DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Upf1 and mov10a

DIOPT Version :9

Sequence 1:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster
Sequence 2:	XP_002662576.2	Gene:	mov10a / 566858	ZFINID:	ZDB-GENE-091230-8	Length:	1001	Species:	Danio rerio

Alignment Length:	709	Identity:	199/709 - (28%)
Similarity:	292/709 - (41%)	Gaps:	170/709 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 YQYEKTFGPLVRLEAEYDQKLKESATQENIEVRWDVGLNKKTIAYFTLAKTDSDMK--------L 333
            |:|......|.:.:.|..:.|..|..|....||             .|..|...||        |
Zfish   314 YRYPAYLKELAKYKLEDSEHLPASLKQHLPRVR-------------RLLDTQLCMKNYSERFHLL 365

  Fly   334 MHGDELRLH-----YVGELYNPWSEIGH------VIKVP---DN-----FGDDVGLELKSSTNAP 379
            :|.:|:::.     |  :||.....:..      ::|||   :|     .||.:.:.|....|.|
Zfish   366 LHLEEIQMEVDIKKY--DLYGKTMTLDKTNKKLLILKVPGVAENRPSVLRGDKLNVCLSDDRNQP 428

  Fly   380 VKCTSNFT--VDFIWKCTSFDRMTRALCKFAIDRNSVSNFIYSRL---LGHGRAD-----SNDEV 434
            :.....:.  |:.......|.|  :.|.||..:......|..:|.   |.|...:     :...|
Zfish   429 ITVYEGYVHRVELDKVILGFSR--KLLQKFVNNMKFDVEFNINRFPLRLQHRAVELAVQHALGNV 491

  Fly   435 LFRGPQPKLFSAPHLPDL---------NRSQVYAVKHAL---QRPLS-LIQGPPGTGKTVTSATI 486
            ||  |..|......||.|         |..|..||:|.|   .||.. ||.||||||||||....
Zfish   492 LF--PSDKDTGHSELPHLSMFNKDLENNPEQKAAVQHILSGSSRPAPYLIFGPPGTGKTVTVVEA 554

  Fly   487 VYQLVKLHGGT-VLVCAPSNTAVDQLTEKI--HRTNLKVVRVCAKSREAIDSPVSFLALHNQIRN 548
            :.|:.|....: :|.|||||:|.|.|.|::  |....::.|:||.||:....|...|
Zfish   555 IKQVDKSKAQSHILACAPSNSACDLLCERLLGHVDAHRIYRLCAPSRDPRTVPQKLL-------- 611

  Fly   549 METNSELKKLQQLKDETGELSSADEKRYRNLKRAAENQLLEAAD------VICCTCVGAG---DG 604
                                      ::.|...|.::.||.:.:      :|..|.|.||   .|
Zfish   612 --------------------------KHSNWNEAQDSFLLPSKETLIGYSIIVVTLVTAGRLVSG 650

  Fly   605 RLSRVKFTSILIDESMQSTEPECMVPV------VLGAKQLILVGDHCQLGPVVMCKKAARAGLSQ 663
            .::...||.|.|||:.|:.||||::.:      :.|  ||:|.||..|||||:....|...||.|
Zfish   651 GVAMGHFTHIFIDEAGQAVEPECIIGIAGLLDPLKG--QLVLAGDPQQLGPVLRSPLAQLHGLGQ 713

  Fly   664 SLFERLVVLGIR---------------PFRLEVQYRMHPELSQFPSNFFYEGSLQNGVCAEDRRL 713
            ||.|||:.....               ..:|...||.||.:.:.|:..|||..||  |.|.....
Zfish   714 SLLERLMKRNALYQKSQDDNSKYDSRFVTKLLRNYRSHPAILKIPNELFYENELQ--VFANQMER 776

  Fly   714 KLDFPW---PQPERPMFFLVTQGQEEIAGSGTSFLNRTEAANVEKITTRFL----KAGIK---PE 768
            :....|   |:...|:.|....|::|...:..||.|.||...:.......:    |.|:.   |.
Zfish   777 EAFCQWEHLPRKGFPVVFHGVMGKDEREANSPSFFNVTEIEVIVNYLNNLMQTQGKKGLPKLGPN 841

  Fly   769 QIGIITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIASVDAFQGREKDIIIMSCVRS-------NE 826
            .||||.||..|...:.:.:...|.|  :.:::|::.||:.|||:|:.:||:|.|||       ::
Zfish   842 DIGIIAPYRKQVEKIRKALNTVGEL--KKWKDIKVGSVEEFQGQERKVIIVSTVRSSVNYVKMDQ 904

  Fly   827 RQGIGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNF-----------YKD 874
            ...||||::.:|.|||:||||..:|:||||.:|:|...|...:.:           |||
Zfish   905 DFNIGFLSNEKRFNVAMTRAKGLLIVVGNPVILSKDPTWQKFIQYCEQEQGYTGFDYKD 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500
		DNA2	122..897	CDD:224037	199/709 (28%)
		Mis12	210..299	CDD:283509	5/21 (24%)
		AAA_19	458..>515	CDD:289986	30/61 (49%)
		AAA_12	661..857	CDD:289832	72/227 (32%)
mov10a	XP_002662576.2	P-loop_NTPase	517..>709	CDD:304359	73/227 (32%)
		AAA_11	517..704	CDD:289831	72/222 (32%)
		DNA2	<634..963	CDD:224037	107/334 (32%)
		AAA_12	711..934	CDD:289832	71/226 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810