Protein Alignment CG10362 and pdzd8

DIOPT Version :9

• Sequence 1: NP_572771.1
• Gene: CG10362 / 32157
• FlyBaseID: FBgn0030358
• Length: 1037
• Species: Drosophila melanogaster
• Sequence 2: XP_021328830.1
• Gene: pdzd8 / 561279
• ZFINID: ZDB-GENE-110310-2
• Length: 1180
• Species: Danio rerio
• Alignment Length: 1234
• Identity: 289/1234 - (23%)
• Similarity: 499/1234 - (40%)
• Gaps: 317/1234 - (25%)

  Fly     8 ILLLCLIFLLIGGVVMILLQYLIFIKFSNLP-------------------------DESEEQKQA 47
            ::.|.|:....|.||.:|||.|:..:.|..|                         |.:.:|..:
Zfish     1 MIYLILLSAFSGAVVTLLLQLLLLYRRSPEPVARTVQYVKVVPDPALKDYFSSQQADSAPQQPDS 65

  Fly    48 NAKYTLPLNIKQTARNLKRLSNSGLGGGAGN----------GCENHQESLRRASALVSLNFVMQF 102
            .:    |::.:..|.:.|:......|.....          |...|..   :|.....||.::.|
Zfish    66 PS----PVSKQPEAASPKQQETPVPGSSPKQQPSSPPPPSLGDPQHSS---KAETCDFLNAIILF 123

  Fly   103 LFHEFKNSNRVRKWFYRKLSIELDELISKTTTGKLLDKLTIKELELGDQFPDVKSLSVHNVELDK 167
            ||.|.:::..||.|..:|:.:|.:||:...|.|:||:.|:::::.||:..|..|:..:.......
Zfish   124 LFRELRDTPVVRHWITKKIKVEFEELLQTKTAGRLLEGLSLRDVSLGNSVPVFKTARLMKPVAVN 188

  Fly   168 DEQRIENLDLLLDINYVGNFTTSIDADMVLGKKGSITLRVKQLSGMARLQFTRKPYTHWSISFLG 232
            ::...|.|:..:|:.|.|.|..:||.|:|.||...:.:::.:::|..:|||||.|:||||.|||.
Zfish   189 EDNMPEELNFEVDLEYNGGFHLAIDVDLVFGKSAYLFVKMTRVAGRLKLQFTRMPFTHWSFSFLE 253

  Fly   233 DPELILDIESKYQGRQMQSNITNLISNQIRKAVRRKHTLPNYKLRYKPFFHWTAEED-ASDCDIQ 296
            ||.:..:::|:::||.: ..:|::|.||:::.::|||||||||:||||||.:..:.. .|.||:.
Zfish   254 DPLIDFEVKSQFEGRPL-PQLTSIIVNQLKRVIKRKHTLPNYKIRYKPFFPFQVQPPLMSSCDLD 317

  Fly   297 --------PNGLLTVKLAELSRLM---GYPGASETYCTITLAPVPFIEASQRDSRNVLISLDVFI 350
                    ..|.|.|.|.|.|||.   .|...:..:||..|:...:.|.::...:      :..:
Zfish   318 ISIRDTLLVEGRLRVTLVECSRLFILGSYERETYVHCTFELSSDEWREKTRSSIK------ETEV 376

  Fly   351 HKAKNQQIGIVFK----QSGSQV-VRIESVLPNTPACKSNLLAGDVLVAIEGRPVTTIQQIAKVV 410
            .|..:..:|:.|:    ..|..| |.||:|.||:||..::|..||.|:||.|..||:..|:.|::
Zfish   377 IKGPSGSVGMTFRHVPASDGDTVHVSIETVTPNSPAALADLQRGDRLIAIGGVKVTSSVQVPKLL 441

  Fly   411 KTLQATVFSL---RIERIIP----GIIR-----------------------------------ND 433
            |.....|..|   .:...:|    |:::                                   ||
Zfish   442 KQAGERVIVLYERPVRHHVPTGGLGMLQETLGPMEEPSYLPQPGGYEEDPAPITTMDISENKDND 506

  Fly   434 AILED-------------FEKYED-------------------IGDL-----------------P 449
            :..|:             .:..||                   :|.:                 |
Zfish   507 SEFEELNVESKTAAAPVTIDTKEDFLLSVNQSPKKTVANLAKPLGSISPILNRRLNLQSPLKTQP 571

  Fly   450 SSYPCQPKLETDEAA------TADPTP----------KHLVV--------------KPSLSGTPT 484
            ...|..|.|:..|.:      |..|.|          .|:.|              :|::..:|.
Zfish   572 KESPKPPTLKNAEPSEQPQRPTVPPPPPPARPPVPPRPHIKVTSASSEAQSLVEGNEPTVEKSPE 636

