DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Upf1 and HELZ2

DIOPT Version :9

Sequence 1:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster
Sequence 2:	XP_024307774.1	Gene:	HELZ2 / 85441	HGNCID:	30021	Length:	2677	Species:	Homo sapiens

Alignment Length:	908	Identity:	217/908 - (23%)
Similarity:	338/908 - (37%)	Gaps:	307/908 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 WKPLIADRCFLAW-----LVKQPSEQGQLR----------------ARQISAAQINKLE------ 243
            ||.|:.......|     |:::..|..|.|                ||::.:....:::
Human  1828 WKQLLELVELQRWPEAAALIQEKGEASQRRELVQVQRSHCGHFLEVARELGSGDTLQVQLGTSLQ 1892

  Fly   244 --------ELW--KENIEATFQDLEKPGIDSEPAHVLL----RYEDGYQYEKTFGPLVRLE---- 290
                    :||  ........:.:|:|| |.....|..    ||.|..:|...:.|...||
Human  1893 HGFLVPSPQLWTVAPGFSLCLEHVERPG-DCFSGRVYRAPRDRYRDVDEYACVWEPFCALESATG 1956

  Fly   291 --AEYDQKLKESATQENIEVRWDV----------------------------------------- 312
              ||.|     |.|.:::.|.|:.
Human  1957 AVAEND-----SVTLQHLSVSWEASRTPQGQLQGAFRLEAAFLEENCADINFSCCYLCIRLEGLP 2016

  Fly   313 ---------------GLNKKTIAYFTLAKTDSDMKLMHGD-------------------ELRLHY 343
                           |||.....|..:|         ||.                   .|.:|:
Human  2017 APTASPRPGPSSLGPGLNVDPGTYTWVA---------HGQTQDWDQERRADRQEAPRRVHLFVHH 2072

  Fly   344 VGELYNPWSEIGHVIKVPDNFGDDVGLELKSSTNAPVKCTSNFTVDFIWKCTSFDRMTRALCKFA 408
            :|           :.|||:..       |:..|        .|||:.:.|.....|...|:...
Human  2073 MG-----------MEKVPEEV-------LRPGT--------LFTVELLPKQLPDLRKEEAVRGL- 2110

  Fly   409 IDRNSVSNFIYSRLLG--------HGRADSNDEVLFRGPQPKLFSAP------------------ 447
               ...|..:.|..||        .||:....::....|.|...||.
Human  2111 ---EEASPLVTSIALGRPVPQPLCRGRSAPPLQLPLWPPAPPCMSAQGGCPLSVIPSRFLERQTY 2172

  Fly   448 HLP----DLNRSQVYAVKHALQRPLSLIQGPPGTGKTVTSATIVYQLVK---------------- 492
            ::|    .||.||..||:.||::|.::||||||||||:....||:...|
Human  2173 NIPGGRHKLNPSQNVAVREALEKPFTVIQGPPGTGKTIVGLHIVFWFHKSNQEQVQPGGPPRGEK 2237

  Fly   493 -LHGGTVLVCAPSNTAVDQLTE-KIHRTNLKVVRVCAKSREAIDSPV------------------ 537
             |.|..:|.|.|||.:||.|.. .:.|..||.:||.::..||.:.||
Human  2238 RLGGPCILYCGPSNKSVDVLAGLLLRRMELKPLRVYSEQAEASEFPVPRVGSRKLLRKSPREGRP 2302

  Fly   538 ----SFLALHNQIRNMET--NSELK----KLQQLKDETGEL-SSADEKRYRNLKRAAENQLLEAA 591
                ..:.||::||....  :||:|    :||:     ||| |..|...|:.:...|....|:..
Human  2303 NQSLRSITLHHRIRQAPNPYSSEIKAFDTRLQR-----GELFSREDLVWYKKVLWEARKFELDRH 2362

  Fly   592 DVICCTCVGAGDGRLSRVKFTSILIDESMQSTEPECMVPVVL--GAKQLILVGDHCQLGPVVMCK 654
            :||.|||..|....|..:....||:||:..:||||.::|:|.  .|::::|:|||.||.|||..:
Human  2363 EVILCTCSCAASASLKILDVRQILVDEAGMATEPETLIPLVQFPQAEKVVLLGDHKQLRPVVKNE 2427

  Fly   655 KAARAGLSQSLFERLVVLGIRPFRLEVQYRMHPELSQFPSNFFYEGSLQNGVCAEDRRLKLDFPW 719
            :....||.:|||||   .......|:.|||||..:..|||..||:..|:.              |
Human  2428 RLQNLGLDRSLFER---YHEDAHMLDTQYRMHEGICAFPSVAFYKSKLKT--------------W 2475

  Fly   720 PQPERPMFFLVTQGQE-------EIAGSGTSFL------NRTEAANVEKIT-----TRFLKAG-- 764
            ....||...|...|:|       .:.|...|.|      |....||:|::.     |:.|..|
Human  2476 QGLRRPPSVLGHAGKESCPVIFGHVQGHERSLLVSTDEGNENSKANLEEVAEVVRITKQLTLGRT 2540

  Fly   765 IKPEQIGIITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIASVDAFQGREKDIIIMSCVRSNERQG 829
            ::|:.|.::|||..|.:.:.:.::.:|      ...:.::|:...||.|...:::|.||:..:..
Human  2541 VEPQDIAVLTPYNAQASEISKALRREG------IAGVAVSSITKSQGSEWRYVLVSTVRTCAKSD 2599

  Fly   830 -------------IGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYKDRKVLV 879
                         :||:.||.::|||:|||:.|:.::|:..:|....||..||:|.:.::.||
Human  2600 LDQRPTKSWLKKFLGFVVDPNQVNVAVTRAQEGLCLIGDHLLLRCCPLWRSLLDFCEAQQTLV 2662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500	12/79 (15%)
		DNA2	122..897	CDD:224037	217/908 (24%)
		Mis12	210..299	CDD:283509	24/135 (18%)
		AAA_19	458..>515	CDD:289986	28/74 (38%)
		AAA_12	661..857	CDD:289832	60/228 (26%)
HELZ2	XP_024307774.1	ZnF_U1	39..69	CDD:197732
		AAA_11	541..705	CDD:331082
		UvrD_C_2	715..915	CDD:328976
		RNB	1334..1693	CDD:214935
		AAA_11	2180..2427	CDD:315699	85/251 (34%)
		AAA_12	2434..2639	CDD:315700	60/227 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810