DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10362 and AgaP_AGAP002576

DIOPT Version :9

Sequence 1:	NP_572771.1	Gene:	CG10362 / 32157	FlyBaseID:	FBgn0030358	Length:	1037	Species:	Drosophila melanogaster
Sequence 2:	XP_003436160.1	Gene:	AgaP_AGAP002576 / 1273392	VectorBaseID:	AGAP002576	Length:	1080	Species:	Anopheles gambiae

Alignment Length:	1124	Identity:	482/1124 - (42%)
Similarity:	658/1124 - (58%)	Gaps:	172/1124 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NILLLCLIFLLIGGVVMILLQYLIFIKFSNLPD---ESEEQKQA--NAKYTLP-LNIKQTARNLK 65
            |:||.||:..:||.|||:|:||..|:::..||:   |.|.|:::  :.:|.|| :...:.:|...
Mosquito     5 NLLLFCLMSCVIGAVVMLLIQYYAFVRYFRLPELHQEEENQRKSAFSERYVLPDVTTIRPSRRAI 69

  Fly    66 RLSNSGLGGGAGNGCENHQESLRRASALVSLNFVMQFLFHEFKNSNRVRKWFYRKLSIELDELIS 130
            ||::|.|...|.|....|.......|.::::|.::|||:.|.:.||||||||:||||:|||||||
Mosquito    70 RLTSSQLLSRAFNLFVFHAPDQESKSTIMAINLILQFLYFELRQSNRVRKWFHRKLSLELDELIS 134

  Fly   131 KTTTGKLLDKLTIKELELGDQFPDVKSLSVHNVELDKDEQRIENLDLLLDINYVGNFTTSIDADM 195
            |||||||.|||||::|:||.|||::|:..:|.|:|..||..||:||:|||::|.|||..:|||||
Mosquito   135 KTTTGKLFDKLTIRDLDLGSQFPEIKNFRLHAVDLHPDEGHIESLDVLLDLHYEGNFRLTIDADM 199

  Fly   196 VLGKKGSITLRVKQLSGMARLQFTRKPYTHWSISFLGDPELILDIESKYQGRQMQSNITNLISNQ 260
            |||||||:.|||||:||:||||||||||||||:||:.||::.||::|.:||||||||||:|||||
Mosquito   200 VLGKKGSLALRVKQVSGLARLQFTRKPYTHWSLSFINDPKVELDVQSHFQGRQMQSNITSLISNQ 264

  Fly   261 IRKAVRRKHTLPNYKLRYKPFFHWTAEEDASDCDIQPNGLLTVKLAELSRLMG-YPGASETYCTI 324
            ||||:|||||||||||||||||| ..|||....:|.|||.|.|.:||:|||.. ....:..|||:
Mosquito   265 IRKAIRRKHTLPNYKLRYKPFFH-RVEEDYELNEIVPNGSLEVTIAEISRLNAPIRTLTHVYCTL 328

  Fly   325 TLAPVPFIEASQRDSR--NVLISLDVFIHKAKNQQIGIVFKQSGSQVVRIESVLPNTPACKSNLL 387
            |||.:|::.|.|:|.:  .:::|||:.|||||||||||||||| .|.|.|::|:|||||.|:.|.
Mosquito   329 TLAHMPWVVARQQDDQGATMIVSLDIEIHKAKNQQIGIVFKQS-DQTVLIDAVIPNTPASKAELR 392

  Fly   388 AGDVLVAIEGRPVTTIQQIAKVVKTLQATVFSLRIERIIPGIIRNDAILEDFE-KYEDIGDLPSS 451
            .||||::|:|:.||.|.|:.||:|||...:|.|||||::||.|||||:|:|:| ::|:|
Mosquito   393 RGDVLLSIQGKRVTNISQVPKVIKTLNRPMFVLRIERLVPGQIRNDALLDDYEPEFEEI------ 451

  Fly   452 YPCQPKL-----ETDEA-----ATADPTPKHLVVK---------PSLSGTPTNSP--KKSNLIAK 495
               .|.|     :..||     .||....:.|..:         .|.|.||..:|  |.|.::..
Mosquito   452 ---DPNLNITFVKNVEAVQIGGGTAVLRERKLARRNSKDNSGGESSHSNTPGTTPVKKSSTIVVG 513

  Fly   496 AIKKTMSRESGDKDRDKDKDKDKDKDKDKDKDKDKDKDKDKDKGKEEVEEPVNYFYQHSTIDCPF 560
            ..:.:..|.|..:.......|.|..:                         |..:.|||:||..|
Mosquito   514 GAETSTPRGSFSEPAAAGGPKPKALN-------------------------VECYPQHSSIDAEF 553

