DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Upf1 and ZNFX1

DIOPT Version :9

Sequence 1:NP_001285145.1 Gene:Upf1 / 32153 FlyBaseID:FBgn0030354 Length:1180 Species:Drosophila melanogaster
Sequence 2:NP_066363.1 Gene:ZNFX1 / 57169 HGNCID:29271 Length:1918 Species:Homo sapiens


Alignment Length:1138 Identity:228/1138 - (20%)
Similarity:386/1138 - (33%) Gaps:410/1138 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    92 VKELPPHACKYCGIHDPATVVMCNNCRKWFCNGRGSTSGSHIINHLVRAKHREVTL--HGEGPLG 154
            :|||..|:.......:    ::|...||...:.....|..|::..|..:|..:|.|  :..|.:.
Human   170 LKELLSHSSMKSNFLE----LICQVLRKACSSKMDRQSVLHVLGILKNSKFLKVCLPAYVVGMIT 230

  Fly   155 ETILEC---YSCGVRNVF-----VLGFIPAKADSVVVLLCRQPCAAQNSLK--DMNWDQEQWKPL 209
            |.|.:.   |...:.|:.     ::...||.:.....:|......:.|:|:  .::.::|..|.|
Human   231 EPIPDIRNQYPEHISNIISLLQDLVSVFPASSVQETSMLVSLLPTSLNALRASGVDIEEETEKNL 295

  Fly   210 IADRCFLAWLVKQPSEQGQLRARQISAAQ---INKLEELWKENIEATFQDL---EKPGIDSEPAH 268
            ...:..:..| ::...:|.||....:..|   .:.:|......|..|:.::   |:|.:  .|..
Human   296 EKVQTIIEHL-QEKRREGTLRVDTYTLVQPEAEDHVESYRTMPIYPTYNEVHLDERPFL--RPNI 357

  Fly   269 VLLRYEDGYQYEKTFGPLVRLEAEYDQKLKESATQ--ENIEVRWDVGLNKKTIAYFTLAKTDSDM 331
            :..:|:....|..|...|:|  .::.:.|:|...:  ::.|   |.||.|:..            
Human   358 ISGKYDSTAIYLDTHFRLLR--EDFVRPLREGILELLQSFE---DQGLRKRKF------------ 405

  Fly   332 KLMHGDELRLHYVGELYNPW-SEIGHVIKVPDNFGDDVGLELKSSTNA------PVKCTSNFTVD 389
                 |::|:::...:..|. |..|.|.||  .| |...|:.....|:      .:.|.|....:
Human   406 -----DDIRIYFDTRIITPMCSSSGIVYKV--QF-DTKPLKFVRWQNSKRLLYGSLVCMSKDNFE 462

  Fly   390 FIWKCTSFDRMTRALCKFAI--------------------------------------------- 409
            .....|..:|....||:..:                                             
Human   463 TFLFATVSNREQEDLCRGIVQLCFNEQSQQLLAEVQPSDSFLMVETTAYFEAYRHVLEGLQEVQE 527

  Fly   410 -----DRNSVSNFIYSR----LLGHGRAD---------SNDEVL-----FRGPQPKLFSAPHLPD 451
                 .||.|....:.:    ||..||.|         :..|.|     .|.|:..:......|.
Human   528 EDVPFQRNIVECNSHVKEPRYLLMGGRYDFTPLIENPSATGEFLRNVEGLRHPRINVLDPGQWPS 592

  Fly   452 -----LNRSQVYAVKHALQRPLSLIQGPPGTGKTVTSATIVYQL--------VKLHGGTVLVCAP 503
                 |:.||:.|::.||.|.|::||||||||||.....||..|        :.|....:||...
Human   593 KEALKLDDSQMEALQFALTRELAIIQGPPGTGKTYVGLKIVQALLTNESVWQISLQKFPILVVCY 657

  Fly   504 SNTAVDQLTEKIHR-TNLKVVRVCAKSREAI-----------------DSPV----SFLALHNQI 546
            :|.|:||..|.|:. ....:|||..:|...|                 :.|:    :::::..|:
Human   658 TNHALDQFLEGIYNCQKTSIVRVGGRSNSEILKQFTLRELRNKREFRRNLPMHLRRAYMSIMTQM 722

