DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Upf1 and setx

DIOPT Version :9

Sequence 1:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster
Sequence 2:	XP_005161583.1	Gene:	setx / 562474	ZFINID:	ZDB-GENE-070402-1	Length:	2368	Species:	Danio rerio

Alignment Length:	888	Identity:	220/888 - (24%)
Similarity:	349/888 - (39%)	Gaps:	285/888 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 VKQPSEQGQLRARQISAAQINKLEELWKENIEATFQDLEK--PGIDSEP-------AHVLLRYE- 274
            :...||....:..|...|.:||              .:.|  |.:|..|       ...:|::|
Zfish  1450 ISSTSEPPSYKVYQRPEAPVNK--------------PVNKPMPTMDQSPKFDLSVLTQAILKWEY 1500

  Fly   275 ---DGY-------------------------QYEKTFGPLVRL---EAEYDQKLKESATQENIEV 308
               |.|                         :|..|..||:.:   |...::.|||...:..::|
Zfish  1501 RMLDNYKAFGSPLDLCQLPLKEVPVNFSSYLEYFNTLYPLLLINAFEEMANEWLKEGRVKLYLKV 1565

  Fly   309 RWDVGLNKKTIAYFTLA-KTDSDMKLMHGDELRLHYVGELYNPWSEIGHVIKVPDNFG------- 365
            :.....|:...|.|... ..:.|:|.::..|      .:|...|        :|||.|
Zfish  1566 QGIEYSNRTASASFIAGLSQECDVKQIYPKE------DDLVLLW--------LPDNTGAYAQDEP 1616

  Fly   366 -------------------------DDVGLELK-----SSTNA-PVKCTSNFTVDFIWKCTSFDR 399
                                     ..:.|.::     ||.|: ||.|      :.:....|..|
Zfish  1617 NFHDLHPHFGYVSRSNVLNRTPGSRSTLNLTIQTRGNVSSVNSQPVLC------EVVGSLISIFR 1675

  Fly   400 MTRALCKFAIDRNSVSNFIYSRLLGHGRADSNDEVLFRGPQPKLFSAPHL--------------- 449
            ..||||                            :|..||..:...|||:
Zfish  1676 EFRALC----------------------------LLRNGPMLRPLLAPHVSFFTHSLDGPSDLDA 1712

  Fly   450 PDLNRSQVYAVK------HALQR--PLSLIQGPPGTGKTVTSATIVYQLV-----------KLHG 495
            |:.||.|..|:.      |..|:  ...||.|||||||:.|...::|:|:           .||.
Zfish  1713 PEFNRDQARAIACGIAMIHRKQKTPKFLLIHGPPGTGKSKTIGGLLYKLLSSATNSSATVGNLHS 1777

  Fly   496 GT----VLVCAPSNTAVDQLTEKI----------------------------------------- 515
            .:    ||:|||||.|:|.|.:|:
Zfish  1778 KSRRTRVLLCAPSNAAIDSLMKKVILIFKEKCRNINAPQGNCGDINLVRLGNERTISKSLKPFSL 1842

  Fly   516 -HRTNLKVVRV-------CAKSREAIDSPVSFLALHNQIRNMETNSELKKL-----QQLKDETGE 567
             |:|..:..|.       ..:.:|.:|..:..|: |...:..:.::|.|.|     |.||:..|
Zfish  1843 DHQTKARAQRAQQTVESDVHRRKEQLDQMIENLS-HQCAKTQKNSTEFKNLLEQKKQFLKEREG- 1905

  Fly   568 LSSADEKRYRNLKRAAENQLLEAADVICCTCVGAGD-------GRLSRVKFTSILIDESMQSTEP 625
             .|...|..|..::.::..:|:.|.|||||...:|.       .||....|:.::|||:.|:.|.
Zfish  1906 -LSRQIKECRGRRQESQALVLQNAHVICCTLSTSGSIVLENAFRRLGHEPFSCVIIDEASQAKET 1969

  Fly   626 ECMVPVVLGAKQLILVGDHCQLGPVVMCKKAARAGLSQSLFERLVVLGIRP--------FRLEVQ 682
            |.::|::.....:|||||..||.|.|:.:||...|..|||..|| ...:.|        ..|.:|
Zfish  1970 ETLIPMLYRCPSVILVGDPNQLPPTVVSQKAKEFGFDQSLMARL-CKSLHPSNSKLPPILLLSMQ 2033

  Fly   683 YRMHPELSQFPSNFFYEGSLQNGVCAEDRRLKLDFPWPQPERPMFFLVTQGQEEIAGSGTSFLNR 747
            |||||::.:|||.:.|..:|:|......:|..|.:|: :|.:  .|.|..|:|  .....||:|.
Zfish  2034 YRMHPDICEFPSKYIYNSALKNDCETAQKRCSLSWPF-KPYK--VFDVMDGRE--TKERDSFINH 2093

  Fly   748 TEAANVEKITTRFLKAGIKPE--QIGIITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIASVDAFQ 810
            .|.:.|..:    ||...|.:  ::|:||||..|:..::..::..| ::.:|  ::|:.:||.||
Zfish  2094 KEVSLVGLL----LKLLCKEQAVRVGVITPYNAQKHRILDAIKTSG-INKQL--QVEVDTVDGFQ 2151

  Fly   811 GREKDIIIMSCVRSNERQG-IGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLL----- 869
            |||.|.||:||||::...| |||:.:.:|:||.:|||||.:.|:|:.:.|.:|..|..|:
Zfish  2152 GREMDCIIVSCVRASSEMGSIGFVGNRQRMNVTITRAKFSLFILGHLRTLREQSDWGALIEDAGR 2216

  Fly   870 ----------NFYKDRKVLVEGSLNNLKESLIH--FQKPKKLV 900
                      ||..|.|.:|:...|.|..||.|  ..:|..::
Zfish  2217 RECIINTMQKNFESDVKKIVKQKPNPLSRSLSHPPIDRPSAVI 2259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500	6/28 (21%)
		DNA2	122..897	CDD:224037	219/883 (25%)
		Mis12	210..299	CDD:283509	20/119 (17%)
		AAA_19	458..>515	CDD:289986	27/79 (34%)
		AAA_12	661..857	CDD:289832	72/206 (35%)
setx	XP_005161583.1	SEN1_N	37..>322	CDD:289496
		AAA_11	1714..1998	CDD:289831	75/286 (26%)
		AAA_12	2005..2197	CDD:289832	71/204 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D62494at2759
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820