DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Upf1 and Mov10l1

DIOPT Version :9

Sequence 1:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster
Sequence 2:	XP_006521619.1	Gene:	Mov10l1 / 83456	MGIID:	1891384	Length:	1239	Species:	Mus musculus

Alignment Length:	995	Identity:	230/995 - (23%)
Similarity:	381/995 - (38%)	Gaps:	327/995 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 RLASITNDLAD-LQFEEEDDEPGSSYVKELPPHACKYCGIHDPATVVMCNNCRKWFCNGRGSTSG 130
            |||:.|....| ...:||..|.|::..|:.|...    |:..|.                   ..
Mouse   361 RLANSTEISPDGCACKEESREKGNTPEKQEPEPG----GLIPPG-------------------EK 402

  Fly   131 SHIINHLVRAKHREVTLHGEGP--LGETILECYSCGVRNVFVLG---FIPAKADSVVVLLCRQPC 190
            :||:          ||...:.|  ..|.:|.|:|     .|::|   .:...:....::..|:|
Mouse   403 THIV----------VTCSAKNPGRCKELLLLCFS-----DFLIGRHLEVSVVSSEEALIAVREP- 451

  Fly   191 AAQNSLKDMNWDQ-EQWKPLIADRCFLAWLVKQPSEQGQLRARQISAAQINKLEELWKENIE-AT 253
                    .:|.: :..:.|::.:..:....::.:.:.||.:........::|::..::.|: .|
Mouse   452 --------FSWKKPKSSQTLVSAKTTVVVTTQKRNSRRQLPSFLPQYPIPDRLKKCVEQKIDILT 508

  Fly   254 FQDLEKPGIDSEPAHVLLRYEDGYQYEKTFGPLVRLEAEYDQKLKESATQENIEVRWDVGLNKKT 318
            ||.|            |....:...|::.|..|:.||                |:..::.|.:..
Mouse   509 FQPL------------LAELLNMSNYKEKFSTLLWLE----------------EIHAEIELKEYN 545

  Fly   319 IAYFTLAK------------TDSDMKLMHGDELRLHYVGELYNPWSEIGHVIK----VPDNFGDD 367
            ::...|.:            .:|...|..||:|.|.  .:.||     ||||:    |.:...:|
Mouse   546 MSRVVLKRKGDLLVLEVPGLAESRPSLYAGDKLILK--SQEYN-----GHVIEYIGYVMEIHEED 603

  Fly   368 VGLELKSSTNAPVKCTSNF---TVDFIWKCTSFDRMTRALCKFAI-------------------- 409
            |.|:|    |...:...||   .|:|     :::|.|...|.:|:
Mouse   604 VTLKL----NPGFEQMYNFEPMDVEF-----TYNRTTSRRCHYALEQVIHLGVKVLFPEEIILQS 659

  Fly   410 -------------------------------------DRNSVSNFIYS----------------- 420
                                                 |..|::|.|.:
Mouse   660 PQVTGNWSLAQDTKNDGQSITNITRNDGQSMTKVTRNDSQSITNIIRNDGQSITNVTRNDGQPIT 724

  Fly   421 --------------------------------------RLLG--------HGRADSNDEVLFRGP 439
                                                  |.:|        ...|::.||:.....
Mouse   725 KVTRNNSQSITNITRNDGQPITKNKKTVKDQTKHTTEERHVGTTDQPEKASSTAETMDEIQIPKA 789

  Fly   440 QPKLFSAPHLPDLNRSQVYAVKHALQ---RPLS-LIQGPPGTGKTVTSATIVYQL-VKLHGGTVL 499
            :.|.|   ..|.||.:|..||:..|.   |||. ::.||||||||||....|.|: ..|....:|
Mouse   790 RDKEF---FNPVLNENQKLAVRRILSGDCRPLPYILFGPPGTGKTVTIIEAVLQVHYALPDSRIL 851

  Fly   500 VCAPSNTAVDQLTEKIHRTNLKVVRVCAKSREAIDSPVSFLALHNQIRNMETNSELKKLQQLKDE 564
            ||||||:|.|.:..::|.:  ||::           |.:.:.::...|..||..:..| ...:|
Mouse   852 VCAPSNSAADLVCLRLHES--KVLK-----------PAAMVRVNATCRFEETIIDAIK-PYCRD- 901

  Fly   565 TGELSSADEKRYRNLKRAAENQLLEAADVICCTCVGAGDGRLSRVK---FTSILIDESMQSTEPE 626
             ||          ::.||:..:      :|..||..||......|:   ||.:.:||:.|::|||
Mouse   902 -GE----------DIWRASRFR------IIITTCSSAGLFYQIGVRVGYFTHVFVDEAGQASEPE 949

  Fly   627 CMVPVVLGAK---QLILVGDHCQLGPVVMCKKAARAGLSQSLFERLVVLGIRP------------ 676
            |::|:.|.:.   |::|.||..|||||:..:.|...||:.|:.|||:   .||
Mouse   950 CLIPLGLISDINGQIVLAGDPMQLGPVIKSRLAMAYGLNVSMLERLM---SRPAYLRDENAFGAC 1011

  Fly   677 --------FRLEVQYRMHPELSQFPSNFFYEGSLQNGVCAEDRRLKLDFPW---PQPERPMFFLV 730
                    .:|...||.|..|...||..||...|:  |||:.:.:.....|   |:...|:.|..
Mouse  1012 GAYNPLLVTKLVKNYRSHSALLALPSRLFYHRELE--VCADPKVVTSLLGWEKLPRKGFPLIFHG 1074

  Fly   731 TQGQEEIAGSGTSFLNRTEAANVEK---ITTRFLKAGIKPEQIGIITPYEGQRAYLVQYMQYQGS 792
            .:|.|...|...|:.:..||..|.:   :..|.:.:.:..:.||:||||..|    |:.::.  .
Mouse  1075 VRGNEAREGRSPSWFSPAEAVQVMRYCCLLARSVSSQVSSKDIGVITPYRKQ----VEKIKI--L 1133

  Fly   793 LHSRLYQEIEIASVDAFQGREKDIIIMSCVRSNE------RQGIGFLNDPRRLNVALTRAKFGII 851
            |.:....:|::.||:.|||:|..:|::|.|||||      |..:|||::.:|.|||:||.|..:|
Mouse  1134 LRNVDLTDIKVGSVEEFQGQEYLVIVISTVRSNEDRFEDDRYFLGFLSNSKRFNVAITRPKALLI 1198

  Fly   852 IVGNPKVLAKQQLWNHLLNF 871
            |:|||.||.:...:..||.:
Mouse  1199 ILGNPHVLVRDPCFGALLEY 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500	20/156 (13%)
		DNA2	122..897	CDD:224037	217/939 (23%)
		Mis12	210..299	CDD:283509	14/89 (16%)
		AAA_19	458..>515	CDD:289986	28/61 (46%)
		AAA_12	661..857	CDD:289832	70/227 (31%)
Mov10l1	XP_006521619.1	S1-like	119..>161	CDD:373072
		DEXXQc_Mov10L1	798..1027	CDD:350836	80/263 (30%)
		SF1_C_Upf1	1028..1218	CDD:350195	65/197 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910