Protein Alignment Upf1 and mov10l1

DIOPT Version :10

• Sequence 1: NP_572767.1
• Gene: Upf1 / 32153
• FlyBaseID: FBgn0030354
• Length: 1180
• Species: Drosophila melanogaster
• Sequence 2: NP_001072624.1
• Gene: mov10l1 / 780080
• XenbaseID: XB-GENE-1217451
• Length: 1244
• Species: Xenopus tropicalis
• Alignment Length: 1006
• Identity: 241/1006 - (23%)
• Similarity: 388/1006 - (38%)
• Gaps: 279/1006 - (27%)

  Fly    42 STSQSQTQNDQLEIAQRCSAGDSHPRLA-SITN----DLADLQFEEEDDEPGSSYV-KELPPHAC 100
            |..:|::.:|..:.||..|......::: |:|:    |.|||    ....|.|... .||   ..
 Frog   319 SKPKSESMSDTTQTAQAFSFPPRERQMSVSVTSYCEKDKADL----HQTAPFSVLTNNEL---TA 376

  Fly   101 KYCGIH---DPATVVMCNNCRKWFCNGRGST----SGSHIINHLVRAKHREVTLHG--------- 149
            |:|.:.   ..||..:.|||.|:.   ||||    ||                |:|
 Frog   377 KFCQLGYKVSSATPSLFNNCTKFV---RGSTDPLSSG----------------LYGPLRHCPEPS 422

  Fly   150 ----EGP-LGETILECYSC--------GVRNVFVLGFIPAKADSVVVLLCRQ-----PCAAQNSL 196
                |.| ||.||.|..||        ||.:..:.....|....||:|...:     .|.|:|
 Frog   423 DDPMEQPVLGATIHEEQSCNMDSNVNSGVTDSVLQHSSNAPTSEVVILPGEKTFIIVTCEARN-- 485

  Fly   197 KDMNWDQEQWKPLIADRCFLAWLVKQPSEQGQLRARQIS--------AAQINKLEELWKEN---- 249
                  ..:.|.|:. .||..:::.:..| |.:.:.:.|        |::..|:.:.:..|
 Frog   486 ------PGRCKELLL-LCFSDFMIGRCLE-GTVESEEESFLLPPVEFASKQKKVPQEYMSNSRTV 542

  Fly   250 IEATFQDLEKPGIDS----EPAHVLLR-----YEDGYQYEKTFGPLVRLEAEYDQKLKESATQEN 305
            :.|..:.:.:..:.|    .|....||     ..|....|...|.::.| :.|.:::......|:
 Frog   543 LSAPHKRISRRQLPSFLPLYPIPDRLRKCTEQKMDILALEPCLGEVLTL-SNYRKRMSTLLWLED 606

  Fly   306 IEVRWDV------GLNKKTIAYFTLAKTDSDMK----LMHGDELRLHYVGELYNPWSEIGHVIKV 360
            |....::      |:..:....|.|.:.....:    |..||::.|.|..........:|.::::
 Frog   607 IHAEMEIQEFSLSGVCLQKRGGFLLLEVPGIAEGRPFLNQGDKVFLKYQELTTTAIQFVGLIVEI 671

  Fly   361 PDNFGDDVGLELKSSTNAPVKCTSNF---TVDFIWKCTSFDRMTRALCKFAIDR----------- 411
            .:.       |:....|..::.:..|   .|:|:     .:|:|...|:||:::
 Frog   672 HEE-------EITLRVNEELEQSYKFEPMDVEFV-----VNRVTSRRCQFAVEQAEHLGQKVLFP 724

  Fly   412 NSV---SNFIYSRLLGH----------GRADSNDEVLFRGPQPKLFSAPHLPD------------ 451
            ::|   |..:.||....          |..::|..    .|..:..:|.::.|
 Frog   725 DTVELQSPQVASRDTSEIDCPEKKEKTGYQETNQS----NPTSRGKNAVYMSDMVTVATQTSTKG 785

