DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Upf1 and ighmbp2

DIOPT Version :9

Sequence 1:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster
Sequence 2:	NP_001038365.1	Gene:	ighmbp2 / 556484	ZFINID:	ZDB-GENE-050419-258	Length:	997	Species:	Danio rerio

Alignment Length:	743	Identity:	214/743 - (28%)
Similarity:	324/743 - (43%)	Gaps:	186/743 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 LEAEYDQKLKES-ATQENIEVRWDVGLNKKTIAYFTLAKTDSDMKLMHGDELRLHYVGEL---YN 349
            |:.|.:.:|:|: |.|||:.::   .|..|.:..         |||..|.:....| |.|   :.
Zfish    14 LQEEREAELEETRAWQENVSLK---NLQHKGVCL---------MKLQIGSQHTGMY-GRLLVIFE 65

  Fly   350 PWSEIGHVIKVPDNF--GDDVGLELKSSTNAPVKCTSNFTVDFIWKCTSFDRMTRALCKFA---- 408
            |...||..:...:.|  ||.:||........|.:..|....          |.|:|....|
Zfish    66 PRKCIGLSVLPSNTFGPGDIIGLYQAEGQALPTQLGSGVVT----------RATQASLTVAFDDT 120

  Fly   409 -----IDRNSVSNFI-------YSRL---------LGHGRADSNDEVLFRGPQPKLFSAPHL--- 449
                 :||:.:.|.:       |.||         ..:|.|.....|||...||.:.|  ||
Zfish   121 QDGTNLDRDGLYNLMKLANDVTYRRLSSALKSLNGYSNGPASHLISVLFGYSQPGILS--HLYAL 183

  Fly   450 ----PDLNRSQVYAVKHAL-QRPLSLIQGPPGTGKTVTSATIVYQLVKLHGGTVLVCAPSNTAVD 509
                ..|:.||..||..|: |:.:::|.||||||||.|...::.|.|| ....||.|||||.|||
Zfish   184 EFNNTKLDDSQKEAVSFAISQKDVAIIHGPPGTGKTTTVVEVILQAVK-QQQKVLCCAPSNVAVD 247

  Fly   510 QLTEKIHRTNLKVVRVCAKSR--EAIDS-PVSFLALHNQIRNMETN---------SELKKLQ--- 559
            .|.|::.:..:||:|:...:|  |:|.. .:..:..|:...|:.::         :|:||.:
Zfish   248 NLVERLAKNKVKVLRLGHPARLLESIQKHSLDAVLAHSDNTNIISDIRKDMDKAFNEIKKARDKG 312

  Fly   560 ---QLKDETGELSSADEKRYRNLKRAAENQLLEAADVICCTCVGAG-DGRLSRV---KFTSILID 617
               .|:.|.|||    .:..|..:..|.:|:|:.||||..|..||. ||.|..:   .|..::||
Zfish   313 QRSNLRREIGEL----RRELRTREETAISQILKRADVILATNTGASDDGPLKHLPNDHFDLVVID 373

  Fly   618 ESMQSTEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAARAGLSQSLFERLV-VLGIRPFR-LE 680
            |..|:.|..|.: .:|.|::.||.||:.||.|.:..:.||..|||.||.|||: ..|....| |.
Zfish   374 ECAQALESSCWI-ALLKARKCILAGDYKQLPPTIKSQSAASKGLSVSLMERLIKKYGDSVVRMLT 437

  Fly   681 VQYRMHPELSQFPSNFFYEGSL-------------QNGVC-AEDRRLKLDFPWPQPERPMFFLVT 731
            .||||:..:.|:.|...|:|.|             ..||. .|:.|:.|            .||
Zfish   438 TQYRMNSAIMQWASEQMYQGKLIAHPSVEKHLLRDLAGVADVEETRIPL------------LLV- 489

  Fly   732 QGQEEIAGSGTSFLNRTE-------------AANVEKITTRFLKAGIKPEQIGIITPYEGQRAYL 783
                :.||.|.:.:..|:             |.:::.:|    :||::.:.|.||.||..|...|
Zfish   490 ----DTAGCGLNEMENTDEQSKGNQGEVDIVALHIKALT----EAGVQVKDIAIIAPYNLQVDLL 546

  Fly   784 VQYMQYQGSLHSRLYQEIEIASVDAFQGREKDIIIMSCVRSNERQGIGFLNDPRRLNVALTRAKF 848
            .|.:.::       |.|:||.|||.||||||:.:::|.||||.:..:|||.:.||:|||:|||:.
Zfish   547 RQKLSHK-------YAELEIKSVDGFQGREKEAVVLSLVRSNRKGEVGFLAEDRRINVAVTRARR 604

  Fly   849 GIIIVGNPKVLAKQQLWNHLL----------------------NFYKDRKVLVEGSLNNLKESLI 891
            .:::|.:.:.:........|:                      |:.:|.|    ...|..|::..
Zfish   605 QLVVVCDSQTVRNHDFLKSLVDYMSKHGELRTAFEYLEDCVAQNYTRDEK----DKQNKGKDTTS 665

  Fly   892 HFQKP-----------KKLVNSMNIGAH 908
            ..||.           ||..|:.|.||:
Zfish   666 AKQKTKKQDKKPEQEHKKSANNKNSGAN 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500
		DNA2	122..897	CDD:224037	208/730 (28%)
		Mis12	210..299	CDD:283509	3/9 (33%)
		AAA_19	458..>515	CDD:289986	29/57 (51%)
		AAA_12	661..857	CDD:289832	72/224 (32%)
ighmbp2	NP_001038365.1	TIGR00376	25..639	CDD:273041	197/672 (29%)
		AAA_19	196..254	CDD:289986	29/58 (50%)
		AAA_12	416..612	CDD:289832	72/223 (32%)
		R3H_Smubp-2_like	719..778	CDD:100070
		zf-AN1	901..937	CDD:279736
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810