DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Upf1 and AT2G19120

DIOPT Version :9

Sequence 1:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster
Sequence 2:	NP_179502.1	Gene:	AT2G19120 / 816429	AraportID:	AT2G19120	Length:	1090	Species:	Arabidopsis thaliana

Alignment Length:	945	Identity:	235/945 - (24%)
Similarity:	367/945 - (38%)	Gaps:	308/945 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 RQPCAAQNSLKDMNWDQEQWKPLIADRCFLAWLVKQPSEQGQLRARQISAAQINKLEELWKENIE 251
            |||.:..:|.:.:::.|..:              |:|       |...:..|...:|.|.:   |
plant   199 RQPKSGHSSSRKVSYSQRSF--------------KKP-------ATSSTQYQDTSVERLIR---E 239

  Fly   252 ATFQDLEKPGIDSEPAHVLLRYEDGYQYEKTFGPLVRLEAE---YDQ--KLKESATQENIEVR-- 309
            .|.:...:...|:|...|..|:|...:|.:.|.||:..|..   |..  :|.|:.|...:.::
plant   240 VTNEKFWRHPEDTELRSVPERFESMEEYVRVFEPLLFEECRAQLYSTWVELAEANTYVKVRIKSI 304

  Fly   310 -------WDVGLN----------KKTIAYFT--LAKTDSDMKLMHGDELR--------------- 340
                   :||.||          :..:|..:  |.::|.|    |.|..|
plant   305 ERRERGWYDVILNSLNGCKWAFKEGDVAVLSTPLPESDED----HEDAGRVAGTVRRHIPVDTRD 365

  Fly   341 -----LH-YVGELYNPWSEI--GHVIKVPDNFGDDVGLELKSSTNAPVKCTSNFTVDFIWKCTSF 397
                 || |||......|:|  .|:::           :||...              ||..|..
plant   366 PRGATLHFYVGNSGGTGSKIDDSHILR-----------KLKPQD--------------IWHLTVL 405

  Fly   398 DRMTRALCKFAIDRNSVSNFIYSRLLGHGRADSNDEVLFRGPQPKLF-----SAPHLPD------ 451
            ..:.      ...|..|:...:|||    .....:.:|  .|.|:.|     ..|..||
plant   406 GSLA------TTQREYVALHAFSRL----NPQMQNAIL--NPSPEQFPSYEEQTPATPDCFTTSF 458

  Fly   452 ---LNRS----QVYAVKHALQR---------------PLSLIQGPPGTGKTVT-------SATIV 487
               |:||    |:.|:..|...               |.:|:|||||||||.|       ...:.
plant   459 VDHLHRSFNAPQLAAIHWAAMHTAAGTSSGVKKQEPWPFTLVQGPPGTGKTHTVWGMLNVIHLVQ 523

  Fly   488 YQ------LVKLHGGT-----------------------------------------VLVCAPSN 505
            ||      |.||...|                                         :|||||||
plant   524 YQQYYTSLLKKLAPETYNQANECSSSDNILSGSIDEVLQNMDHNLFRTLPKLCAKPRMLVCAPSN 588

  Fly   506 TAVDQLTE------------KIHRTNLKVVRVCAKSREAIDSPVSFLALHNQIRNMETNSELKKL 558
            .|.|:|..            :::|.::..|.|.::||.|  ..||.....:|:..:..:..|:.:
plant   589 AATDELLSRVLDRGFIDGEMRVYRPDVARVGVDSQSRAA--QAVSVERRSDQLLAISRDEILRHM 651

  Fly   559 QQLKDETGELS-------------------------------SADEKRYRNLK------------ 580
            :.|:.:..::|                               |.|:||...|:
plant   652 RNLRLQETQISQNIAGLKRELNAAAFATRSQGSVGVDPEVLISRDQKRDALLQHLAAVVEARDKV 716

  Fly   581 --------------RAAENQLLE------------AADVICCTCVGAGDGRLSRVK--FTSILID 617
                          ||..|..||            .|:::..|...:|....||:.  |..::||
plant   717 LVEISRLLIVEGKFRAGNNFNLEEARASLEASFANEAEIVFTTVSSSGRKLFSRLTHGFDMVVID 781

  Fly   618 ESMQSTEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAARAGLSQSLFERLVVLGIRPFRLEVQ 682
            |:.|::|...:.|:.|||.:.:||||..||...|:.|.|.....|:|||||..:.|.....|.||
plant   782 EAAQASEVGVLPPLALGAARCVLVGDPQQLPATVISKAAGTLLYSRSLFERFQLAGCPTLLLTVQ 846

  Fly   683 YRMHPELSQFPSNFFYEGSLQNGVCAEDRRLKLDFPWPQPERPMFFLVTQGQEEIAGSGTSFLNR 747
            |||||::..|||.:||:|.|::.........::.:..|.....:||.::.|:|...|...|:.|.
plant   847 YRMHPQIRDFPSRYFYQGRLKDSESISSAPDEIYYKDPVLRPYLFFNISHGRESHRGGSVSYENV 911

  Fly   748 TEA-------ANVEKITTRFLKAGIKPEQIGIITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIAS 805
            .||       .:::| |.:.|.||  ...:|:||||:.|...|..  ::..:|.....:||.|.:
plant   912 DEARFCVGVYMHLQK-TLKSLGAG--KVSVGVITPYKLQLKCLKH--EFGNALGQDELKEIYINT 971

  Fly   806 VDAFQGREKDIIIMSCVRSNERQGIGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLN 870
            ||||||:|:|:|||||||:: ..|:||::|.||:|||||||:..:.::||...|.|.:.|..|::
plant   972 VDAFQGQERDVIIMSCVRAS-GHGVGFVSDIRRMNVALTRARRALWVMGNASALMKSEDWAALIS 1035

  Fly   871 FYKDRKVLVEGSLNNLKESL-IHFQKPKKLVNSMN 904
            ..:.|...:|      .:|| :.|..||  |:|.|
plant  1036 DARGRNCFME------MDSLPLDFPIPK--VSSYN 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500	11/61 (18%)
		DNA2	122..897	CDD:224037	230/936 (25%)
		Mis12	210..299	CDD:283509	20/93 (22%)
		AAA_19	458..>515	CDD:289986	30/137 (22%)
		AAA_12	661..857	CDD:289832	78/202 (39%)
AT2G19120	NP_179502.1	AAA_11	466..818	CDD:289831	75/353 (21%)
		P-loop_NTPase	711..>813	CDD:304359	26/101 (26%)
		AAA_12	825..1022	CDD:289832	78/202 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D62494at2759
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820