Protein Alignment CG10362 and pdzd-8

DIOPT Version :9

• Sequence 1: NP_572771.1
• Gene: CG10362 / 32157
• FlyBaseID: FBgn0030358
• Length: 1037
• Species: Drosophila melanogaster
• Sequence 2: NP_001360498.1
• Gene: pdzd-8 / 177716
• WormBaseID: WBGene00008274
• Length: 1365
• Species: Caenorhabditis elegans
• Alignment Length: 1398
• Identity: 304/1398 - (21%)
• Similarity: 518/1398 - (37%)
• Gaps: 486/1398 - (34%)

  Fly    13 LIFLLIG---GVVMILLQYLIFIKFSNLPDESEEQKQANAKYTLPLNIKQTARNLKRLSNSGLGG 74
            ||..|:|   ||:::|....|||.....|  ..:|.|...:...|..|.:..|...:....|.|.
 Worm     2 LIAFLVGFICGVLLLLGILYIFIVDPWAP--PTDQPQPPIEQFRPAQIPEELRTFLKSGEDGQGI 64

  Fly    75 GAGNGCENHQESLRRASALVSLNFVMQFLFHEFKNSNRVRKWFYRKLSIELDELISKTTTGKLLD 139
            .....|.             |::.::..||.|.|::..:|:|.:::|.:|::::.:::..|:|:.
 Worm    65 SKWESCN-------------SISLLLHMLFQEHKDTRALRRWVHKRLQMEMNDITTRSAAGRLIQ 116

  Fly   140 KLTIKELELGDQFPDVKSLSVHNVELDKDEQRIENLDLLLDINYVGNFTTSIDADMVLGKKGSIT 204
            ::.|:||.||.:|..:.|:.|.:||:..|:...:.:..:|||:|.|.|.||||...::.||.|::
 Worm   117 EIRIRELSLGTKFMTINSIRVESVEMADDKNTFDKIVFILDIDYSGGFETSIDVSTIIAKKASLS 181

  Fly   205 LRVKQLSGMARLQFTRKPYTHWSISFLGDPELILDIESKYQGRQMQSNITNLISNQIRKAVRRKH 269
            :::.:|:||.|:..:|:||.||:.||:..|....||.|:.||.|:: .:..:|...||::::|||
 Worm   182 VKITKLTGMVRVILSRQPYHHWTFSFVSQPIFETDINSQIQGHQLK-RLIPIIKEAIRRSLQRKH 245

  Fly   270 TLPNYKLRYKPFF----HWTAEEDASDCDIQPNGLLTVKLAELSRL----------MGYPGASET 320
            ..||||:||:|||    ...:....|...|:..|.:.|.:.:.|||          ..|    |.
 Worm   246 VWPNYKIRYRPFFPNPIFQASPPINSFTHIKMEGGIEVTVLQCSRLKNALLLDDKNKNY----EV 306

  Fly   321 YCTITLAPVPFIE-ASQRDSRNVLISLDVFIHKAKNQQIGIVFKQ-------SGSQVVRIESVLP 377
            |||:::...|.:: ..|....|||::   |.....:..||:||.:       :.::.|::.:|..
 Worm   307 YCTVSIESRPIVQNEEQGHVVNVLLT---FSRYDVSSPIGLVFDKNVAATGNNTNRAVKVCTVED 368

  Fly   378 NTPACKSNLLAGDVLVAIEGRPVTTIQQIAKVVKTLQATV--FSLRIERIIPGI----------- 429
            |:.|.|:....|||||||...|:.:.:|   ..:.||:|.  .::.:||.:..|
 Worm   369 NSLADKAAFKPGDVLVAINNVPIRSERQ---ATRFLQSTTGDLTVLVERSLDDIDEEESKEAAEI 430

  Fly   430 -----------------------IRNDAILEDFEKYED----IGDLPS----------------- 450
                                   |.|:::..|.:..:|    ||.:|:
 Worm   431 VVSTVRDIDGTGSVNDTADSTSLISNNSVANDRDSLKDDDKTIGGIPAKDGKINATALAARRRHS 495

  Fly   451 --------------------------SYPCQPKLETDEAATADPTPKHLVVKPSLSGTPTNSPKK 489
                                      .:...|.:....|.:| ..|:.|:.:||.....|.|  :
 Worm   496 VSNLESSVIDTNTESVASSIFGLDAHKFDKPPSVSVQRAESA-RVPQLLISQPSFDLRRTQS--E 557

  Fly   490 SNLIAKAIKKTMSRES-----------------GDKDRD-----------------KDKDK---- 516
            |:|.||.|...:|..:                 ||.:|.                 :||||
 Worm   558 SHLDAKVIDAVLSSSADFGMENSVEDEIKMLLVGDLNRSASAGHNLDPQLLGVVKREDKDKTLTQ 622

  Fly   517 ----------------------------------------------------------------- 516
                                                                             
 Worm   623 ADASKGLALIASQTGSVASLSSMISNRTDTGTEDGGDDEEAHLDRKRSASTRKAKIQATFAAGKK 687

  Fly   517 ---------------------------------DKDKDKD------------KDKDKDKDKDKDK 536
                                             |.|.::|            |.|:...|:.|:|
 Worm   688 KVLDLMPQKRKNTDASDLNGESIEIGADAGSLYDTDTNRDPSIGRSPMAVVGKRKESPSDEKKEK 752

