DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Upf1 and Upf1

DIOPT Version :9

Sequence 1:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster
Sequence 2:	XP_003751614.1	Gene:	Upf1 / 684558	RGDID:	1589127	Length:	1124	Species:	Rattus norvegicus

Alignment Length:	1217	Identity:	741/1217 - (60%)
Similarity:	867/1217 - (71%)	Gaps:	150/1217 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVDTYAPSS-ALSFLDMDDNELLPGADTQPTQYDYRDFTMPSTSQSQTQN-------------- 50
            |||:.|.||| .|:|||.::.||| |||||.:::::.|||:||.:|:....
  Rat     1 MSVEAYGPSSQTLTFLDTEEAELL-GADTQGSEFEFTDFTLPSQTQTPPGGPGGAGGPGGAGAGG 64

  Fly    51 --DQLE-------IAQRCSAGDSHPRLASITNDLADLQFEEEDDEPGSSYVKELPPHACKYCGIH 106
              .||:       |.|..:..||   :|..:..||:|.|||  ||..:.|.|:||.|||.|||||
  Rat    65 AAGQLDAQVGPEGILQNGAVDDS---VAKTSQLLAELNFEE--DEEDTYYTKDLPVHACSYCGIH 124

  Fly   107 DPATVVMCNNCRKWFCNGRGSTSGSHIINHLVRAKHREVTLHGEGPLGETILECYSCGVRNVFVL 171
            |||.||.||..:||||||||:||||||:|||||||.:|||||.:||||||:||||:||.||||:|
  Rat   125 DPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKCKEVTLHKDGPLGETVLECYNCGCRNVFLL 189

  Fly   172 GFIPAKADSVVVLLCRQPCAAQNSLKDMNWDQEQWKPLIADRCFLAWLVKQPSEQGQLRARQISA 236
            ||||||||||||||||||||:|:||||:|||..||:|||.|||||:||||.||||.|||||||:|
  Rat   190 GFIPAKADSVVVLLCRQPCASQSSLKDINWDSSQWQPLIQDRCFLSWLVKIPSEQEQLRARQITA 254

  Fly   237 AQINKLEELWKENIEATFQDLEKPGIDSEPAHVLLRYEDGYQYEKTFGPLVRLEAEYDQKLKESA 301
            .||||||||||||..||.:||||||:|.||.||||||||.|||:..|||||:|||:||:|||||.
  Rat   255 QQINKLEELWKENPSATLEDLEKPGVDEEPQHVLLRYEDAYQYQNIFGPLVKLEADYDKKLKESQ 319

  Fly   302 TQENIEVRWDVGLNKKTIAYFTLAKTDS-----------DMKLMHGDELRLHYVGELYNPWSEIG 355
            ||:||.||||:|||||.||:|||.||||           ||:||.|||:.|.|.|:|...|..||
  Rat   320 TQDNITVRWDLGLNKKRIAFFTLPKTDSGNEDLVIIWLRDMRLMQGDEICLRYKGDLAPLWKGIG 384

  Fly   356 HVIKVPDNFGDDVGLELKSSTNAPVKCTSNFTVDFIWKCTSFDRMTRALCKFAIDRNSVSNFIYS 420
            ||||||||:||::.:||:||..|||:.|.||.|||:||.||||||..||..||:|..|||.:||.
  Rat   385 HVIKVPDNYGDEIAIELRSSVGAPVEVTHNFQVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYH 449

  Fly   421 RLLGHGRADSNDEVLFRGPQPKLFSAPHLPDLNRSQVYAVKHALQRPLSLIQGPPGTGKTVTSAT 485
            :||||    ..::|:.:...||.|:|..|||||.|||||||..||||||||||||||||||||||
  Rat   450 KLLGH----EVEDVVIKCQLPKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSAT 510

  Fly   486 IVYQLVKLHGGTVLVCAPSNTAVDQLTEKIHRTNLKVVRVCAKSREAIDSPVSFLALHNQIRNME 550
            |||.|.:...|.||||||||.||||||||||:|.|||||:||||||||||||||||||||||||:
  Rat   511 IVYHLARQGNGPVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMD 575

