DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Upf1 and HELZ

DIOPT Version :9

Sequence 1:NP_001285145.1 Gene:Upf1 / 32153 FlyBaseID:FBgn0030354 Length:1180 Species:Drosophila melanogaster
Sequence 2:XP_006722277.1 Gene:HELZ / 9931 HGNCID:16878 Length:1970 Species:Homo sapiens


Alignment Length:1280 Identity:263/1280 - (20%)
Similarity:460/1280 - (35%) Gaps:371/1280 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 NCRKWFCNGRGSTSG-SHIINHLVRAKHREVTLHGEGPLGETILECYSCGVRNVFVLGFIPAKAD 179
            ||::|. .|:.:.:| .|.:..:..|.:.|:.    |...:||          ||..|..|....
Human   328 NCQEWI-GGKMAQNGLDHYVYKVGIAFNTEIF----GTFRQTI----------VFDFGLEPVLMQ 377

  Fly   180 SVVVLLCRQPCAAQNSLKDM------------NWDQEQWKPLIADRCFLAWLVKQPSEQGQLRAR 232
            .|::     ..|:...|:.:            .||... |.:|.         .:|:|...|...
Human   378 RVMI-----DAASTEDLEYLMHAKQQLVTTAKRWDSSS-KTIID---------FEPNETTDLEKS 427

  Fly   233 QISAAQIN-KLEELWKENIEATFQDLEKPGIDSEPAHVLLRYEDGYQYEK---TFGPLVRLEAEY 293
            .:...||. ..::|:.:::  ..:.|.|....|. .|.||..|:..||::   |.|      |..
Human   428 LLIRYQIPLSADQLFTQSV--LDKSLTKSNYQSR-LHDLLYIEEIAQYKEISNTSG------AST 483

  Fly   294 DQKLKESATQE-----------NIEVRWDVGLNKKTIAYFTLAKTDSDMKLMHGDELRLHYVGEL 347
            .:.|.:..|..           |::|:..:      :|.|.|.......|....        |:|
Human   484 SRILLQDTTNVTRGFSCCSKLFNLKVQLQI------LASFMLTGVSGGAKYAQN--------GQL 534

  Fly   348 YNPWSEIGHVIKVPDNFGDD--VGLELKSSTNA----PVK----CTSNFTVDFIWKCT------- 395
            :..:       |:.:...:|  .|..:.:..||    ||.    ..:..|.:.:::.|       
Human   535 FGRF-------KLTETLSEDTLAGRLVMTKVNAVYLLPVPKQKLVQTQGTKEKVYEATIEEKTKE 592

  Fly   396 -SFDRMTRALC---------------KFAIDRNSVSNFIYS--RLLGHGRADSNDEVLFRGPQPK 442
             .|.|::|..|               :|.::|..:....|:  |:..:|       |||    |.
Human   593 YIFLRLSRECCEELNLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNG-------VLF----PD 646

  Fly   443 LFSAPHL-------------PDLNRSQVYAV-----KHALQRPLSLIQGPPGTGKTVTSATIV-Y 488
            :...|.:             |.||..|..||     ..|:|.|..||.||.|||||.|.|..| :
Human   647 ISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLAIQLPPVLIIGPYGTGKTFTLAQAVKH 711

  Fly   489 QLVKLHGGTVLVCAPSNTAVD-QLTEKIH------RTNLKVVRVCAKSR--EAIDSPVSFLALHN 544
            .|.:.....:|:|..||:|.| .:.:.:|      ....:.:||..::|  :.:...|....|  
Human   712 ILQQQETSRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCL-- 774

  Fly   545 QIRNMETNSELKKLQQLKDETGELSSADEKRYRNLKRAAENQLLEAADVICCTCVGAGDGRLSRV 609
             |.:..:..::.:.:.:                 ||.......|..:..:|...:..|       
Human   775 -ISSAHSTFQMPQKEDI-----------------LKHRVVVVTLNTSQYLCQLDLEPG------- 814

  Fly   610 KFTSILIDESMQSTEPECMVPVVLGAK--QLILVGDHCQLGPVVMCKKAARAGLSQSLFERLVVL 672
            .||.||:||:.|:.|.|.::|:.|..:  :::|.|||.||.|.|..:.|....|..||.:||...
Human   815 FFTHILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEH 879

