DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Upf1 and mov10b.2

DIOPT Version :9

Sequence 1:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster
Sequence 2:	NP_001037805.1	Gene:	mov10b.2 / 555950	ZFINID:	ZDB-GENE-060526-371	Length:	1015	Species:	Danio rerio

Alignment Length:	1061	Identity:	251/1061 - (23%)
Similarity:	398/1061 - (37%)	Gaps:	329/1061 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 QTQNDQLEIAQRCSAG--------DSHPRLASITNDLADL---QFEEED---DEPGSSYVKELPP 97
            :.:|:.|.||...:.|        :::.|..|..|.|.|:   :|.:.|   .:|..|.|.....
Zfish     4 RNRNNYLSIAAVRTIGLDFIEMLEETNRRSISDRNTLTDIYNTEFRDRDGGVKDPNFSRVLYALR 68

  Fly    98 HACK---------------YCGIHDPATVVMCNNCRKWF------CNGRGSTSGSHIINHLVRAK 141
            :|.|               ..|:||           :||      .|...:|.|:  ::.:..:.
Zfish    69 NANKARLSRTGRVYFNTNVRTGLHD-----------QWFRPRRRQQNQANATPGN--VSSVTPSS 120

  Fly   142 HREVTLHGEGPLGETILECYSCGVRNVFVLGFIPAKADSVVVLLCRQPCAAQNSLKDMNWDQEQW 206
                   .:||      .|...|||         |:...|..:|.|     .|:....::..::|
Zfish   121 -------DQGP------SCPESGVR---------ARRKLVKYILQR-----LNTTDRSHFIADKW 158

  Fly   207 KPLIADRCFLAWLVKQPSEQGQLRARQISAAQINKLEELWKENI--EA---------------TF 254
            ...::...::        |.|::|. .:..|::.:| :|:.||.  ||               |.
Zfish   159 GVRVSSELYI--------EDGKIRI-SVDEAEVYEL-KLFVENTGQEAVYFTYYTALCWLQYFTL 213

  Fly   255 QDLEKPGIDS-------EPAHVLLRYED----------GYQYEKTFGPLVR-------LEAEYDQ 295
            :|..|...::       |...|::|::.          .::::|...|..|       :||||..
Zfish   214 EDSRKVTRNNPLRLEPREKYEVIVRFKSSHVGVYSATLAFEFKKNTQPTTRSFHIVRFIEAEYRS 278

  Fly   296 KLKE--SATQENIEVRWDVG--------------------------LNK-----KTIAYFTLAKT 327
            ||..  ..|:....:|.::.                          |.|     .|.....|.|.
Zfish   279 KLAALLGPTEPYKPLRLNISEPENCIIDEGFPPDGYLQNFLVNVLPLGKYIPPPDTTILAELLKE 343

  Fly   328 DSDMKLMHG----------------------------DELRLHYVGELYNPWSEIGHVIKVPDNF 364
            |...::..|                            :|.::|...:.||..|...|    .|..
Zfish   344 DCSSRIFRGKLKDLQSLLQSPLTFDNYAERFDLLLYLEECQMHVDIKRYNKDSVTLH----RDRD 404

  Fly   365 GDDVGLELKS-STNAP-------VKCTSNFTVDF--IWKCTSF------DRMTRALCK------- 406
            ...:||.|.. |.|.|       :..|.:..|.|  :.|...:      |::...|.|
Zfish   405 KRLMGLNLPGVSENRPSVLRGDHLLLTKSEEVTFSNVTKYKGYVHRVELDQVKLGLSKRFLKDVY 469

  Fly   407 ---------FAIDRNSVSNFIYSRLLGHGRADSNDEVLF----RGPQPKLFSAPHLPDLNR---- 454
                     |.::|..|.  :..|.:......:..:|||    |...|  .|.|.|...:|
Zfish   470 IDKMKFRVEFTVNRIPVR--LQHRAVHMAVQHNLKDVLFPMASRSLNP--VSPPALRLFDRKLEY 530