  Fly   485 NSPKKSNLIAKAIKKTMSRESGDKDRDKDKDKDKD---------KDKDKDK---DKDKDKDKDKD 537
            .:...:....|.::|...:....|...|..:..:|         :|..|||   .....:|...:
Zfish   637 KTQPNTGNGEKPVEKIPVKPPEPKPVSKHPEPTEDILNIPATNKQDSAKDKISESSSNTRDSVDE 701

  Fly   538 KGKEEVEEPVNYFYQHSTIDCPFSPLIHMEDVCSFQLDNSSRFLNVCVFGKS---AGESVLLGYN 599
            :|..|..|.:   |::.|.....:.:|       |:::::.:||||.::.|:   .|..:.||:.
Zfish   702 QGLWESSETM---YRNRTARWNKASVI-------FEVESNHKFLNVALWCKNPFKLGSLLCLGHV 756

  Fly   600 NVQIGQILVECSETS-------LNQCLKQ--ISLNPASLQAVKTHPLSNQSGFNPNLCFGDILFG 655
            ::::..:.:||..||       ...|..:  .|::..:|:::.||     .|||..||:||:...
Zfish   757 SLRLEHLALECISTSSAEYQSTFRLCAPEPRASVSRTALRSLSTH-----KGFNEKLCYGDVTLN 816

  Fly   656 FSWM--GNPNLTVGDVPIKSTSKSQSPARNPLAGDRVASEDQSQFLKLTSSMADSSTSGESSSGT 718
            |:::  |..:|:.|   :....:..|.....|. ||  .:::.|.|.:|       ......||.
Zfish   817 FTYLADGESDLSSG---LMERERKGSLQEEDLK-DR--EKEREQVLMVT-------RDEPIYSGM 868

  Fly   719 TAAPRAHDFVRTHFHRATQCDFCGKKIWLKDAMQCQECSMCCHKKCIVKCQMATVCGPVDCTGSI 783
            ......|:|..|.|...|.|::|.||:|.|.|.||..||..|||||..||.:
Zfish   869 QIGEMRHNFQDTQFQNPTYCEYCKKKVWTKAASQCMICSYVCHKKCQEKCLL------------- 920

  Fly   784 PATSSTPSMASRPEFTITQADNPQIVDSS--TGATPFDETSAASGGDQGQIQSPTASGLDVHRSS 846
                                ::|..|.:|  .||.|..:::.          :...:||..|..:
Zfish   921 --------------------EHPYCVAASDRRGADPEAKSTI----------NRATTGLTRHIIN 955

  Fly   847 LTGMLAQGIKRQASNLDIPGIVSSLTGSGQQVNSKSLPPSPQHTPSRKSSIVEEATPALQQNPFE 911
            .:..|..  .||.....:...|:.: |||      .:.|||:|||:            ...|...
Zfish   956 TSSRLLN--LRQVPKARLAEQVADM-GSG------VVEPSPKHTPN------------TSDNESS 999

  Fly   912 SVTQHLEALPLDCPELSFEQVIVITEPIIRHTRNEDLMNLAKSTSKLLYAALPPDERVAKINELL 976
            ....:..|.|...|..|....:|..|..:    ::.:....|...:.||..||.|||..|:..:|
Zfish  1000 DTETYTGASPSKQPAGSSGSKLVRKEGGL----DDSVFIAVKEIGRDLYRGLPTDERSQKLELML 1060

  Fly   977 TKLKVALDAETEGYTLMNDAEKATESSPWKS------DRSDERVQALSIIMLYLCTGLQHAQGV 1034
            .||:..:|.|.|....::..|:.|..|..|:      .:|.||:|||:::|::...|::..:.|
Zfish  1061 DKLQQEIDQELEHNNSLSTEERDTIDSRRKTLITAALAKSGERLQALTLLMIHYRAGIEDLESV 1124

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10362	NP_572771.1	PDZ	358..424	CDD:294084	26/73 (36%)
		DegQ	<370..437	CDD:223343	26/108 (24%)
		C1	725..774	CDD:237996	23/48 (48%)
pdzd8	XP_021328830.1	PDZ_signaling	371..453	CDD:238492	27/87 (31%)
		DegQ	<403..551	CDD:333159	28/147 (19%)
		C1	875..917	CDD:237996	21/41 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579362
Domainoid	1	1.000	173	1.000	Domainoid score	I3642
eggNOG	1	0.900	-	-		E1_KOG3532
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50075
OrthoDB	1	1.010	-	-		D1195477at2759
OrthoFinder	1	1.000	-	-		FOG0007039
OrthoInspector	1	1.000	-	-		otm24420
orthoMCL	1	0.900	-	-		OOG6_108089
Panther	1	1.100	-	-	O	PTHR21519
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4025
SonicParanoid	1	1.000	-	-		X5132
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.750