  Fly   551 TNSELKKLQQLKDETGELSSADEKRYRNLKRAAENQLLEAADVICCTCVGAGDGRLSRVKFTSIL 615
            :..||:|||||||||||||||||||||.|||.||.:||..|||||||||||||.||::::|.|||
  Rat   576 SMPELQKLQQLKDETGELSSADEKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSIL 640

  Fly   616 IDESMQSTEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAARAGLSQSLFERLVVLGIRPFRLE 680
            ||||.|:|||||||||||||||||||||||||||||||||||:||||||||||||||||||.||:
  Rat   641 IDESTQATEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQ 705

  Fly   681 VQYRMHPELSQFPSNFFYEGSLQNGVCAEDRRLK-LDFPWPQPERPMFFLVTQGQEEIAGSGTSF 744
            |||||||.||.||||.||||||||||.|.||..| .||.||||::||||.|||||||||.||||:
  Rat   706 VQYRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIASSGTSY 770

  Fly   745 LNRTEAANVEKITTRFLKAGIKPEQIGIITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIASVDAF 809
            ||||||||||||||:.||||.||:||||||||||||:|||||||:.||||::||||:||||||||
  Rat   771 LNRTEAANVEKITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAF 835

  Fly   810 QGREKDIIIMSCVRSNERQGIGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYKD 874
            ||||||.||:||||:||.|||||||||||||||||||::|:|||||||.|:||.||||||::||:
  Rat   836 QGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLSYYKE 900

  Fly   875 RKVLVEGSLNNLKESLIHFQKPKKLVNSMNIGAHFMSTIIADAKEVMVPGSIYDRSGGYGQGRQM 939
            :|.||||.||||:|||:.|.||:||||::|.||.||:|.:.||:|.::|||:||||   .|||.
  Rat   901 QKALVEGPLNNLRESLMQFSKPRKLVNTVNPGARFMTTAMYDAREAIIPGSVYDRS---SQGRP- 961

  Fly   940 VGQSMNGGQYGGSGGGPYGNSPLGYGTPSSNSMVGFGLGNGGNGAAGGNNNFGGAGPSWAAAHLH 1004
                                |.:.:.|....||:                   .||||..||.
  Rat   962 --------------------SNMYFQTHDQISMI-------------------SAGPSHVAAM-- 985

  Fly  1005 HDSIGYISNEHGAAALGNMPVPVGMFMNMSNIPPRFYNQHQQAIMAVKQNRAIQQQTGNFSPGNS 1069
                             |:|:|..:.|     ||                   ....|.|...|
  Rat   986 -----------------NIPIPFNLVM-----PP-------------------MPPPGYFGQAN- 1008

  Fly  1070 GPGVTGVGVGRSATPGGNKKTNKLGKSRVTGGGTGGAPLTQGSSVCNAAPYSQHPMPLS-LQMTQ 1133
            || ..|.|..:|.|..|.::.|:.|   :.|......|.:|.|....:.|:||..:... :.|:|
  Rat  1009 GP-AAGRGTPKSKTGRGGRQKNRFG---LPGPSQTTLPNSQASQDVASQPFSQGALTQGYVSMSQ 1069

  Fly  1134 PSGFALSQ----QPELSQD--FGQ--ISQMDGLLSQDVAFNASGERS 1172
            ||  .:||    |||||||  .|.  .||:|..||||..:  .|||:
  Rat  1070 PS--QMSQPGLSQPELSQDSYLGDEFKSQIDVALSQDSTY--QGERA 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500	122/150 (81%)
		DNA2	122..897	CDD:224037	596/786 (76%)
		Mis12	210..299	CDD:283509	68/88 (77%)
		AAA_19	458..>515	CDD:289986	46/56 (82%)
		AAA_12	661..857	CDD:289832	162/196 (83%)
Upf1	XP_003751614.1	DNA2	140..915	CDD:224037	591/786 (75%)
Upf1	XP_003751614.1	DEXXQc_UPF1	476..709	CDD:350797	195/232 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347654
Domainoid	1	1.000	332	1.000	Domainoid score	I1105
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2185
Inparanoid	1	1.050	1351	1.000	Inparanoid score	I127
OMA	1	1.010	-	-		QHG54950
OrthoDB	1	1.010	-	-		D62494at2759
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	1	1.000	-	-		oto98263
orthoMCL	1	0.900	-	-		OOG6_101981
Panther	1	1.100	-	-	LDO	PTHR10887
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3712
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810