Protein Alignment Upf1 and Helz

DIOPT Version :9

• Sequence 1: NP_001285145.1
• Gene: Upf1 / 32153
• FlyBaseID: FBgn0030354
• Length: 1180
• Species: Drosophila melanogaster
• Sequence 2: NP_001261848.1
• Gene: Helz / 39613
• FlyBaseID: FBgn0036451
• Length: 2103
• Species: Drosophila melanogaster
• Alignment Length: 1412
• Identity: 302/1412 - (21%)
• Similarity: 474/1412 - (33%)
• Gaps: 449/1412 - (31%)

  Fly     3 VDTYAPSSALSFLDMDDNELLPGADTQPTQYDYRDFTMPSTSQSQTQNDQLEIAQRCSAGDSHPR 67
            :.:||.||:.|         ..|:.:          ||.|:|.|..:.:.|..|.:.:||...|
  Fly   217 IGSYASSSSSS---------STGSSS----------TMSSSSTSLHKTNDLLAAMKLTAGKHQP- 261

  Fly    68 LASITNDLADLQFEEEDDEPGSSYVKELPPHACKYCGI----------------HDPATVVMCNN 116
                  ...|....::.|:..       |...|.||.|                |.  .|:|.:.
  Fly   262 ------GSGDGSGSDQGDQAA-------PSTTCSYCTITFQTRNELRQHCQTEAHQ--KVIMSDE 311

  Fly   117 CR--KWFCNGRGST----------SGSHIINHLVRAKHREVTLHGEGPLGE-------------- 155
            .|  ||....||.|          |.:||.::..:.    |..||:..|.|
  Fly   312 GRDWKWRPPPRGYTLDTYSLCETFSEAHICHYGAQC----VEAHGQDELNEWKERFEYRRMRMQK 372

  Fly   156 -TILECYSCGVRNVFVLGFIPAKADSVVV--------LLCRQ----PCAAQNSLKDMNWDQEQWK 207
             ...|.|........:..:|.|.|...|:        ..|.|    ..:::.|.::..:..|..|
  Fly   373 ACEKELYGKSYTEQVLDRWIQATAPERVMCERVPDMEARCEQQLVTSISSKTSKREWLFQLETKK 437

  Fly   208 PL-------IADRCFLA---------------------WLVKQPSEQGQLRARQISAAQINKLEE 244
            ||       .|.|...|                     ||....|:..  .:.:.||..|:::..
  Fly   438 PLKAVALLQDAHRNHFALKSIKMCKPTESSMELKSDQEWLAGSSSQSE--TSNEDSATLIHEITV 500

  Fly   245 LWKENIEATFQDLEKPGIDSEPAHV------LLRYEDGYQYEKTFGPLVRLEAEYDQKLKESATQ 303
            .:...|..||:......:..||..|      :|...|..:.|:....::          ..|||
  Fly   501 EFHTEIYGTFRQAICFDVGQEPLLVRHLCVDVLPVNDAEKIEEIKRDII----------NSSAT- 554

  Fly   304 ENIEVRWDV------------GLNKKTIAY---------------------FTLAK-TDSDMKLM 334
                 ||||            |.:.||.||                     |||.: |..:.:|.
  Fly   555 -----RWDVANTQLTRFETTIGTHLKTEAYLSDLEHERELLERYPCPRAATFTLTQSTIVEKRLT 614

  Fly   335 HGD-ELRLH---YVGEL--------YNPWSEI---GHVIKVPDNFGDD---------------VG 369
            ..: ..|:|   .|.|:        ||..:.:   .:.|..|......               :|
  Fly   615 QNNYRSRIHELLSVEEIARYEQIARYNVRTRLTVASNYILTPAGMATSTAKYSLAGELFALMRLG 679

  Fly   370 LELKSSTNAPVKCTSNFTVDFIWK----CTSFDRMTRALCKFAIDRNSVSNFIYSRLLGHG---- 426
            .::...|:......||.:..:|.|    .:..|...||:.: |:..:...|.||.:|....
  Fly   680 KDISEDTSPGRLILSNCSSVYISKPEDPDSKADPTKRAVYE-ALIEDKGKNVIYLKLSAKCVEAM 743

  Fly   427 --RADSNDEV-----LFRGPQPK-------------LFSAPHL-----------------PDLN- 453
              :||:..||     |.|.|..:             :|.|..|                 |.||
  Fly   744 ALQADTELEVDIQFQLNRMPYCEWHNAVDKITDFRLIFPATELEPSIPWTPKKQWADSCEPKLNA 808

  Fly   454 --RSQVYAVKHAL--QRPLSLIQGPPGTGKTVTSATIVYQLVKLHGGTVLVCAPSNTAVD-QLTE 513
              |..|.|:..||  :.|..|:.||.|||||.|.|..:.||:......:|:|..||:|.| .:.|
  Fly   809 KQREAVNAITTALSIKLPPILLIGPFGTGKTYTLAQAIKQLLTQPEAKILICTHSNSAADLYIKE 873