  Fly   455 -----SQVYAVKHALQRPLS-LIQGPPGTGKTVTSATIVYQLVK-LHGGTVLVCAPSNTAVDQLT 512
                 |.|..:.....:|.. |:.||||||||||....:.|:.| :....:|.|||||:|.|||.
Zfish   531 NFQQYSAVCNIVAGTSKPAPYLVFGPPGTGKTVTIVEAIKQVEKNIPDAYILACAPSNSAADQLC 595

  Fly   513 EKI----HRTNLKVVRVCAKSREAIDSPVSFLALHNQIRNMETNSELKKLQQLKDETGELSSADE 573
            ||:    |....|:.|:.|.||...|.|                      :.|||.    .:.||
Zfish   596 EKLITSEHVDAHKIYRLYASSRNQKDIP----------------------KILKDN----CNVDE 634

  Fly   574 KRYRNLKRAAENQLLEAADVICCTCVGAG---DGRLSRVKFTSILIDESMQSTEPECMVPV--VL 633
            :.   :....:..|: :..::.||.|.||   .|..|...||...:||:..:.|.|.::.|  :|
Zfish   635 EM---IDFPCKEDLM-SYKILICTLVTAGRLVTGGFSEDHFTHNFVDEAGHAVESETIISVAGLL 695

  Fly   634 GAK--QLILVGDHCQLGPVVMCKKAARAGLSQSLFERLVV------LGIRPF------RLEVQYR 684
            .|:  ||:|.||..||||::....|...||..||.|||:.      .|...|      :|.:.||
Zfish   696 NAEKGQLVLAGDPKQLGPILRSPLAINHGLDVSLLERLMTQNDLYKRGDVEFDNRYVSKLIMNYR 760

  Fly   685 MHPELSQFPSNFFYEGSLQNGVCAEDRRLKLDFPW---PQPERPMFFLVTQGQEEIAGSGTSFLN 746
            .||.:.:.|:..||:|.|:  .||::........|   |....|:.|....|::|...:..||.|
Zfish   761 SHPYILEVPNRLFYDGELK--ACADEISSNQYCMWEHLPSKGFPVIFHGVPGKDERESNSPSFFN 823

  Fly   747 RTEAANV-----EKITTRFLKAGIK---PEQIGIITPYEGQRAYLVQ-------YMQYQGSLHSR 796
            ..| .|:     :|:.....|.||.   |:.||||.||..|...:.:       :..|.|
Zfish   824 IYE-INILVDYLKKLLLTQPKKGISRIFPKDIGIIAPYRKQVEKIKRAIDADKDFQDYMG----- 882

  Fly   797 LYQEIEIASVDAFQGREKDIIIMSCVRS-------NERQGIGFLNDPRRLNVALTRAKFGIIIVG 854
             ...:::.||:.|||:|:.:|::|.|||       :|...||||.:.:|.|||:||||..:|:||
Zfish   883 -IDNLKVGSVEEFQGQERKVIMVSTVRSSVKYISLDETFNIGFLKNEKRFNVAVTRAKSLLIMVG 946

  Fly   855 NPKVLAKQQLWNHLLNFYKDR 875
            ||.:|...:.|...::|..:|
Zfish   947 NPMILRTDESWGRFIDFCLER 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500	28/171 (16%)
		DNA2	122..897	CDD:224037	229/951 (24%)
		Mis12	210..299	CDD:283509	25/129 (19%)
		AAA_19	458..>515	CDD:289986	25/58 (43%)
		AAA_12	661..857	CDD:289832	73/232 (31%)
mov10b.2	NP_001037805.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..130		8/50 (16%)
		MYCBPAP	<189..>262	CDD:291319	11/72 (15%)
		AAA_11	552..718	CDD:289831	64/195 (33%)
		P-loop_NTPase	552..>714	CDD:304359	63/191 (33%)
		DNA2	<642..983	CDD:224037	106/336 (32%)
		DEAG box	677..680		2/2 (100%)
		AAA_12	725..948	CDD:289832	72/231 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810