  Fly   537 DKGKEEVEE----------------PVNYFYQHSTIDCPFSPLIHMEDV-----CSFQLDNSS-- 578
            .:.|:::.|                |:......:|....|.   ..:||     ..|:.|:..
 Worm   753 KRLKKKLSESPKIRRAAGSAQKDQSPMTTIKARTTKSVQFQ---KFQDVMWGQSLHFEFDSPPES 814

  Fly   579 ------RFLNVCVFG---KSAG---------------------------------------ESVL 595
                  |:|||.|..   ||||                                       :.:|
 Worm   815 TTRTVIRYLNVTVHAKEVKSAGTPTTSATNVPNATPSTPDSIASSSTNTDNSVPTNISADSKPIL 879

  Fly   596 LGYNNVQIGQILVECSETSLNQC------LKQISLNPASLQAVKTHP-------LSNQSGFNPNL 647
            ||..::.:.|::.:|..| |:.|      |||    |.:....:|.|       .:..:|::|.|
 Worm   880 LGSVSLFVPQLIDDCRLT-LSNCHREVYQLKQ----PNTSSPPQTSPDDPMLAEFARHAGYDPRL 939

  Fly   648 CFGDILFGFSWMGNPNLTVGDVPIKSTSKSQSPARNPLAGDRVASEDQSQFLKLTSSMADSSTSG 712
            |||||..||.:..|      ..|:.....|         ||.  |||:   |....:..|.::..
 Worm   940 CFGDITLGFRYFPN------GFPVDKAINS---------GDE--SEDE---LNRIHNSKDVASPT 984

  Fly   713 ESSSGTTAAPRAHDFVRTHFHRATQCDFCGKKIWLKDAMQCQECSMCCHKKCIVKCQMATVCGPV 777
            ...|....:|.:||:...:...:|.|..|..||||::|..|..|.:.||.||:||..    .|.:
 Worm   985 RPFSPPALSPASHDWKLWYGKNSTTCAMCRGKIWLRNASSCSRCLVICHNKCVVKAN----SGGI 1045

  Fly   778 DCTGSIPATSSTP-------SMASRPEFTITQADNPQIVDSSTGATPFDETSAASGGDQGQIQSP 835
            .||   |....||       |.....|.:.::.|:|.:   :.|....|||.:..      :|||
 Worm  1046 ACT---PQQHLTPPSNLQLHSDEHFEEISASELDHPSV---TPGDHQIDETRSLI------MQSP 1098

  Fly   836 TASGLDVHRSSLTGML---------------------AQGIKRQASNLDIPGIVSSL-------T 872
            :...     ||:.|.|                     .:|.|::..: |..|...::       |
 Worm  1099 STPS-----SSIAGSLDTPEMSKRARFRKVTEKFSNWRKGGKKKDDD-DFIGRRETIDTDSCADT 1157

  Fly   873 GS--GQQVNSKSLPPSPQHTPSRKSSIVEEATPALQQNPFESVTQHLEALPLDCPELSFEQVIVI 935
            ||  .|.::::..|      .:....::.:..|.|..:||.|             .|.|:.....
 Worm  1158 GSLQSQDISNRDSP------MASIQDVLSDVLPGLDGSPFIS-------------GLYFQPGNAY 1203

  Fly   936 TEPIIRHTRNEDLMNLAKSTSKLLYAALPPDERVAKINELLTKLKVAL-DAETEGYTLMNDAEKA 999
            .|..||:         ||...:.::..||.::||.:||..:.:::.|: :.:....::|.:....
 Worm  1204 NEQTIRN---------AKMLGREIFCDLPSEQRVERINSQIDRIQTAIRETKDNRLSVMQNGGDI 1259

  Fly  1000 TESSPWKSDRSDERVQALSIIMLYLCTGLQHAQ 1032
            :|||. |....|||:|||:::||:.|:.||..|
 Worm  1260 SESSA-KFQGLDERLQALAVVMLHYCSALQDCQ 1291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10362	NP_572771.1	PDZ	358..424	CDD:294084	21/74 (28%)
		DegQ	<370..437	CDD:223343	22/102 (22%)
		C1	725..774	CDD:237996	18/48 (38%)
pdzd-8	NP_001360498.1	degP_htrA_DO	<347..492	CDD:273938	27/147 (18%)
		PDZ	<354..414	CDD:214570	17/62 (27%)
		C1	997..1042	CDD:237996	18/48 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158738
Domainoid	1	1.000	175	1.000	Domainoid score	I2190
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	295	1.000	Inparanoid score	I1663
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1195477at2759
OrthoFinder	1	1.000	-	-		FOG0007039
OrthoInspector	1	1.000	-	-		oto20488
orthoMCL	1	0.900	-	-		OOG6_108089
Panther	1	1.100	-	-	LDO	PTHR21519
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4025
SonicParanoid	1	1.000	-	-		X5132
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.930