  Fly   514 KIHRTNLKVVRVCAKSREAIDSPVSFLALHNQIRNMETNSELKKLQQLKDETGELSSADEKRYRN 578
            .:|          ....|.:.........:::..:...|..::| ..:.|..|           |
  Fly   874 YLH----------PWIEEGLKEATPLRVYYHKRWSATVNGVVQK-YCITDGVG-----------N 916

  Fly   579 LKRAAENQLLEAADVICCTCVGAGDGRLSRVK--FTSILIDESMQSTEPECMVPVVLG--AKQLI 639
            ..|.....::....|:....:......|...|  ||.|.:||:.|:.|.|.::|:.|.  :.:::
  Fly   917 FLRPTVEDIMRHRIVVVTLSISMELATLGLPKGLFTHIFLDEAAQAMECEAIMPLALANDSTRIV 981

  Fly   640 LVGDHCQLGPVVMCKKAARAGLSQSLFERLVVLGIRPFRLEV----QYRMHPELSQFPSNFFYEG 700
            |.|||.|:.|.:....|....|..||.|||.......|..::    .||.|..:.:|.|..|||
  Fly   982 LAGDHMQMSPELFSAFAKERKLHISLLERLYDHYPSNFPCKILLCENYRAHEAIIRFTSELFYE- 1045

  Fly   701 SLQNGVCAEDRRLKLDFPWPQPER--PMFFLVTQGQEEIAGSGTSFLNRTEAANVEKITTRFLK- 762
                      ::|......|:.:|  |:.|..|:|::....:.|:|.|..|...|.:..:...|
  Fly  1046 ----------QKLVASGKQPRHDRFYPLTFFTTRGEDVQDKNSTAFYNNAEVYEVVERVSELRKR 1100

  Fly   763 -----AGIKPEQIGIITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIASVDAFQGREKDIIIMSCV 822
                 ..:....|||:|||..      |..:.:..|..|....|.:..|...||::...:.:|.|
  Fly  1101 WPSAWGKLNDTSIGIMTPYSD------QVFRIRSELRKRRMGGISVERVLNVQGKQFRAVFLSTV 1159

  Fly   823 RSNER---QG-----------------IGFLNDPRRLNVALTRAKFGIIIVGNPKVLAK----QQ 863
            |:...   ||                 .|||::.:.||.|:|||:..:.:||:|..|..    ::
  Fly  1160 RTRRTCMPQGSAPGSASTTSIGDADADYGFLSNSKLLNTAITRAQSLVAVVGDPVALCSIGRCRK 1224

  Fly   864 LWNHLLNFYKDRKVLVEGSLNNLKESLIHFQKPKKLVNSMNIGAHFMSTIIADAKEVMVPGSIYD 928
            :|...:....:.|.|...:.:||:..|          :.:.:...::...:|..   .||.::..
  Fly  1225 VWERFIEICDEHKSLFGLTWSNLRSQL----------DGVELKRGYVLNPLAPE---FVPRALQP 1276

  Fly   929 RSGGYGQGRQMVGQSMNGGQYGGSGGGPYGNSPLGYGTPSSNSMVGFGLGNGGNGAAGGNNNFGG 993
            .:    ..|:.....:||.|:|..|.||.| .|..:.                 .|||    ..|
  Fly  1277 EA----YLREQAALYLNGPQHGHGGHGPPG-PPAHFA-----------------NAAG----MLG 1315

  Fly   994 AGPSWAAAHLHHDSIGYISNEHGAAALGNMPVPVGMFMNMSNIPPRFYNQHQQAIMAVKQNRAIQ 1058
            .||: ||||.        .|:..||          |..|...:....|:.| .|:||.    |:.
  Fly  1316 PGPA-AAAHQ--------MNQMAAA----------MAANQQQLTAHMYSTH-MAMMAA----AVG 1356

  Fly  1059 QQTGNFSPGNSGPGVTGVGVG---------------------------RSATPGGNKKTNKLGKS 1096
            .::|| .||....|..|.|.|                           |...|||...|.:.|
  Fly  1357 GKSGN-GPGPGTGGGPGPGPGPPPHYGGGGGGGGHMGMRGPPPPAPHLRGMPPGGPPPTQQPG-- 1418

  Fly  1097 RVTGGGTGGAPLTQGSSVCNAAPYSQHPMPLSLQMTQPSGFALSQQP 1143
               |.|.||.|         ..||.|:|   ::|..:|.....:|.|
  Fly  1419 ---GAGGGGGP---------PPPYGQYP---AMQHWRPPQQGQNQGP 1450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500	43/233 (18%)
		DNA2	122..897	CDD:224037	212/1000 (21%)
		Mis12	210..299	CDD:283509	18/115 (16%)
		AAA_19	458..>515	CDD:289986	23/59 (39%)
		AAA_12	661..857	CDD:289832	57/227 (25%)
Helz	NP_001261848.1	zf-CCCH	329..353	CDD:279036	5/27 (19%)
		TIGR00376	657..1236	CDD:273041	140/618 (23%)
		AAA	810..>886	CDD:99707	27/85 (32%)
		AAA_12	1003..1213	CDD:289832	57/226 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438986
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D27889at6960
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10887
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850