ISNIVFTSLFVLEMLLKLSACGLFDYISNPYNIFDGIIVIISVCEIV-GQADG---GFSVLRTFR 696

  Fly   540 LLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPET-- 602
            |||:.|:.::..:||..::.|:.:|.::.:...||.|||.||::|||.|||.:|.|.....:|  
Zfish   697 LLRVLKLVRFLPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFTLRLENGDTVS 761

  Fly   603 ---NFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLA 664
               ||::...|::|||||||.||||.|:|.|:     |......::||:.|:.||||.|.|:.:|
Zfish   762 DRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM-----ASTSPYAALYFVALMTFGNYVLFNLLVA 821

  Fly   665 IAVDNLANAQELTAAE------EEQVEEDKEKQLQELEKEME----------------ALQADGV 707
            |.|:......:.:.::      .:..:|||.::|.....||:                ::..:..
Zfish   822 ILVEGFQAEGDASRSDTDDDMSSDYGDEDKLRELLNSGTEMKMQTLMPISNGHLEPRASMPPNNT 886

  Fly   708 HVE------------------NGDGAV------------------------APS----KSKGKKK 726
            ||:                  |.:.:.                        ||:    ...|:::
Zfish   887 HVQFNSTPRTEVSHIYSQSRRNSNTSTELHDQRSLSSLWGSRRSSWNSLGHAPNLLRRAQSGERE 951

  Fly   727 ----------------EEEKK-----------EEEEVTEGPKPML-------------------- 744
                            |:||.           :..|:.:.|:|.|                    
Zfish   952 SLLSGPGRDSIDDNLSEDEKSSLGGVSCLGSFDFPELLQVPRPYLECNGRLDGGYNSSPNITHPE 1016

  Fly   745 -------------------------PYS----------SMFILSPTNPIRRGAHWVVNLPYFDFF 774
                                     ||.          |:::.:|.|..|.....|:....||..
Zfish  1017 PTSTQGAEDDEFEESWCLILKRLLEPYKPQWCRDHEDWSLYLFAPQNNFRMRCQKVITHKMFDHI 1081

  Fly   775 IMVVISMSSIALAAEDP-VRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFW 838
            ::..|..:.|.:|.|.| ::.:|.....|...:|.||.:|..||.:|:|.||:...|||||:..|
Zfish  1082 VLFFIFFNCITIALERPDIQPDSTERIFLKVSNYIFTVIFVAEMTVKVVSLGLYAGPGSYLKSSW 1146

  Fly   839 NIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKN 903
            |::|..:|..:.|.....::.|...:.|..::.||:||.||||:.|.|.|.||.|.:.::.||:.
Zfish  1147 NVLDGFLVFVSIVDILVSLASSGGNRILGILRVLRLLRTLRPLRVISRAPGLKLVVETLITSLRP 1211

  Fly   904 VVNILIVYILFQFIFSVIGVQLFNGKFFYCT--DESKHTS-AECQGSYFKYEEDELLPKQELRVW 965
            :.||:::...|..:|.::|||||.|||::|.  |....|: :||..:.:|              |
Zfish  1212 IGNIVLICCAFFIVFGILGVQLFKGKFYHCEGFDTRNITNKSECLQAKYK--------------W 1262

  Fly   966 KPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFF 1030
            ..|.:::||:..|:::||.:.:.:||..::...:.|...|:.||:|....|.:::|.:.::..||
Zfish  1263 IRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVAVDQQPIRNHNPWMLLYFISFLLIVSFF 1327

  Fly  1031 FVNIFVALIIITF----QEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFK------ 1085
            .:|:||.:::..|    |:|.|.|.:..| :|.||             |...|.|...:      
Zfish  1328 VLNMFVGVVVENFHKCRQDQEEEEARRRE-EKRQK-------------RMEKKRRKALQRPYYAD 1378

  Fly  1086 YKVWRIVVST-----PFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLK 1145
            |...|:.:.|     ..:.||.::|..|.|.:.|:::.|....::.|||.|..||.:|.:|..||
Zfish  1379 YSPTRLYIHTLCTSHYLDLFITIIIAINVLTMSMEHYRQPKYLDEGLKYCNYFFTLVFVIEAALK 1443

  Fly  1146 IIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGSNS---IN---VGFLRLFRAARLIKLLRQG 1204
            ::.||.:.|||:.||..||..||.||:.....|...|:   ||   :..:|:.|.||::|||:..
Zfish  1444 LVAFGFRRFFKERWNQLDLAIVLLSIMGITLEEIDLNASLPINPTIIRIMRVLRIARVLKLLKMA 1508

