DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Upf1 and MAA3

DIOPT Version :9

Sequence 1:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster
Sequence 2:	NP_001329005.1	Gene:	MAA3 / 827233	AraportID:	AT4G15570	Length:	818	Species:	Arabidopsis thaliana

Alignment Length:	857	Identity:	226/857 - (26%)
Similarity:	364/857 - (42%)	Gaps:	211/857 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 LAWLVKQPSEQGQLRARQISAAQINKLEELWKENIEATFQDLEKPGIDSEPAHVLLRYEDGYQYE 280
            |.|..||.:::.:.:.|:.|..::|.::..:|: ::..|:..| |.:..|....:|:.:||   |
plant    24 LGWDYKQLTKENERKNRKDSKEKLNVVKNTYKD-VDDYFETFE-PLLFEEVKAQILQNKDG---E 83

  Fly   281 KTFGPLVRLEAE-------------YDQKLKESATQENIEVRWDVGLNKKTIAYFTLAKTDSDMK 332
            :.....:||..|             |:.:..|...|.::.:     |:|:.:...:...:.....
plant    84 EASVCKMRLVMECNEGEGFHFLLVTYEHEEDEYLAQNDLLL-----LSKEEVKGNSFPSSYGFAV 143

  Fly   333 LMH--GDELRLH-YVGELYNPWSEIGHVIKVPDNFGDDVGLELKSS-TNAPVKCTSNFTVDFIWK 393
            :.|  .:.|||. |:.|         .::::..|        .||| |.:.::..||........
plant   144 VEHRQNNLLRLRMYLAE---------DIVQITKN--------TKSSRTKSFIQALSNMRSLITSS 191

  Fly   394 CTSFDR--MTRALCKFA------IDRNSVSNFIYSRLL--------GHGRADSNDEV-LFRGPQP 441
            .:..|:  .:..||..:      |...|||:..:..|:        |.|     ||. ...||..
plant   192 ASPIDKRVFSLKLCGLSTIIREYIALRSVSSLPFKDLIFTAAEKSCGFG-----DEAWKISGPLN 251

  Fly   442 KLFSAPHLPDLNRSQVYAVKHALQR-PLSLIQGPPGTGKTVTSATIVYQLVKL------------ 493
            :.|:    .:||:||..|:...|.| ...|||||||||||.|..:|:..::..
plant   252 EFFN----ENLNKSQKEAIDVGLSRKSFVLIQGPPGTGKTQTILSILGAIMHATPARVQSKGTDH 312

  Fly   494 ---------------HGG---------------------------------------------TV 498
                           |.|                                             .|
plant   313 EVKRGIQMTIQEKYNHWGRASPWILGVNPRDAIMPEDGDDGFFPTSGNELKPEVVNASRKYRLRV 377

  Fly   499 LVCAPSNTAVDQLTEKIHRTNL----------KVVRVCAKSREAIDSPVSFLALHNQIRNMETNS 553
            |||||||:|:|::..::..:.|          |:||:..|:..::.| ||...|..|.|    .|
plant   378 LVCAPSNSALDEIVLRLLSSGLRDENAQTYTPKIVRIGLKAHHSVAS-VSLDHLVAQKR----GS 437

  Fly   554 ELKKLQQLKDETGELSSADEKRYRNLKRAAENQLLEAADVICCTCVGAGDGRLSRVK--FTSILI 616
            .:.|.:|  ..||  :..|..|         ..:||.|.::..|...:|...|::..  |..::|
plant   438 AIDKPKQ--GTTG--TDIDSIR---------TAILEEAAIVFATLSFSGSALLAKSNRGFDVVII 489

  Fly   617 DESMQSTEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAARAGLSQSLFERLVVLGIRPFRLEV 681
            ||:.|:.||..::|:....||:.||||..||...|:...|..:|...|:||||...|.....|:.
plant   490 DEAAQAVEPATLIPLATRCKQVFLVGDPKQLPATVISTVAQDSGYGTSMFERLQKAGYPVKMLKT 554

  Fly   682 QYRMHPELSQFPSNFFYEGSLQNGVCAEDRRLKLDFPWPQPE--RPM-FFLVTQGQE-EIAGSGT 742
            |||||||:..|||..||||:|::|   .|...:....|.:..  .|. ||.:.:|:| :..|:..
plant   555 QYRMHPEIRSFPSKQFYEGALEDG---SDIEAQTTRDWHKYRCFGPFCFFDIHEGKESQHPGATG 616

  Fly   743 SFLNRTEAANVEKITTRFLKAGIKPE-----QIGIITPYEGQ-RAYLVQYMQYQGSLHSRLYQEI 801
            |.:|..|...|..|..|.:.  :.||     |:.||:||..| :.:..::.:..|:...::   :
plant   617 SRVNLDEVEFVLLIYHRLVT--MYPELKSSSQLAIISPYNYQVKTFKDRFKEMFGTEAEKV---V 676

  Fly   802 EIASVDAFQGREKDIIIMSCVRSNERQGIGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWN 866
            :|.:||.|||||||:.|.||||:||...||||::.||:||.:||||..:::||:...|....||.
plant   677 DINTVDGFQGREKDVAIFSCVRANENGQIGFLSNSRRMNVGITRAKSSVLVVGSAATLKSDPLWK 741

  Fly   867 HLLNFYKDRKVL--VEGSLNNL--KESLIHFQKPKKLVNSMNIGAHFMSTIIADA---KEVMVPG 924
            :|:...:.|..|  |...|||.  :|:|    :..||...|.         |.||   ::..:|.
plant   742 NLIESAEQRNRLFKVSKPLNNFFSEENL----ETMKLTEDME---------IPDAPLYEDESLPV 793

  Fly   925 SIYDRSGGYGQG 936
            :.|.....:|.|
plant   794 APYGGDDDFGDG 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500	8/32 (25%)
		DNA2	122..897	CDD:224037	216/813 (27%)
		Mis12	210..299	CDD:283509	20/95 (21%)
		AAA_19	458..>515	CDD:289986	28/129 (22%)
		AAA_12	661..857	CDD:289832	77/205 (38%)
MAA3	NP_001329005.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D62494at2759
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820