  Fly   561 SPLIHMEDVCSFQLDNSSRFLNVCVFGKSAGESVLLGYNNVQIGQILVECSETSLNQCLKQISLN 625
            :..|.::|.|:|||.....:||:.|||||..|..||||.|:.|..|||||:|:.|...||:..|.
Mosquito   554 NSFIRLDDPCTFQLMEKYSYLNLSVFGKSNEEHRLLGYLNIPINSILVECNESHLGHHLKKYPLL 618

  Fly   626 PASLQAVKTHPLSNQSGFNPNLCFGDILFGFSWMGNPNLTVGDVPIKSTSKSQSPARNPLAGDRV 690
            |.....|..||||.||||:.|.|:||:|..|.|.|:...::.. |..:|||:            :
Mosquito   619 PPEAIDVSNHPLSMQSGFDQNYCYGDVLLSFVWDGSALASLSS-PTAATSKA------------I 670

  Fly   691 ASEDQSQFLKLTS-----SMADSSTSG-------ESSSGTTAAP----RAHDFVRTHFHRATQCD 739
            ::|::.|.|...|     .:.|..|.|       .:||..|..|    :.|||:||||||.||||
Mosquito   671 SAENKKQRLITISRGSADKLDDDRTDGLPLDAKPSASSTFTQLPAQQQQQHDFIRTHFHRTTQCD 735

  Fly   740 FCGKKIWLKDAMQCQECSMCCHKKCIVKCQMATVCGPVD----------------CTGSIPATSS 788
            :||||||||||:||::|:||||||||.|||.:|||...:                .||.|.|..:
Mosquito   736 YCGKKIWLKDAVQCRDCAMCCHKKCINKCQSSTVCTANESSAGTASDRSSTTSSTSTGIIMAAGA 800

  Fly   789 TPSMAS----------RPEFTITQADNPQI-VDSSTGATPFDETSAASGGDQGQIQSP------- 835
            ..||||          :|||.:|:.::|.| |:        |....|....|.|:|..
Mosquito   801 AASMASTAAATVGTNQQPEFKVTEPESPTIEVE--------DFVDIAEEQQQQQLQQQQQQQQQQ 857

  Fly   836 -------------TASGLDVHRSSLTGMLAQGIKR--QASNLDIPGIVSSLTGSGQQVNSKSLPP 885
                         ..|.|:.||.|.:.:|.||:||  .|:||.||      |..|...:||||||
Mosquito   858 QQQQQQQQQQQIVPKSKLETHRQSFSDLLVQGLKRVNSANNLSIP------TMGGLNPSSKSLPP 916

  Fly   886 SPQHTPSRKSSIVEEATPALQQNPFESVTQHLEALPLDCPELSFEQVIVITEPIIRHTRNEDLMN 950
            :||||| ||.|:..     :..|||..|||.||:||.|..||:.||::.:|.|:|.:..::.||.
Mosquito   917 TPQHTP-RKQSLAN-----VNANPFLLVTQRLESLPEDVNELNMEQIVDLTAPLIEYGPSDTLMA 975

  Fly   951 LAKSTSKLLYAALPPDERVAKINELLTKLKVALDAETEGYTLMNDAEKATESSPWKSDRSDERVQ 1015
            ||||:||.:|....||.|..|||:||:||.:|||.||...:::|..::::.||......::.:..
Mosquito   976 LAKSSSKAMYGDCEPDVRTEKINKLLSKLHIALDYETINQSVLNATKESSSSSSGSGAGANSKAA 1040

  Fly  1016 ALSIIMLYLCTGLQHAQGV 1034
            |.:       ...||..|:
Mosquito  1041 AAA-------AARQHQIGL 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10362	NP_572771.1	PDZ	358..424	CDD:294084	38/65 (58%)
		DegQ	<370..437	CDD:223343	38/66 (58%)
		C1	725..774	CDD:237996	38/48 (79%)
AgaP_AGAP002576	XP_003436160.1	PDZ_serine_protease	<375..429	CDD:238487	29/53 (55%)
AgaP_AGAP002576	XP_003436160.1	C1	721..763	CDD:237996	34/41 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	387	1.000	Domainoid score	I2317
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H137905
Inparanoid	1	1.050	786	1.000	Inparanoid score	I1475
OMA	1	1.010	-	-		QHG50075
OrthoDB	1	1.010	-	-		D1195477at2759
OrthoFinder	1	1.000	-	-		FOG0007039
OrthoInspector	1	1.000	-	-		oto108387
Panther	1	1.100	-	-	LDO	PTHR21519
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5132
TreeFam	0	0.000	Not matched by this tool.
	11	11.080