  Fly  1205 YTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVEN---SITRHNNFQSFIQ 1266
            ..:|.||.|.||:...:..:.||..:||||||.:|:::||.:.. |.||   .::||..||:|..
Zfish  1509 TGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLDC-TEENPCEGLSRHATFQNFGM 1572

  Fly  1267 GVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGS---TLAYAYFVSFIFFCSFLMLNL 1328
            ..:.|||.:||:.|..||...|  :.|.:|.       |.|   .|:..|||:|:....|:::|:
Zfish  1573 AFLTLFRVSTGDNWNGIMKDTL--RECKNDK-------CLSYLPLLSPLYFVTFVLMAQFVLVNV 1628

  Fly  1329 FVAVIMDNFDYLTRD-----------------------SSILGAHHLDEFVRIWAEYDPNATGKI 1370
            .|||:|.:.:....|                       :|:.||..|:           ....||
Zfish  1629 VVAVLMKHLEESNIDAREEAEMDAELKLELEAGRRQSTASVGGAAGLE-----------GTDAKI 1682

  Fly  1371 HYTEMYDMLKNMDPPLG----FGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRE----- 1426
            . |..:|..|  ||..|    .|....:|:       :::| :|...:.....|:..|.|     
Zfish  1683 E-TLSHDQGK--DPNYGNFLTVGRPSISRM-------LSLP-NDSYMLYPIKPLYGSIHERSSKQ 1736

  Fly  1427 -------NLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAG 1484
                   :||:..:..|  |.|.|::        |..|.:.....||....||: :......:.|
Zfish  1737 DCTLPGSSLSLGTQPSE--DSAVMQV--------PGAASQTSLASVPAPRPLNQ-RARTSNAFRG 1790

  Fly  1485 FLILESWRSTRFGQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSPSLRHNG- 1548
               |...::.:...:||  ...:.:||.:.||:..             |..|.|.:.||:...| 
Zfish  1791 ---LRRQQAIKSDSIDS--TYADSRDALQIPSKPC-------------SSDNLHLKVPSVPIGGR 1837

  Fly  1549 ----SPLARSPSPRR--------RGHQYIHHDIGFSDTV-----SNVVEMVKETRHPRHGNS--H 1594
                ||....|.|.|        ..|.|....|....|.     ...|.:....|..||..|  |
Zfish  1838 SAPCSPQTSPPPPLRNRTASVQTNRHVYSQRSIPCRQTAIKPHPDAAVRLNTNRRASRHSLSPHH 1902

  Fly  1595 PRYPRGSWSASTSPARSP-----SPSRY-----GGHLSRSKRTQLP--YPTYGTTSLCQRSRSPS 1647
            |.....:.|..:....:|     |..:|     .|.||   :.|:|  :.|:|.....|:..|.|
Zfish  1903 PSLSSDTQSQDSLHVGAPRHQDTSLRKYNSMENNGFLS---QPQIPRRHSTHGEELRLQQDPSSS 1964

  Fly  1648 PARLQEMRERDRLGYGIDMGVTHVQHSYPTLASRRAGIGRRLPP-----------------TPSK 1695
            .:......::|::             |.|.::..        ||                 |||.
Zfish  1965 SSSSSHTPKKDKM-------------SPPCISIE--------PPAESEVVSQECSSVLRRRTPSF 2008

  Fly  1696 PSTLQLKPTNINFPKLNASPTHTHHSTP--------HSVHSLPHHRDLLRDPRDMYYSSRERER 1751
            .|.|..:  :::.|.:...| |.....|        ..|.||....:||.|.....:|.....|
Zfish  2009 DSALPRE--SLDLPDVQDEP-HLPSRLPLPQFSFDQSDVSSLSSLSELLSDSDQSTHSIAHESR 2069

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 98/335 (29%)
Ion_trans 441..677 CDD:334124 85/240 (35%)
Ion_trans 769..1050 CDD:334124 90/288 (31%)
Ion_trans 1094..1345 CDD:334124 92/290 (32%)
GPHH 1346..1416 CDD:339854 15/73 (21%)
Ca_chan_IQ 1418..1492 CDD:337190 17/85 (20%)
cacna1hbXP_021331616.1 Ion_trans 1..323 CDD:306908 97/330 (29%)
Ion_trans 601..828 CDD:306908 85/235 (36%)
Ion_trans 1075..1347 CDD:306908 88/285 (31%)
Ion_trans 1392..1597 CDD:306908 75/207 (36%)
Herpes_TAF50 <1739..2026 CDD:308764 67/341 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

Return to query results.
Submit another query.