DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Upf1 and upf1

DIOPT Version :9

Sequence 1:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster
Sequence 2:	NP_998639.1	Gene:	upf1 / 406783	ZFINID:	ZDB-GENE-040426-2836	Length:	1100	Species:	Danio rerio

Alignment Length:	1194	Identity:	741/1194 - (62%)
Similarity:	866/1194 - (72%)	Gaps:	128/1194 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVDTYAPSS-ALSFLDMDDNELLPGADTQPTQYDYRDFTMPSTSQSQTQNDQLEIAQRCSAGD- 63
            |||:.|.||| .|:|||.::.||| |||||.:::::.|||:||.:|:|.|. |.::..:.:..|
Zfish     1 MSVEAYGPSSQTLTFLDTEEAELL-GADTQGSEFEFTDFTLPSQTQTQGQT-QSQLDNQVNGPDG 63

  Fly    64 ----SHPRLASITNDLADLQFEEEDDEPGSSYVKELPPHACKYCGIHDPATVVMCNNCRKWFCNG 124
                ....:...:..||:|.|||  ||..:.|.|.||.|||.||||||||.||.||..:||||||
Zfish    64 VLPNGEDAVGKTSQLLAELNFEE--DEEDTYYTKVLPVHACSYCGIHDPACVVYCNTSKKWFCNG 126

  Fly   125 RGSTSGSHIINHLVRAKHREVTLHGEGPLGETILECYSCGVRNVFVLGFIPAKADSVVVLLCRQP 189
            ||:||||||:|||||||.:|||||.:||||||:||||:||.||||:|||||||||||||||||||
Zfish   127 RGNTSGSHIVNHLVRAKCKEVTLHKDGPLGETVLECYNCGCRNVFLLGFIPAKADSVVVLLCRQP 191

  Fly   190 CAAQNSLKDMNWDQEQWKPLIADRCFLAWLVKQPSEQGQLRARQISAAQINKLEELWKENIEATF 254
            ||:|:||||:|||..||:|||.|||||:||||.||||.|||||||:|.||||||||||||..||.
Zfish   192 CASQSSLKDINWDSSQWQPLIQDRCFLSWLVKIPSEQEQLRARQITAQQINKLEELWKENPTATL 256

  Fly   255 QDLEKPGIDSEPAHVLLRYEDGYQYEKTFGPLVRLEAEYDQKLKESATQENIEVRWDVGLNKKTI 319
            :||||||:|.||.||||||||.|||:..|||||:|||:||:|||||.||:||.||||:|||||.|
Zfish   257 EDLEKPGVDEEPQHVLLRYEDAYQYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRI 321

  Fly   320 AYFTLAKTDS-DMKLMHGDELRLHYVGELYNPWSEIGHVIKVPDNFGDDVGLELKSSTNAPVKCT 383
            |||||.|||| ||:||.|||:.|.|.|::...|..||||||||||:||::.:||:||..|||:..
Zfish   322 AYFTLPKTDSGDMRLMQGDEICLRYKGDMAPLWKGIGHVIKVPDNYGDEIAIELRSSAGAPVEVP 386

  Fly   384 SNFTVDFIWKCTSFDRMTRALCKFAIDRNSVSNFIYSRLLGHGRADSNDEVLFRGPQPKLFSAPH 448
            .||.|||:||.||||||..||..||:|..|||.:||.:||||    ..::|:.:...||.|:|..
Zfish   387 HNFQVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGH----EVEDVIIKCQLPKRFTAQG 447

  Fly   449 LPDLNRSQVYAVKHALQRPLSLIQGPPGTGKTVTSATIVYQLVKLHGGTVLVCAPSNTAVDQLTE 513
            |||||.|||||||..|||||||||||||||||||||||||.|.:...|.||||||||.|||||||
Zfish   448 LPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCAPSNIAVDQLTE 512

  Fly   514 KIHRTNLKVVRVCAKSREAIDSPVSFLALHNQIRNMETNSELKKLQQLKDETGELSSADEKRYRN 578
            |||:|.|||||:||||||||||||||||||||||||::..||:||||||||||||||:||||||.
Zfish   513 KIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDETGELSSSDEKRYRA 577

  Fly   579 LKRAAENQLLEAADVICCTCVGAGDGRLSRVKFTSILIDESMQSTEPECMVPVVLGAKQLILVGD 643
            |||.||.:||..|||||||||||||.||::::|.|||||||.|:|||||||||||||||||||||
Zfish   578 LKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVVLGAKQLILVGD 642

