DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Upf1 and ZGRF1

DIOPT Version :9

Sequence 1:NP_001285145.1 Gene:Upf1 / 32153 FlyBaseID:FBgn0030354 Length:1180 Species:Drosophila melanogaster
Sequence 2:NP_060862.3 Gene:ZGRF1 / 55345 HGNCID:25654 Length:2104 Species:Homo sapiens


Alignment Length:779 Identity:200/779 - (25%)
Similarity:326/779 - (41%) Gaps:184/779 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   211 ADRC-FLAWLVKQPSEQGQLRARQISAAQINKLEELWKENIEATF--QDLEKPGI---DSEPAHV 269
            |||| |..||                            |::...:  |:..:||:   |.:...:
Human  1379 ADRCKFFKWL----------------------------EDVTPGYSTQEGARPGMVLSDIKSIGL 1415

  Fly   270 LLR------YED-------GYQYE-KTFG---------------PLVRLEAEYDQKLKESATQEN 305
            .||      ||:       |:.:: |.:|               |..:|..:..:|.:.||..:|
Human  1416 YLRSQKIPLYEECQLLVRKGFDFQRKQYGKLKKFTTVNPEFYNEPKTKLYLKLSRKERSSAYSKN 1480

  Fly   306 IEVRWDVGLNKKTIAYFTLAKTDSDMKLMHGDELRLHYVGELYNPWSEIGHV----IK--VPDNF 364
                 |:.:..||:.:                ||........:...|.|..:    :|  .|.|:
Human  1481 -----DLWVVSKTLDF----------------ELDTFIACSAFFGPSSINEIEILPLKGYFPSNW 1524

  Fly   365 GDDVGLELKSSTNAPVKCTSNFTV-DFIWKCTSFDRMTRALCKFAIDRNS---VSNFIYSRLL-- 423
            ..::.:......||..:.|:...: |:      |:..|..|.::.:..:|   |||...|:..  
Human  1525 PTNMVVHALLVCNASTELTTLKNIQDY------FNPATLPLTQYLLTTSSPTIVSNKRVSKRKFI 1583

  Fly   424 --GHGRADSNDEVLFRGPQPKLFS-APHLPDLNRSQVYAVKHALQR------------------P 467
              ......:..|:|..|...||.| ...:..||:.|..|:....|.                  |
Human  1584 PPAFTNVSTKFELLSLGATLKLASELIQVHKLNKDQATALIQIAQMMASHESIEEVKELQTHTFP 1648

  Fly   468 LSLIQGPPGTGKTVTSATIVYQLVKLHGGT------------VLVCAPSNTAVDQLTEKIHRTNL 520
            :::|.|..|.||:...|.::...|:|...:            :|:.:.:|.|||::...:.....
Human  1649 ITIIHGVFGAGKSYLLAVVILFFVQLFEKSEAPTIGNARPWKLLISSSTNVAVDRVLLGLLSLGF 1713

  Fly   521 K-VVRVCAKSREAIDSPVSFLALHNQIRNMETNSELKKLQQLKDETGELSSAD----EKRYRNLK 580
            : .:||  .|...|..|:...:||....|  .:.:||:|..|..|  :|:..:    .|.....|
Human  1714 ENFIRV--GSVRKIAKPILPYSLHAGSEN--ESEQLKELHALMKE--DLTPTERVYVRKSIEQHK 1772

  Fly   581 RAAENQLLEAADVICCTCVGAGDGRLSRVKFTSILIDESMQSTEPECMVPVV-LGAKQLILVGDH 644
            ......||:...|:..||.......::.:||..:::||..|.|||..::|:. ...::||||||.
Human  1773 LGTNRTLLKQVRVVGVTCAACPFPCMNDLKFPVVVLDECSQITEPASLLPIARFECEKLILVGDP 1837

  Fly   645 CQLGPVVMCKKAARA-GLSQSLFERLVVLGIRPFRLEVQYRMHPELSQFPSNFFYEGSLQNGVCA 708
            .||.|.:....||.. ||.|:||:||.::|.:|..|..|||.||.:|...::.||:|:|.|||..
Human  1838 KQLPPTIQGSDAAHENGLEQTLFDRLCLMGHKPILLRTQYRCHPAISAIANDLFYKGALMNGVTE 1902

  Fly   709 EDRRLKLDFPW-PQPERPMFFLVTQGQEEIAGSGTSFLNRTEAANVEKITTRFLKAGIKPEQIGI 772
            .:|...|:  | |    .:.|...:|.|:|. ...||.|..||....|:....:.:||....||:
Human  1903 IERSPLLE--WLP----TLCFYNVKGLEQIE-RDNSFHNVAEATFTLKLIQSLIASGIAGSMIGV 1960

  Fly   773 ITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIASVDAFQGREKDIIIMSCVRSNERQGIGFLNDPR 837
            ||.|:.| .|.:.::......|....:.:::::||||||.||:|||:||||:.:   :||::..:
Human  1961 ITLYKSQ-MYKLCHLLSAVDFHHPDIKTVQVSTVDAFQGAEKEIIILSCVRTRQ---VGFIDSEK 2021

  Fly   838 RLNVALTRAKFGIIIVGNPKVLAKQQLW------------------------NHLLNFYKDRKV 877
            |:||||||.|..::||||...|.|.|||                        ||||..|.:::|
Human  2022 RMNVALTRGKRHLLIVGNLACLRKNQLWGRVIQHCEGREDGLQHANQYEPQLNHLLKDYFEKQV 2085

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Upf1NP_001285145.1 UPF1_Zn_bind 98..249 CDD:286500 7/38 (18%)
DNA2 122..897 CDD:224037 200/779 (26%)
Mis12 210..299 CDD:283509 22/122 (18%)
AAA_19 458..>515 CDD:289986 16/86 (19%)
AAA_12 661..857 CDD:289832 75/196 (38%)
ZGRF1NP_060862.3 AAA_11 1614..1844 CDD:289831 58/235 (25%)
DNA2 <1739..2057 CDD:224037 115/332 (35%)
AAA_12 1855..2039 CDD:289832 73/194 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2085..2104 1/1 (100%)
DUF2439 4..73 CDD:287368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..359
zf-GRF 1347..1391 CDD:284302 8/39 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1112
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D62494at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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