  Fly   547 RNME------------------------------------------------------------- 550
            :..|                                                             
Human   723 KESEQELHEGAKTLECTMRGVLREQYLQKYISPQHWESLMNGPVQDSEWICFQHWKHSMMLEWLG 787

  Fly   551 ----------------------------------------------------------------- 550
                                                                             
Human   788 LGVGSFTQSVSPAGPENTAQAEGDEEEEGEEESSLIEIAEEADLIQADRVIEEEEVVRPQRRKKE 852

  Fly   551 ---TNSELKKL-----------------------------------QQLKDETGELSS------- 570
               .:.||.|:                                   :::|||..:|::       
Human   853 ESGADQELAKMLLAMRLDHCGTGTAAGQEQATGEWQTQRNQKKKMKKRVKDELRKLNTMTAAEAN 917

  Fly   571 -------------------------AD--------EKRYR-NLKRAAENQL------LEAADVIC 595
                                     ||        |::|| :.:|.||.:|      |:.|.|:.
Human   918 EIEDVWQLDLSSRWQLYRLWLQLYQADTRRKILSYERQYRTSAERMAELRLQEDLHILKDAQVVG 982

  Fly   596 CTCVGAGDGR--LSRVKFTSILIDESMQSTEPECMVPVVLGAKQLILVGDHCQLGPVV-MCKKAA 657
            .|..||...|  |.:|:...::::|:.:..|...:..:....:.|||:|||.||.|.. :...|.
Human   983 MTTTGAAKYRQILQKVEPRIVIVEEAAEVLEAHTIATLSKACQHLILIGDHQQLRPSANVYDLAK 1047

  Fly   658 RAGLSQSLFERLVVLGIRPFRLEVQYRMHPELSQFPSNFFYEGSLQN-----------GVCAEDR 711
            ...|..|||||||.:.|...||..|:||.||:::..:...|: .|:|           ||.:.  
Human  1048 NFNLEVSLFERLVKVNIPFVRLNYQHRMCPEIARLLTPHIYQ-DLENHPSVLKYEKIKGVSSN-- 1109

  Fly   712 RLKLDFPWPQPERPMFFLVTQGQEEIAGSGTSFLNRTEAANVEKITTRFLKAGIKPEQIGIITPY 776
                          :||:.....|:....|.|..|:.||..|.::...||.....|.||.|:|.|
Human  1110 --------------LFFVEHNFPEQEIQEGKSHQNQHEAHFVVELCKYFLCQEYLPSQITILTTY 1160

  Fly   777 EGQRAYLVQYMQYQGSLHSRLYQEIEIASVDAFQGREKDIIIMSCVRSNERQGIGFLNDPRRLNV 841
            .||...|.:.|.      ::.:..:.:..||.:||.|.|||::|.||||:...:|||....|:.|
Human  1161 TGQLFCLRKLMP------AKTFAGVRVHVVDKYQGEENDIILLSLVRSNQEGKVGFLQISNRICV 1219

  Fly   842 ALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYKD 874
            ||:|||.|:..:||.::|||..||:.:::..::
Human  1220 ALSRAKKGMYCIGNMQMLAKVPLWSKIIHTLRE 1252

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Upf1NP_001285145.1 UPF1_Zn_bind 98..249 CDD:286500 29/165 (18%)
DNA2 122..897 CDD:224037 221/1108 (20%)
Mis12 210..299 CDD:283509 17/94 (18%)
AAA_19 458..>515 CDD:289986 26/64 (41%)
AAA_12 661..857 CDD:289832 68/206 (33%)
ZNFX1NP_066363.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 75..140
AAA_11 597..1038 CDD:289831 73/440 (17%)
AAA_19 604..>667 CDD:289986 25/62 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 796..819 0/22 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 876..896 0/19 (0%)
DNA2 <903..1254 CDD:224037 106/373 (28%)
AAA_12 1051..1234 CDD:289832 67/205 (33%)
NF-X1-zinc-finger 1372..1417 CDD:100116
NF-X1-zinc-finger 1461..1505 CDD:100116
LELP1 <1498..1562 CDD:291701
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1112
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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