DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Upf1 and MOV10

DIOPT Version :9

Sequence 1:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster
Sequence 2:	NP_001123551.1	Gene:	MOV10 / 4343	HGNCID:	7200	Length:	1003	Species:	Homo sapiens

Alignment Length:	906	Identity:	244/906 - (26%)
Similarity:	364/906 - (40%)	Gaps:	255/906 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 FEEEDDE------PGSSYVKELPPHACK--YCGIHDPATVVMCNNCRKWFCNGRGSTSGSHIINH 136
            |..||.|      ||..|  ||..| ||  :.| :.||||:       |...|.|. |||.
Human   179 FYNEDQELPCPLGPGECY--ELHVH-CKTSFVG-YFPATVL-------WELLGPGE-SGSE---- 227

  Fly   137 LVRAKHREVTLHGEGPLGETILECYSCGVRNVFVLGFIPAKADSVVVLLCRQPCAAQNSLKDMNW 201
                                       |....::..|:.|.|.|        |.|||  ||.|.
Human   228 ---------------------------GAGTFYIARFLAAVAHS--------PLAAQ--LKPMT- 254

  Fly   202 DQEQWK-------PLIADRCFLAWLVKQPSEQGQL--RAR----QISAA-----QINKLEELWKE 248
               .:|       |::.:|.          |:|:.  ||:    ::|.|     ...:|.:|...
Human   255 ---PFKRTRITGNPVVTNRI----------EEGERPDRAKGYDLELSMALGTYYPPPRLRQLLPM 306

  Fly   249 NIEATFQDLEKPGIDSEP---AHVLLRYEDGYQ---YEKTFGPLVRLE---AEYDQKLKESATQE 304
            .::.|       .|.:.|   |.:..:.|...:   ||.....|:.||   .|:|.:..:   .|
Human   307 LLQGT-------SIFTAPKEIAEIKAQLETALKWRNYEVKLRLLLHLEELQMEHDIRHYD---LE 361

  Fly   305 NIEVRWD-VGLNKKTIAYFTLAKTDSDMKLMHGDELRLHYVGELY--NPWSEIGHVIKVPDNFGD 366
            ::.:.|| |..|.:.:.......|:|...::.||.|......|.:  :|.:..|.|.||.   .|
Human   362 SVPMTWDPVDQNPRLLTLEVPGVTESRPSVLRGDHLFALLSSETHQEDPITYKGFVHKVE---LD 423

  Fly   367 DVGLELKSSTNAPVKCTSNFTVDFIWKCTSFDRMTRALCKFAIDRNSVSNFIYSRLLGHGRADSN 431
            .|.|....|..:.......|.|:|     :|:|....:...|::           |.|..
Human   424 RVKLSFSMSLLSRFVDGLTFKVNF-----TFNRQPLRVQHRALE-----------LTGRW----- 467

  Fly   432 DEVLFRGPQPKLF-----SAPHLP------------DLNRSQVYAVKHAL---QRPLS-LIQGPP 475
              :|:    |.||     ..|.||            :.|..|:.|::|.:   .||.. :|.|||
Human   468 --LLW----PMLFPVAPRDVPLLPSDVKLKLYDRSLESNPEQLQAMRHIVTGTTRPAPYIIFGPP 526

  Fly   476 GTGKTVTSATIVYQLVK-LHGGTVLVCAPSNTAVDQLTEKIHRTNL--KVVRVCAKSREAIDSPV 537
            |||||||....:.|:|| |....:|.|||||:..|.|.::: |.:|  .:.|:.|.||:....|
Human   527 GTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRL-RVHLPSSIYRLLAPSRDIRMVP- 589

  Fly   538 SFLALHNQIRNMETNSELKKLQQLKDETGELSSADEKRYRNLKRAAENQLLEAADVICCTCVGAG 602
                           .::|.......:.||.....:|:            |:...|:..|.:.|
Human   590 ---------------EDIKPCCNWDAKKGEYVFPAKKK------------LQEYRVLITTLITA- 626

  Fly   603 DGRLSRVK-----FTSILIDESMQSTEPECMVPV--VLGAK-------QLILVGDHCQLGPVVMC 653
             |||...:     ||.|.|||:....|||.:|.:  ::..|       ||:|.||..|||||:..
Human   627 -GRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMEVKETGDPGGQLVLAGDPRQLGPVLRS 690

  Fly   654 KKAARAGLSQSLFERLVVL---------GIRP---FRLEVQYRMHPELSQFPSNFFYEGSLQNGV 706
            ....:.||..||.|||:..         |..|   .:|...||.||.:...|:..:|||.||  .
Human   691 PLTQKHGLGYSLLERLLTYNSLYKKGPDGYDPQFITKLLRNYRSHPTILDIPNQLYYEGELQ--A 753

  Fly   707 CAEDRRLKLDFPW---PQPERPMFFLVTQGQEEIAGSGTSFLNRTEAANVEKITTRFL------- 761
            ||:....:....|   |:...|:.|....|::|..|:..||.|..|||.|.......|
Human   754 CADVVDRERFCRWAGLPRQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKLLLAPSSKKG 818

  Fly   762 KAGIKPEQIGIITPYEGQRAYLVQYMQY-QGSLHSRL-----YQEIEIASVDAFQGREKDIIIMS 820
            ||.:.|..:|:|:||..|    |:.::| ...|...|     .:::::.||:.|||:|:.:|::|
Human   819 KARLSPRSVGVISPYRKQ----VEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILIS 879

  Fly   821 CVRSNER-------QGIGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYKD 874
            .|||::.       ..:|||.:|:|.|||:||||..:||||||.:|.....|...|.|.|:
Human   880 TVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIIVGNPLLLGHDPDWKVFLEFCKE 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500	37/170 (22%)
		DNA2	122..897	CDD:224037	226/856 (26%)
		Mis12	210..299	CDD:283509	21/108 (19%)
		AAA_19	458..>515	CDD:289986	27/61 (44%)
		AAA_12	661..857	CDD:289832	76/230 (33%)
MOV10	NP_001123551.1	DEXXQc_Helz-like	498..733	CDD:350796	78/265 (29%)
		DEAG box	645..648		2/2 (100%)
		SF1_C_Upf1	734..939	CDD:350195	70/210 (33%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269\|PubMed:22791714	921..965		7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	966..1003
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810