Protein Alignment Upf1 and helz2a

DIOPT Version :9

• Sequence 1: NP_001285145.1
• Gene: Upf1 / 32153
• FlyBaseID: FBgn0030354
• Length: 1180
• Species: Drosophila melanogaster
• Sequence 2: XP_003198895.2
• Gene: helz2a / 562461
• ZFINID: ZDB-GENE-120920-1
• Length: 2656
• Species: Danio rerio
• Alignment Length: 1086
• Identity: 266/1086 - (24%)
• Similarity: 420/1086 - (38%)
• Gaps: 300/1086 - (27%)

  Fly     5 TYAPSSALSFLDMDDNELLPGA-DTQPTQYDYRDFTMPSTSQSQTQNDQLEIAQRCSAGDSHPRL 68
            |:|.|....:||:....||... |....:|...|..:.....|:..:.|....::.:|.....:|
Zfish  1674 TWASSPVRRYLDVIVQRLLHSVIDKTDVKYTTLDINLSCLEFSRKNDQQSAYERKANALHFALKL 1738

  Fly    69 ASITNDLADLQFEEEDDEPGSSYVKELPPHACKY--------CGIHDPATVV------------- 112
            :|             ..|...:|:.||.|....:        ..|.:...::
Zfish  1739 SS-------------QSERKVAYIVELNPLGTNFKVSFPLNRSSISENLDIMSRDLLLAVQPEFD 1790

  Fly   113 MCNNCR--KWFCNGR-GSTSGSHIINHLVRAKHREVTLHGEGPLGETILECYSCGVRNVFVLGFI 174
            :.||..  ||  ..| .|.|.|||        |.||.......                 |:.::
Zfish  1791 VTNNSMILKW--ERRIYSFSNSHI--------HAEVKQQNPNS-----------------VMAYV 1828

  Fly   175 PAKADSVVVLLCRQPCAAQNSLKDMNWDQEQWKPLIADRCFLAWLVKQPSEQGQLRARQ----IS 235
            |||.         ..|.| :::::.||:.            :..|:::......:.|||    :|
Zfish  1829 PAKT---------WKCIA-DAIREQNWNA------------IFPLIEELQRNSGINARQFHETLS 1871

  Fly   236 AAQINK---------LEELW-----KENIE-----ATFQDLEKPGID---------------SEP 266
            |::..|         ..||:     .|.:|     :|.:.|..|.|.               .:|
Zfish  1872 ASKCTKNYDPLHAEHYAELYLRIKQGEAVEVQLGASTARGLMTPSIQLFVVHPKFEICVEHVRDP 1936

  Fly   267 AHVLLRY-----EDGY----QYEKTFGPLVRLEAEYDQKLKESATQEN-------IEVRWDVGLN 315
            ......|     ...|    .|:..:.|:..:|:      ..||..||       :.::|: ..|
Zfish  1937 VKCFSEYALSSSRSSYNLYKDYQAIWRPMCEMES------ASSAVAENESILIVDVPLKWE-NSN 1994

  Fly   316 KKTIAYFTLAKTDSDMKLMHGDELRLHY------VGELYNP-----------------WSEIGHV 357
            .|.:..|.|...|...:.....:||..:      :.:..:|                 |...|.:
Zfish  1995 PKRLQGFFLLPLDKKSQWSIDCDLRNSFLCIRTRIQKQSSPFLESAQNTALMDIPSFTWVVHGVI 2059

  Fly   358 IKVPDNFGDDVGLELKSSTNAPVKC----------------------TSNFTVDFIWKCTSFDRM 400
            .:..:.       |.|.|||...|.                      .:.||::.|.|.....|.
Zfish  2060 TEAEET-------ESKESTNQEPKSLRIDFLINHMPMTNIPEQIFHERTRFTLELIPKLLPDVRK 2117

  Fly   401 TRALCKFAIDRNSVSNFIYSRLL-----------GHGRADSNDEVLFRGPQPKLFSAPHLPDLNR 454
            ..|:.........|.|....|.:           ..||.:.|.           :....|..||.
Zfish  2118 ENAIDSLTKANQLVKNIAMGRRITSDRGCKIPNQNTGRFEINS-----------YHPSGLSHLNN 2171

