DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Upf1 and ECM32

DIOPT Version :9

Sequence 1:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster
Sequence 2:	NP_011103.1	Gene:	ECM32 / 856923	SGDID:	S000000978	Length:	1121	Species:	Saccharomyces cerevisiae

Alignment Length:	789	Identity:	225/789 - (28%)
Similarity:	353/789 - (44%)	Gaps:	169/789 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 RQPCAAQNS-----LKDMNWDQEQWKPLIADRCFLAWLVKQPSEQGQLRARQISAAQINKL---- 242
            |:|..:.|.     .|..|.:::..||.:.::.....:.|:...:.|  .:.....:..||
Yeast   398 REPSISPNENTTSITKSRNRNKKASKPTLNEKSKTTTMPKKLETKNQ--EKNNGKTKDGKLIYEE 460

  Fly   243 -EELWKENIEATFQDLEKPGIDSEPAHVLLRYEDGYQYEKTFGPLVRLEAEYDQKLKESATQENI 306
             |.|.:.|   ||:.             .|.|.|...|...:...:.||    |||:....| |.
Yeast   461 GEPLTRYN---TFKS-------------TLSYPDLNTYLNDYSFALFLE----QKLENEFVQ-NF 504

  Fly   307 EVRWDVGLNKKTIAYFTLAKTDSDMKL------------------------MHGDELRLHYVGEL 347
            .:.|.  .|:|..|:....:.:::.:|                        ...||.::.|:
Yeast   505 NILWP--RNEKDTAFIINVEKNNNSELEKLLPANLLALGRPAFNERQPFFFCTQDEQKVWYI--- 564

  Fly   348 YNPWSEIGHVIKVPDNFGDDVGL-ELKSSTNAPVKCTSNFTVDFIWKCTSFDRMTRALCKFAIDR 411
                    .:.::....|..|.| ||.|..|..:. |.|.:..|....|| .:.:|.|  ||:.|
Yeast   565 --------FIKELSIQRGKYVLLVELFSWNNLSLP-TKNGSSQFKLLPTS-AQTSRIL--FAMTR 617

  Fly   412 NSVSNFIYSRLLGHGRADSNDEVLFRGPQPKLFSAPHL----PDLNRSQVYAVKHALQRPLSLIQ 472
            .:...||             |.:|.:.|..:::....|    ..|||||..||:|.|...::::|
Yeast   618 ITNPKFI-------------DLLLGQKPIKEIYFDNRLKFSSDKLNRSQKTAVEHVLNNSITILQ 669

  Fly   473 GPPGTGKTVTSATIVYQLV-KLHGGTVLVCAPSNTAVDQLTEKI--HRTNLKVVRVCAKSRE--- 531
            ||||||||.|...|:.|:: :.|...:|..|.||.|:|.:.|||  :|..:|::|:.:|.:|
Yeast   670 GPPGTGKTSTIEEIIIQVIERFHAFPILCVAASNIAIDNIAEKIMENRPQIKILRILSKKKEQQY 734

  Fly   532 AIDSPVSFLALHNQI-RNMETNSELKKLQQLKDET--GEL--SSADEKRYRNLKRAAENQLLEAA 591
            :.|.|:..:.|||.: :|:..:     :|.:.::|  ||:  .|.|.|.|:. |....|:::..:
Yeast   735 SDDHPLGEICLHNIVYKNLSPD-----MQVVANKTRRGEMISKSEDTKFYKE-KNRVTNKVVSQS 793

  Fly   592 DVICCTCVGAGDGRLSRVKFTSILI-DESMQSTEPECMVPVVL-GAKQLILVGDHCQLGPVVMCK 654
            .:|..|.:.||...|..:|...::| ||:.||:|...:||:.| |.:..:.|||..||.......
Yeast   794 QIIFTTNIAAGGRELKVIKECPVVIMDEATQSSEASTLVPLSLPGIRNFVFVGDEKQLSSFSNIP 858

  Fly   655 KAARAGLSQSLFERLVVLGI--RPFRLEVQYRMHPELSQFPSNFFYEGSLQNGVCAEDRRLKLDF 717
            :     |..|||||::..|.  .|..|:.||||||::|:||....|.|.|::||..|.:
Yeast   859 Q-----LETSLFERVLSNGTYKNPLMLDTQYRMHPKISEFPIKKIYNGELKDGVTDEQK------ 912

  Fly   718 PWPQPERPMFFL---------VTQGQEEIAGSGTSFLNRTEAANVEK-ITTRFLKAGIKPEQIGI 772
            .||..:.|:||.         |...|.:|.  |.::.|:.|...:.| |....|...:..|:||:
Yeast   913 AWPGVQHPLFFYQCDLGPESRVRSTQRDIV--GFTYENKHECVEIVKIIQILMLDKKVPLEEIGV 975

  Fly   773 ITPYEGQRAYLVQYM---------------QYQ--------------GSLHS---RLYQEIEIAS 805
            ||||..||..|...:               :|.              |||.:   .:...:.:|:
Yeast   976 ITPYSAQRDLLSDILTKNVVINPKQISMQQEYDEIELFNAAGSQGTAGSLQNNVINIINGLHVAT 1040

  Fly   806 VDAFQGREKDIIIMSCVRSNERQGIGFLNDPRRLNVALTRAKFGIIIVGNPKVLAK-QQLWNHLL 869
            ||:|||.||..||.||||:|....||||.|.|||||||||||.|:|:|||..||.| ..||...:
Yeast  1041 VDSFQGHEKSFIIFSCVRNNTENKIGFLRDKRRLNVALTRAKHGLIVVGNKNVLRKGDPLWKDYI 1105

  Fly   870 NFYKDRKVL 878
            .:.::::|:
Yeast  1106 TYLEEQEVI 1114

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500	13/71 (18%)
		DNA2	122..897	CDD:224037	225/789 (29%)
		Mis12	210..299	CDD:283509	18/93 (19%)
		AAA_19	458..>515	CDD:289986	24/57 (42%)
		AAA_12	661..857	CDD:289832	88/239 (37%)
ECM32	NP_011103.1	DNA2	244..1119	CDD:224037	225/789 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10887
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910