DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Upf1 and AT5G52090

DIOPT Version :9

Sequence 1:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster
Sequence 2:	NP_200022.1	Gene:	AT5G52090 / 835285	AraportID:	AT5G52090	Length:	676	Species:	Arabidopsis thaliana

Alignment Length:	653	Identity:	174/653 - (26%)
Similarity:	275/653 - (42%)	Gaps:	199/653 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   452 LNRSQVYAVKHALQ-------RPLSLIQGPPGTGKTVTSATIVYQLVKLHGGTVLVCAPSNTAVD 509
            ||.||..|:...|:       ..:.||.|||.||||.|.||:::.|:||...|| ||||:|||:.
plant    58 LNSSQEDAILGCLETRNCTHKNSVKLIWGPPRTGKTKTVATLLFALLKLRCKTV-VCAPTNTAIV 121

  Fly   510 QLTEK-------------------------------IHRTNLKVVRVCAKSR------------- 530
            |:|.:                               |::.:..::.|....|
plant   122 QVTSRLLSLFKENSTAENATYRLGNIILSGNRDRMGINKNDHVLLDVFLDERIGKLGKLFSPFSG 186

  Fly   531 --EAIDSPVSFLALHNQIRNMETN-SELKKLQQLKDET------------GE-----LSSADEK- 574
              :.::|.:.|  |.|.....|.: .||::::::.:|.            ||     .:|..|:
plant   187 WMQRLESLIQF--LENPEGKYERHVYELEEVERMNEEDEREEVVVNIPTFGEFVQKNFNSLSEEV 249

  Fly   575 ----------------------------------------------------RYRNLKRAAENQL 587
                                                                |:...||.:::.|
plant   250 KTCIVDLYTHLPKVYLPYEDVKKMIASRQTLQRIRYFLRENSSRVDFEEGNFRFDCFKRLSDDCL 314

  Fly   588 -------------------------LEAADVICCTCVGAGDGRLSRVKFTSIL-IDESMQSTEPE 626
                                     |:.||:|.||..||.:..:.|.....:| :||:.|..|.|
plant   315 KALRLLPKRFEIPDMLENEDIRKFCLQNADIILCTASGAAEMNVERTGNVELLVVDEAAQLKECE 379

  Fly   627 CMVPVVL-GAKQLILVGDHCQLGPVV---MCKKAARAGLSQSLFERLVVLGIRPFRLEVQYRMHP 687
            .:..:.| |.:..||:||..||..:|   ||:||.   ..:|||||||:||.....|:|||||||
plant   380 SVAALQLPGLRHAILIGDEFQLPAMVHNEMCEKAK---FGRSLFERLVLLGHNKHLLDVQYRMHP 441

  Fly   688 ELSQFPSNFFYEGSLQNGVCAED-----RRLKLDFPWPQPERPMFFLVTQGQEEIAGSGTSFLNR 747
            .:|:||:..||.|.:::....::     |.||.:    ..:...|..|.:|:||. |.|.|..|.
plant   442 SISRFPNKEFYGGRIKDAENVKESIYQKRFLKGN----MFDSFSFINVGRGKEEF-GDGHSPKNM 501

  Fly   748 TEAANVEKITTRFLKAGIKPE---QIGIITPYEGQ-RAYLVQYMQYQGSLHSRLYQEIEIASVDA 808
            .|.|.:.:|.:...|...:..   .:|:::||:|| ||...:......||..:.: .:.:.|||.
plant   502 VEVAVISEIISNLYKVSCERRMKVSVGVVSPYKGQMRAIQEKIGDKYSSLSGQQF-TLNVRSVDG 565

  Fly   809 FQGREKDIIIMSCVRSNERQGIGFLNDPRRLNVALTRAKFGIIIVGNPKVLA-KQQLWNHLLNFY 872
            |||.|:||||:|.||||....:||||:.:|.|||||||:..:.::||...|| ...:|..|::..
plant   566 FQGGEEDIIIISTVRSNGNGKVGFLNNRQRANVALTRARHCLWVIGNETTLALSGSIWATLISES 630

  Fly   873 KDRKVLVEGSLNNLKESLIHFQKPKKLVNSMNIGAHFMSTIIADAKEVMVPGSIYDRSGGYGQGR 937
            :.|     |..::..:.:       .|.::||      ..::.|....:  ||:..|:   |.||
plant   631 RTR-----GCFHDATDEM-------NLRDAMN------EALLEDVSSSL--GSLSLRN---GHGR 672

  Fly   938 QMV 940
            :.|
plant   673 RNV 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500
		DNA2	122..897	CDD:224037	163/608 (27%)
		Mis12	210..299	CDD:283509
		AAA_19	458..>515	CDD:289986	28/94 (30%)
		AAA_12	661..857	CDD:289832	78/204 (38%)
AT5G52090	NP_200022.1	AAA_11	57..408	CDD:289831	75/352 (21%)
		DEXDc	83..>165	CDD:238005	27/82 (33%)
		DNA2	<324..616	CDD:224037	106/300 (35%)
		AAA_12	415..612	CDD:289832	76/202 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810