  Fly   644 HCQLGPVVMCKKAARAGLSQSLFERLVVLGIRPFRLEVQYRMHPELSQFPSNFFYEGSLQNGVCA 708
            ||||||||||||||:||||||||||||||||||.||:|||||||.||.||||.||||||||||.|
Zfish   643 HCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQYRMHPALSAFPSNIFYEGSLQNGVTA 707

  Fly   709 EDRRLK-LDFPWPQPERPMFFLVTQGQEEIAGSGTSFLNRTEAANVEKITTRFLKAGIKPEQIGI 772
            .||..| .||.||||::||||.|||||||||.||||:|||||||||||||||.||||.||:||||
Zfish   708 ADRLKKGFDFQWPQPDKPMFFYVTQGQEEIASSGTSYLNRTEAANVEKITTRLLKAGAKPDQIGI 772

  Fly   773 ITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIASVDAFQGREKDIIIMSCVRSNERQGIGFLNDPR 837
            ||||||||:|||||||:.||||::||||:||||||||||||||.||:||||:||.||||||||||
Zfish   773 ITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPR 837

  Fly   838 RLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYKDRKVLVEGSLNNLKESLIHFQKPKKLVNS 902
            |||||||||::|:|||||||.|:||.|||||||:||::||||||.||||:|||:.|.||:||||:
Zfish   838 RLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVLVEGPLNNLRESLMQFSKPRKLVNT 902

  Fly   903 MNIGAHFMSTIIADAKEVMVPGSIYDRSGGYGQGRQMVGQSMNGGQYGGSGGGPYGNSPLGYGTP 967
            :|.||.||||.:.||:|.|:|||:||||                     |.|.|   |.:.:.|
Zfish   903 INPGARFMSTAMYDAREAMIPGSVYDRS---------------------STGRP---SNMYFQT- 942

  Fly   968 SSNSMVGFGLGNGGNGAAGGNNNFGGAGPSWAAAHLHHDSIGYISNEHGAAALGNMPVPVGMFMN 1032
                                                 ||.:|.|..  |...:|::.:|:...:.
Zfish   943 -------------------------------------HDQVGMIGT--GPNPMGSLNIPIPFNLV 968

  Fly  1033 MSNIPPRFYNQHQQAIMAVKQNRAIQQQTGNFSPGNSGPGVTGVGVGRSATPGGNKKTNKLGKSR 1097
            |..:||                           ||..|. |.|...||.|..|  |...:.|:.|
Zfish   969 MPPMPP---------------------------PGYLGQ-VNGPAAGRGAPKG--KTGGRGGRQR 1003

  Fly  1098 VTGGGTGGA-----PLTQGSSVCNAAPYSQHPMPLS-LQMTQPSGFALSQ----QPELSQD--FG 1150
            ..|.|..|:     |.:|.|....:.|:||.|:... :.|:|||  .:||    |||||||  .|
Zfish  1004 NRGTGNHGSGQPNMPNSQASQDLVSQPFSQGPLTQGYITMSQPS--QMSQPGLSQPELSQDSYLG 1066

  Fly  1151 Q--ISQMDGLLSQDVAFNASGERS 1172
            .  .||||..||||..:  .|||:
Zfish  1067 DEFKSQMDVALSQDSTY--QGERA 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500	122/150 (81%)
		DNA2	122..897	CDD:224037	597/776 (77%)
		Mis12	210..299	CDD:283509	68/88 (77%)
		AAA_19	458..>515	CDD:289986	46/56 (82%)
		AAA_12	661..857	CDD:289832	163/196 (83%)
upf1	NP_998639.1	UPF1_Zn_bind	100..251	CDD:286500	122/150 (81%)
		DNA2	124..889	CDD:224037	592/768 (77%)
		AAA_19	457..>514	CDD:289986	46/56 (82%)
		AAA_12	660..857	CDD:289832	163/196 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589181
Domainoid	1	1.000	333	1.000	Domainoid score	I1108
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2185
Inparanoid	1	1.050	1367	1.000	Inparanoid score	I125
OMA	1	1.010	-	-		QHG54950
OrthoDB	1	1.010	-	-		D62494at2759
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	1	1.000	-	-		oto40877
orthoMCL	1	0.900	-	-		OOG6_101981
Panther	1	1.100	-	-	LDO	PTHR10887
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1079
SonicParanoid	1	1.000	-	-		X3712
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800