  Fly   452 ---------------LNRSQVYAVKHALQ---RPLS-LIQGPPGTGKTVTSATIVYQL-VKLHGG 496
                           ||..|..|||..|.   ||.. ::.||||||||||....:.|: ..|...
 Frog   786 SGSPVKKKGQFFNNLLNNHQKLAVKRILGGECRPTPYILFGPPGTGKTVTIIEAILQIYYALPDS 850

  Fly   497 TVLVCAPSNTAVDQLTEKIHRTN-------LKVVRVCAKSREAIDSPVSFLALHNQIRNMETNSE 554
            .:|||||||:|.|.:..::|::|       ::|...|.......|:...:......||.
 Frog   851 RILVCAPSNSAADLVCLRLHQSNQLEPGSMVRVNATCRLEETVCDAVRPYCGPGEDIRK------ 909

  Fly   555 LKKLQQLKDETGELSSADEKRYRNLKRAAENQLLEAADVICCTCVGAG---DGRLSRVKFTSILI 616
                              ..|:|               :|..||..||   ...|....||.:.:
 Frog   910 ------------------ASRFR---------------IIISTCSSAGMFYQIGLRVGHFTHVFV 941

  Fly   617 DESMQSTEPECMVPVVLGAK---QLILVGDHCQLGPVVMCKKAARAGLSQSLFERLVVLGIRPF- 677
            ||:.|::||||::|:.|.::   |:||.||..||||::..:.:...||:.|..|||:.   ||.
 Frog   942 DEAGQASEPECLIPLGLISEVTGQIILAGDPMQLGPIIKSRVSLAYGLNVSFLERLMA---RPLY 1003

  Fly   678 -------------------RLEVQYRMHPELSQFPSNFFYEGSLQNGVCAEDRRLKLDFPW---P 720
                               :|...||.|..|...||..||...|:  |||:...:.....|   |
 Frog  1004 LRDEESYGACGNYNPLLITKLMKNYRSHAALLHLPSKLFYHKELE--VCADPAVVNKLLRWDKLP 1066

  Fly   721 QPERPMFFLVTQGQEEIAGSGTSFLNRTEAANVEK---ITTRFLKAGIKPEQIGIITPYEGQRAY 782
            ....|:.|...:|.|...||..|:.|.:||....:   :..:.:...:..:.||:||||.
 Frog  1067 HKGFPLIFHGVRGTEMREGSNPSWFNPSEAVQAMRYCCVLAKHVTTSVSAKDIGVITPYR----- 1126

  Fly   783 LVQYMQYQGSLHSRLYQEIEIASVDAFQGREKDIIIMSCVRSNE-------RQGIGFLNDPRRLN 840
             .|..:.:..|.:....:|::.||:.|||:|..:||:|.|||.|       |..:|||..|:|.|
 Frog  1127 -KQVEKIRTLLRTADLSDIKVGSVEEFQGQEFLVIIISMVRSCEDSLHEDSRHLLGFLCSPKRFN 1190

  Fly   841 VALTRAKFGIIIVGNPKVLAKQQLWNHLLNF 871
            ||:||.|..:|::|||.||.|......||.:
 Frog  1191 VAITRPKALLIVLGNPHVLVKDPCICALLEY 1221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_572767.1	UPF1_Zn_bind	98..249	CDD:401391	43/192 (22%)
		1B_UPF1-like	302..390	CDD:394815	15/100 (15%)
		TIGR00376	355..880	CDD:273041	161/622 (26%)
		DEXXQc_UPF1	451..684	CDD:350797	75/297 (25%)
mov10l1	NP_001072624.1	S1-like	32..>73	CDD:464176
		DEXXQc_Mov10L1	801..1029	CDD:350836	74/269 (28%)
		SF1_C_Upf1	1030..1221	CDD:350195	65/198 (33%)