DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Upf1 and helz2b

DIOPT Version :9

Sequence 1:NP_001285145.1 Gene:Upf1 / 32153 FlyBaseID:FBgn0030354 Length:1180 Species:Drosophila melanogaster
Sequence 2:XP_699251.2 Gene:helz2b / 570654 ZFINID:ZDB-GENE-070912-617 Length:2781 Species:Danio rerio


Alignment Length:838 Identity:212/838 - (25%)
Similarity:330/838 - (39%) Gaps:193/838 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   191 AAQNSLKDMNWDQ----------------------EQWKPLIADRCFLAWLVKQPSEQGQLRARQ 233
            |...:::|..||:                      .:|.|   ||.|       .||:......|
Zfish  1977 AIVEAVRDEKWDEAKSLVLAAHVKDNSRNSELSDTSRWDP---DRTF-------TSEEDHYTDFQ 2031

  Fly   234 IS-----AAQINKLEE----LW---------KENIEATFQDLEKP-----GIDSEPAHVLLRYED 275
            |:     ..|:....|    .|         ..:.|...:..:.|     .|...|:..  .|.:
Zfish  2032 INLKVGDTVQVQLTSERDRGYWAPTVQLFRLSSSFEICVEHTDNPIKCFSRIADHPSKG--SYSN 2094

  Fly   276 GYQYEKTFGPLVRLEAEYDQKLKESATQ---------ENIEVRWD------------VGLNKKTI 319
            ..:|.:.:.||..:|:        :||.         ||:.:.||            ..:.|..|
Zfish  2095 VEEYVQIWRPLCEMES--------AATAVDDSDCVVIENVAITWDDSRLSGNFSLPEENIKKWAI 2151

  Fly   320 AY------FTLAKTDSDMKLMHGDELRLHYVGELYNPWSEIGHVIKV-----PDNFGDD---VGL 370
            .:      ..:.|.|.:.......||     ...|..|  :.|.:..     |:|.|:.   :..
Zfish  2152 EFDLGRCLLCIRKRDLEQNQAEQSEL-----DPKYFTW--VAHAVTTLCSDSPENSGNKFKIINF 2209

  Fly   371 ELK-SSTNAP-VKCTSNFTVDFIWKCTSFDRMTRALCKFAIDRNSVSNF-IYSRLLGHGRADSND 432
            .:| :|...| .|....|||:.|.|.....|...|:.........|.|. :..|::..   .||.
Zfish  2210 NVKYASMKIPKFKRNETFTVEIIPKLLPDIRKESAVNNLKGANELVQNIALKHRIVNQ---SSNQ 2271

  Fly   433 EV----LFRGPQPKLFSAPHLPDLNRSQVYAVKHALQRPLSLIQGPPGTGKTVTSATIVYQLVKL 493
            :|    |.|...|     ..||.||.||..|::.||....::|||||||||||..|.|||...:|
Zfish  2272 DVPLYLLMREEAP-----AGLPQLNESQFKALEKALNGKFTIIQGPPGTGKTVVGAYIVYWFSQL 2331

  Fly   494 HG---------------GTVLVCAPSNTAVDQLTEKIHR--TNLKVVRVCAKSREAIDSPV--SF 539
            :.               ..:|.|.|||.:||.:.|.:.:  ..||::||.::..|..:.|.  |.
Zfish  2332 NSRNLWRLKDPTDKDKREVILYCGPSNKSVDVVAEYLLKFGEKLKLLRVYSRQMEMQEYPYPGSN 2396

  Fly   540 LALHNQIRNMETNSELKKL---------------------QQLKDETGELSSADEKRYRNLKRAA 583
            |.|.::.|...:..||:.:                     .::|.:...|:..|.:.|:.|...|
Zfish  2397 LQLSHKSRQERSKPELRAITLHHRIRMGHNPYSQRITDFDDRIKSDPYSLTDTDIEEYKKLLNDA 2461

  Fly   584 ENQLLEAADVICCTCVGAGDGRLSR-VKFTSILIDESMQSTEPECMVPVV-LGAKQLILVGDHCQ 646
            ....||..|:|.|||..|....|.: :....|||||...:|||:.:||:| ...::::|:|||.|
Zfish  2462 RLHELERHDIILCTCTAAASPNLKKTLSARQILIDECAMATEPQTLVPLVSFKPEKVVLLGDHKQ 2526

  Fly   647 LGPVVMCKKAARAGLSQSLFERLVVLGIRPFRLEVQYRMHPELSQFPSNFFYEGSLQNGVCAEDR 711
            |.|:|......|.|:::|||||.:   .|...|:.|||||.|:.:|||..:|...|:..|.....
Zfish  2527 LRPIVKNNHVRRLGMTRSLFERYM---DRAIMLDTQYRMHEEICKFPSEAYYNDMLKTVVRERTS 2588

  Fly   712 RLKLDFPWPQPERPMFFLVTQGQE------EIAGSGTSFLNRTEAANVEKITTRFLKAG-IKPEQ 769
            .|..:....:..:.:.|...:|:|      ...|:..|..|..|.....:|..:.:..| ::||.
Zfish  2589 VLNAETEGRRQSKRILFGDIRGEEIGLVVSTARGNENSKANFDEVKKAVEICIQLVTVGRVRPED 2653

  Fly   770 IGIITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIASVDAFQGREKDIIIMSCVR---SNE----- 826
            |.|::||..|.|      |.:..|.....:...:.::...||.|...:|:|.||   |:|     
Zfish  2654 IAILSPYNAQVA------QIRERLSDFELKGFTVTTITKSQGSEWQYVILSIVRSCPSDEIEPMP 2712

  Fly   827 -----RQGIGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYKDRKVLV 879
                 .:.|||:.|..::||.:|||:.|:.|:||..||.....|..||..|.....:|
Zfish  2713 SREWLSKHIGFVGDENQINVGITRAQVGLCILGNQAVLNCSPAWQKLLKHYSGHGCVV 2770

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Upf1NP_001285145.1 UPF1_Zn_bind 98..249 CDD:286500 16/97 (16%)
DNA2 122..897 CDD:224037 212/838 (25%)
Mis12 210..299 CDD:283509 19/111 (17%)
AAA_19 458..>515 CDD:289986 27/71 (38%)
AAA_12 661..857 CDD:289832 61/215 (28%)
helz2bXP_699251.2 AAA_11 530..725 CDD:289831
AAA 553..688 CDD:99707
DNA2 <647..959 CDD:224037
P-loop_NTPase <662..>721 CDD:304359
UvrD_C_2 735..935 CDD:304668
RNB 1255..1482 CDD:279157
RNB 1544..1845 CDD:214935
AAA_11 2289..2532 CDD:289831 76/242 (31%)
AAA_19 2297..>2368 CDD:289986 27/70 (39%)
AAA_12 2543..2746 CDD:289832 59/211 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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