  Fly   673 GIRPFRLEV----QYRMHPELSQFPSNFFYEGSLQNGVCAEDRRLKLDFPWPQPERPMFFLVTQG 733
            ....|...:    .||.|..:..:.|..||||.|   :.:..:....||      .|:.|...:|
Human   880 YPAEFPCRILLCENYRSHEAIINYTSELFYEGKL---MASGKQPAHKDF------YPLTFFTARG 935

  Fly   734 QEEIAGSGTSFLNRTE----AANVEKITTRFLKAGIKPE--QIGIITPYEGQRAYLVQYMQYQGS 792
            ::....:.|:|.|..|    ...||::..::..|..|.:  .||::|||..      |..:.:..
Human   936 EDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYAD------QVFRIRAE 994

  Fly   793 LHSRLYQEIEIASVDAFQGREKDIIIMSCVR---------------------SNERQGIGFLNDP 836
            |..:...::.:..|...||::..::.:|.||                     |.|....|||::.
Human   995 LRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNY 1059

  Fly   837 RRLNVALTRAKFGIIIVGNPKVLAK----QQLWNHLLNFYKDRKVLVEGSLNNLKESLIHFQKPK 897
            :.||.|:|||:..:.:||:|..|..    ::.|...:....:     ..||:.     |.|::.|
Human  1060 KLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHE-----NSSLHG-----ITFEQIK 1114

  Fly   898 KLVNSMNIGAHFMSTIIADAKEVMVPGSI-YDRSGGYGQGRQM--VGQSMNGGQ---YGGSG--- 953
            ..:.::.:...::...:|..   .:|.:: ...||...:.:|.  .|:|::..|   :...|   
Human  1115 AQLEALELKKTYVLNPLAPE---FIPRALRLQHSGSTNKQQQSPPKGKSLHHTQNDHFQNDGIVQ 1176

  Fly   954 -------G------------GPYGN-----SPLGYGTPSSNSMVGFGLGNGGNGAAGGNNNFGGA 994
                   |            ||:.|     ||:....|.:.:.:.:     .....|||......
Human  1177 PNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILY-----VPAVYGGNVVMSVP 1236

  Fly   995 GP-SWAAAH----------LHHDSIGYISN---EHGAAALGNMPVPVGMFMNMSNIPP----RFY 1041
            .| .|....          .|..::.|..|   .||..:    |:|.|    :.:.||    :..
Human  1237 LPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLQTHGRGS----PIPYG----LGHHPPVTIGQPQ 1293

  Fly  1042 NQHQQAIMAVKQNRAIQQQTGNFSPGNSGPGVTGVGVGRSATPGGNKKTNKLGKSRVTGGGTGGA 1106
            ||||:      :::..|.:.|.....||||.:..:     .||  .||..:..:..:.......:
Human  1294 NQHQE------KDQHEQNRNGKSDTNNSGPEINKI-----RTP--EKKPTEPKQVDLESNPQNRS 1345

  Fly  1107 PLTQGSSVCNA-------------------APYSQ--------HPMPLSLQMTQPSGFAL----- 1139
            |.::.|.|..:                   ||::|        ||:|   |:.:|. |.:     
Human  1346 PESRPSVVYPSTKFPRKDNLNPRHINLPLPAPHAQYAIPNRHFHPLP---QLPRPP-FPIPQQHT 1406

  Fly  1140 ---SQQPELSQDFGQI-SQMDGLLSQDVAFNASGERSLNQFSQPY 1180
               .||..|.:...|| .|.:.::.|....|...::...|.|..|
Human  1407 LLNQQQNNLPEQPNQIPPQPNQVVQQQSQLNQQPQQPPPQLSPAY 1451

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Upf1NP_001285145.1 UPF1_Zn_bind 98..249 CDD:286500 28/146 (19%)
DNA2 122..897 CDD:224037 191/902 (21%)
Mis12 210..299 CDD:283509 20/92 (22%)
AAA_19 458..>515 CDD:289986 24/63 (38%)
AAA_12 661..857 CDD:289832 54/226 (24%)
HELZXP_006722277.1 zf-CCCH 181..205 CDD:279036
AAA_11 669..861 CDD:289831 58/218 (27%)
P-loop_NTPase 669..>766 CDD:304359 31/96 (32%)
DNA2 <785..1099 CDD:224037 82/352 (23%)
UvrD_C_2 868..1079 CDD:304668 54/225 (24%)
PHA03160 <1656..1815 CDD:165431
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1112
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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