  Fly   455 SQVYAVKHALQRPLSLIQGPPGTGKTVTSATIVY------QLVKLHGG---TVLVCAPSNTAVDQ 510
            ||..|::.||..|.:||||||||||||....|:|      |.::..|.   .:|.|.|||.:||.
Zfish  2172 SQSKAIREALTNPFTLIQGPPGTGKTVVGVHILYWLHKNIQQLQASGSKKRAILYCGPSNKSVDV 2236

  Fly   511 LT-EKIH-RTNLKVVRVCAKSREAIDSP---------------------VSFLALHNQIRNMETN 552
            :. ..:| |.:||.:||.:...|.::.|                     :|.:|||:.||. |.|
Zfish  2237 VAGHLLHLRDHLKPLRVYSDQMEMLEFPYPGCNLKLSRNSKRGEKPNTELSSIALHHLIRK-EGN 2300

  Fly   553 ---SELKKLQQLKDETGELSSADEKRYRN-LKRAAENQLLEAADVICCTCVGAGDGRLSR-VKFT 612
               ::::..........:|:..:.|.:|. ||:|.:::||. .|||.|||..|....|:. :.|.
Zfish  2301 PFSTQIRAFDMKVQRGDQLTDEERKLFREILKKARKHELLH-HDVILCTCTAASHPALAETLDFK 2364

  Fly   613 SILIDESMQSTEPECMVPVVL-GAKQLILVGDHCQLGPVVMCKKAARAGLSQSLFERLVVLGIRP 676
            .|:|||...:||||..:|:|. ..:|::|:|||.||.|||.|:.|.|.|:|:|||||.:.   ..
Zfish  2365 QIIIDECAMATEPEAFIPLVAHKPEQIVLLGDHKQLQPVVHCEVAERLGMSRSLFERYME---NA 2426

  Fly   677 FRLEVQYRMHPELSQFPSNFFYEGSLQNGVCAEDRRLKLDFPWPQPERPMFFLVTQGQEEI---- 737
            ..|:.||||..::..||||.||.|.||.|:.|:.:.    |.....:..:.|...:|:|:.
Zfish  2427 LMLDTQYRMQEDICAFPSNEFYGGRLQTGIPAKSKL----FLTQTKQTCIVFGHVEGKEKSLVVR 2487

  Fly   738 --AGSGTSFLNRTEAANVEKITTRFLKAGIKPEQIGIITPYEGQRAYLVQYMQYQGSLHSRLYQE 800
              .|:..|..|..||..|.::.....:||||.:.|.|:|||..|.|.:.:      |||:...::
Zfish  2488 TEQGNENSKANMEEAEEVVRVAILLTEAGIKTKDIAILTPYNAQVAKISE------SLHNNHIRD 2546

  Fly   801 IEIASVDAFQGREKDIIIMSCVRSNERQGI-------------GFLNDPRRLNVALTRAKFGIII 852
            |.:.::...||.|...:|||.|||..:..|             ||:.||.::||.:|||:.|:.|
Zfish  2547 ITVNTIMRSQGSEWRYVIMSTVRSCPKSEIETQPPKSWIMKRLGFITDPHQVNVGITRAQEGLCI 2611

  Fly   853 VGNPKVLAKQQLWNHLLNFYKDRKVLVEGSLNNLKESLIHFQKPKK 898
            :||..:|....||..|||.|:::..:|..:      .||..::|.:
Zfish  2612 IGNENLLRCSSLWRKLLNHYQEKGCVVNPA------RLIQVRQPPR 2651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500	31/192 (16%)
		DNA2	122..897	CDD:224037	240/942 (25%)
		Mis12	210..299	CDD:283509	21/135 (16%)
		AAA_19	458..>515	CDD:289986	27/66 (41%)
		AAA_12	661..857	CDD:289832	70/214 (33%)
helz2a	XP_003198895.2	AAA_11	614..807	CDD:289831
		P-loop_NTPase	639..>683	CDD:304359
		DNA2	<741..1055	CDD:224037
		UvrD_C_2	817..1017	CDD:304668
		RNB	1338..1698	CDD:214935	7/23 (30%)
		AAA_11	2168..2405	CDD:289831	83/238 (35%)
		AAA_19	2176..2246	CDD:289986	28/69 (41%)
		P-loop_NTPase	<2366..2438	CDD:304359	35/74 (47%)
		AAA_12	2414..2614	CDD:289832	68/212 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810