Protein Alignment Upf1 and helz2b

DIOPT Version :10

• Sequence 1: NP_572767.1
• Gene: Upf1 / 32153
• FlyBaseID: FBgn0030354
• Length: 1180
• Species: Drosophila melanogaster
• Sequence 2: XP_699251.3
• Gene: helz2b / 570654
• ZFINID: ZDB-GENE-070912-617
• Length: 2781
• Species: Danio rerio
• Alignment Length: 839
• Identity: 214/839 - (25%)
• Similarity: 333/839 - (39%)
• Gaps: 195/839 - (23%)

  Fly   191 AAQNSLKDMNWDQ----------------------EQWKPLIADRCFLAWLVKQPSEQGQLRARQ 233
            |...:::|..||:                      .:|.|   ||.|       .||:......|
Zfish  1977 AIVEAVRDEKWDEAKSLVLAAHVKDNSRNSELSDTSRWDP---DRTF-------TSEEDHYTDFQ 2031

  Fly   234 IS-----AAQINKLEE----LW---------KENIEATFQDLEKP-----GIDSEPAHVLLRYED 275
            |:     ..|:....|    .|         ..:.|...:..:.|     .|...|:..  .|.:
Zfish  2032 INLKVGDTVQVQLTSERDRGYWAPTVQLFRLSSSFEICVEHTDNPIKCFSRIADHPSKG--SYSN 2094

  Fly   276 GYQYEKTFGPLVRLEAEYDQKLKESATQ---------ENIEVRWD------------VGLNKKTI 319
            ..:|.:.:.||..:|:        :||.         ||:.:.||            ..:.|..|
Zfish  2095 VEEYVQIWRPLCEMES--------AATAVDDSDCVVIENVAITWDDSRLSGNFSLPEENIKKWAI 2151

  Fly   320 AY------FTLAKTDSDMKLMHGDELRLHYVGELYNPWSEIGHVIKV-----PDNFGDD---VGL 370
            .:      ..:.|.|.:.......||     ...|..|  :.|.:..     |:|.|:.   :..
Zfish  2152 EFDLGRCLLCIRKRDLEQNQAEQSEL-----DPKYFTW--VAHAVTTLCSDSPENSGNKFKIINF 2209

  Fly   371 ELK-SSTNAP-VKCTSNFTVDFIWKCTSFDRMTRALCKFAIDRNSVSNF-IYSRLLGHGRADSND 432
            .:| :|...| .|....|||:.|.|.....|...|:.........|.|. :..|::..   .||.
Zfish  2210 NVKYASMKIPKFKRNETFTVEIIPKLLPDIRKESAVNNLKGANELVQNIALKHRIVNQ---SSNQ 2271

  Fly   433 EV----LFRGPQPKLFSAPHLPDLNRSQVYAVKHALQRPLSLIQGPPGTGKTVTSATIVYQLVKL 493
            :|    |.|...|     ..||.||.||..|::.||....::|||||||||||..|.|||...:|
Zfish  2272 DVPLYLLMREEAP-----AGLPHLNESQFKALEKALNGKFTIIQGPPGTGKTVVGAYIVYWFSQL 2331

  Fly   494 HG---------------GTVLVCAPSNTAVDQLTEKIHR--TNLKVVRVCA-------------- 527
            :.               ..:|.|.|||.:||.:.|.:.:  ..||::||.:
Zfish  2332 NSRNLWRLKDPTDKDKREVILYCGPSNKSVDVVAEYLLKFGEKLKLLRVYSRQMEMQEYPYPGSN 2396

  Fly   528 -----KSREAIDSP-VSFLALHNQIRNMETNSELKKL----QQLKDETGELSSADEKRYRNLKRA 582
                 |||:....| :..:.||::|| |..|...:::    .::|.:...|:..|.:.|:.|...
Zfish  2397 LQLSHKSRQECSKPELRAITLHHRIR-MGHNLYSQRITDFDDRIKSDPYSLTDTDIEEYKKLLND 2460

  Fly   583 AENQLLEAADVICCTCVGAGDGRLSR-VKFTSILIDESMQSTEPECMVPVV-LGAKQLILVGDHC 645
            |....||..|:|.|||..|....|.: :....|||||...:|||:.:||:| ...::::|:|||.
Zfish  2461 ARLHELERHDIILCTCTAAASPNLKKTLSARQILIDECAMATEPQTLVPLVSFKPEKVVLLGDHK 2525

  Fly   646 QLGPVVMCKKAARAGLSQSLFERLVVLGIRPFRLEVQYRMHPELSQFPSNFFYEGSLQNGVCAED 710
            ||.|:|......|.|:::|||||.:   .|...|:.|||||.|:.:|||..:|...|:..|....
Zfish  2526 QLRPIVKNNHVRRLGMTRSLFERYM---DRAIMLDTQYRMHEEICKFPSEAYYNDMLKTVVRERT 2587

  Fly   711 RRLKLDFPWPQPERPMFFLVTQGQE------EIAGSGTSFLNRTEAANVEKITTRFLKAG-IKPE 768
            ..|..:....:..:.:.|...:|:|      ...|:..|..|..|.....:|..:.:..| ::||
Zfish  2588 SVLNAETEGRRQSKRILFGDIRGEEIGLVVSTARGNENSKANFDEVKKAVEICIQLVTVGRVRPE 2652

  Fly   769 QIGIITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIASVDAFQGREKDIIIMSCVR---SNE---- 826
            .|.|::||..|.|      |.:..|.....:...:.::...||.|...:|:|.||   |:|
Zfish  2653 DIAILSPYNAQVA------QIRERLSDFELKGFTVTTITKSQGSEWQYVILSIVRSCPSDEIEPM 2711

  Fly   827 ------RQGIGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYKDRKVLV 879
                  .:.|||:.|..::||.:|||:.|:.|:||..||.....|..||..|.....:|
Zfish  2712 PSREWLSKHIGFVGDENQINVGITRAQVGLCILGNQAVLNCSPAWQKLLKHYSGHGCVV 2770

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_572767.1	UPF1_Zn_bind	98..249	CDD:401391	16/97 (16%)
		1B_UPF1-like	302..390	CDD:394815	24/124 (19%)
		TIGR00376	355..880	CDD:273041	175/603 (29%)
		DEXXQc_UPF1	451..684	CDD:350797	89/275 (32%)
helz2b	XP_699251.3	None